Bidirectional relationship between depression and activities of daily living and longitudinal mediation of cognitive function in patients with Parkinson’s disease by Yue Xu, Yue Xu, Durong Chen, Meiqi Dong, Yun Zhang, Yun Zhang, Hongmei Yu, Hongmei Yu, Hongmei Yu, Yanqing Han, Yanqing Han, Yanqing Han

“…ObjectiveTo investigate the bidirectional relationship between depression and activities of daily living (ADL) in Parkinson’s disease (PD) patients and explore the mediating role of cognitive function over time.MethodsData from 892 PD patients from the Parkinson’s Progression Markers Initiative (PPMI) database were included in this study, and depression, cognitive function, and ADL were measured using the Geriatric Depression Scale (GDS-15), Montreal Cognitive Assessment Scale (MoCA), and Unified Parkinson’s Disease Rating Scale, Part II (UPDRS II) respectively. …”
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Gastrointestinal symptoms and bowel habits in 53 046 healthy Danish blood donors: a nationwide cross-sectional study by Christian Erikstrup, Ole Birger Pedersen, Henrik Hjalgrim, Erik Sørensen, Jens Frederik Dahlerup, Klaus Rostgaard, Mikkel Steen Petersen, Sisse Rye Ostrowski, Susan Mikkelsen, Khoa Manh Dinh, Thorsten Brodersen, Janna Nissen, Anne Karmisholt Grosen, Jens Kjærgaard Boldsen, Simon Mark Dahl Baunwall, Mie Topholm Bruun, Bitten Aagaard, Christina Mikkelsen, Christian Lodberg Hvas

“…Objective To characterise gastrointestinal symptoms and bowel habits in healthy blood donors and explore symptom phenotypes and their associated factors.Methods Between November 2020 and March 2023, 53 046 participants in the nationwide Danish Blood Donor Study completed a questionnaire including 13 gastrointestinal symptoms, defaecation pattern regularity, stool frequency, and stool consistency. …”
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Psychometric properties of the Arabic emotional and behavioral reaction to intrusions questionnaire among sample of Arabic speaking adults by Emmanuelle Awad, Diana Malaeb, Amthal Alhuwailah, Mai Helmy, Muna Barakat, Rabih Hallit, Sami El Khatib, Mohamad Rahal, Syed Arman Rabbani, Reem Alzayer, Nada H. Farrag, Rita El Hajjar, Jinan Mallouh, Souheil Hallit, Feten Fekih-Romdhane, Sahar Obeid, Rita ElHagar

“…This study aimed to psychometrically evaluate and validate a translation of the Emotional and Behavioral Reaction to Intrusions Questionnaire (EBRIQ) in Arabic, for adults who speak the language. Methods The snowball sampling technique was used to recruit adults (n = 755) from five Arab countries (Lebanon, United Arab Emirates, Egypt, Jordan, and Kuwait), who completed the Arabic EBRIQ. …”
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Imaging flow cytometry-based cellular screening elucidates pathophysiology in individuals with Variants of Uncertain Significance by Irena Josephina Johanna Muffels, Hans R. Waterham, Giuseppina D’Alessandro, Guido Zagnoli-Vieira, Michael Sacher, Dirk J. Lefeber, Celine Van der Vinne, Chaim M. Roifman, Koen L. I. Gassen, Holger Rehmann, Desiree Y. Van Haaften-Visser, Edward S. S. Nieuwenhuis, Stephen P. Jackson, Sabine A. Fuchs, Femke Wijk, Peter van Hasselt

“…To address this challenge, we propose a high-throughput screening of cellular functionality through an imaging flow cytometry (IFC)-based platform. Methods Six assays to evaluate autophagic-, lysosomal-, Golgi- health, mitochondrial function, ER stress, and NF-κβ activity were developed in fibroblasts. …”
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RETRACTED ARTICLE: A prospective diagnostic model for breast cancer utilizing machine learning to examine the molecular immune infiltrate in HSPB6 by Lizhe Wang, Yu Wang, Yueyang Li, Li Zhou, Sihan Liu, Yongyi Cao, Yuzhi Li, Shenting Liu, Jiahui Du, Jin Wang, Ting Zhu

