Dietary index for gut microbiota and its protective role against kidney stones: evidence of diabetes as a mediator from NHANES cross-sectional data by Lei Wang, Junjun Wu, Ziwen Jiang, Chao Wang, Fuxiang Lin, Yuxiang Zhong, Pengpeng Zhao, Wei Wei, Jianhua Huang, Zhanping Xu

“…The role of DI-GM and its mediation by diabetes in KS pathogenesis remains unclear.ObjectiveTo investigate the association between DI-GM and KS prevalence, assess the mediation effect of diabetes, and explore subgroup-specific effects and underlying mechanisms.MethodsA cross-sectional analysis of NHANES (2007–2018) data was conducted using a stratified, multistage probability sampling design. …”
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Non-cancerous CT findings as predictors of survival outcome in advanced non-small cell lung cancer patients treated with first-generation EGFR-TKIs. by Pakorn Prakaikietikul, Pattraporn Tajarenmuang, Phumiphat Losuriya, Natee Ina, Thanika Ketpueak, Thanat Kanthawang

“…<h4>Purpose</h4>To identify non-cancerous factors from baseline CT chest affecting survival in advanced non-small cell lung cancer (NSCLC) treated with first-generation Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors (EGFR-TKIs).<h4>Methods</h4>Retrospective study of 172 advanced NSCLC patients treated with first-generation EGFR-TKIs as a first-line systemic treatment (January 2012 to September 2022). …”
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Smart Pharmaceutical Monitoring System With Personalized Medication Schedules and Self-Management Programs for Patients With Diabetes: Development and Evaluation Study by Jian Xiao, Mengyao Li, Ruwen Cai, Hangxing Huang, Huimin Yu, Ling Huang, Jingyang Li, Ting Yu, Jiani Zhang, Shuqiao Cheng

“…ObjectiveThis study aims to develop and establish a stand-alone diabetes management service system designed to enhance self-management support for patients, as well as to assess its performance with experienced health care professionals. MethodsDiabetes Universal Medication Schedule (DUMS) system is grounded in official medicine instructions and evidence-based data to establish medication constraints and drug-drug interaction profiles. …”
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Efficacy and Safety of Cataract Surgery Combined with Ab Interno Canaloplasty and Micro-Trabecular Bypass Stent Surgery in Open-Angle Glaucoma by Porter MS, Flowers A, Wood BP, Gallardo MJ

“…Matthew S Porter,1 Addie Flowers,1 Brandon P Wood,1 Mark J Gallardo2 1Texas Tech University Health Sciences Center School of Medicine, Lubbock, TX, USA; 2El Paso Eye Surgeons, El Paso, TX, USACorrespondence: Matthew S Porter, Department of Ophthalmology and Visual Sciences, Texas Tech University Health Sciences School of Medicine, 3601 4th St, Lubbock, TX, 79430, USA, Tel +1-806-742-2011, Email [email protected]: To evaluate the effectiveness of canaloplasty via an ab-interno technique using the iTrack (Nova Eye Medical, Fremont, USA) combined with microtrabecular bypass stent surgery with the Hydrus microstent (Ivantis, Inc, Irvine, CA) following cataract surgery (CE) in patients with primary open-angle glaucoma (POAG).Methods: A retrospective, two-center, case series of 51 POAG eyes that underwent phacoemulsification followed by canaloplasty combined with microtrabecular bypass stent surgery. …”
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Cluster analysis of cutting technique—a valuable approach for assessing anterior cruciate ligament injury risk? by Lasse Mausehund, Anri Patron, Sami Äyrämö, Sami Äyrämö, Tron Krosshaug

“…By combining multiple biomechanical variables, cluster analyses could help us identify safe and risky cutting technique strategies.PurposeTo identify common movement strategies during cutting maneuvers and to assess their association with ACL injury risk.MethodsA total of 754 female elite handball and football players, including 59 with a history of ACL injury, performed a sport-specific cutting task while 3D biomechanics were recorded. …”
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Immune profiling of human vestibular schwannoma secretions identifies TNF-α and TWEAK as cytokines with synergistic potential to impair hearing by Sasa Vasilijic, Richard Seist, Zhenzhen Yin, Lei Xu, Konstantina M. Stankovic

“…This knowledge gap significantly limits the development of effective treatments aimed at preventing, stabilizing, or reversing VS-induced SNHL. Methods To identify effector molecules involved in VS-induced SNHL, we analyzed 47 immune-related factors secreted by tumor tissue in over 50 patients with sporadic VS and studied their correlation with preoperative hearing ability and tumor size. …”
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Circular RNA encoded by PPARG in the peripheral blood and a lipopolysaccharide-induced cardiomyocyte inflammation model is identified as a marker of fulminant myocarditis by Shasha Huang, Shumin He, Fei Xiao, Yang Zhou, Su Lyu

