Disproportionality analysis of upadacitinib-related adverse events in inflammatory bowel disease using the FDA adverse event reporting system by Shiyi Wang, Xiaojian Wang, Jing Ding, Xudong Zhang, Hongmei Zhu, Yihong Fan, Changbo Sun

“…Subgroup analysis indicated that the most prevalent AEs among the elderly included pulmonary embolism, cataract, and sepsis, whereas the 18–65 age group most frequently reported acne, abdominal pain, and nasopharyngitis. The median onset time for AEs related to upadacitinib was 41.00 days (interquartile range [IQR] 10–141.5 days), with the majority occurring within 3 months of treatment initiation (n = 269, 66.09%), particularly in the first month (n = 171, 42.01%).ConclusionOur findings affirm clinical observations and reveal potential new AE signals for upadacitinib, underscoring the need for prospective clinical studies to verify these results and clarify their clinical relevance. …”
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A quantitative assessment of the time to complete the Master of Medicine research thesis in a cohort of paediatrics registrars at the University of the Witwatersrand, South Africa by J Parry, A Coovadia

“…The survey had a 70.5% response rate (n=148 respondents, of whom 141 fully completed the survey). The median (interquartile range) time to complete the MMed research thesis was 30 (21 - 42) months. …”
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The burden and outcomes of firearm injuries at two district-level emergency centres in Cape Town, South Africa: A descriptive analysis by L Bush, C Hendrikse, C Van Koningsbruggen, K Evans

“…Of the 776 patients with firearm injuries who were included, the median age was 27 years, and 91% were male. A total of 520 (67%) patients self-presented, and there were 18 (2.3%) deaths in the emergency centre and a further 23 (3%) as inpatients. …”
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Do shorter delays to care and mental health system renewal translate into better occupational outcome after mental disorder diagnosis in a cohort of Canadian military personnel who... by David Boulos, Mark A Zamorski

“…Taylor series linearisation methods and sample design weights were applied in generating descriptive and regression analysis statistics.Primary outcome The outcome was release from military service for medical reasons, assessed using administrative data for the 508 individuals with a mental disorder diagnosis.Results 17.5% (95% CI 16.0% to 19.0%) of the cohort had a mental disorder diagnosis after an Afghanistan-related deployment, of which 21.3% (95% CI 17.2% to 25.5%) had a medical release over a median follow-up of 3.5 years. Medical release risk was elevated for individuals diagnosed before 30 April 2008 relative to those with recent diagnoses (adjusted HR (aHR)=1.77 (95% CI 1.01 to 3.11)) and for individuals with a long delay to care (>21 months after return) relative to those with intermediate delays (8–21 months, aHR 2.47=(95% CI 1.28 to 4.76)).Conclusions Mental health services renewal in the CAF was associated with a better occupational outcome for those diagnosed with mental disorders. …”
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Interaction between walkability and fine particulate matter on ischemic heart disease: A prospective cohort study in China by Jiayun Zhang, Peng Shen, Yixing Wang, Zihan Li, Lisha Xu, Jie Qiu, Jingjing Hu, Zongming Yang, Yonghao Wu, Zhanghang Zhu, Hongbo Lin, Zhiqin Jiang, Liming Shui, Mengling Tang, Mingjuan Jin, Feng Tong, Kun Chen, Jianbing Wang

“…Joint effects were explored and visualized using a 3D wireframe plot. Results: Over a median follow-up of 5.14 years, 1735 incident cases of IHD were identified. …”
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Insights from serial cardiovascular magnetic resonance imaging show early progress in diastolic dysfunction relates to impaired right ventricular deformation by Sören J. Backhaus, Alexander Schulz, Torben Lange, Simon F. Rösel, Lennart S. Schmidt-Schweda, Shelby Kutty, Johannes T. Kowallick, Julia Treiber, Andreas Rolf, Samuel Sossalla, Gerd Hasenuß, Andreas Schuster

“…Repeat rest and exercise-stress CMR was performed in median 2.94 years after recruitment during which timeframe some HFpEF patients had undergone interatrial shunt device (IASD) implantation. …”
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Feasibility study to assess the delivery of a lifestyle intervention (TreatWELL) for patients with colorectal cancer undergoing potentially curative treatment by Annie S Anderson, Ronan E O’Carroll, Martine Stead, Robert J C Steele, Mary Wells, Maureen Macleod, Anna Campbell, Jacqui A Sugden, Jackie Rodger, Jennifer McKell

