Derivation of a simple risk calculator for predicting clinical worsening in patients with pulmonary hypertension due to interstitial lung disease by K. El-Kersh, R. Bag, N. Bhatt, C. King, A. Waxman, F. Rischard, H. Kim, D. Cella, E. Shen, SD Nathan

“…Background: Pulmonary hypertension due to interstitial lung disease (ILD-PH) portends very poor clinical outcomes, with a median survival time of 1.5 to 2 years. Currently, there is no tool to assess the risk of clinical worsening in patients with ILD-PH. …”
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Ibrutinib disrupts blood-tumor barrier integrity and prolongs survival in rodent glioma model by Sanghee Lim, Minhye Kwak, Jeonghan Kang, Melissa Cesaire, Kayen Tang, Robert W. Robey, William J. E. Frye, Baktiar Karim, Donna Butcher, Martin J. Lizak, Mahalia Dalmage, Brandon Foster, Nicholas Nuechterlein, Charles Eberhart, Patrick J. Cimino, Michael M. Gottesman, Sadhana Jackson

“…Finally, Ibrutinib, combined with doxil, prolonged median survival in rodent glioma models (27 vs. 16 days, p < 0.0001) with brain imaging showing a − 53% versus − 75% volume change with doxil alone versus combination therapy (p < 0.05). …”
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Investigation Report and Analysis Knowledge, attitudes and vaccination status regarding HPV vaccines among female healthcare workers at vaccination clinics in Beijing city: a surve... by Haikun QIAN, Wenyan JI, Luodan SUO

“…Respondents came from immunization clinics actually providing HPV vaccination services, with a clinic coverage rate of 64.09% (496/774). The median HPV knowledge composite score was 9 (IQR = 8 – 10). 1 520 respondents (79.92%) held positive attitudes toward HPV vaccination. …”
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Prognostic value of serum inflammatory markers in patients with esophageal squamous cell carcinoma undergoing surgery: a two-center retrospective cohort study by Yaqin Dong, Fan Wang, Jiaying Deng, Tong Tong, Xiangxun Chen, Liming Wu, Yichun Wang, Mei Kang, Yutong Xu, Guangjie Shi, Liyang Zhu

“…This study aimed to identify independent prognostic factors for patients undergoing operation for esophageal cancer and to construct a nomogram model for predicting median overall survival (mOS). Methods A cohort of 660 patients with esophageal cancer from two clinical centers in China was recruited, comprising a training cohort (n = 511) and a validation cohort (n = 149). …”
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Real-World Treatment Patterns, Survival, and Costs for Ovarian Cancer in Canada: A Retrospective Cohort Study Using Provincial Administrative Data by Manjusha Hurry, Shazia Hassan, Soo Jin Seung, Ryan N. Walton, Ashlie Elnoursi, Jacob D. McGee

“…The only treatment required for 74% of stage I patients and 54% of stage II patients was first-line (1L) platinum chemotherapy; in advanced stages (III/IV) 24% and 20%, respectively, did not receive further treatment after 1L therapy. The median overall survival (mOS) for the whole cohort was 5.13 years. …”
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Impact of the Timing of Enzyme Replacement Therapy Initiation and Cognitive Impairment Status on Outcomes for Patients with Mucopolysaccharidosis II (MPS II) in the United States:... by Karen S. Yee, David Alexanderian, Yidie Feng, Xiaowei Ren, Bernd Schweikert, Olulade Ayodele

“…Evaluation of developmental and behavioral signs and symptoms in the full study population showed that communication delay (70.0% of patients), cognitive delay (62.1%), behavioral problems (52.9%), and toileting delay (50.0%) were particularly common; earliest documented signs and symptoms were motor delay (median [range] age at first documentation: 4.2 [0.9-18.7] years) and behavioral problems (4.4 [0.6-13.7] years). …”
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Left atrial strain predicts paroxysmal atrial fibrillation recurrence after catheter ablation: a 1-year study using three-dimensional speckle-tracking echocardiography by Rui Zhang, He Li, Yan Wang, Tianle Yu, Jiacheng Li, Yumeng Wu, Zhiwen Yu, Cuixing Liang, Dan Yu, Li Xue

