Hypofractionated radiotherapy combined with a PD-1 inhibitor, granulocyte macrophage-colony stimulating factor, and thymosin-α1 in advanced metastatic solid tumors: a multicenter P... by Jiamin Yu, Li Yin, Wenjie Guo, Qiang Wang, Juying Liu, Lansheng Zhang, Hongxun Ye, Jianhong Xia, Youyou Xia, Jianfeng Wu, Wanwei Wang, Yanguang Yang, Dan Zong, Xia He, Lijun Wang, Hong Jiang

“…Abstract Purpose This multicenter Phase II clinical study assessed the efficacy and safety of hypofractionated radiotherapy (HFRT) in combination with a PD-1 inhibitor, granulocyte macrophage-colony stimulating factor (GM-CSF), and thymosin-α1 in patients with heavily treated metastatic solid tumors. Methods Patients were enrolled between September 2022 and May 2024. …”
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Serum metabolome indicators of early childhood development in the Brazilian National Survey on Child Nutrition (ENANI-2019) by Marina Padilha, Victor Nahuel Keller, Paula Normando, Raquel M Schincaglia, Nathalia C Freitas-Costa, Samary SR Freire, Felipe M Delpino, Inês RR de Castro, Elisa MA Lacerda, Dayana R Farias, Zachary Kroezen, Meera Shanmuganathan, Philip Britz-Mckibbin, Gilberto Kac

“…We investigated associations between children’s serum metabolome and early childhood development (ECD). Methods: Untargeted metabolomics was performed on serum samples of 5004 children aged 6–59 months, a subset of participants from the Brazilian National Survey on Child Nutrition (ENANI-2019). …”
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Real-world enrollment for a prospective clinico-genomic database using a pragmatic technology-enabled platform by Alexia Exarchos, Ariel B. Bourla, Maneet Kaur, Katja Schulze, Sophia Maund, Yi Cao, Yihua Zhao, Elizabeth H. Williams, Sarah C. Gaffey, Richard Zuniga, Shaily Lakhanpal, Vladan Antic, Michelle Doral, Johanna Sy, Neal J. Meropol, Anne C. Chiang

“…The objective was to evaluate the feasibility of a pragmatic, technology-enabled platform at community-based research sites for development of a prospective clinico-genomic database supported by centralized electronic health record (EHR)–based patient ascertainment and data processing. Methods: Adults with stage IV or recurrent metastatic non-small cell lung cancer or extensive-stage small-cell lung cancer were enrolled at 23 US sites upon initiating a standard line of therapy. …”
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Rationale and design for Healthy Hearts in Manufacturing (HHM): A pragmatic single-arm hybrid effectiveness-implementation study for hypertension management and tobacco cessation by Hanzi Jiang, Yao Tian, Jennifer Bannon, Amy E. Krefman, Lawrence C. An, Dustin D. French, Claude R. Maechling, Jane Holl, Richard Chagnon, Theresa L. Walunas, Christopher Burch, Anthony Musci, Darce Latsis, Dawn Carey, Megan McHugh

“…The Healthy Hearts in Manufacturing (HHM) study aims to implement and test these interventions in WHCs. Methods: Two organizations that operate WHCs at manufacturing sites volunteered to participate in the 58-month HHM research study. …”
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Exploring the multi-targeted mechanism of Saikosaponin A in prostate cancer treatment: a network pharmacology and molecular docking approach by Genbao Zhu, Genbao Zhu, Genbao Zhu, Zhiming Jiang, Niuping Zhu, Niuping Zhu, Donghui Wang, Donghui Wang, Tianpeng Guo, Tianpeng Guo, Yiqing Meng, Yiqing Meng, Yi Zhu, Yi Zhu, Kemeng Tan, Mengxue Hu, Heng Tang, Xuannian Wang, Xuannian Wang