“…It was delivered in three face-to-face counselling sessions (plus nine phone calls) by lifestyle coaches over three phases (1: presurgery, 2: surgical recovery and 3: post-treatment recovery).Primary outcome Feasibility measures (recruitment, retention, programme implementation, achieved measures, fidelity, factors affecting protocol adherence and acceptability).Secondary outcomes Measured changes in body weight, waist circumference, walking and self-reported physical activity, diet, smoking, alcohol intake, fatigue, bowel function and quality of life.Results Of 84 patients diagnosed, 22 (26%) were recruited and 15 (18%) completed the study. Median time for intervention delivery was 5.5 hours. …”
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Real-world treatment patterns and clinical characteristics in patients with moderate-to-severe systemic lupus erythematosus: an analysis of the SLE Prospective Observational Cohort... by Raj Tummala, Richard A Furie, Laurent Arnaud, Eric F Morand, Martin Aringer, Stephanie Chen, Barnabas Desta, Alberta Hoi, Bo Ding, Christine Peschken, Jonatan Hedberg, Tina Grünfeld Eén, Alessandro Sorrentino, Danuta Kielar

“…In the overall population, median (IQR) SLEDAI-2K scores decreased within 12 months (baseline: 8.0 (6.0–12.0); 12 months: 4.0 (2.0–8.0)) and remained stable thereafter. …”
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Prevalence and correlates of burn-out among Nigerian medical doctors during the COVID-19 pandemic: a cross-sectional study by Ruth Eshikotse Pius, Janet Ngozi Ajuluchukwu, Alero Ann Roberts

“…Personal, work-related and patient-related burn-out were evaluated with the use of the Copenhagen Burnout Inventory.Results The number of doctors enrolled in this study was 251 with a median age of 34; 51.4% were males. The percentage of doctors who had personal, work-related and patient-related burn-out were 62.2%, 52.2 % and 27.5%, respectively. …”
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Integrating a quality improvement experiential platform into medical student education by Amy S. Stanley, René M. Kronlage, Miranda J. Reid, Hannah G. Rains, Colleen J. Kalynych, Michele N. Lossius, Janice A. Taylor, Carolyn K. Holland

“…This was shown through (1) a voluntary feedback survey that reported positive feedback from participants with 93% of respondents indicating they “strongly agreed” or “agreed” to positive perception questions; (2) significantly higher scores (p < 0.001) on the BASiC-QI Scale for project participants vs. non-participants; (3) the completion of 4.25 PDSA cycles per QI team; and (4) a 10.1% reduction in median patient time in clinic. Conclusions This study supports the utility of incorporating a student-led QI/PS interactive platform into student-run clinics to increase knowledge and attitude in implementing QI/PS endeavors while simultaneously improving clinic metrics and outcomes for patients.…”
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Tear glucose is associated with the presence and severity of diabetic retinopathy by Ningyao Cao, Lili Feng, Wei Xu, Fanglin He, Caiwen Xiao, Yan Liu, Weirong Xu, Jingjing Cui, Yuqian Guo, Lianqing Yao, Wenwen Xia, Fei Chen, Yong Li, Chuandi Zhou, Xiaofang Xu

“…Results In this study, 160 patients were included, with a median age of 64.0 years, and 88 (55.0%) patients were males. …”
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Planetary health education in undergraduate medical education in Germany: results from structured interviews and an online survey within the national PlanetMedEd Project by Fabio Grieco, Sandra Parisi, Anne Simmenroth, Michael Eichinger, Michael Eichinger, Janina Zirkel, Janina Zirkel, Sarah König, Jana Jünger, Jana Jünger, Eva Geck, Eva-Maria Schwienhorst-Stich

“…Based on integrated findings, 35 medical schools (90%) offered Planetary Health Education, with a median of two educational activities, including both stand-alone courses and lectures integrated into other courses. …”
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Frailty in older adults admitted to hospital: outcomes from the Western Sydney Clinical Frailty Registry by Julee McDonagh, Richard I Lindley, Karen Byth, Reejamol John, Caleb Ferguson

“…The primary outcome of this study was rehospitalisation and/or mortality at 12 months. Results Median age 82 years; half the cohort were classified as mild-moderately frail, and 21% were classified as severely frail. …”
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Racial and ethnic disparities in longitudinal trajectories of cardiovascular risk factors in U.S. middle-aged and older adults. by Matthew E Dupre, Radha Dhingra, Hanzhang Xu, Scott M Lynch, Qing Yang, Cassie Ford, Michael D Green, Ying Xian, Ann Marie Navar, Eric D Peterson

