JAK2 V617F as a Marker for Long-Term Disease Progression and Mortality in Polycythemia Vera and its Role in Economic Modeling by Jonas Hjelmgren, Kristoffer Nilsson, Gunnar Birgegård

“…**Objective:** We validate an economic model for PV that uses Janus Kinase 2 (JAK2) burden as a surrogate endpoint to predict DP (thrombosis, myelofibrosis, and acute leukemia) and overall survival (OS) based on progression-specific mortality. …”
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Genome-wide transcriptome analysis and drug target discovery reveal key genes and pathways in thyroid cancer metastasis by Minjing Zou, Amal Qattan, Monther Al-Alwan, Hazem Ghebeh, Naif Binjumah, Latifa Al-Haj, Khalid S. A. Khabar, Abdulmohsen Altaweel, Falah Almohanna, Abdullah M. Assiri, Abdelilah Aboussekhra, Ali S. Alzahrani, Ali S. Alzahrani, Yufei Shi

“…MethodsWe performed genome-wide transcriptome analysis comparing gene expression profile of metastatic thyroid cancer cells (Met) with primary tumor cells established from transgenic mouse models of papillary thyroid cancer (PTC), follicular thyroid cancer (FTC), poorly differentiated thyroid cancer (PDTC), and anaplastic thyroid cancer (ATC).ResultsGenes involved in tumor microenvironment (TME), inflammation, and immune escape were significantly overexpressed in Met cells. …”
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Artificial intelligence: a useful tool in active tuberculosis screening among vulnerable groups in Romania - advantages and limitations by Beatrice Mahler, Beatrice Mahler, Beatrice Mahler, Alexandru Stoichiță, Alexandru Stoichiță, Alexandru Stoichiță, Dragoș Băiceanu, Dragoș Băiceanu, Traian-Constantin Panciu, Traian-Constantin Panciu, Dragoș Dendrino, Dragoș Dendrino, Mihaela Mihai, Mihaela Mihai, Raluca Bobocea, Elmira Ibraim, Elmira Ibraim, Mara Bălteanu, Mara Bălteanu, Oana Popescu, Oana Popescu, Mădălina Oana Burecu, Mădălina Oana Burecu, Ioana Mădălina Moșteanu, Ioana Mădălina Moșteanu, Vanessa Veronese, Radu Matache, Radu Matache, Ioana Munteanu, Ioana Munteanu, Ioana Munteanu, Cristina Popa, Cristina Popa, Justina Antonela Dragomir, Justina Antonela Dragomir, Justina Antonela Dragomir

“…The current study highlighted, at an AI threshold value of 0.4, that 89% of the screened people benefited from a correct assessment using the AI associated with the radiological examination. ROC curve analysis indicates an AUC of 0.923 (95% CI:0.893–0.947; significance level p < 0.0001) which shows that the test has a high capacity to accurately detect individuals with TB and also to rule out those who do not have the disease, with sensitivity 87.1, specificity 91.6 and criterion >0.3585.ConclusionOur study brings to the fore the significance of integrating AI software X-vision with bacteriological diagnosis in detecting TB among vulnerable groups in Romania. …”
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Propuesta de rutas de conectividad para la conservación de la biodiversidad en Sierra Maestra, Cuba by Adonis Ramón Puebla, Yandy Rodríguez Cueto, Pedro M. Álvarez-Amargos

“…[Metodología]: Se desarrolla un modelo de costo-distancia en ArcGIS con base en un mapa de fricción o resistencia al desplazamiento, elaborado a partir de la selección y la evaluación de un grupo de criterios para establecer los niveles de dificultad para la conectividad en función de la pendiente del terreno, la cobertura del suelo, la red hídrica y vial, y la distribución de los asentamientos poblacionales. …”
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The Kerlan-Jobe Orthopaedic Clinic Shoulder & Elbow Score used as a Patient-Reported Outcome Measure for the Youth and High School Aged Baseball Athlete by Ryan Monti, Alicia Fernandez-Fernandez

“…# Background The Kerlan-Jobe Orthopaedic Clinic Shoulder & Elbow Score (KJOC) provides questions for the overhead athlete that can aid with determining if someone is throwing with or without pain. …”
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An in-vivo herb-drug interaction study of IME-9 and glimepiride in nicotinamide-STZ-induced diabetic rats by Archana K. Thikekar, Asha B. Thomas, Sohan S. Chitlange

“…This led to a reduction in Vd and CL together with an increase in t1/2 and mean residence time. …”
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Análisis comparativo de susceptibilidad de erosión y evaluación de incertidumbre en la subcuenca del Río Claro, Costa Rica by Iván Pérez-Rubio, Daniel Flores, Christian Vargas, Andreas Mende, Francisco Jiménez

“…Los mapas de susceptibilidad de erosión fueron validados independientemente por medio de la función características operativas del receptor (ROC, por sus siglas en inglés). [Resultados]: El modelo de redes neuronales artificiales obtuvo un poder predictivo superior al de regresión logística con base en el valor calculado del área debajo de la curva (AUC, por sus siglas en inglés). …”
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3-Acetyldeoxynivalenol induces pyroptosis in leydig cells via METTL3-mediated N6-methyladenosine modification of NLRP3 by Yangyun Wang, Chaoliang Shi, Wei Jiao, Xiaoxiang Wan