“…However, the mechanism underlying the effects of SSA in prostate cancer treatment remains elusive.MethodsIn this study, a network pharmacology approach was applied to identify relevant targets from drug- and disease-related databases, and intersections were analyzed using Venny2.1 to construct a Protein-Protein interaction (PPI) interaction network. …”
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How can cervical screening meet the needs of vulnerable women? A qualitative comparative study with stakeholder perspectives from seven European countries by Partha Basu, Martin McKee, Adriana Băban, Marc Bardou, Ana Fernandes, Margarida Teixeira, Rebecca Moore, Nuno Lunet, David Ritchie, Romeu Mendes, Eric Lucas, Paolo Giorgi Rossi, Rosa Legood, Berit Andersen, Diana Taut, Keitly Mensah, João Firmino-Machado, Mariana Amorim, Mette Tranberg, Laura Bonvicini, Anneli Uusküla, Pia Kirkegaard, Paola Mantellini, Ines Baia, Liu Sun, Lise Rochaix, Camilla Fiorina, Luca Ghirotto, Anna Tisler, Firmino Machado, Rikke Buus Bøje, Raquel Rico Berrocal, Noemi Auzzi, Kerli Reintamm, Yulia Panayotova, Tatyana Kotzeva, Anna Foss, Rachel Greenley, Letizia Bartolini, Giusy Iorio, Cláudia Gouvinhas, Florian Nicula, Alexandra Tolnai, Vanessa Moore, Isabel Mosquera Metcalfe, Violette Delisle, Irina Todorova, Helena Ros Comesana, Meritxel Mallafré-Larrosa, Ginevra Papi, Nicoleta-Monica Pașca, Christiane Dascher-Nadel, Olivra Djuric

“…Data collection took place in Bulgaria, Denmark, Estonia, France, Italy, Portugal and Romania.Participants Represented stakeholders at various levels, including user representatives (vulnerable women), healthcare professionals, social workers, programme managers and decision makers.Methods 14 meetings lasting 2 hours each were held in these seven countries between October 2021 and June 2022. …”
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Anti-TNBC effects of Lappaol F by targeting epithelial-mesenchymal transition via regulation of GSK-3β/YAP/β-catenin and PI3K/AKT pathways by Qiqi Meng, Qiqi Meng, Zhiping Li, Xiaofeng He, Yuanhao Hu, Guiyun Wu, Jiawen Huang, Zhuohui Luo, Zhuohui Luo, Yingjie Hu, Xiaoling Shen

“…The present study aimed to reveal the potential mechanism of LAF against TNBC by in vivo and in vitro experiments.MethodsIn situ, transplantation-induced MDA-MB-231 solid tumor model in NCG mice and cultured MDA-MB-231 and Hs-578T cells were used to evaluate the anti-TNBC effect of LAF. …”
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Solid Predominant Histology and High Podoplanin Expression in Cancer-Associated Fibroblast Predict Primary Resistance to Osimertinib in EGFR-Mutated Lung Adenocarcinoma by Yuji Uehara, MD, Hiroki Izumi, MD, PhD, Tetsuro Taki, MD, PhD, Tetsuya Sakai, MD, PhD, Hibiki Udagawa, MD, PhD, Eri Sugiyama, MD, PhD, Shigeki Umemura, MD, PhD, Yoshitaka Zenke, MD, PhD, Shingo Matsumoto, MD, PhD, Kiyotaka Yoh, MD, PhD, Shoko Kubota, MD, PhD, Keiju Aokage, MD, PhD, Naoya Sakamoto, MD, PhD, Shingo Sakashita, MD, PhD, Motohiro Kojima, MD, PhD, Michiko Nagamine, MD, PhD, Yukio Hosomi, MD, PhD, Masahiro Tsuboi, MD, PhD, Koichi Goto, MD, PhD, Genichiro Ishii, MD, PhD

“…We investigated the impact of tumor cell histology and tumor microenvironment on the efficacy of osimertinib. Methods: We evaluated surgically resected adenocarcinoma from patients treated with first-line osimertinib at the National Cancer Center Hospital East (2016–2023), evaluating clinicopathologic characteristics, tumor cell histology, podoplanin expression in cancer-associated fibroblasts (CAFs) identified by immunohistochemistry, and outcomes. …”
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Outcomes of COVID-19 in the Omicron-predominant wave: large-scale real-world data analysis with a comparison to influenza by Koichi Miyashita, Hironao Hozumi, Kazuki Furuhashi, Eiji Nakatani, Yusuke Inoue, Hideki Yasui, Yuzo Suzuki, Masato Karayama, Noriyuki Enomoto, Tomoyuki Fujisawa, Naoki Inui, Toshiyuki Ojima, Takafumi Suda

