Post-vaccination campaign evaluation of systemic and mucosal immunity of trivalent oral poliovirus vaccine in Karachi, Pakistan (2020–2021): a cross-sectional studyResearch in cont... by Ali Faisal Saleem, Visalakshi Jeyaseelan, Zaubina Kazi, Mahjabeen Zehra, Muhammad Masroor Alam, Grace Macklin, Rocio Lopez Cavestany, Sajid Muhammad, Najeeb Rehman, Ondrej Mach

“…We assessed the humoral and mucosal immune responses in children who received two doses of tOPV (during vaccination campaigns) in Karachi, Pakistan. Methods: A cross-sectional survey was conducted in four peri-urban sites (Cattle Colony, Ibrahim Hyderi, Ali Akber Shah, Rehri Goth) Karachi, Pakistan. …”
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Utilizing multidisciplinary mobile outreach clinics to provide comprehensive diabetic foot care to patients experiencing homelessness by Kris M. Boelitz, MD, Jaeyoung Lee, BS, Michael D. Pepin, BS, Yiming Zhang, MS, Mallory Gibbons, MSN, NP, Frances J. Lagana, DPM, Shahida Balaparya, EdD, MBA, RVT, Lindsey Carr, Jessin Varghese, BS, NP, Caitlin Sorensen, MD, Jessica P. Simons, MD, MPH, Douglas Jones, MS, MD, Andres Schanzer, MD, Tammy T. Nguyen, MD, PhD

“…We sought to evaluate the feasibility of implementing a multidisciplinary mobile outreach clinic for unhoused individuals with a focus on diabetic foot care and screening to overcome the SDoH-associated barriers to care. Methods: The multidisciplinary mobile clinic (MMC) model focused on a physician-driven volunteer initiative to recruit medical specialties in diabetic foot care from a large academic medical center. …”
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Efficacy and cost-effectiveness of an ACT and compassion-based intervention for women with breast cancer: study protocol of two randomised controlled trials {1} by Inês A. Trindade, Andreia Soares, David Skvarc, Diogo Carreiras, Joana Pereira, Óscar Lourenço, Filipa Sampaio, Bruno de Sousa, Teresa C. Martins, Paula Boaventura, Joana Marta-Simões, Mind Project Team, Helena Moreira

“…This paper presents the study protocol of two randomised controlled trials that aim to test the efficacy and cost-effectiveness of an optimised version of the Mind programme in women with breast cancer. Methods Participants will be women diagnosed with breast cancer randomly assigned to the Mind programme or a support group intervention (active control) in a 1:1 ratio for study 1, while study 2 includes one more arm (treatment as usual; inactive control) and a 2:2:1 ratio. …”
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Two-year trajectory of functional recovery and quality of life in post-intensive care syndrome: a multicenter prospective observational study on mechanically ventilated patients wi... by Junji Hatakeyama, Kensuke Nakamura, Shigeaki Inoue, Keibun Liu, Kazuma Yamakawa, Takeshi Nishida, Shinichiro Ohshimo, Satoru Hashimoto, Naoki Kanda, Shotaro Aso, Shinya Suganuma, Shuhei Maruyama, Yoshitaka Ogata, Akira Takasu, Daisuke Kawakami, Hiroaki Shimizu, Katsura Hayakawa, Takeshi Yoshida, Taku Oshima, Tatsuya Fuchigami, Hironori Yawata, Kyoji Oe, Akira Kawauchi, Hidehiro Yamagata, Masahiro Harada, Yuichi Sato, Tomoyuki Nakamura, Kei Sugiki, Takahiro Hakozaki, Satoru Beppu, Masaki Anraku, Noboru Kato, Tomomi Iwashita, Hiroshi Kamijo, Yuichiro Kitagawa, Michio Nagashima, Hirona Nishimaki, Kentaro Tokuda, Osamu Nishida