“…This study attempted to identify the abnormal expression of circRNAs in the peripheral blood of patients with FM and to evaluate the potential diagnostic value. Methods Peripheral blood was collected from 5 children with FM and 5 sex- and age-matched healthy controls; total RNA was extracted from each sample, and the extracted RNA from each group was pooled. …”
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Laser Based ¹³C-urea Breath Test in Quantitative Assessment of Bacterial Colonization, Severity of Inflammation and Atrophy in Gastric Mucosa by E. V. Stepanov, V. T. Ivashkin

“…To analyze the dependence of the results of diode laser spectroscopy (DLS) based 13C-UBT on age, nosology, activity and severity of the inflammatory process, the degree of atrophy and metaplasia.Materials and methods. The 13C-UBT DLS was performed in 525 patients before the start of eradication therapy and in 196 patients 10–12 weeks after its completion. …”
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Effect of COVID-19 Lockdown on Alcohol Consumption Among the Youths in Kampala, Uganda. A Cross-Sectional Study by Namiiro AM, Audo R, Nannungi CD, Pitua I, Kiberu D, Talemwa P, Mujuni E, Lwesabula A, Ageimo P, Khaukha AZ, Kuol MJ, Egaru L, Koire M, Ssewante N

“…This study assessed the impact of the COVID-19 lockdown on alcohol consumption among youths in Kampala, Uganda.Methods: A quantitative cross-sectional study among randomly selected youth aged 18– 35 years living in the five divisions of Kampala. …”
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Modulating the anti-inflammatory and barrier protective effects on intestinal epithelial cells utilizing an aqueous Aspalathus linearis extract in vitro by Shana De Bruyn-Orr, Stefan Abel, Mariam Rado, Mariska Lilly

“…Purpose: The study aims to compare the anti-inflammatory and barrier protective effects of an unfermented and fermented rooibos aqueous extract on intestinal porcine epithelial cells (IPEC-J2). Methods: Aqueous extracts of unfermented and fermented rooibos were prepared, and chemical and antioxidant analysis were performed of each extract. …”
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Flow cytometric characterisation of acute leukaemia in adolescent and adult Ethiopians by Jemal Alemu, Balako Gumi, Aster Tsegaye, Abdulaziz Sherif, Fisihatsion Tadesse, Amha Gebremedhin, Rawleigh Howe

“…Objective: This study aimed to determine the immunophenotypes of acute leukaemia by flow cytometry at Tikur Anbessa Specialised Hospital, Addis Ababa, Ethiopia. Methods: A cross-sectional study was conducted on adolescent and adult inpatients consecutively admitted from April 2019 to June 2021. …”
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A nomogram for predicting mortality risk in geriatric patients with hip fractures complicated by pneumonia: A multicenter study by Kaiming Zhang, Xiangwei Li, Yujia Xiao, Cheng Zhou, Yu Liu, Fan Zhen, Hao Zhang, Mao Nie

“…This study aimed to analyze demographic characteristics, mortality rates, postoperative outcomes, and perioperative comorbidities, identify risk factors for mortality, and develop a nomogram for predicting the prognosis of these patients. Methods: Data on patients hospitalized for arthroplasty for hip fractures from 2020 to 2023 at three hospitals were retrospectively analyzed. …”
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Small Intestinal Bacterial Overgrowth Syndrome as a Risk Factor for Ventricular Tachycardia in Chronic Heart Failure with Left Ventricular Systolic Dysfunction by M. V. Fadeeva, M. R. Skhirtladze, V. T. Ivashkin

“…To identify the relationship between rhythm disturbances, including ventricular tachycardia (VT), and the small intestinal bowel bacterial overgrowth syndrome in chronic heart failure (CHF) with left ventricular systolic dysfunction. Materials and methods. The study included 60 patients with CHF with systolic dysfunction of the left ventricle (left ventricular ejection fraction less than 50 %). …”
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Co-modulation of a circular form of PCDH11Y during neuroendocrine differentiation of prostate cancer by Giovanni Pecoraro, Ilaria Leone, Silvia Nuzzo, Santiago Negueruela, Giovanni Smaldone, Lorena Buono

“…Circular RNAs (circRNAs) have emerged as potential biomarkers due to their stability and tissue-specific expression.MethodsIn this study, we investigated the circRNA landscape during neuroendocrine transdifferentiation (NED) of PC cells using the androgen-sensitive LNCaP and androgen-insensitive DU145 cell lines. …”
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“Effect of oral systemic administration of vitamin D on the rate of maxillary canine retraction: A randomized controlled trial” by Davender Kumar, Revathi Mn, Rekha Sharma, Ashuma Sachdeva, Nameksh Raj Bhupali, Ravinder Solanki