“…The objective of this research was to perform bioinformatics analyses on breast cancer-related datasets to gain a comprehensive understanding of the molecular mechanisms at play and to identify key genes associated with the disease. Methods The toolkit analyses involve techniques such as differential gene expression analysis, Gene Set Enrichment Analysis (GSEA), Weighted Co-Expression Network Analysis (WGCNA), and Machine Learning algorithms. …”
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Assessing the neuroprotective potential of Eucalyptus globulus essential oil in a 6-hydroxydopamine rat model of Parkinson's disease by Aracely Janneth Naranjo-Viteri, Matías Jávega Cometto, Matías Caverzan, Leandro Gabriel Champarini, María Paula Zunino, Rogelio E. Abburra, Claudia B. Hereñú, Rosana Crespo

“…Given the rising prevalence of the neurodegenerative disorder, Parkinson's disease, in aging populations, this study aims to investigate the effect of Eucalyptus globulus EO (EuEO) in a rat Parkinson model induced by bilateral lesion with the neurotoxin, 6-hydroxydopamine (6-OHDA). Methods: EuEO composition was determined by GC–MS. …”
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Intervertebral Disc Degeneration in Long-Term Postoperative Patients with Adolescent Idiopathic Scoliosis: MRI Evaluation 34-51 Years after Surgery and its Changes during Middle an... by Tsutomu Akazawa, Toshiaki Kotani, Tsuyoshi Sakuma, Yasushi Iijima, Yoshiaki Torii, Jun Ueno, Atsuhiro Yoshida, Ken Tomochika, Sumihisa Orita, Yawara Eguchi, Kazuhide Inage, Yasuhiro Shiga, Junichi Nakamura, Yusuke Matsuura, Takane Suzuki, Hisateru Niki, Seiji Ohtori, Shohei Minami

“…Introduction: This study aimed to identify factors associated with intervertebral disc degeneration (DD) in adolescent idiopathic scoliosis (AIS) patients who reached middle and older age after surgery. Methods: A total of 252 AIS patients who underwent spinal fusion surgery between 1968 and 1988 were included in this survey-based study. …”
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Liver cancer risk and changes in lifestyle habits after successful hepatitis C virus therapy post-DAA HCV therapy: lifestyle changes and liver cancer risk by Núria Granel, Gemma Iserte, Concepció Bartres, Neus Llarch, Anna Pla, Víctor Sapena, Zoe Mariño, Sabela Lens, Ramón Vilana, Isabel Nuñez, Anna Darnell, Ernest Belmonte, Ángeles García-Criado, Alba Díaz, Marco Sanduzzi-Zamparelli, Carla Fuster, Sergio Muñoz-Martínez, Carmen Ayuso, Jordi Rimola, Alejandro Forner, Alexandre Soler, Ferran Torres, José Ríos, Jordi Bruix, Andrew M. Moon, Xavier Forns, María Reig

“…Our study investigates lifestyle changes that occur in HCV patients with Sustained Virological Response (SVR) after direct-acting antiviral (DAA) treatment. Methods In this prospective, single-center study, HCV patients with advanced liver disease (F3/F4) treated and cured with DAA were invited to fill a lifestyle habits questionnaire in and perform abdominal ultrasound (US), blood extraction and anthropometric measurements within the 1st month after SVR and every 6 months thereafter until 48 months of follow-up, LC development, death, or loss to follow-up. …”
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Immune microenvironment spatial landscapes of tertiary lymphoid structures in gastric cancer by Yi Xie, Haoxin Peng, Yajie Hu, Keren Jia, Jiajia Yuan, Dan Liu, Yanyan Li, Xujiao Feng, Jian Li, Xiaotian Zhang, Yu Sun, Lin Shen, Yang Chen

“…However, understanding the complex and diverse immune microenvironment within TLS requires comprehensive analysis. Methods We examined the prognostic impact of TLS within the tumour core (TC) of 59 GC patients undergoing immunotherapy. …”
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Trabeculectomy versus stepwise treatment for breaking the attack of acute primary angle closure in patients with long attack duration: study design and protocol for a multicentre r... by Jing Jiang, Qing Zhang, Bo Qu, Chao Dai, Mingguang He, Ye Zhang, Ning-Li Wang, Shuning Li, Guangxian Tang, Su Jie Fan, Zhi Li, Chi Liu, Xinqi Chang, Yanyan Cheng

