Liver damage in patients living with HIV on antiretroviral treatment with normal baseline liver function and without HBV/HCV infection: an 11-year retrospective cohort study in Gua... by Jun Yu, Hao Liang, Fengxiang Qin, Junjun Jiang, Chunwei Qin, Yunxuan Huang, Bingyu Liang, Yuexiang Xu, Jiegang Huang, Zhiliang Xu, Chuanyi Ning, Yanyan Liao, Ning Zang, Jingzhen Lai, Wudi Wei, Li Ye, Xionglin Qin

“…Objective To characterise the association between duration of exposure to antiretroviral treatment (ART) and liver damage in HIV patients with an initially normal baseline liver function and without hepatitis B virus (HBV)/hepatitis C virus (HCV) infection.Methods A retrospective cohort study was conducted in HIV-infected individuals with normal liver function parameters at ART initiation and without HBV/HCV infection, from 14 April 2004 to 13 April 2015 in Guigang city, Guangxi, China. …”
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Efficacy and safety of the Russian protease inhibitor narlaprevir at treatment-naive and earlier treated noncirrhotic patients with the 1st genotype chronic hepatitis C (PIONEER st... by M. V. Mayevskaya, V. T. Ivashkin, O. O. Znoyko, Ye. A. Klimova, D. T. Abdurakhmanov, I. G. Bakulin, P. O. Bogomolov, E. Z. Burnevich, M. Yu. Galushko, N. I. Geyvandova, K. V. Zhdanov, Ye. V. Esaulenko, S. N. Kizhlo, D. Yu. Konstantinov, N. I. Mironova, V. G. Morozov, Ye. A. Strebkova, I. G. Nikitin, M. F. Osipenko, V. D. Pasechnikov, O. I. Sagalova, I. M. Khayertynova, V. P. Chulanov, A. A. Yakovlev, I. A. Vasyutin, Ye. P. Tarkhova, E. N. Krasavina, M. Yu. Samsonov

“…To estimate efficacy and safety of narlaprevir (NVR) with ritonavir (RTV), pegilated interferon (peg-IFN) and ribavirin (RBV) at treatmentnaïve and earlier treated noncirrhotic patients with chronic hepatitis C caused by the 1st virus genotype in double blind placebo-controlled 3rd phase study (PIONEER). Material and methods. The main group received NVR (200 mg od orally) in combination to RTV (100 mg) and pegIFN/RBV for 12 weeks that was followed by peg-IFN/ RBV for 12 weeks. …”
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Cerebellum abnormalities in vascular mild cognitive impairment with depression symptom patients: A multimodal magnetic resonance imaging study by Yirong Chen, Liling Chen, Liyu Hu, Jianjun Wang, Jinhuan Zhang, Hanqing Lyu, Jinping Xu, Jianxiang Chen, Haibo Yu

“…Objective: This study aimed to investigates the gray matter volume and functional alterations in the cerebellum of svMCI patients, with and without depression symptoms, and their correlation with cognitive and depressive symptoms. Methods: We enrolled 16 svMCI patients with depression symptoms (svMCI+D), 15 without (svMCI-D), and 12 normal controls (NC). …”
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Uptake and hesitancy of the second booster dose of COVID-19 vaccine among the general population in China after the surge period of the COVID-19 pandemic: a large-scale national st... by Xin Liu, You Xin, Ling Zhang, Yijin Wu, Shu Jing, Zhenwei Dai, Tianrui Ren, Xiaoyang Liu, Jiaqi Fu, Xu Chen, Weijun Xiao, Hao Wang, Yiman Huang, Wenjun Wang, Xiaofen Gu, Li Ma, Shaokai Zhang, Yanqin Yu, Li Li, Tianzuo Gao, Tianyou Zhao, Yimin Qu, Xinyan Liu, Xiaoyou Su, Youlin Qiao

