Psychometric properties and meaningful change thresholds for the QOL-E instrument in patients with myelodysplastic neoplasms by Esther Natalie Oliva, Shien Guo, Jennifer Lord-Bessen, Aylin Yucel, Roberto Latagliata, Massimo Breccia, Giuseppe A. Palumbo, Grazia Sanpaolo, Marta Riva, Valeria Santini, Uwe Platzbecker, Guillermo Garcia-Manero, Pierre Fenaux, Christopher G. Pelligra

“…The objective of this study was to evaluate the psychometric performance of the QOL-E in patients with LR-MDS.MethodsData from four clinical trials in MDS (MEDALIST, DARB-MDS, EQoL-MDS, and RevMDS trials) were used to assess construct validity, reliability, and responsiveness. …”
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Impact of Dietary Intake and Cardiorespiratory Fitness on Glycemic Variability in Adolescents: An Observational Study by Mingliang Ge, Stephanie R Lebby, Shivani Chowkwale, Caleb Harrison, Grace M Palmer, Keith J Loud, Diane Gilbert-Diamond, Mary Ellen Vajravelu, Jennifer L Meijer

“…Objectives: This study assessed the feasibility of measuring glycemic patterns using continuous glucose monitoring (CGM) in adolescents, aged 14–22 y, to estimate the relationship between VO2 max and glucose patterns. Methods: Healthy adolescents (n = 30) were recruited for a treadmill VO2 max test and to complete the following activities for 7–10 d: 1) wear a Dexcom G6 CGM, 2) complete ≥3 24-h dietary recalls, and 3) complete 1 at-home oral glucose tolerance test (OGTT, 75 g glucose). …”
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Impact of bedroom light exposure on glucose metabolic markers and the role of circadian-dependent meal timing: A population-based cross-sectional study by Qi Li, Yu-xiang Xu, Xiu-zhen Lu, Yu-ting Shen, Yu-hui Wan, Pu-yu Su, Fang-biao Tao, Xin Chen, Ying Sun

“…We aimed to explore the association between intensity and duration of bedroom LAN exposure with glucose metabolism markers, and the role of circadian-dependent meal timing in these associations. Methods: Real-ambient bedroom LAN exposure was measured using a portable illuminance meter for two consecutive days. …”
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Intravenous versus subcutaneous tocilizumab in Takayasu arteritis: multicentre retrospective study by Patrice Cacoub, Arsène Mekinian, David Saadoun, Pavel I Novikov, Savino Sciascia, Corrado Campochiaro, Olivier Fain, Ilya Smitienko, Nicolas Schleinitz, Patrick Jégo, Francesco Muratore, Carlo Salvarani, Elena Galli, Sabine Berthier, Marc Lambert, François Maurier, Isabelle Kone-Paut, Sergey Moiseev, Masataka Kuwana, Alexandre Belot, Martin Michaud, Francis Gaches, Achille Aouba, Xavier Puechal, Karim Sacre, Tiphaine Goulenok, Alessandro Tomelleri, Thomas Sené, Elena Marina Baldissera, Luigi Boiardi, Abid Awisat, Ygal Benhamou, Vahan Mukuchyan, Mathieu Vautier, Azeddine Dellal, Lucie Biard, Julie Seguier, José Hernández-Rodríguez, Olivier Espitia, Sebastien Humbert, Guillaume Denis, Nolan Hassold, Dagna Lorenzo, Helene Munoz Pons, Jean Baptiste Gaultier, Le Mouel Edwige, Antoinette Perlat, Bertrand Lioger, Jonathan Broner, Virginie Dufrost, Faten Frikha, Alexandra Audemard-Verger, Pascal Woaye-Hune, Pierre Zeminsky, Moya Alvarado, Matheus Vieira, Alberto Lo Gullo