“…<h4>Results</h4>Among 10,292 participants (median age: 61), approximately 32% had an overall favorable profile of CVD risk factors. …”
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Immune gene features and prognosis in colorectal cancer: insights from ssGSEA typing by Anwen Huang, Jinxiu Wu, Jiakuan Wang, Chengwen Jiao, Yunfei Yang, Huaiwen Xiao, Li Yao

“…Results CRC samples were divided into high and low Immunity groups based on the median value of the immunity score. Between the two groups, a total of 1550 DEGs were identified and 395 differentially expressed immune-related genes (DE-IRGs) were identified by intersection with 2483 IRGs. …”
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Treatment Patterns and Outcomes Among Patients With Advanced or Recurrent Endometrial Cancer Initiating First-Line Therapy in the United States by Robert L. Coleman, Jamie Garside, Jean Hurteau, Joehl Nguyen, Monica Kobayashi

“…Of the patients who received at least 1 LOT, use of immunotherapy in the second-line setting was more common in the dMMR/MSI-H subgroup. Median overall survival ranged from 14.1 to 31.8 months across the 5 most frequently used first-line treatment regimens in the ≥1 LOT cohort and became shorter with each subsequent LOT. …”
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Space-time Characteristics of 16 PM2.5-bound Phthalates (PAEs) in Ambient Air from Shanghai: Profiles, Sources, Meteorological Effects, and Exposure Risks by Janvier Munyaneza, Md Faysal Hossain, Qilong Jia, Yusen Duan, Guangli Xiu

“…Densely populated sites and those situated in periphery of manufacturing areas seemed to exhibit higher mean concentrations of Σ6PAEs. Daily mean and median concentrations comprising all the species (Σ16PAEs) were generally higher in samples collected during colder periods (38.3 and 37.5 ng m−3, respectively) rather than within samples gathered in warmer periods (31 and 26.9 ng m−3, respectively), though there wasn’t a statistically significant difference between mean concentrations for both periods (ANOVA: p > 0.05, F stat. < F critical). …”
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Mortality and risk of cardiac complications among immediate survivors of accidental electric shock: a Danish nationwide cohort study by Christian Torp-Pedersen, Sam Riahi, Lars Køber, Steen Møller Hansen, Peter Søgaard, Rikke Mortensen, Søren Hjortshøj

“…Each patient was matched for age and sex with five random controls from the Danish population.Main outcome measures Mortality, cardiac procedures and cardiac diseases following electric shock.Results A total of 7390 electric shock patients were seen at an emergency ward and 4072 electric shock patients were admitted to a hospital. The median patient age was 28.6 years (Q1–Q3, 21.3–37.7) for the emergency ward patients and 26.4 years (Q1–Q3, 18.3–37.4) for admitted patients. …”
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The good, the bad, and the ugly: Compliance of e-pharmacies serving India and Kenya with regulatory requirements and best practices. by Gautam Satheesh, Sammy Masibo, Sasi Kumar Tiruttani, Irene Khayoni, Benjamin Palafox, Devaki Nambiar, Jaison Joseph, Emmanuel Kweyu, Abdul Salam, Francis Wafula, Catherine Goodman

“…On average, websites serving Kenya met 8.9 of the 12 (74%) Kenyan regulatory requirements, while those serving India met 7.5 of the 14 (54%) 'proposed requirements'. …”
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Human Papillomavirus, Human Immunodeficiency Virus, and Oral Microbiota Interplay in Nigerian Youth (HOMINY): A Prospective Cohort Study Protocol by Jia Liu, Esosa Osagie, Paul Akhigbe, Nosakhare Idemudia, Ozoemene Obuekwe, Ruxton Adebiyi, Nicolas Schlecht, Yana Bromberg, Fidelis E Eki-Udoko, Nosayaba Osazuwa-Peters, Modupe Oluseun Coker

“…This study aims to investigate oral HR-HPV susceptibility and persistence among children and adolescents living with HIV (CALHIV) and to understand the roles of perinatal HIV exposure, infection, antiretroviral treatment, and the oral microbiome.Methods and analysis This prospective cohort study is ongoing at the University of Benin Teaching Hospital (UBTH), Nigeria, involving mother-child pairs followed at 6-month intervals for 2 years. …”
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