“…To improve coverage of the second booster dose, it is crucial to investigate the prevalence of vaccine hesitancy among the general population during this period and explore the reasons for this phenomenon. Methods A cross-sectional survey was conducted between January 5 to February 9, 2023. …”
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Universal capillary screening for chronic autoimmune, metabolic and cardiovascular diseases: feasibility and acceptability of the UNISCREEN study by Sara Angiulli, Aurora Merolla, Elisa Borgonovo, Rebecca De Lorenzo, Serena Spadoni, Barbara Fontana, Giuseppina Manganaro, Elena Rela, Alberto Bongiovanni, Rita Peracino, Chiara Bellino, Giulia Pata, Eleonora Bianconi, Sabina Martinenghi, Francesca Ulivi, Cristina Renzi, Cristina Renzi, Emanuele Bosi, Emanuele Bosi, UNISCREEN Study Group, Sara Angiulli, Aurora Merolla, Alberto Bongiovanni, Rebecca De Lorenzo, Elena Rela, Rita Peracino, Chiara Bellino, Giuseppina Manganaro, Elisa Borgonovo, Sara Critelli, Aldo Fici, Martina Mallus, Giulia Morocutti, Giulia Pata, Clara Soggetti, Chiara Calabrese, Alberico Di Resta, Maria Pia Ruggiero, Antonella Spano’, Francesca Biasco, Manuel Stocchi, Pietro Melodia, Giuseppe Ancona, Andrea Laurenzi

“…BackgroundUNISCREEN is a general population study aiming at evaluating feasibility and acceptability of universal screening for chronic autoimmune (type 1 diabetes and celiac disease) and metabolic/cardiovascular diseases (dysglycemia, type 2 diabetes, dyslipidemia, hypertension) across all age groups using capillary blood sampling by fingerprick to measure disease risk markers.MethodsUNISCREEN was conducted in the Cantalupo fraction, Cerro Maggiore, Milan, Italy, counting 3,061 inhabitants between 1 and 100 years of age. …”
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Revealing viral hepatitis epidemiology in the Democratic Republic of Congo: insights from yellow fever surveillance reanalysis by Patrick Mukadi-Kakoni, Yannick Munyeku-Bazitama, Gracia Kashitu-Mujinga, Marguerite Manwana-Pemba, Niclette Zenga-Bibi, Patient Okitale-Talunda, Christelle Mbelu-Kabongo, Fleurette Domai-Mbuyakala, Elisabeth Pukuta-Simbu, Pierre Mutantu-Nsele, Yoshinao Kubo, Sheila Makiala-Mandanda, Steve Ahuka-Mundeke, Koya Ariyoshi, Jean-Jacques Muyembe-Tamfum

“…This study investigates the seroepidemiology of viral hepatitis A (HAV), B (HBV), C (HCV), and E (HEV) among cases initially suspected to be yellow fever, aiming to elucidate the epidemiology of viral hepatitis in the Democratic Republic of Congo (DRC) and provide insights for improving public health interventions. Methods A retrospective cross-sectional study was conducted using serum samples collected between 2017 and 2018 through national yellow fever surveillance in the DRC. …”
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Distal Femur Type III Open Fractures: Functional Outcome Analysis by Arul R Bhagyaraj, Anand Ashok, Manisha J Kumar, Krupakaran Ganesan, Anand Kurian, Dan B Inja, Manasseh Nithyananth, Vinoo M Cherian, Jeremy Bliss

“…The decision of single-stage fixation or staged reconstruction is often multifactorial with a need to assess their impact through functional outcomes. Methods: Patients who underwent surgical fixation for open distal femoral fractures from January 2015 to December 2020 were included. …”
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The INFLUENCE 3.0 model: Updated predictions of locoregional recurrence and contralateral breast cancer, now also suitable for patients treated with neoadjuvant systemic therapy by M.C. Van Maaren, T.A. Hueting, D.J.P. van Uden, M. van Hezewijk, L. de Munck, M.A.M. Mureau, P.A. Seegers, Q.J.M. Voorham, M.K. Schmidt, G.S. Sonke, C.G.M. Groothuis-Oudshoorn, S. Siesling

“…The previously developed INFLUENCE tool was rebuild, including a recent population and patients who received neoadjuvant systemic therapy (NST). Methods: Women, surgically treated for nonmetastatic breast cancer, diagnosed between 2012 and 2016, were selected from the Netherlands Cancer Registry. …”
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Enhanced myofibroblast differentiation of eMSCs in intrauterine adhesions by Jun Song, Meiqi Li, Yuan Tao, Yumeng Li, Canrong Mai, Jingting Zhang, Lan Yao, Shaoquan Shi, Jianyong Xu