“…Objective: The trial was conducted to determine the effects of systemically delivered Vitamin D (1,25 dihydroxycholecalciferol) on the rate of maxillary canine retraction till the space closure and on the root resorption. Materials and methods: A two-arm parallel randomized controlled trial was conducted in patients with Angle's Class I bimaxillary protrusion requiring at least upper first premolars extraction and distal movement of canine for malocclusion correction. …”
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Pre-diagnostic risk factors for brain cancer incidence and survival: insights from the Golestan Cohort Study by Parisa Rezanejad-Asl, Peyvand Parhizkar Roudsari, Negar Rezaei, Maryam Sharafkhah, Gholamreza Roshandel, Hossein Poustchi, Sadaf Sepanlou, Reza Malekzadeh

“…We aimed to explore the pre-diagnostic factors for brain cancer incidence and survival in northeastern Iran. Methods Data for the current study were derived from the Golestan Cohort Study, the largest cohort study in the Middle East on over 50,000 participants aged 40 to 75 years with a median follow-up of 15 years. …”
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Association of liver biopsy pathology on outcome of patients undergoing heart transplantation by Lauren S. Eichenwald, MD, Raffi Karagozian, MD, Adam J. Eichenwald, PhD, John Morrissey, MD MBA, Saurav Kini, MD, Ariella Stein, MSCIS-HI, Amanda R. Vest, MBBS MPH

“…We determine the relationship between liver fibrosis severity and mortality rates for HT patients. Methods: A retrospective cohort study of adults listed for HT who underwent a liver biopsy for evaluation of early or advanced liver fibrosis from August 12, 2004 to February 16, 2022. …”
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Role of Computed Tomography in Predicting Programmed Death Ligand-1 Positivity in Gastric Adenocarcinoma by Yu ZH, Ma WQ, Ren JW, Zhang XT, Chu L

“…Zhi-Hong Yu,1,&ast; Wei-Qin Ma,2,&ast; Ji-Wei Ren,3 Xu-Ting Zhang,3 Lin Chu3 1Department of Ultrasound, Shanxi Provincial People’s Hospital, The Fifth Hospital of Shanxi Medical University, The Fifth Clinical Medical College of Shanxi Medical University, Taiyuan, Shanxi, 030012, People’s Republic of China; 2Department of CT/MRI, Lvliang People’s Hospital, Shanxi Province, Lvliang, Shanxi, 033000, People’s Republic of China; 3Department of Radiology, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, Shanxi, 030013, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Xu-Ting Zhang; Ji-Wei Ren, Department of Radiology, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, No. 3 Zhigongxin Street, Taiyuan, Shanxi, 030013, People’s Republic of China, Tel +86 18335172028, Email [email protected]; [email protected]: To examine the association between computed tomography (CT) imaging characteristics and programmed death ligand-1 (PD-L1) expression in patients with gastric adenocarcinoma (GAC), and to develop a nomogram model for prediction.Methods: The patients were randomly allocated into a training set and a validation set at a ratio of 7:3. …”
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Clinical characteristics of patients with coronary artery disease by smoking status by Olga V. Nakhratova, Daria P. Tsygankova, Joseph M. Tsenter, Evgeny D. Bazdyrev

“…AIM: To evaluate the prevalence of smoking types and analyze the features of clinical and medical history characteristics of smoking patients with stable coronary artery disease (CAD). MATERIALS AND METHODS: Data of 381 patients with CAD hospitalized for routine myocardial revascularization were analyzed. …”
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The Effects of Digital eHealth Versus Onsite 2-Day Group-Based Education in 255 Patients With Irritable Bowel Syndrome: Cohort Study by Birgitte Berentsen, Camilla Thuen, Eline Margrete Randulff Hillestad, Elisabeth Kjelsvik Steinsvik, Trygve Hausken, Jan Gunnar Hatlebakk

“…ObjectiveThis cohort study aimed to investigate the effects of a digital web-based multidisciplinary eHealth program on the domains of symptom severity (Irritable Bowel Syndrome Symptom Severity Scale [IBS-SSS]), quality of life (irritable bowel syndrome quality of life [IBS-QOL]), anxiety and depression (Hospital Anxiety and Depression Scale), and a measure of general client satisfaction (client satisfaction questionnaire), compared with an onsite multidisciplinary 2-day group-based education program (“IBS-school”), in 2 cohorts of 255 patients with IBS. MethodsPatients diagnosed with IBS, aged 15-70 years, were enrolled after referral to the Section of Gastroenterology at Haukeland University Hospital, Norway. …”
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