“…Additionally, we identified that METTL3 also methylates and stabilizes c-MyB mRNA, which subsequently binds to the promoter region of NLRP3, thereby enhancing its transcription. …”
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Clinical and measurement variables affecting halitosis intensity following cysteine challenge test by Wanki Lee, Jung Hwan Jo, Young-Seok Park, Ji Woon Park

“…The Community Periodontal Index of Treatment Needs (CPITN), Winkel’s Tongue Coating Index, and salivary flow rate were assessed. VSC levels significantly increased immediately after cysteine challenge (p < 0.001 for hydrogen sulfide, p < 0.001 with standard GC and p < 0.05 with portable GC for methyl mercaptan). …”
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Self-other distinction modulates the sense of self-agency during joint actions by Laura Zapparoli, Marika Mariano, Lucia Maria Sacheli, Tommaso Berni, Caterina Negrone, Carlo Toneatto, Eraldo Paulesu

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Sciatic nerve analysis in thyroid hormone transporters Mct8 and Oatp1c1 knockout mice by Steffen Mayerl, Andrea Alcaide Martin, Reinhard Bauer, Heike Heuer

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Intra-specific variation in mortality of even-aged Cryptomeria japonica (L. f.) D. Don. forests can be explained using relationships among long-term stand characteristics by Keiko Fukumoto, Tomohiro Nishizono, Fumiaki Kitahara

“…Competition, individual size, and stand density were selected for the best logistic model (area under the curve (AUC) = 0.74, Brier score = 0.042), whereas age and site productivity were not (p > 0.05). …”
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Association between red blood cell distribution width-to-albumin ratio at admission and all-cause mortality in patients with acute pancreatitis based on the MIMIC-III database. by Qingsong Wu, Lianyi Liao, Qingjun Deng

“…The receiver operating characteristic (ROC) analysis indicated that RAR had a moderate predictive value for all-cause mortality at 28 days, with an area under the curve (AUC) of 0.669 (95%CI, 0.617-0.720; p<0.05), and the cutoff value was 4.39. …”
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Range of Motion and Muscle Stiffness Differences in Junior Tennis Players with and without a History of Shoulder Pain by Joshua Colomar, Javier Peña, Jordi Vicens-Bordas, Ernest Baiget

“…It was hypothesized that players with a history of shoulder pain would show a reduced glenohumeral internal rotation (IR) and total arc of motion (TAM) and increased stiffness in internal rotator muscles compared to those without shoulder pain…”
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Evaluation Effective Dose for Patients Undergoing Dental X-Ray Examination by Edrees M. Tahir Nury, Bayan Saber Ibrahim

“…For 16-30 years old were 3.270 μSv, 1.170 μSv forfemales and males, respectively. …”
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The Clinical Utility of the Seated Wall Angel as a Test with Scoring by Chad Kofoed, Allison Palmsten, Jonathon Diercks, Michael Obermeier, Marc Tompkins, Terese L Chmielewski

“… # Results Mean (SD) SWA score on the injured side was significantly lower than the uninjured side at initial testing \[1.6 (1.0) vs 2.2 (1.1), p = 0.045] and significantly increased at follow-up testing \[2.4 (1.0), p = 0.041]. …”
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Shoulder and Hip Range of Motion and Strength Changes Throughout a Season in College Softball Players by Cameron R Guy, Giorgio Zeppieri Jr., Michelle L Bruner, Katie Davis, Kevin W Farmer

“…Subjects underwent passive ROM (External rotation \[ER\], internal rotation \[IR\], total arc of motion \[TAM\]) and strength (ER/IR at the shoulder, abduction/extension at the hip) measurements at preseason and postseason timepoints…”
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Trajectories of systemic immune inflammation index and mortality risk in patients with moderate-to-severe traumatic brain injury: a retrospective cohort study by Zhiyong Tang, Zhiyong Tang, Canlin Liao, Zerui Zhuang, Zhennan Xu, Mingfa Liu, Haixiong Xu

“…Compared to patients in Group 1, those in Groups 2 and 3 had a higher risk of all-cause hospital mortality (odds ratio [OR] 4.09; 95% confidence interval [CI] 1.21, 19.75) and (OR 5.84; 95% CI 1.52, 30.67), respectively. ROC analysis revealed an area under the curve (AUC) of 0.838, sensitivity: 75.0%, and specificity: 83.8% for mortality in this cohort.ConclusionThis study identified three distinct SII trajectories, suggesting that post-TBI SII trajectories are heterogeneous patterns associated with mortality. …”
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Comparative Analysis of Utility and Efficacy of Ozone Therapy versus Laser Therapy in Periarthritis Shoulder by Sunil Kumar, Harish Kumar, Prashant Pratap Singh, Dinesh Kumar, Vyutpanna Mishra, Ishan Ahmad

“…Introduction: Adhesive capsulitis of shoulder due to uncertain etiology of glenohumeral joint characterized by spontaneous onset of pain and reduction in the arc of active and passive movements at glenohumeral joint and essentially normal radiograph. …”
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Real-World Parkinson&#x2019;s Hand Tremor Detection Using Ensemble Learning Techniques by Sungwook Hur, Jieming Zhang, Moon-Hyun Kim, Tai-Myoung Chung

“…The results of our five-fold cross-validation experimental evaluation using the PD-BioStampRC21 dataset show that our method achieved an accuracy of 86.67% and an AUC score of 95.56%, representing a significant improvement over the baseline model&#x2019;s accuracy of 72.67% and surpassing other existing methods. …”
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