“…Since prompt and effective treatment is pivotal in preserving visual function as well as avoiding APAC-induced blindness, direct trabeculectomy may largely benefit long-attacking patients with APAC in China.Purpose The Long-Attacking Acute Angle Closure study aims to compare long-term visual function and safety after different initial treatment strategies: direct surgery (trabeculectomy) or stepwise protocol for patients with APAC with attack duration longer than 72 hours.Methods and analysis This is a pragmatic, multicentre, randomised controlled trial targeting Chinese patients with APAC duration longer than 72 hours. …”
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An initial benchmark of the quality of the diagnosis and surgical treatment of breast cancer in South Africa by S Nietz, H Cubasch, I Buccimazza, S Čačala, B Phakathi, M Joffe, W C C Chen, S Norris, P Ruff

“…To measure the adherence rates to quality indicators among women with breast cancer in SA. Methods. Ten quality indicators were evaluated for 3 545 breast cancer patients across four SA surgical breast units using a shared electronic patient record system. …”
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Leveraging Comprehensive Echo Data to Power Artificial Intelligence Models for Handheld Cardiac Ultrasound by D.M. Anisuzzaman, PhD, Jeffrey G. Malins, PhD, John I. Jackson, PhD, Eunjung Lee, PhD, Jwan A. Naser, MBBS, Behrouz Rostami, PhD, Grace Greason, BA, Jared G. Bird, MD, Paul A. Friedman, MD, Jae K. Oh, MD, Patricia A. Pellikka, MD, Jeremy J. Thaden, MD, Francisco Lopez-Jimenez, MD, MSc, MBA, Zachi I. Attia, PhD, Sorin V. Pislaru, MD, PhD, Garvan C. Kane, MD, PhD

“…Objective: To develop a fully end-to-end deep learning framework capable of estimating left ventricular ejection fraction (LVEF), estimating patient age, and classifying patient sex from echocardiographic videos, including videos collected using handheld cardiac ultrasound (HCU). Patients and Methods: Deep learning models were trained using retrospective transthoracic echocardiography (TTE) data collected in Mayo Clinic Rochester and surrounding Mayo Clinic Health System sites (training: 6432 studies and internal validation: 1369 studies). …”
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Outbreak of carbapenem resistant Klebsiella pneumoniae in a neurorehabilitation unit: Genomic epidemiology reveals complex transmission pattern in a tertiary care hospital by Maria Grazia Silvotti, Erika Scaltriti, Luca Bolzoni, Beatrice Zerbi, Gabriella Tocci, Andrea Zappavigna, Gianfranco Lamberti, Federico Donati, Franco Federici, Stefano Pongolini, Giuliana Lo Cascio

“…We report an outbreak by KPC-Kp, in a neurorehabilitation unit in Italy, analysed through whole-genome sequencing (WGS) for transmission routes reconstruction to improve management of KPC-Kp infections in rehabilitation units. Methods: We investigated cases and KPC-Kp isolates collected from February to October 2022 from hospital surveillance. …”
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The development of a nurse-led preoperative anaesthesia screening tool by Delphi consensus by M B Nejthardt, P Alexandris, S Bechan, M F A Bijli, S Chetty, J M Dippenaar, M Gibbs, M Johnson, H Kluyts, R Llewellyn, M Motiang, P Mogane, P Motshabi, B Mrara, F Roodt, U Singh, S Spijkerman, E Turton, J van der Westhuizen, B Biccard

“…This would ensure adequate time for optimisation of high-risk patients preoperatively and limit avoidable day-of-surgery cancellations. Methods. A systematic review was conducted to identify preoperative screening questions for use in a three-round Delphi consensus process. …”
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JAK/STAT3 signaling promotes pain and depression-like behaviors in rats with bone cancer pain by regulating Th17 cell differentiation by Shuyan Wu, Jundan Jiang, Danfeng Wang, Daoyi Lin, Mingxue Lin, Pinzhong Chen, Jianghu Chen, Honghong Zhang, Ying Wang, Xiaohui Chen, Xiaochun Zheng

