Radiation dose and fraction in immunotherapy: one-size regimen does not fit all settings, so how does one choose? by Marka Crittenden, Sandra Demaria, C Norman Coleman, Jonathan Schoenfeld, Arta Monjazeb, Samir Khleif, Seema Gupta, Andrew Sikora, Zachary Morris, Chandan Guha, Stephen Shiao, Silvia Chiara Formenti, Bhadrasain Vikram, Mansoor M Ahmed

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Single-cell transcriptome-wide Mendelian randomization and colocalization reveals immune-mediated regulatory mechanisms and drug targets for COVID-19Research in context by Hui Ying, Xueyan Wu, Xiaojing Jia, Qianqian Yang, Haoyu Liu, Huiling Zhao, Zhihe Chen, Min Xu, Tiange Wang, Mian Li, Zhiyun Zhao, Ruizhi Zheng, Shuangyuan Wang, Hong Lin, Yu Xu, Jieli Lu, Weiqing Wang, Guang Ning, Jie Zheng, Yufang Bi

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Real-world data of dacomitinib as first-line treatment for patients with EGFR-mutant non-small-cell lung cancer by Ji Eun Shin, Hyun Ae Jung, Sehhoon Park, Jong-Mu Sun, Se-Hoon Lee, Jin Seok Ahn, Myung-Ju Ahn, Byoung Yong Shim

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Disproportionality analysis of upadacitinib-related adverse events in inflammatory bowel disease using the FDA adverse event reporting system by Shiyi Wang, Xiaojian Wang, Jing Ding, Xudong Zhang, Hongmei Zhu, Yihong Fan, Changbo Sun

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The management and clinical outcome of paracetamol poisoning in South African adults: A single-centre retrospective review by C Kotze, J Swanepoel, E C Kruger, E Decloedt

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Rapid response electroencephalography decreases time to seizure diagnosis in pediatric acute care patients by Nevedha Rajan, Toni Kavanagh, Maite LaVega‐Talbott, Sandeep Gangadharan

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Considerations for Establishing a Behavioral Policy-Making and Nudge Institution within the Country's Executive Structure by Seyed Kamal Vaezi, Maryam Darbandi

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Effects of irrigation and organic fertilizer on pumpkin yield, quality, and water-fertilizer use efficiency in arid northwest China by Meng Yin, Jinxia Zhang, Liangliang Du, Lin Ding, Tao Zhong, Pengliang Tian, Runheng Yang

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Non-classical pulmonary exacerbation in cystic fibrosis revealing ALK-Translocated lung cancer: A case report by Mohamad Hadhud, Johnathan Arnon, Anat Hershko-Moshe, Adi Hollander, Noa Hurvitz-Lehmann, Assaf Potruch, Henny Azmanov, Rottem Kuint, Nurith Hiller, Elie Picard, Naama Sebbag-Sznajder, Shira Leebhoff, Michael Wilschanski, Myriam Grunewald, Liron Birimberg-Schwartz, Malena Cohen-Cymberknoh

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Estimation of respiratory syncytial virus-associated hospital admissions in five European countries: a modelling studyResearch in context by Caroline Klint Johannesen, David Gideonse, Richard Osei-Yeboah, Toni Lehtonen, Ombeline Jollivet, Rachel A. Cohen, Arantxa Urchueguía-Fornes, María Herrero-Silvestre, Mónica López-Lacort, Rolf Kramer, Thea K. Fischer, Terho Heikkinen, Harish Nair, Harry Campbell, Michiel van Boven, Harish Nair, Hanna Nohynek, Anne Teirlinck, Louis Bont, Peter Openshaw, Andrew Pollard, Veena Kumar, Elizabeth Begier, Jim Janimak, Jenny Hendrix, Rolf Kramer, Alejandro Orrico Sánchez, Eva Molero

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Effect of rhGH treatment on lipidome and brown fat activity in prepuberal small for gestational age children: a pilot study by Lorena González, Carolina Gonzalez-Riano, Pablo Fernández-García, Rubén Cereijo, Aina Valls, Andrea Soria-Gondek, Nativitat Real, Belén Requena, Joan Bel-Comos, Patricia Corrales, David Jiménez-Pavón, Coral Barbas, Francesc Villarroya, David Sánchez-Infantes, Marta Murillo