“…Abstract Purpose Studies on COVID-19 mortality during the Omicron-predominant wave have focused primarily on the inpatient/emergency room setting, and real-world data including both inpatients and outpatients are lacking. Methods Patients diagnosed with COVID-19 (n = 27,440,148) or influenza (n = 8,179,641) from January 2020 to April 2023 were identified using nationwide claims data in Japan. …”
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Development and evaluation of a recombinant monoclonal human antibody with virus-neutralizing activity against the F glycoprotein of respiratory syncytial virus by Sergey A. Klotchenko, Ekaterina A. Romanovskaya-Romanko, Marina A. Plotnikova, Anastasia A. Pulkina, Aram A. Shaldzhyan, Dmitry S. Balabashin, Victoria A. Toporova, Teimur K. Aliev, Natalia E. Gyulikhandanova, Dmitry A. Lioznov

“…To design plasmid vectors for efficient production of the recombinant monoclonal antibody FM1 in a eukaryotic expression system targeting the RSV fusion (F) glycoprotein and to evaluate its activity against RSV subtypes A and B in vitro. Materials and methods. Constructs encoding the recombinant antibody FM1 were designed using genetic engineering. …”
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Hybrid peptides inspired by the RWQWRWQWR sequence inhibit cervical cancer cells growth in vitro by Natalia Ardila-Chantré, Claudia Marcela Parra-Giraldo, Yerly Vargas-Casanova, Andrea Carolina Barragán-Cardenas, Ricardo Fierro-Medina, Zuly Jenny Rivera-Monroy, Jhon Erick Rivera-Monroy, Javier Eduardo García-Castañeda

“…Specifically, we worked by combining the RWQWRWQWR sequence derived from bovine lactoferricin with different functional peptides such as anticancer peptides, cervical cancer cell-targeting peptides, and cell-penetrating peptides. Methods: Hybrid peptides and precursors were synthesized by solid-phase peptide synthesis using the Fmoc/tBu strategy, purified via reverse phase (RP)-solid phase extraction, and characterized by RP-high performance liquid chromatography (RP-HPLC) chromatography and mass spectrometry. …”
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Hyssopus cuspidatus volatile oil: a potential treatment for steroid-resistant asthma via inhibition of neutrophil extracellular traps by Xu Wang, Hui-Ming Peng, Meng-Ru Zhang, Jing-Jing Li, Chuan-Peng Zhao, Ya-Li Zhang, Si-Yu Wang, Si-Ying Zhu, Jian-Kang Lu, Hai-Long Yin, Qiang Yin, Jin-Bo Fang

“…However, the therapeutic impact and underlying mechanisms of Hyssopus cuspidatus Boriss.’s volatile oil (HVO) in SRA have not been fully elucidated. Methods This study established an ovalbumin/lipopolysaccharide (OVA/LPS)-induced SRA mice model to evaluate the therapeutic effect of HVO on SRA. …”
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Predictive value of enhanced CT and pathological indicators in lymph node metastasis in patients with gastric cancer based on GEE model by Ling Yang, Yingying Ding, Dafu Zhang, Guangjun Yang, Xingxiang Dong, Zhiping Zhang, Caixia Zhang, Wenjie Zhang, Youguo Dai, Zhenhui Li

“…Abstract Objectives A predictive model was developed based on enhanced computed tomography (CT), laboratory test results, and pathological indicators to achieve the convenient and effective prediction of single lymph node metastasis (LNM) in gastric cancer. Methods Sixty-six consecutive patients (235 regional lymph nodes) with pathologically confirmed gastric cancer who underwent surgery at our hospital between December 2020 and November 2021 were retrospectively reviewed. …”
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Exploring mental health in veterinary students: common stressors and effective coping strategies: a narrative review by Rahib K. Islam, Emily K. Cobb, Hannah K. McCowan, Kylie Watson, Kaustuv Bhattacharya, Kaustuv Bhattacharya, Anjali Chandra, Warda Mohiuddin, Karen Gruszynski, Karen Gruszynski, Amanda H. Wilkerson, John J. Dascanio, Robert E. Davis, Vinayak K. Nahar, Vinayak K. Nahar