“…This multicenter prospective study investigated the 2-year trajectory of PICS and its components as well as factors contributing to deterioration or recovery in mechanically ventilated patients with coronavirus disease 2019 (COVID-19), and also attempted to identify possible countermeasures. Methods Patients who survived COVID-19 requiring mechanical ventilation completed questionnaires on the Barthel index, Short-Memory Questionnaire, Hospital Anxiety and Depression Scale, and EuroQol 5 dimensions 5-level every six months over a two-year period. …”
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Prognostic utility of neutrophil gelatinase-associated lipocalin (NGAL) levels for cardiovascular events in patients with stable coronary artery disease treated with percutaneous c... by Ting-Yu Lin, Hsin-Bang Leu, Yen-Wen Wu, Wei-Kung Tseng, Tsung-Hsien Lin, Hung-I Yeh, Kuan-Cheng Chang, Ji-Hung Wang, Wei-Hsian Yin, Chau-Chung Wu, Chun-Yao Huang, Shing-Jong Lin, Chien-Yi Hsu, Jaw-Wen Chen

“…Hypothesis We aimed to investigate the prognostic role of NGAL levels in a prospective cohort study of patients with stable CAD treated with percutaneous coronary intervention (PCI). Methods A total of 2,238 stable patients with CAD and a previous PCI were enrolled in a multicenter prospective observational study (The National Taiwan Biosignature Research, NTBR) in Taiwan. …”
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Deciphering molecular and cellular ex vivo responses to bispecific antibodies PD1-TIM3 and PD1-LAG3 in human tumors by Alfred Zippelius, Petra Herzig, Pratiksha Gulati, Christian Klein, Marta Trüb, Kirsten D Mertz, Robert Rosenberg, Viola Heinzelmann-Schwarz, Mark Wiese, Didier Lardinois, Pablo Umana, Marina Natoli, Klas Hatje, Fabian Junker, Zhiwen Jiang, Iakov I Davydov, Markus Germann, Daniel Marbach, Adrian Zwick, Patrick Weber, Stefan Seeber, Lothar Tietze, Laura Codarri-Deak, Henry Kao

“…Similarly, little is known on the differential effects of dual, compared with single, checkpoint inhibition.Methods We here performed in-depth characterization, including multicolor flow cytometry, single cell RNA sequencing and multiplex supernatant analysis, using tumor single cell suspensions from patients with cancer treated ex vivo with novel bispecific antibodies targeting programmed cell death protein 1 (PD-1) and TIM-3 (PD1-TIM3), PD-1 and LAG-3 (PD1-LAG3), or with anti-PD-1.Results We identified patient samples which were responsive to PD1-TIM3, PD1-LAG3 or anti-PD-1 using an in vitro approach, validated by the analysis of 659 soluble proteins and enrichment for an anti-PD-1 responder signature. …”
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Association between joint exposure to ambient air pollutants and carotid plaque: The mediating role of cardiometabolic risk factors by Yunfei Li, Ze Han, Xiaoyu Zhao, Yueruijing Liu, Zhiyuan Wu, Jinqi Wang, Xia Li, Xiuhua Guo, Lixin Tao

“…Our objective is to assess the association between exposure to joint air pollutants and carotid plaque and explore the mediating role of cardiometabolic factors in this relationship. Methods: The Beijing Health Management Cohort (BMHC) study followed participants recruited from 2013 to 2014 until December 31, 2020. …”
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Exploring expressed concerns and uncanny feeling in patients with shortness of breath calling out-of-hours primary care by Michelle Spek, Dorien L. Zwart, Esther de Groot, Michelle R. Timmerman, Maarten van Smeden, Daphne C. A. Erkelens, Anna S. M. Dobbe, Mathé Delissen, Frans H. Rutten, Roderick P. Venekamp

“…We therefore explored the relation between expressed concerns and researcher’s judged uncanny feeling among patients who contact OHS-PC for SOB with potential life-threatening events (LTEs) as the outcome. Methods This is an explorative cross-sectional study. …”
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Efficacy and safety of Janus kinase inhibitors in the treatment of psoriasis and psoriatic arthritis: An analysis of evidence from 2014 to 2022 by Jiao Wang, Tian Ma, Xiaoying Sun, Liu Liu, Seokgyeong Hong, Huijung Cha, Miao Zhang, Jiale Chen, Naixuan Lin, Bin Li, Xin Li