“…Objectives In this large multicentre study, we compared the effectiveness and safety of tocilizumab intravenous versus subcutaneous (SC) in 109 Takayasu arteritis (TAK) patients.Methods We conducted a retrospective multicentre study in referral centres from France, Italy, Spain, Armenia, Israel, Japan, Tunisia and Russia regarding biological-targeted therapies in TAK, since January 2017 to September 2019.Results A total of 109 TAK patients received at least 3 months tocilizumab therapy and were included in this study. …”
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Implementing adaptive e-learning for newborn care in Tanzania: an observational study of provider engagement and knowledge gains by Peter Andrew Meaney, Christine Lynn Joyce, Ambrose Agweyu, Joseph R Mwanga, Marc Berg, Adolfine Hokororo, Hanston Ndosi, Alex Dahlen, Theopista Jacob, Florence Salvatory Kalabamu, Rishi Mediratta, Boris Rozenfeld, Zachary Haines Smith, Neema Chami, Namala Mkopi, Castory Mwanga, Enock Diocles

“…The objectives of this study were to (1) assess implementation success with use of in-person support and nudging strategy and (2) describe baseline provider knowledge and metacognition.Methods 6-month observational study at one zonal hospital and three health centres in Mwanza, Tanzania. …”
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Dupilumab in children with eosinophilic esophagitis: a retrospective multicenter study by Mohammed Hasosah, Ghassan Sukkar, Asharf AlSahafi, Ali Zaidan, Nouf Ghous, Abdulmajed Alshahrani, Ziyad Al Zahrani, Naif Hasosah, Mansour Qurashi, Loie Goronfolah, Ali Alsharief, Nagla Kamal

“…This study aimed to describe children with EoE that is difficult to treat using conventional treatment and to identify symptomatic, histological, and endoscopic improvements after dupilumab treatment. Materials and methods We conducted a retrospective multicenter study in children with confirmed EoE and performed a chart review of patients prescribed dupilumab for EoE. …”
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Loss of MEF2C function by enhancer mutation leads to neuronal mitochondria dysfunction and motor deficits in mice by Ali Yousefian-Jazi, Suhyun Kim, Jiyeon Chu, Seung-Hye Choi, Phuong Thi Thanh Nguyen, Uiyeol Park, Min-gyeong Kim, Hongik Hwang, Kyungeun Lee, Yeyun Kim, Seung Jae Hyeon, Hyewhon Rhim, Hannah L. Ryu, Grewo Lim, Thor D. Stein, Kayeong Lim, Hoon Ryu, Junghee Lee

“…However, the mechanism behind genetic mutations in the non-coding region of genes that affect epigenetic modifications remains unclear. Methods Convolutional neural network was used to identify an ALS-associated SNP located in the intronic region of MEF2C (rs304152), residing in a putative enhancer element. …”
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Several factors that predict the outcome of large B‐cell lymphoma patients who relapse/progress after chimeric antigen receptor (CAR) T‐cell therapy can be identified before cell a... by Alice Sýkorová, František Folber, Kamila Polgárová, Heidi Móciková, Juraj Ďuraš, Kateřina Steinerová, Aleš Obr, Adriana Heindorfer, Miriam Ladická, Ľubica Lukáčová, Erika Čellárová, Ivana Plameňová, David Belada, Andrea Janíková, Marek Trněný, Tereza Jančárková, Vít Procházka, Andrej Vranovský, Margaréta Králiková, Jan Vydra, Lukáš Smolej, Ľuboš Drgoňa, Martin Sedmina, Eva Čermáková, Robert Pytlík

“…Abstract Aim The aim of this study was to analyse the outcomes of patients with large B‐cell lymphoma (LBCL) treated with chimeric antigen receptor T‐cell therapy (CAR‐Tx), with a focus on outcomes after CAR T‐cell failure, and to define the risk factors for rapid progression and further treatment. Methods We analysed 107 patients with LBCL from the Czech Republic and Slovakia who were treated in ≥3rd‐line with tisagenlecleucel or axicabtagene ciloleucel between 2019 and 2022. …”
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Anthropometric measurements as markers of elevated blood pressure among Portuguese children and adolescents by Edmar Mendes, Paulo Farinatti, Alynne Andaki, Susana Vale, Andreia Pizarro, Maria Paula Santos, Clarice Martins, Jorge Mota