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Jianpi Yiqi Busui prescription alleviates myasthenia gravis by regulating Th17 through the TAK1/P38 MAPK/eIF-4E signaling pathway by Zhuming Chen, Jing Lu, Tianying Chang, Dongmei Zhang, Yibin Zhang, Miao Liu, Tong Wu, Peng Xv, Jian Wang

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Free fatty acids may regulate the expression of 11β-hydroxysteroid dehydrogenase type 1 in the liver of high-fat diet golden hamsters through the ERS-CHOP-C/EBPα signaling pathway... by Dandan Liu, Peipei Tian, Yilin Hou, Tingxue Zhang, Xiaoyu Hou, Lifang Liu, Xiaolong Li, Kunjie Zheng, Chao Wang, Guangyao Song

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A dehazing and enhancement algorithm for heterogeneous images of underground mining environments in coal mines by Xuhui ZHANG, Yanbin XIE, Wenjuan YANG, Chao ZHANG, Jicheng WAN, Zheng DONG, Yanqun WANG, Jie JIANG, Long LI

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Inequalities in total fertility rate in Sierra Leone, 2008–2019 by Augustus Osborne, Umaru Sesay, Mohamed S. Bah, Camilla Bangura, Bright Opoku Ahinkorah

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Effectiveness of antipsychotic medication in patients with schizophrenia in a real world retrospective observational study in Ethiopia by Mulualem Kelebie, Getasew Kibralew, Gebresilassie Tadesse, Gidey Rtbey, Mekidem aderaw, Wondale Endeshaw, Mitiku Belachew, Mulu Muche, Diemesew Getnet, Setegn Fentahun

“…The antipsychotic drugs are high-affinity antagonists of dopamine D2 receptors that are most effective against psychotic symptoms, but antipsychotic drugs can have side effects that overshadow their advantages, like sedation, extrapyramidal symptoms, and weight gain, which are often experienced as adverse effects. …”
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Unpacking the benefits of black soldier fly frass fertilizer towards nematode suppression and potato production by Emmanuel O. Anedo, Emmanuel O. Anedo, Emmanuel O. Anedo, Dennis Beesigamukama, Benson Mochoge, Nicholas K. Korir, Solveig Haukeland, Solveig Haukeland, Xavier Cheseto, Moses Nyongesa, Patrick Pwaipwai, Sevgan Subramanian, Abdou Tenkouano, Betty Kibaara, Chrysantus M. Tanga

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Upadacitinib in active non-radiographic axial spondyloarthritis: 2-year data from the phase 3 SELECT-AXIS 2 study by Filip Van den Bosch, Atul Deodhar, Denis Poddubnyy, Walter P. Maksymowych, Désirée van der Heijde, Tae-Hwan Kim, Mitsumasa Kishimoto, Xenofon Baraliakos, Xianwei Bu, Ivan Lagunes-Galindo, In-Ho Song, Peter Wung, Koji Kato, Anna Shmagel

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Cell-free DNA: a metabolic byproduct with diagnostic and prognostic potential in rheumatic disorders by Fancheng Liu, Fancheng Liu, Yazhen Su, Yazhen Su, Xinling Liu, Li Zhao, Li Zhao, Zewen Wu, Zewen Wu, Yang Liu, Yang Liu, Liyun Zhang, Liyun Zhang

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Implementation of model-informed precision dosing for tamoxifen therapy in patients with breast cancer: A prospective intervention study by Ruben Y.M. van Nijnatten, Sanne M. Buijs, Bram C. Agema, Raphaël M.J. Fischer, Inge Ghobadi Moghaddam-Helmantel, Caroline M.E. Contant, Felix E. de Jongh, Auke M.T. Huijben, Manon Kop, Annemieke van der Padt-Pruijsten, Hanneke J.M. Zuetenhorst, Ron H.N. van Schaik, Birgit C.P. Koch, A. Jager, Stijn L.W. Koolen, Ron H.J. Mathijssen

“…It is converted by CYP2D6 into endoxifen, its most active metabolite. …”
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