“…Conventional echocardiography and 3DSTE were performed prior to and one year(median period of 12.2 months) after RFCA. Global three-dimensional left atrial (LA) strain parameters, along with those of the left ventricle, were measured and analyzed statistically. …”
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Associations of prognostic nutritional index with cardiovascular all-cause mortality among CVD patients with diabetes or prediabetes: evidence from the NHANES 2005–2018 by WenYi Xu, Li Zhang, Li Zhang, QianKun Yang, Ying Cao, Rui Rao, Li Lv, Qin Cen, Qiong Wei, LuLing Yang

“…The predictive accuracy of PNI for survival outcomes was evaluated using time-dependent receiver operating characteristic curve (ROC) analysis.ResultsDuring a median follow-up of 61 months (interquartile range, 33-103 months), 507 of the 1509 (33.60%) diabetic or prediabetic CVD patients died. …”
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TIGIT inhibitor M6223 as monotherapy or in combination with bintrafusp alfa in patients with advanced solid tumors: a first-in-human, phase 1, dose-escalation trial by Wei Gao, Ping Hu, Aung Naing, Meredith McKean, Anthony Tolcher, Lillian L Siu, Keyvan Tadjalli-Mehr, Anja Victor, Emilia Richter, Marco A F Nogueira Filho, Thomas Kitzing, Stephan Gleicher, Daniel Holland

“…MTD was not reached. Overall, median overall survival and progression-free survival were 7.6 (95% CI 4.9, 12.0) and 1.4 (95% CI 1.3, 1.8) months, respectively. …”
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The synergistic effect of the triglyceride-glucose index and a body shape index on cardiovascular mortality: the construction of a novel cardiovascular risk marker by Hao-ming He, Ying-ying Xie, Qiang Chen, Yi-ke Li, Xue-xi Li, Sun-jing Fu, Na Li, Yan-ru Han, Yan-xiang Gao, Jin-gang Zheng

“…Results A total of 673 (3.9%) cardiovascular deaths occurred during a median follow-up of 8.92 years. Individuals with high TyG and high ABSI (TyG > 9.04 and ABSI > 0.085) were at the highest cardiovascular mortality risk both in individuals with (HR = 1.714, 95% CI 1.123–2.616) and without diabetes (HR = 1.402, 95% CI 1.003–1.960), suggesting a synergistic effect. …”
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Risk Factors Associated with Falls and Fractures Following Prescription of Opioids Among Privately Insured Patients with Osteoarthritis by Stuart Silverman, Patricia Schepman, J. Bradford Rice, Craig G. Beck, William Pajerowski, Alan G. White, Sheena Thakkar, Rebecca L. Robinson, Birol Emir

“…Spine (15.8%) and hip (12.5%) fractures were most common. Median time to fall or fracture was 18.6 and 13.9 months, respectively. …”
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Emergency and critical care medicine residents’ competency to identify patient ventilator asynchrony using a mechanical ventilator waveform analysis in Addis Ababa, Ethiopia: a mul... by Wegderes Bogale, Merahi Kefyalew, Finot Debebe

“…The overall competency of identifying PVA by MV waveforms was 30%. A median of 3 (IQR 1–4) PVAs were correctly identified. …”
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QuickStroop for screening for minimal hepatic encephalopathy in patients with cirrhosis by Christian Labenz, Simon J. Gairing, Leonard Kaps, Alena F. Ehrenbauer, Eva M. Schleicher, Sophie Mengel, Julius F.M. Egge, Maria M. Gabriel, Peter R. Galle, Heiner Wedemeyer, Alexander Zipprich, Cristina Ripoll, Robin Greinert, Benjamin Maasoumy

“…QuickStroop predicted PHES-MHE with a sensitivity of 74% and a specificity of 89%, and took a median of only 34.5 s to complete. The acceptable discriminative ability of QuickStroop was confirmed in the validation cohort (AUC 0.81). …”
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Effects of E-Cigarette Liquid Ratios on the Gravimetric Filter Correction Factors and Real-Time Measurements by Austin Close, Jane Blackerby, Heather Tunnell, Jack Pender, Eric Soule, Sinan Sousan

