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11701
The development and evaluation of a tublysine-based antibody-drug conjugate with enhanced tumor therapeutic efficacy
Published 2025-02-01“…Tub114, a novel Tubulysin B analog with a hydrophilic ethylene glycol moiety, has been conjugated to the anti-HER2 antibody DX-CHO9, forming the ADC DX126-262. This study examines the efficacy, pharmacokinetics, and safety profile of DX126-262, with a focus on Tubulysin-associated liver toxicity. …”
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11702
CONSTRUCTIVE GEOMETRY IN IMPLEMENTATIONS OF MODERN 3D GRAPHICS
Published 2023-04-01“…In particular, the steps of creating a solid model of a pyramid, which is formed by cutting it off with a plane from a regular quadrangular pyramid, are illustrated by the basis of calculations and constructions, which are performed using techniques of constructive geometry. …”
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11703
Mellom skrifta og barnet – tre barnehagelærarar sine strategiar i høgtlesing av bildebøker med få ord og med fleire ord
Published 2025-02-01“…The research utilizes two forms of empirical material: (1) Three ECEC teachers have filmed two reading sessions each – one of a book with fewer words and one book with more words, and (2) video-supported conversations with the teachers, offering reflections on the reading sessions. …”
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11704
Trends in vegetation cover changes in Bonny area of the Niger Delta
Published 2013-07-01“…The one–layered forest has mangrove trees of 3-14 m high without undergrowth forming the only layer while the two-layered forest has a top layer made up of Rhizophora species (3-32 m high) depending on the height of trees at each site and a ground layer composed mainly of the fern Acrostichum aureum and seedlings of the tree species. …”
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11705
Exploring the antibacterial and anti-biofilm activity of two Iranian medical-grade kinds of honey on multidrug-resistant Pseudomonas aeruginosa
Published 2025-02-01“…Abstract Introduction Pseudomonas aeruginosa is a prominent multidrug-resistant and biofilm-forming bacteria. Mono-floral honey, enriched with a variety of biological compounds, can be categorized as medical-grade honey due to its notable pharmacological benefits. …”
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11706
Population structure, selection signal and introgression of gamecocks revealed by whole genome sequencing
Published 2025-02-01“…Gamecocks are distributed worldwide, forming different breeds and strains. However, the single or multiple origin of global gamecocks has not been fully established and much remains unknown about genetic introgression events between gamecocks and other chickens. …”
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11707
The sphingosine‐1‐phosphate signaling pathway (sphingosine‐1‐phosphate and its receptor, sphingosine kinase) and epilepsy
Published 2025-02-01“…Sphingosine‐1‐phosphate (S1P) is an important lipid molecule. It not only forms the basis of cell membranes but is also an important bioactive mediator. …”
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11708
Research of <i>PNPLA3</i> I148M Gene Polymorphism in Patients with Non-Alcoholic Fatty Liver Disease, with Liver Cirrhosis and with Hepatocellular Carcinoma
Published 2023-11-01“…The study was conducted according to the “case-control” design, three main groups were formed: a group with NAFLD (n = 46), a group with LC (n = 61), a group with HCC (n = 50), as well as a control group (n = 70), for all groups we performed genotyping of the rs738409 polymorphism of the PNPLA3 gene. …”
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11709
Variations in the physicochemical properties of soil, enzyme activities, and the characteristics of bacterial communities within algal biocrusts and subsoils across different plant...
Published 2025-04-01“…Among them, the ABSCs in the community of H. scoparium are not conducive to forming bacterial network modularity (Modularity= 0.336 < 0.4). …”
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11710
Laguna de fracasos
Published 2024-12-01“…We perform theories, we investigate modes of escaping the lineal narrativity, using polyphonic and choral forms of thinking / moving / saying / existing. We inhabit the irony of a virtuality that imposes a distance on us and at the same time it hacks all geographical borders. …”
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11711
Analisis Forensik Digital untuk Investigasi Kasus Cyberbullying pada Media Sosial Tiktok
Published 2024-10-01“…Abstract TikTok is currently a widely popular social media platform among users and is also a media where various forms of cyberbullying are encountered. Cases of cyberbullying on TikTok can be subject to legal prosecution through digital forensic investigations. …”
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11712
Results of Selective Biochemical Screening for Lysosomal Acid Lipase Deficiency and Sequencing of the <i>LIPA</i> Gene in the Risk Group Patients
Published 2025-02-01“…Samples from 2805 patients are collected as dried blood spots on filter paper test forms. Biochemical study of the lysosomal acid lipase (LAL) enzyme activity was carried out according to Hamilton’s protocol of, using 4-methylumbelliferyl palmitate as a substrate and LAL inhibitor Lalistat-2. …”
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11713
Fuzzy Inference System Mamdani dalam Prediksi Produksi Kain Tenun Menggunakan Rule Berdasarkan Random Tree
Published 2022-06-01“…This method uses the concept of a random tree decision tree in forming rules. The rules are made based on the criteria in determining the amount of woven fabric production, including production costs, demand, and stock. …”
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11714
Межмуниципальный анализ структуры и эффективности формирования бюджетов
Published 2024-12-01“…Cross-Municipal Analysis of Budget Structure and Forming Effectiveness // Research in Economic and Financial Problems. 2024. № 4. …”
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11715
Antagonism of Eucalyptus endophytic fungi against some important crop fungal diseases
Published 2025-02-01“…Endophytic fungi colonize plants without causing symptoms, throughout or at least a significant part of their life cycle, forming a plant-fungal association. In this study, endophytic fungi were isolated from Eucalyptus camaldulensis trees, and their antifungal activity was evaluated against four significant plant pathogens namely Botrytis cinerea, Fusarium oxysporum f. sp. lycopersici, Macrophomina phaseolina, and Rhizoctonia solani. …”
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11716
A Pilot Study Assessing Left Ventricle Diastolic Function in the Parasternal Long-axis View
Published 2024-11-01“…The study population of 40 (included rate 14%) was formed after the exclusion criteria were applied to 285 patients who met these conditions. …”
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11717
Distribution of Aeromonas bacterial population in water, sediment and Nile tilapia in fish culture pond, Guder, Ethiopia
Published 2020-07-01“…The level of bacterial population in water, sediment and fish tissue were done by following standard methods and expressed as colony-forming units (CFU) in water per milliliter (CFU ml-1), sediment and fish tissues(CFU g-1).The results revealed more bacterial population in sediment (3.43 x106 to 5.54 x 106 CFU g-1) than in water (1.45x106 to 4.0x106 CFU ml-1) and fish tissues (1.06 ± 1.10x104 to 1.74 ± 10.8x104 CFU g-1in gill filaments; 1.62 ± 11.2x104 to 2.82 ± 13.0x104 CFU g−1 in intestine from; and 0.82 ± 5.9x104 to 1.60 ± 12.1.6x104 CFU g-1; in kidney from 0.48 ± 5.0 to 0.77 ± 4.1x104 CFU g-1. in skin). …”
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11718
Assessing the Suitability of Snail-Shell Powder as a Partial Replacement of Cement in Concrete Production.
Published 2024“…It makes any shape when cast in any formwork and forms a solid mass when cured at a suitable temperature and humidity This research titled “Assessing the suitability of snail-shell powder as partial replacement of cement in concrete” aims at the utilization of snail shells as a partial replacement of ordinary Portland cement. …”
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11719
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11720
غوطهوری کاغذ در مومزنبورعسل امولسیونشده با روش اولتراسونیک و بررسی تأثیر آن بر ویژگیهای کاغذ...
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