“…Because the eMSCs (endometrial mesenchymal stem/stromal cells) play a critical role in both supporting the gland development and also preparing the environment for embryo implantation through decidualization, the characteristics and functions were compared between the eMSCs derived from IUA and non-IUA patients, to uncover the important roles of eMSCs in IUA and also the underlying mechanisms. Methods Endometrium biopsies were collected from IUA patients and controls. …”
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Relationship between albumin-corrected anion gap and lumbar spine bone mineral density: a cross-sectional study by Aiguo Liu, Aiguo Liu, Ting Ying, Shuang Deng, Chenxu Wang, Chenxu Wang, Ziwen Zhao, Sitong Zhang, Han Xiao, Chengqing Yi, Dejian Li

“…ObjectivesThis study aimed to investigate the relationship between albumin-corrected anion gap (ACAG) and lumbar spine bone mineral density (BMD) in a diverse population, assessing how variations in ACAG levels correlate with changes in lumbar spine BMD and the potential implications for osteoporosis risk.MethodsA cross-sectional analysis was conducted involving 3,057 participants (1,555 males and 1,502 females). …”
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CytoSorb hemoadsorption of apixaban during cardio-pulmonary bypass for heart transplantation by Anouk Frering, MD, Antoine Abi Lutfallah, MD, Aude Carillion, MD, PhD, Daniel Wendt, MD, Pascal Leprince, MD, PhD, Adrien Bougle, MD, PhD, Guillaume Lebreton, MD, PhD

“…The aim of this short communication is to describe the perioperative effects of the use of the CytoSorb hemoadsorption device during emergency CPB for a heart transplant patient. Methods: A 61-year-old male patient wait-listed for heart transplantation was admitted to our hospital to benefit from a heart transplantation. …”
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Nicotine dependence is associated with an increased risk of developing chronic, non-communicable inflammatory disease: a large-scale retrospective cohort study by Khalaf Kridin, Khalaf Kridin, Khalaf Kridin, Cristian Papara, Katja Bieber, David A. De Luca, Jan Philipp Klein, Marlene A. Ludwig, Philip Curman, Philip Curman, Philip Curman, Philip Curman, Artem Vorobyev, Astrid Dempfle, Ralf J. Ludwig

“…For most CIDs, there are inconsistent, scant, or no reports on the risk of CID associated with nicotine dependence.MethodsTo address this gap, we leveraged TriNetX, analyzing data from over 120 million electronic health records (EHRs). …”
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Mechanical chest compression increases intrathoracic hemorrhage complications in patients receiving extracorporeal cardiopulmonary resuscitation by Yoshihisa Matsushima, Tatsuhiro Shibata, Kodai Shibao, Rei Yamakawa, Miyu Hayashida, Toshiyuki Yanai, Takashi Ishimatsu, Takehiro Homma, Shoichiro Nohara, Maki Otsuka, Yoshihiro Fukumoto

“…This study investigated the relationship between mechanical CPR and severe intrathoracic hemorrhage during ECPR compared to manual CPR. Methods: We conducted a single-center retrospective study of consecutive patients who underwent ECPR from April 2017 to March 2024 according to a standard institutional protocol. …”
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Transcription factor RUNX1 regulates coagulation factor XIII-A (F13A1): decreased platelet-megakaryocyte F13A1 expression and clot contraction in RUNX1 haplodeficiency by Fabiola Del Carpio-Cano, Natthapol Songdej, Liying Guan, Guangfen Mao, Lawrence E. Goldfinger, Jeremy G.T. Wurtzel, Kiwon Lee, Michele P. Lambert, Mortimer Poncz, A. Koneti Rao

“…Objectives: To understand RUNX1 regulation of F13A1 expression in platelets/megakaryocytes and the mechanisms and consequences of decreased F13A1 in RHD. Methods: We performed studies in platelets, human erythroleukemia (HEL) cells, and human CD34+ cell-derived megakaryocytes including on clot contraction in cells following small inhibitor RNA knockdown (KD) of RUNX1 or F13A1. …”
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Supra-Annular Versus Intra-Annular Self-Expanding Valves in Small Aortic Annulus: A Propensity Score-Matched Study by Michel Pompeu Sá, MD, MSc, MHBA, PhD, Danial Ahmad, MD, MPH, Yisi Wang, MPH, Floyd Thoma, BS, Amber Makani, MD, Dustin Kliner, MD, Catalin Toma, MD, David West, MD, Derek Serna-Gallegos, MD, Ibrahim Sultan, MD