“…Background: The efficacy and safety of Janus kinase (JAK) inhibitors as novel therapeutic agents for psoriasis (PSO) and psoriatic arthritis (PsA) have not yet been systematically evaluated. Methods: Randomized controlled studies (RCTs) assessing JAK inhibitors to treat PSO or PsA published before September 1, 2022, were searched in the PubMed, Embase, and Cochrane Library databases. …”
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Viral load suppression rate of third-line antiretroviral therapy and its association with gender among HIV patients after second-line treatment failure in Africa: a systematic revi... by Tilahun Degu Tsega, Sintayehu Simie Tsega, Asaye Alamneh Gebeyehu, Getaneh Atikilt Yemata, Rahel Mulatie Anteneh, Almaw Genet Yeshiwas, Getasew Yirdaw, Chalachew Yenew, Anley Shiferaw Enawgaw, Amare Genetu Ejigu, Ahmed Fentaw Ahmed, Zeamanuel Anteneh Yigzaw, Berhanu Abebaw Mekonnen, Meron Asmamaw Alemayehu, Abathun Temesgen, Abebaw Molla, Habitamu Mekonen, Assefa Andargie Kassa, Gashaw Melkie Bayeh

“…This systematic review and meta-analysis aimed to determine the overall viral load suppression rate of third line antiretroviral therapy in Africa and to clarify the contradictory relationship between gender and viral load suppression, based on existing primary studies. Methods A systematic review and meta-analysis were conducted using PubMed, Medline, Cochrane Library, Henari, African Journals Online (AJOL), Web of science, and Google Scholar to access studies up to December 6, 2024. …”
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Effects of Different Vegetation Restoration Measures on the Disintegration Characteristics of Eroded Degraded Land of Pinus massoniana in Red Soil Region by XI Jie, WU Zehua, LIN Qiang, WU Jieling, ZHANG Liu, ZHOU Shiqi, ZHOU Qin, SUN Lili, ZHA Xuan

“…[Objective] To investigate the characteristics of soil disintegration under different vegetation restoration measures in degraded land of Pinus massoniana, compare the improvement of soil disintegration in severely degraded P. massoniana land in granite red soil area of Southern China by different vegetation restoration measures, and reveal the interactions between the influencing factors of soil disintegration in granite red soil area in Southern China. [Methods] In this study, a severely degraded land of P. massoniana in Changting County was selected as the research area, and a degraded land of P. massoniana was used as the control group (CK). …”
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Type 2 diabetes mellitus’ impact on heart failure patients’ exercise tolerance: a focus on maximal fat oxidation during exercise by Huiying Zhu, Huiying Zhu, Jianchao Pan, Jianxuan Wen, Jianxuan Wen, Xiaojing Dang, Xiaojing Dang, Xiankun Chen, Xiankun Chen, Yunxiang Fan, Yunxiang Fan, Weihui Lu, Weihui Lu, Wei Jiang, Wei Jiang

“…ObjectiveTo explore the impact of type 2 diabetes mellitus (T2DM) on exercise tolerance and fat oxidation capacity in patients with heart failure (HF).MethodsWe retrospectively analyzed 108 Chinese patients with HF who were divided into a diabetic group (T2DM group, n = 47) and a non-diabetic group (non-T2DM group, n = 61). …”
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Brand Association and Competitive advantange in alcoholic beer products in Kabale District, Uganda. by Moses, Agaba

“…The target population was 1783 including wholesalers, retailers, customers and brand and marketing managers of Nile Special Lager, Eagle Lager, Senator Extra Lager, club and Bell beer products in the District of Kabale, South Western Uganda. …”
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A Program for Master of Science in Environment and Natural Resources (MENR) by Kabale University