“…Abstract Purpose This cross-sectional study investigated the association between anthropometric measurements and age-related blood pressure (BP) in a large cohort of Portuguese children and adolescents. Methods We included 2972 individuals aged 2–18 years, drawn from previous study databases. …”
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Lipids as key biomarkers in unravelling the pathophysiology of obesity-related metabolic dysregulation by Anis Adibah Osman, Siok-Fong Chin, Lay-Kek Teh, Noraidatulakma Abdullah, Nor Azian Abdul Murad, Rahman Jamal

“…This study was aimed to discern unique metabolite signatures in obese and lean individuals using liquid chromatography-mass spectrometry quadruple time-of-flight (LC-MS/Q-TOF), with the goal of elucidating their roles in obesity. Methods: A total of 160 serum samples (Discovery, n = 60 and Validation, n = 100) of obese and lean individuals with stable Body Mass Index (BMI) values were retrieved from The Malaysian Cohort biobank. …”
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DNGR-1 limits Flt3L-mediated antitumor immunity by restraining tumor-infiltrating type I conventional dendritic cells by Ignacio Melero, Ruth Conde-Garrosa, David Sancho, Santos Mañes, Alfonso R Sanchez-Paulete, Francisco J Cueto, Carlos del Fresno, Paola Brandi, Alexis J. Combes, Elena Hernández-García, Michel Enamorado, Christian P Bromley, Manuel J Gomez, Santiago Zelenay, Salvador Iborra, Matthew F. Krummel

“…DNGR-1 has been involved in both cross-presentation of dead cell-associated antigens and processes of disease tolerance, but its role in antitumor immunity has not been clarified yet.Methods B16 and MC38 tumor cell lines were inoculated subcutaneously into wild-type (WT) and DNGR-1-deficient mice. …”
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Factors associated with attention-deficit/hyperactivity disorder among Tunisian children by Asma Guedria, Asma Guedria, Asma Guedria, Mohamed Guedria, Manel Ben Fredj, Manel Ben Fredj, Randaline Ayoub, Randaline Ayoub, Randaline Ayoub, Hela Ben Abid, Hela Ben Abid, Hela Ben Abid, Ahmed Mhalla, Ahmed Mhalla, Ahmed Mhalla, Hela Slama, Hela Slama

“…The aim of this study was to identify risk factors associated with ADHD and to discuss their involvement in the genesis of the disorder.MethodsThis is a case-control study involving a first group of 74 children (mean age = 9 years) diagnosed with ADHD. …”
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Evaluating the World Health Organization’s Hearts Model for Hypertension and Diabetes Management: A Pilot Implementation Study in Guatemala by Irmgardt Alicia Wellmann, Luis Fernando Ayala, Taryn M. Valley, Vilma Irazola, Mark D. Huffman, Michele Heisler, Peter Rohloff, Rocío Donis, Eduardo Palacios, Manuel Ramírez-Zea, David Flood

“…The study’s objective is to report outcomes from a pilot implementation trial of integrated hypertension and diabetes management based on the HEARTS model in Guatemala. Methods: We conducted a single-arm pilot implementation trial over six months from October 2023 to May 2024 in 11 Guatemalan Ministry of Health primary care facilities in two districts. …”
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Comprehensive genomic and transcriptomic profiling of pulmonary nodules in synchronous multiple primary lung cancer by Xingsheng Liu, Kun Qian, Lei Su, Xiaoru Tian, Xin Zhao, Tengteng Wang, Li Han, Zhenzhen Li, Peilong Zhang, Ruotian Wang, Baodong Liu, Yuanbo Li, Xiaogang Tan, Yi Zhang

“…Therefore, our study aims to meticulously investigate genomic distinctions among multiple pulmonary nodules within individual patients. Methods We performed targeted DNA sequencing on tumor specimens and conducted bulk RNA transcriptome analysis on 53 multiple nodules originating from 26 lung cancer patients. …”
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Safety of influenza vaccination during pregnancy: a systematic review by Brian Hutton, David Moher, Danielle B Rice, Claire Butler, Andrea C Tricco, Becky Skidmore, Candyce Hamel, Chantelle Garritty, Paul A Khan, Marco Ghassemi, Charlene Soobiah, Leila Esmaeilisaraji, Dianna M Wolfe, Deshayne Fell, Mona Hersi, Nadera Ahmadzai, Alan Michaud, Angela Sinilaite