“…IAVs (Portico/Navitor). Methods: Single-center data with patients with SAA (maximum diameter <23 mm) who underwent TAVR from 2013 to 2023 with SEVs, followed by 1:1 propensity score matching (PSM). …”
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CD21low B cells reveal a unique glycosylation pattern with hypersialylation and hyperfucosylation by Peter Tobias Felixberger, Peter Tobias Felixberger, Geoffroy Andrieux, Andrea Maul-Pavicic, Andrea Maul-Pavicic, Sigune Goldacker, Sigune Goldacker, Ina Harder, Ina Harder, Sylvia Gutenberger, Sylvia Gutenberger, Jonathan J. M. Landry, Vladimir Benes, Till Fabian Jakob, Melanie Boerries, Melanie Boerries, Lars Nitschke, Reinhard Edmund Voll, Reinhard Edmund Voll, Klaus Warnatz, Klaus Warnatz, Baerbel Keller, Baerbel Keller

“…The glycosylation pattern of B cells in CVID patients has not been addressed to date.ObjectiveThe objective of this study was to examine the surface glycome of B cells in patients with CVID and associated immune dysregulation.MethodsWe performed surface lectin staining on B cells from peripheral blood and tonsils, both ex vivo and after in vitro stimulation. …”
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The impact of margins and re‐resection in pediatric synovial sarcoma by Andres F. Espinoza, Priya B. Shetty, Jillian C. Jacobson, Hannah Todd, Kelley Harrell, Alfred F. Trappey, John Doski, Eumenia C. Castro, Nicole I. Montgomery, M. Fatih Okcu, Rajkumar Venkatramani, Dai H. Chung, Sanjeev A. Vasudevan

“…We sought to evaluate the adequate resection margin and the role of re‐resection in predicting outcomes in children with synovial sarcomas. Methods A cohort of 36 patients less than 18 years of age at diagnosis who were treated for localized synovial sarcoma at three tertiary pediatric hospitals between January 2004 and December 2020 were included in this study. …”
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Ethnobotany, floristic and phytochemical studies of medicinal plants used to treat uterine fibroids in Mbarara City, Uganda by Calton Nantinda, Esther Lynnet Kisakye, David Musana, Isaac Ssessanga, Ukashar Ssenabulya, Timothy Omara, Ivan Kahwa, Florence Nalimu

“…The TMPs play a vital role in the healthcare within this region, often incorporating conventional diagnostic methods such as ultrasound scans before providing herbal treatments. …”
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Ground-based Characterization of (98943) Torifune 2001 CC21, the Target of the Hayabusa2# Space Mission by Marcel M. Popescu, Eri Tatsumi, Javier Licandro, Miguel R. Alarcon, Javier Rodríguez Rodríguez, Miquel Serra-Ricart, Julia de León, Joaquín Fernandez Martin, David Morate, Gabriel N. Simion, Bogdan Alexandru Dumitru, Daniel Nicolae Berteşteanu, George Pantelimon Prodan, Masatoshi Hirabayashi

“…During 2022–2024, this asteroid was at visible apparent magnitudes brighter than 18.5, allowing for a detailed characterization using ground-based telescope observations. …”
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Formulation Optimization and Quality Analysis of Dendrobium officinale Chewable Tablets by Wenyu ZHANG, Xianshu FU, Xue BAI, Shiwen WU, Jiabin LI, Xiaoping YU, Mingzhou ZHANG, Zihong YE

“…A single-factor experiment was used to study the effects of excipients on the appearance, taste, hardness, and weight difference of chewable tablets, and the optimal formula was selected by combining the response surface optimization and multi-index weight methods. Results showed that the optimal compound ratio of the main ingredients of D. officinale chewable tablets (mass fraction) was D. officinale:P. sibiricum:Z. jujuba=35%:10%:5%, and the corresponding total mass fractions of polysaccharides, flavonoids, and polyphenols were 159.64±0.14, 79.44±0.35, and 78.10±0.28 mg/g, respectively. …”
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