Immune dysfunction revealed by digital spatial profiling of immuno-oncology markers in progressive stages of renal cell carcinoma and in brain metastases by Wei Wei, Michael Hurwitz, Sabina Signoretti, Lucia Jilaveanu, Toni K Choueiri, David L Rimm, Adebowale Adeniran, Sandra Martínez, Harriet M Kluger, David A Schoenfeld, Myrto Moutafi, Dijana Djureinovic, Ross D Merkin, David A Braun, Fabio Parisi

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Hospitalisation rates for epilepsy, asthma and insulin-dependent diabetes in 796 190 school-aged children and young people with and without intellectual disabilities: a record-link... by Angela Henderson, Sally-Ann Cooper, Craig Melville, Michael Fleming, Gillian S Smith, Jill Pell, Deborah Cairns

“…After adjusting for prevalence, pupils with intellectual disabilities and epilepsy had more epilepsy-related admissions than their peers (adjusted Hazard Ratio (aHR) 2.24, 95% CI 1.97, 2.55). For emergency admissions, these stays were longer compared with controls (adjusted incidence rate ratio (aIRR) 2.77, 95% CI 2.13, 3.59). …”
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Risk factors for and incidence of osteoporosis in patients with breast cancer by gender : a nationwide cohort study by Jin Ah Lee, Hye Sun Lee, Soyoung Jeon, Dooreh Kim, YoungJoo Lee, SooYun Bae, Woo-Chan Park, Chang Ik Yoon

“…Endocrine therapy increased osteoporosis risk, particularly among females (hazard ratio [HR], 6.37; 95% confidence interval [CI], 3.74–10.89; p < 0.001). …”
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Characteristics and Health Risks of PM2.5-bound Metals in a Central City of Northern China: A One-year Observation Study by Jinhe Wang, Shuang Zhang, Xiaoguo Qiu, Kai Li, Jiarong Li, Yangang Ren, Chao Zhu, Xi Zhang

“…Regarding the human health risk, children were possibly more exposed to non-carcinogenic risks than adults, with hazard index (HI) values of 47.9 and 6.7, respectively. …”
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Inosine enhances the efficacy of immune‐checkpoint inhibitors in advanced solid tumors: A randomized, controlled, Phase 2 study by Haiqing Zhao, Wei Zhang, Yuting Lu, Yin Dong, Zhihao He, Hongchao Zhen, Qin Li

“…Results Among the 172 participants with advanced malignant solid tumors, 86 each were assigned to the inosine and non‐inosine groups, wherein the median PFS (95% CI) was 7.00 (5.31–8.69) and 4.40 (3.10–5.70) months, respectively (hazard ratio [HR] 0.63; 95% CI 0.44–0.90, p = 0.011), and the ORR was 26.7% and 15.1%, respectively (p = 0.061). …”
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Meta-analysis to evaluate the comparative effectiveness of enzalutamide and abiraterone acetate for first-line treatment of metastatic castration-resistant prostate cancer in real-... by Armen Aprikian, Amit Bahl, Aurelius Omlin, Giulia Baciarello, Abhiroop Chakravarty, Prashanth Kondaparthi, Georgia Gourgioti, Thomas McLean, Alexis Serikoff, Andrew Chilelli

“…A total of 17 studies reported hazard ratios (HRs) for OS, 11 of which were adjusted for baseline characteristics. …”
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Rechallenge therapy versus tyrosine kinase inhibitor (TKI) for advanced metastatic colorectal cancer: a retrospective study by Chenming Liu, Jintao Chen, Yuxing Liu

“…The result indicated that Eastern Cooperative Oncology Group (ECOG) score of 0–1 (hazard ratio [HR] = 0.03, 95% confidence interval [CI]: 0.01–0.17; P < 0.001) and chemotherapy rechallenge (HR = 0.43, 95% CI: 0.23–0.79; P = 0.007) were independent protective factors for overall survival (OS). …”
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Clinical treatment score Post-5 Years (CTS5) predicts the benefit of postmastectomy radiotherapy in patients with T1-2N1 luminal breast cancer by Ke Liu, Guan-Qiao Li, Si-Qi Li, Xue-Qin Chen, San-Gang Wu

“…The chi-square test, binomial logistic regression, Kaplan-Meier analysis, and multivariable Cox proportional hazard model were used for statistical analyses. Results: A total of 11190 patients were included with a median follow-up time of 76 months. …”
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Real-World Analysis of Weight Gain and Body Mass Index Increase Among Patients with HIV-1 Using Antiretroviral Regimen Containing Tenofovir Alafenamide, Tenofovir Disoproxil Fumara... by Bruno Emond, Carmine Rossi, Rachel Rogers, Patrick Lefebvre, Marie-Hélène Lafeuille, Prina Donga

“…Compared with TAF 25 mg, time-to-weight and BMI increase ≥5% in the other treatment cohorts were longer (hazard ratios ranged from 0.77 to 0.94), although findings were generally not statistically significant. …”
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Divergent thinking in groups during cold-water immersion is impaired by cold stress not the cold shock response by Max Kailler Smith, Max Kailler Smith, Rebecca Weller, Rebecca Weller, Tony Duong, Tony Duong, Rebecca McClintock, Rebecca McClintock, Matthew Peterson, Nathaniel Barr, Douglas M. Jones, Timothy L. Dunn

