Real-Life Experiences with Telaprevir in the Treatment of Chronic Genotype 1 Hepatitis C — The TEPS Study by T. Berg, P. Buggisch, D. Hueppe, S. Mauss, H. Wedemeyer, G. Teuber, T. Lutz, K. Stein, S. Wegner, H. Hinrichsen

“…To assess the implementation of therapy stopping rules or shortening of the treatment and their impact on sustained virological response (SVR), as well as the safety and efficacy of the TVR-based therapy during routine daily treatment of patients in Germany.Materials and Methods. 802 patients were assessed (272 treatment naïve, 520 pre-treated) in the noninterventional, multi-center study.Results. 56.6 % of the patients achieved SVR. …”
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Efficient Moving Object Segmentation in LiDAR Point Clouds Using Minimal Number of Sweeps by Zoltan Rozsa, Akos Madaras, Tamas Sziranyi

“…We propose semantic information usage for multi-frame instance segmentation in order to enhance performance measures. …”
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Choanal Atresia: Clinical Features and Factors Affecting Its Surgical Outcomes by Abhilasha Somashekhar, Prem Kumar, Sandhya Poothatta Manolikandy, Syed Mohammed Shoib

“…Conclusion: Management of choanal atresia involves multi-disciplinary approach and preventing restenosis is a challenge. …”
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First scientific research on common bottlenose dolphins in the Calabrian (Italy) Ionian Sea by Maria Assunta Menniti, Adriana Vella, Jessica Alessi

“…The project involved a multi-action approach including scientific field research, citizen science in order to increase the knowledge and awareness regarding the marine environment and dolphins’ conservation, and removal of the marine litter in the SAC Fondali di Stalettì in order to reduce the negative impact these could have on the health of the bottlenose dolphins (entrapment in abandoned fishing ghost nets, plastic ingestion, etc.). …”
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Trichoderma collection from Brazilian soil reveals a new species: T. cerradensis Sp. nov. by Gustavo Henrique Silva Peixoto, Rildo Alexandre Fernandes da Silva, Ana Beatriz Zacaroni, Thais França Silva, Priscila Chaverri, Priscila Chaverri, Danilo Batista Pinho, Sueli Corrêa Marques de Mello

“…Most of the isolates were identified within 17 known species, whereas Trichoderma inhamatum and T. dorothopsis were synonymized under T. lentiforme and T. koningiopsis, respectively, based on multi-locus phylogenetic analysis and GCPRS criteria. …”
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Therapeutic effects of Salvadora persica (Miswak) on patients with mild to moderate gingivitis. by Kawa F. Dizaye, Zainab Yalman Othman

“…Group 1 used S. persica chewing stick only; group 2 used toothbrush only; group 3 used both S. persica and toothbrush, group 4 used S. persica mouthwash and toothbrush; while group 5 used chlorhexidine mouthwash and tooth-brush. The patients’ mouths were examined, recording clinical indices before and after four weeks from the administration of treatments. …”
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Natural compounds in the management of polycystic ovary syndrome: a comprehensive review of hormonal regulation and therapeutic potential by Jingyi Yuan, Zhenmin Li, Yongjiang Yu, Xiuge Wang, Yunyun Zhao

“…Substances such as myo-inositol, resveratrol, berberine, and quercetin have shown promise in mitigating PCOS symptoms. Their multi-target properties offer the potential to achieve outcomes unattainable by single-target pharmaceuticals, particularly in managing heterogeneous conditions. …”
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RETRACTED: Robot Path Planning Method Based on Indoor Spacetime Grid Model by Huangchuang Zhang, Qingjun Zhuang, Ge Li

“…Then, experiments are carried out on the multi-group path planning algorithms of the robot under the spacetime grid, and the feasibility of the STA* algorithm under the indoor spacetime grid and the superiority of the spacetime grid are verified.…”
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“An Intense Level of Self-regulation”: Technological Opportunities and Limitations of Online Intergroup Dialogue by Grant Jackson, Sarah Schiffecker, Oleksandra Poquet

“…In this study, we interviewed 16 college students who had participated in IGD via Zoom regarding their online IGD experience, illuminating a variety of opportunities and limitations related to students’ use of cameras, microphones, and the chat feature; the physical spaces in which students experienced their online IGD; the online display of students’ IGD peers; students’ engagement in multi-tasking during IGD sessions; students’ experiences of small group activities in “breakout rooms”; and how the online delivery of IGD promoted and constrained students’ sense of equity and equality throughout their IGD experience. …”
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Case report of familial hypercholesterolemia with internal carotid neck swelling by Sudesh Kumar, Prajna Ray, Ranita Sahana

“…Familial hypercholesterolemia is a multi-gene disorder affecting 1 in 200-500 individual which is characterized by increased level of total cholesterol and low density lipoprotein (LDL) which deposit cholesterol reach protein leading to xanthomas, corneal arcus and prone to develop risk for atherosclerosis and coronary heart disease. 11 year female, born of consanguineous marriage attended with yellowish patches (Xanthelasma) bilaterally present over upper eyelid, buttock since 5-6 years. …”
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MDCKE: Multimodal deep-context knowledge extractor that integrates contextual information by Hyojin Ko, Joon Yoo, Ok-Ran Jeong