“…Objective We conducted a systematic review to evaluate associations between influenza vaccination during pregnancy and adverse birth outcomes and maternal non-obstetric serious adverse events (SAEs), taking into consideration confounding and temporal biases.Methods Electronic databases (Ovid MEDLINE ALL, Embase Classic+Embase and the Cochrane Central Register of Controlled Trials) were searched to June 2021 for observational studies assessing associations between influenza vaccination during pregnancy and maternal non-obstetric SAEs and adverse birth outcomes, including preterm birth, spontaneous abortion, stillbirth, small-for-gestational-age birth and congenital anomalies. …”
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Effects of Mixing Tree Species on Soil Enzyme Activity and Carbon-Use Efficiency in Eroded Masson Pine Forest by WANG Man, JIANG Yongmeng, ZHANG Shiliang, ZHANG Jinxiu, ZHENG Linmin, ZENG Zhiwei, LYU Maokui, XIE Jinsheng

“…However, it is unclear how tree species mixture affects soil extracellular enzyme stoichiometry and microbial carbon-utilization efficiency in single Pinus massoniana plantation in the eroded red soil area. [Methods] In this study, we used single P. massoniana plantation, and P. massoniana and Schima superba mixed plantation with different restoration years, determined the soil physicochemical properties, extracellular enzyme activity and phospholipid fatty acid markers of different forests, and calculated the soil enzyme stoichiometric ratio and microbial carbon-utilization efficiency (CUE). …”
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Effect of trilaciclib administered before chemotherapy in patients with extensive-stage small-cell lung cancer: A pooled analysis of four randomized studies by Ying Liu, Lin Wu, Dingzhi Huang, Qiming Wang, Chen Yang, Li Zhou, Shuguang Sun, Xiaomei Jiang, Ying Cheng

“…Moreover, myeloprotection effect in 1 L, 2 L/3 L population and effect by risk category were explored. Materials and Methods: Patients with ES-SCLC who received trilaciclib were included. …”
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Detection Rate of Helicobacter Pylori Infection and Atrophic Gastritis Using Serological Markers “GastroPanel®” Among Employees of the National Medical Research Radiological Centre... by A. D. Kaprin, N. S. Sergeeva, S. S. Pirogov, I. I. Alentov, O. К. Yutsevich, V. I. Ryabtseva, G. F. Minibaeva, N. V. Marshutina, T. А. Karmakova

“…Aim: to evaluate, using the “GastroPanel®”, the frequency of detection of H. pylori infection and associated gastric diseases among doctors and medical staff of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, Moscow.Materials and methods. Employees of three branches of the National Medical Research Radiological Centre (n = 434, mean age — 48.5 ± 0.6 years) were examined using laboratory tests “GastroPanel®” (Biohit Oyj, Finland). …”
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Factors associated with early childhood development: results from the Brazilian National Survey on Child Nutrition (ENANI-2019) by Gilberto Kac, Nadya Helena Alves-Santos, Dayana Rodrigues Farias, Nathalia Cristina Freitas-Costa, Raquel Scincaglia, Paula Normando, Inês Rugani, Elisa Maria de Aquino Lacerda, Sandra Crispim, Alexandra Valeria Maria Brentani, Claudia Regina Lindgren Alves

“…Introduction The full achievement of early childhood development (ECD) is a human right and adhering to the nurturing care framework may facilitate it.Objective To evaluate the association between distal and proximal variables and developmental quotient (DQ).Methods Data from 14 159 children <5 years were evaluated in the Brazilian National Survey on Child Nutrition. …”
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Effects of Brackish Water with Different Sodium-Potassium Ratios on Soil Water-Salt Characteristics and Winter Wheat Growth by GAO Weiqiang, ZHANG Tibin, TONG Jiankang, LIU Zhenyuan, LIANG Qing, KUANG Yuxin, CHENG Yu, FENG Hao

“…[Objective] To study the effects of brackish water irrigation on soil water and salt characteristics and crop growth is helpful to guide the safe utilization of brackish water. [Methods] A pot experiment of winter wheat was carried out under the condition of rain-shielding. …”
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