“…This review explores the demographic and psychosocial variables influencing mental health outcomes, highlighting common stressors and coping strategies.MethodsA systematic literature search was conducted using PubMed, CAB Abstracts, and Google Scholar. …”
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End of Pandemic Parental Hesitancy Towards Pediatric COVID-19 Vaccination: A Cross-sectional Survey at Two Lebanese Tertiary Hospitals by Sabine Shehab, Lina Anouti, Celina F. Boutros, Christelle Radi, Silma El Baasiri, Arabia Badih, Rawan Korman, Marwa El Masri, Joudie Alwan, Maha Monzer, Yara Bitar, Mona Kassem, Mayse Naser, Yara Salameh, Sarah Khafaja, Murielle Bou Ghosn, Dany Al Hamod, Sarah Ghadban, Soha Ghanem, Ghassan S. Dbaibo

“…Abstract Background This observational prospective cross-sectional study was conducted during the last 4 months of the COVID-19 pandemic to determine whether parental hesitancy to vaccinate their children against COVID-19 had improved compared to earlier studies in other countries showing high levels of hesitancy. Methods: Parents were surveyed from January 4 until May 16, 2023, at two tertiary medical centers in Beirut, the American University of Beirut Medical Center (AUBMC) and the Saint George Hospital University Medical Center (SGHUMC). …”
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Small intestinal bacterial overgrowth syndrome and systemic inflammation in pathogenesis of hemodynamic changes at liver cirrhosis by R. V. Maslennikov, A. A. Driga, K. V. Ivashkin, M. S. Zharkova, M. V. Mayevskaya, Ch. S. Pavlov, M. G. Arslanyan, N. B. Musina, Ye. N. Berezina, V. T. Ivashkin

“…To estimate the impact of small intestinal bacterial overgrowth (SIBO) to development of hemodynamic disorders at liver cirrhosis (LC). Material and methods. Original study included 50 LC patients and 15 generally healthy controls. …”
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Association between adult body shape index and serum levels of the anti-aging protein Klotho in adults: a population-based cross-sectional study of the NHANES from 2007 to 2016 by Li Gong, Jinghan Xu, Yiyang Zhuang, Liwei Zeng, Zhenfei Peng, Yuzhou Liu, Yinluan Huang, Yutian Chen, Fengyi Huang, Chunli Piao

“…Therefore, the aim of this study was to assess the correlation between ABSI and serum Klotho levels in adults residing in the United States.MethodsA cross-sectional study of participants was conducted based on the 2007–2016 National Health and Nutrition Examination Survey. …”
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Incidence and temporal trends of out-of-hospital cardiac arrest in Shenzhen, China (2011–2018) by Hong Zhu, Junpeng Liu, Tianqi Yang, Yan Zhang, Yanjun Xu, Yunfeng Xu, Hao Wu, Li Li, Yufeng Luo, Cai Wen, Tao Yu

“…This study examines OHCA features and trends in Shenzhen, one of the fastest-growing cities. Methods: This retrospective study analysed data from the Shenzhen Emergency Center database (2011–2018), including ambulance dispatch and pre-hospital medical records. …”
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Biological subphenotypes in patients hospitalized with suspected infection in Thailand: a secondary analysis of a prospective observational studyResearch in context by Prapassorn Poolchanuan, Taylor D. Coston, Viriya Hantrakun, Parinya Chamnan, Gumphol Wongsuvan, Pavan K. Bhatraju, Narisara Chantratita, Direk Limmathurotsakul, T. Eoin West, Shelton W. Wright

“…We sought to identify and differentiate subphenotypes of patients hospitalized with suspected infection in rural Thailand using biological markers implicated in the dysregulated host response. Methods: In a cohort of prospectively enrolled patients hospitalized with suspected infection in northeastern Thailand, we measured 15 circulating biomarkers from a random selection of 585 subjects and developed latent profile models to identify subphenotypes. …”
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The modern options of chronic hepatitis C antiviral therapy with daclatasvir: results of named patient program by V. T. Ivashkin, M. V. Mayevskaya, D. T. Abdurakhmanov, I. G. Bakulin, N. I. Geyvandova, M. L. Zubkin, S. N. Kizhlo, A. V. Kuznetsova, I. B. Latysheva, N. A. Mamonova, V. G. Morozov, O. I. Sagalova, Ye. V. Esaulenko, Ye. O. Lyusina

“…To analyze the efficacy of PTV for chronic hepatitis C within the named patient program of expanded access to daclatasvir. Material and methods. Approval of Ministry of Healthcare of the Russian Federation to import of drugs was received for the treatment of 101 HCV-infected patients with compensated LC, who, been untreated had an urgent need for effective therapy, with estimated life expectancy less than 12 months, in 12 centers of the Russian Federation. …”
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