“…IntroductionA primary hazard of working in cold maritime environments is the potential for a substantial man overboard situation in freezing waters. …”
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Comprehensive Analysis of VOCs in an Industrial Harbor City: Spatiotemporal Distribution, Health Risk, and Potential Sources by Thi-Hieu Le, Chung-Shin Yuan, Chitsan Lin, Zhi-Ping Hsu, I-Hsin Hsu, Lin-Chi Wang

“…Cumulative non-carcinogenic hazard indices were less than 1 indicates an acceptable non-carcinogenic health concern. …”
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Effect of potent nucleos(t)ide analog on alpha fetoprotein changes and occurrence of hepatocellular carcinoma in patients with chronic hepatitis B by Qianqian Ma, Junzhao Ye, Ling Luo, Yanhong Sun, Wei Wang, Shiting Feng, Bing Liao, Bihui Zhong

“…Multivariate Cox regression showed that elevated liver stiffness with shear wave elastography (Hazard ratio (HR) = 1.05, 95% Confidence interval (CI) 1.03–1.08, P < 0.001) and abnormal AFP at baseline (HR = 1.00, 95% CI 1.00–1.00, P < 0.001) were independent risk factors for abnormal AFP in CHB patients, while shear wave elastography (HR = 1.07, 95% CI 1.02–1.12, P < 0.001) was also independent risk factor for HCC. …”
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Tumor characteristics and survival rate of axillary metastatic breast cancer patients: a three decades retrospective cohort study by Seyed Mohamad Sadegh Mousavi-kiasary, Mahdis Bayat, Fereshteh Abbasvandi, Batoul Khoundabi, Fatemeh Mousavi, Atieh Akbari, Maryam Bagherian, Afsoon Zandi, Behnam Honarvar, Mohammad Esmaeil Akbari

“…The pN0 group patients showed a significantly lower Hazard Ratio (HR) for DFS and OS compared to others. …”
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Exposure to high-temperature and high-humidity environments associated with cardiovascular mortality by Yalan Wu, Xiangrong Feng, Jinmei Li, Mengjun Li, Yao Wang, Weihui Lu, Huanhuan Luo

“…Long-term HTH environment exposure increased the risk of an abnormal low-density lipoprotein cholesterol (LDL-C) level (hazard ratio [HR], 1.30–2.44) and abnormal total cholesterol (TC) level (HR, 1.21–2.13), but the impact on high-density lipoprotein cholesterol (HDL-C) level was unclear. …”
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Pre-diagnostic risk factors for brain cancer incidence and survival: insights from the Golestan Cohort Study by Parisa Rezanejad-Asl, Peyvand Parhizkar Roudsari, Negar Rezaei, Maryam Sharafkhah, Gholamreza Roshandel, Hossein Poustchi, Sadaf Sepanlou, Reza Malekzadeh

“…Minimally adjusted and multiple Cox proportional hazards models were used to investigate the association of demographic and behavioral risk factors with brain cancer incidence and survival. …”
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Association of liver biopsy pathology on outcome of patients undergoing heart transplantation by Lauren S. Eichenwald, MD, Raffi Karagozian, MD, Adam J. Eichenwald, PhD, John Morrissey, MD MBA, Saurav Kini, MD, Ariella Stein, MSCIS-HI, Amanda R. Vest, MBBS MPH

“…Trend analysis was performed using Cox proportional hazard model, controlling for MELD-XI. At-risk period starts at the time of waitlist; the end of the follow-up period was mortality on the waitlist, mortality post-HT, or administrative censoring at the end of the study. …”
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Clinical Burden and Healthcare Resource Use of Asthma in Children in the UK by Gouia I, Joulain F, Zhang Y, Morgan CL, Khan AH

“…Risk of re-exacerbation was significantly increased for severe versus mild asthma (hazard ratio [95% CI]: 2.98 [1.90– 4.65], P< 0.001). …”
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Comparative survival outcomes of neoadjuvant and adjuvant therapy in patients with T1c, node-negative, triple-negative breast cancer: A population-based analysis by Yi-Zi Zheng, Jia-Qi Ying, Ting-Ting Wu, Yong-Hui Su, Ou-Chen Wang

“…Kaplan–Meier (KM) analysis and Cox proportional hazards models were performed to assess the prognostic factors for overall survival (OS) and breast cancer–specific survival (BCSS). …”
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A prediction nomogram for residual after negative pressure aspiration for endogenic cesarean scar ectopic pregnancy: a retrospective study by Yan Lei, Na Zhang, Yu Liu, Xin Du

“…Results Predictive factors included in the nomogram included age (hazard ratio [HR]: 1.220, 95% confidence interval [CI]: 1.135—1.316), BMI (HR: 0.890, 95% CI: 0.796—0.986), intraoperative major hemorrhage (HR: 4.457, 95% CI: 1.610—12.292), maximum diameter of the gestational sac (HR: 1.572, 95% CI: 1.295, 1.914), and thickness of the remaining muscle layer of the lower uterine segment (HR: 1.572, 95% CI: 0.014, 0.430). …”
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Diabetic retinopathy further increases risk of cardiovascular disease mortality in a high-risk cohort by Richard Kha, Yasemin Kapucu, Mayuri Indrakumar, George Burlutsky, Aravinda Thiagalingam, Pramesh Kovoor, Paul Mitchell, Gerald Liew

“…After controlling for age, sex, BMI, diabetes, total cholesterol, smoking status, hypertension, previous myocardial infarction and stroke, any DR was associated with 1.8-fold higher risk of CVD mortality (Hazard Ratio [HR] 1.84, 95% Confidence Interval [95% CI: 1.30–2.61]). …”
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