“…In addition, the aerosol size distribution and mass median diameter were measured for all five ECIG ratios. …”
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A pilot cluster randomized controlled trial assessing uptake of PrEP and contraception in hair salons in South Africa by Ingrid V. Bassett, Joyce Yan, Sabina Govere, Sthabile Shezi, Lungile M. Ngcobo, Shruti Sagar, Jana Jarolimova, Dani Zionts, Anele Khumalo, Zinhle Zwane, Christina Psaros, Nduduzo Dube, Robert A. Parker

“…Results Among 134 participants in intervention salons, the median age was 26 years (IQR 22–29). 75% reported visiting the salon at least every 2 months. 27% were using hormonal contraception at enrollment, 31% reported a self-perceived moderate or great chance of getting HIV in the next year, 33% thought their primary sex partner had other partners, 65% did not use condoms in the past month, and 11% reported intimate partner violence (IPV). …”
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Retrospective Analysis of RSV Infection in Pediatric Patients: Epidemiology, Comorbidities, Treatment, and Costs in Dubai (2014-2023) by Jean Joury, Nawal Al Kaabi, Sara Al Dallal, Bassam Mahboub, Mostafa Zayed, Mohamed Abdelaziz, Jennifer Onwumeh-Okwundu, Mark A. Fletcher, Subramanyam Kumaresan, Badarinath C. Ramachandrachar, Mohamed Farghaly

“…The total hospitalization cost was highest in patients <2 years, amounting to US $9 798 174 (median, US $2241.30). **Conclusion:** Among the RSV patients, 49.3% were <2 years of age and few had recognized risk factors. …”
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Keeping Active with Texting after Stroke (KATS): a single-arm feasibility and acceptability study of a behavioural intervention to promote community-based physical activity after s... by Gozde Ozakinci, Stephan U Dombrowski, Andrew Murphy, Albert Farre, Jenna Breckenridge, Jacqui H Morris, Linda A Irvine, Keith Jenkinson

“…All 28 participants who received at least one text message completed the study, indicating 100% retention. Median satisfaction score was 23/25 (range 12–25). …”
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Causal role of plasma liposome in diabetic retinopathy: mendelian randomization (MR) study by Kai Yin, Lu Ding, Xueyan Li, Yuqi Zhang, Siyu Song, Liyuan Cao, Ruixue Deng, Min Li, Zirui Li, Qinjing Xia, Daqing Zhao, Xiangyan Li, Zeyu Wang

“…We conducted a two-sample MR analysis, and statistical analysis were performed using the inverse variance weighted (IVW) with the addition of the MR-Egger, weighted median (WM), constrained maximum likelihood and model averaging (cML-MA) to test for causal associations between lipid levels and DR. …”
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Small Intestinal Bacterial Overgrowth Syndrome as a Risk Factor for Ventricular Tachycardia in Chronic Heart Failure with Left Ventricular Systolic Dysfunction by M. V. Fadeeva, M. R. Skhirtladze, V. T. Ivashkin

“…However, in patients with SIBOS, higher CRP values were observed (median and interquartile range: 3.6 (2.5; 4.1) vs 2.15 (0.4; 5.1); p = 0.041). …”
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Impaired creatinine-based estimated glomerular filtration rate in Thai individuals switching to dolutegravir: illustrating the role of cystatin C testing to aid clinical decision m... by Carlo Sacdalan, Curtis Austin, Aswathy Varma, Suteeraporn Pinyakorn, Eugène Kroon, Donn J. Colby, Phillip Chan, Orlanda Goh, Krittaporn Pornpaisakul, Jintana Intasan, Tassanee Luekasemsuk, Merlin L. Robb, Nitiya Chomchey, Nittaya Phanuphak, Jintanat Ananworanich, Sandhya Vasan, Denise Hsu, the SEARCH 010/RV254 study group

“…Methods Participants started Efavirenz (EFV)-based ART during AHI (n = 214) and switched to DTG-based ART after a median of 97 weeks (IQR 61–145). GFR was estimated by serum creatinine (eGFRcre) every 24 weeks before and after switch. …”
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