“…Utilize their skills to analyse relationships between agricultural production, natural resource depletion, climate change, pollution and land degradation and develop innovative methods and mitigate their effects. iii. Promote professional development through multidisciplinary approaches to solve challenges in environment and natural resources.…”
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Development of a nomogram for predicting pancreatic portal hypertension in patients with acute pancreatitis: a retrospective study by Yong Lv, Hui Luo, Yingjie Zhang, Xiangping Wang, Yanglin Pan, Yunling Li, Qiaoyu Su, Xianchen Zhan, Linhui Zhang, Xiaoyu Kang, Shuhui Liang, Gui Ren

“…This study aims to develop and validate a nomogram to predict PPH in patients with AP.Methods Consecutive patients with AP from 2015 to 2023 were retrospectively included in the study. …”
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Absence of Standard Modifiable Risk Factors in Middle Eastern Patients with Atherosclerotic Cardiovascular Disease. The Jordan Absence of Standard Modifiable Risk Factors (SMuRF-Le... by Hammoudeh AJ, Aldalal’ah M, Smadi EA, Alrishoud D, Alomari A, Alkhawaldeh M, Rizik A, Okour MF, Araydah M

“…This study investigates the prevalence, clinical profiles and outcomes of SMuRF-less patients compared with those who have SMuRFs.Methods: We analyzed data from 6 published registries and from the Jordan SMuRF-less patients study, including baseline demographic features, cardiovascular risk factors, comorbid diseases, utilization of secondary prevention pharmacotherapy and one year outcome in SMuRF-less patients, those with 1– 2 SMuRFs and with 3– 4 SMuRFs. …”
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Efficacy of a Blended Low-Intensity Internet-Delivered Psychological Program in Patients With Multimorbidity in Primary Care: Randomized Controlled Trial by Alicia Monreal-Bartolomé, Adoración Castro, M Ángeles Pérez-Ara, Margalida Gili, Fermín Mayoral, María Magdalena Hurtado, Esperanza Varela Moreno, Cristina Botella, Azucena García-Palacios, Rosa M Baños, Yolanda López-Del-Hoyo, Javier García-Campayo, Jesus Montero-Marin

“…ObjectiveThis study aimed to assess the effectiveness of improved treatment as usual (iTAU) combined with a blended low-intensity psychological intervention delivered using information and communication technologies for the treatment of multimorbidity (depression and type 2 diabetes or low back pain) in primary care settings. MethodsA 2-armed, parallel-group, superiority randomized controlled trial was designed for this study. …”
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Identifikasi Gagal Ginjal Kronis dengan Mengimplementasikan Metode Support Vector Machine beserta K-Nearest Neighbour (SVM-KNN) by Alvin Tarisa Akbar, Novanto Yudistira, Achmad Ridok

“…Identification of chronic kidney failure using the dataset created by L.Jerlin Rubini et. al. had been tested with various classification methods, for example the implementation of the Support Vector Machine (SVM) and K-Nearest Neighbor (KNN). …”
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An Easy and Quick Risk-Stratified Early Forewarning Model for Septic Shock in the Intensive Care Unit: Development, Validation, and Interpretation Study by Guanghao Liu, Shixiang Zheng, Jun He, Zi-Mei Zhang, Ruoqiong Wu, Yingying Yu, Hao Fu, Li Han, Haibo Zhu, Yichang Xu, Huaguo Shao, Haidan Yan, Ting Chen, Xiaopei Shen

“…Moreover, further insights can be gained from the application of the model to improve our understanding of SS. MethodsA total of 5125 patients with sepsis from the Medical Information Mart for Intensive Care-IV (MIMIC-IV) database were divided into training, validation, and test sets. …”
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Environmental surveillance of SARS-CoV-2 for outbreak detection in hospital: A single centre prospective study by Hania Siddiqui, Alexandra M.A. Hicks, Aaron Hinz, Prachi Ray, Jennie Johnstone, Derek R. MacFadden, Jason A. Moggridge, Michael Fralick

“…Objective: To determine whether results from the environmental detection of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) from floor swabs could be provided to the Infection Prevention and Control (IPAC) team in near real-time. Methods: We conducted a 9-week prospective study at a rehabilitation hospital in Toronto, Canada. …”
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