“…To address this issue, this study introduces a Multimodal Deep-Context Knowledge Extractor (MDCKE) that generates hierarchical multi-scale images and captions from original images. …”
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Electro-optic cavities for in-situ measurement of cavity fields by Michael S. Spencer, Joanna M. Urban, Maximilian Frenzel, Niclas S. Mueller, Olga Minakova, Martin Wolf, Alexander Paarmann, Sebastian F. Maehrlein

“…To enable simultaneous intra-cavity sampling alongside excited-state material control, we design a tunable multi-layer cavity, enabling deterministic design of hybrid cavities for polaritonic systems. …”
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Clinical and dermoscopic assessment of the efficacy of topical trichloroacetic acid 70% versus methoxsalen 0.2% paint in stable acral vitiligo by Ahmed R. Elshahed, Amr M. Ammar, Abdallah M. Ali, Mohamed L. Elsaie

“…TCA 70% had a lower effective rate than other studies probably due to resistance of acral vitiliginous lesions to treatment in comparison to other sites of the body. Further larger multi centre studies with different concentration and combination modalities are required to detect promising treatments for vitligo.…”
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Recent centennial drought on the Tibetan Plateau is outstanding within the past 3500 years by Yu Liu, Huiming Song, Zhisheng An, Qiang Li, Steven W. Leavitt, Ulf Büntgen, Qiufang Cai, Ruoshi Liu, Congxi Fang, Changfeng Sun, Kerstin Treydte, Meng Ren, Lidong Mo, Yi Song, Wenju Cai, Quan Zhang, Weijian Zhou, Achim Bräuning, Jussi Grießinger, Deliang Chen, Hans W. Linderholm, Ashish Sinha, Hai Cheng, Lu Wang, Ying Lei, Junyan Sun, Wei Gong, Xuxiang Li, Linlin Cui, Liang Ning, Lingfeng Wan, Thomas W. Crowther, Constantin M. Zohner

“…Here, we present a precisely-dated 3476-year precipitation reconstruction derived from tree-ring δ18O data on the Tibetan Plateau, representing one of the few multi-millennia-long annually-resolved terrestrial δ18O records to date. …”
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Instance-level semantic segmentation of nuclei based on multimodal structure encoding by Bo Guan, Guangdi Chu, Ziying Wang, Jianmin Li, Bo Yi

“…The framework incorporates: (1) A multi-scale feature fusion and knowledge distillation module utilizing the Contrastive Language-Image Pre-training (CLIP) model’s image encoder; (2) A method to transform morphological features of cells into textual descriptions for semantic representation; and (3) A graph neural network approach to learn spatial relationships and contextual information between cell nuclei. …”
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Enhancing vaccine clinical trials participation among elderly: challenges and strategies by Paul Gillard, Samer Nakhle, Darin Brimhall, Ouzama Henry, Narcisa Mesaros

“…However, unique challenges, including multi-morbidities, frailty, and ethically sound informed consent in those with cognitive deficits, require continuous careful reassessments and flexibility. …”
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Coordination of preventive, emergency and restorative trading strategies under uncertain sequential extreme weather events by Xuemei Dai, Jing Zhou, Xu Zhang, Kaifeng Zhang, Wei Feng

“…Then, a joint LE and LF market transaction model is developed to optimize multi-stage trading and minimize overall losses throughout SEWEs. …”
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Upholding United Nations Global Legitimacy in Human Rights Protection and Humanitarian Assistance within the European Union: A Legal Overview of the EU-UN Natural Partnership by Nives Mazur Kumrić

“…Thus, the paper combines doctrinal legal research with the socio-legal approach in outlining the specificities of the EU-UN multi-layered cooperation with respect to human rights protection and humanitarian assistance.…”
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Brittleness evaluation of main coal seams in Permian Taiyuan-Shanxi formations, Baode block, Ordos Basin: based on a convolutional neural network method by Qingfeng ZHANG, Ziling LI, Jikun ZHANG, Shuai HAO, Xiaoguang SUN, Yanjie SHANG, Yun ZUO

“…In this study, a convolutional neural network (CNN) was utilized to construct a conversion model between experimentally obtained elastic modulus, Poisson's ratio, and multi-logging curves. Based on this method, rock mechanical profiles were further established, enabling quantitative evaluation of brittleness. …”
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Pre-therapeutic efficacy of the CDK inhibitor dinaciclib in medulloblastoma cells by Marta Buzzetti, Sonia Morlando, Dimitrios Solomos, Ammara Mehmood, Alexander W. I. Cox, Mattia Chiesa, Yuri D’Alessandra, Michela Garofalo, Caroline H. Topham, Gianpiero Di Leva

“…Together, these findings highlight the potential of multi-CDK inhibition by dinaciclib as an alternative option to CDK4/6 specific inhibition, frequently associated with drug resistance in patients.…”
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