“…This study aimed to investigate the specific role of the JAK/STAT3 pathway in the amygdala in BCP. Methods: A BCP rat model was established by intratibial injection of MRMT-1 carcinoma cells. …”
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PneumoniaCheck, a novel aerosol collection device, permits capture of airborne Mycobacterium tuberculosis and characterisation of the cough aeromicrobiome in people with tuberculos... by Tinaye L. Chiyaka, Georgina R. Nyawo, Charissa C. Naidoo, Suventha Moodley, Jose C. Clemente, Stephanus T. Malherbe, Robin M. Warren, David N. Ku, Leopoldo N. Segal, Grant Theron

“…We evaluated whether PneumoniaCheck (PMC), a commercial aerosol collection device, captures MTBC and the aeromicrobiome of people with TB. Methods PMC was done in sputum culture-positive people (≥ 30 forced coughs each, n = 16) pre-treatment and PMC air reservoir (bag, corresponding to upper airways) and filter (lower airways) washes underwent Xpert MTB/RIF Ultra (Ultra) and 16S rRNA gene sequencing (sequencing also done on sputum). …”
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Association between geriatric nutritional risk index and overactive bladder in the elderly population: a cross-sectional study by Wei Zheng, Wei Zheng, Chuanzan Zhou, Jia Miao, Yunkai Yang, Xuanhan Hu, Heng Wang, Xinyu Zhang, Qi Zhang, Yifan Wang

“…Despite this, research on the relationship between nutritional factors and OAB remains limited.MethodsWe included 17,161 elderly individuals from the National Health and Nutrition Examination Survey conducted between 2005 and 2018. …”
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Differed brain spontaneous neural activity between limb-onset and bulbar-onset amyotrophic lateral sclerosis patients by Si-Jie Chen, Qing-Yang Li, Jiang Zhou, Qian Wu, Yu Zhang, Qian-Qian Zhang, Hao Hu, Xiao-Quan Xu, Fei-Yun Wu, Qi Niu

“…Purpose: To investigate the differences in brain spontaneous neural activity between limb-onset and bulbar-onset amyotrophic lateral sclerosis (ALS-L and ALS-B, respectively) patients using resting-state functional MRI (rs-fMRI) with amplitude of low-frequency fluctuation (ALFF) and regional homogeneity (ReHo). Materials and methods: The rs-fMRI data were collected from 41 ALS patients (11 ALS-B and 30 ALS-L) and 25 healthy controls (HC). …”
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Immune dysfunction revealed by digital spatial profiling of immuno-oncology markers in progressive stages of renal cell carcinoma and in brain metastases by Wei Wei, Michael Hurwitz, Sabina Signoretti, Lucia Jilaveanu, Toni K Choueiri, David L Rimm, Adebowale Adeniran, Sandra Martínez, Harriet M Kluger, David A Schoenfeld, Myrto Moutafi, Dijana Djureinovic, Ross D Merkin, David A Braun, Fabio Parisi

“…The TME of RCC brain metastases, a major cause of morbidity, also remains largely uncharacterized.Methods We performed digital spatial profiling on the NanoString GeoMx platform using 52 validated immuno-oncology markers on RCC tissue microarrays representing progressive stages of RCC, including brain metastases. …”
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Pathomorphological features of the proximal femur in crowe IV hips and their implication on stem selection during total hip arthroplasty by Kaveh Gharanizadeh, Elham Mohammadyahya, Mohammad Reza Bahaeddini, Shayan Amiri, Sajad Noori Gravand, Sepideh Pezeshki, Amir Aminian, Arvin Eslami, Hamed Tayyebi, Mansour Abolghasemian

“…Our goal is to identify and define the differences in the anatomy of the proximal femur between patients with Crowe type IV DDH and normal individuals, in order to determine the appropriate neck cut location in these patients to increase the chances of successfully using a wedge femoral stem. Methods EOS™ images of 40 hips with Crowe type-IV DDH and 40 normal hips were included. …”
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