Surgical Treatment Patterns, Healthcare Resource Utilization, and Economic Burden in Patients with Tenosynovial Giant Cell Tumor Who Underwent Joint Surgery in the United States by Feng Lin, Winghan J. Kwong, Sherry Shi, Irina Pivneva, Eric Q. Wu, John A. Abraham

“…**Discussion:** The high proportion of patients undergoing repeat surgeries and prevalent use of opioids, NSAIDs, and physical/occupational therapy/rehabilitation services suggests an unmet medical need after surgical treatment. **Conclusions:** Surgical resection alone might be inadequate to control TGCT. …”
Get full text

Cost-effectiveness Analysis of Lorlatinib in Patients Previously Treated with Anaplastic Lymphoma Kinase Inhibitors for Non-small Cell Lung Cancer in Greece by George Gourzoulidis, Oresteia Zisimopoulou, Nadia Boubouchairopoulou, Christina Michailidi, Chrissy Lowry, Charalampos Tzanetakos, Georgia Kourlaba

“…In addition, this option addresses a significant unmet medical need.…”
Get full text

Evaluation of the accuracy of a simplified hybrid method versus the traditional digital method for measuring palatal volume by Shailendra Singh Rana, Sharvari Vichare, Abhishek Gupta, Anjana Rajagopalan, Om Prakash Kharbanda

“…A major advantage of this simplified method is that the patient is not exposed to any radiation of CBCT. Also, need for a specific skillset for digitally measuring the palatal volume is not a must.…”
Get full text

The Impact of the COVID-19 Surge Response on Motivation Among Anesthesiology Residents and Fellows: A discussion of findings from semi-structured interviews at Montefiore Medical C... by Sujatha Ramachandran, Kateryna Slinchenkova, Jonathan Leff, David Adams, Sarang Koushik, Omar Viswanath, Naum Shaparin

“…# Background The American Board of Medical Specialties definition of medical professionalism cites the need to acquire, maintain, and advance a value system serving the patients' and public's interests above self-interests.^4^ Medical professionalism is a one of the core physician competencies assessed by both the ACGME training program evaluation and the ABA certification process. …”
Get full text

Placental Vimentin Expression in Preeclampsia and Gestational Diabetes Mellitus by Fırat Asir, Suleyman Cemil Oglak, Tugcan Korak, Fatih Tas, Mehmet Yilmaz, Fikri Erdemci, Firat Sahin, Hayat Ayaz, Emine Zeynep Yilmaz, Gokhan Bolluk

“…CONCLUSION: Vimentin expression patterns in placental tissue sections reveal nuanced regulatory mechanisms, emphasizing the need for further exploration into the functional roles of vimentin in placental physiology and pathology. …”
Get full text

Principles to award learning achievements for lifelong learning in health using micro-credentials: an international Delphi study by Sharon Mitchell, John Hart, Muntaha Gharaibeh, Graham T. McMahon, Anthea Rhoda, Siobhan Fitzpatrick, Tana Wuliji, Janusz Janczukowicz

“…The expert panel agreed on the need for standards that are competency-based, and require evidence of learning indicating what a learner can do. …”
Get full text

Mechanical resistance comparison between interlocking micro-nail and tension band for fractures subject to muscular flexion forces by Alois Foltran Müller, Silvio Henrique de Freitas, Renata Gebara Sampaio Dória, Julia Belotto Guaraná, Fábio de Souza Mendonça, Atanásio Serafim Vidane, Lázaro Manoel de Camargo, Rachel Santos Bueno Carvalho, Antônio Carlos Shimano, Carlos Eduardo Ambrósio, Bruno Watanabe Minto

“…ABSTRACT: The ulna, humerus, femur, tibia, and calcaneus fractures repair, which are under constant tension due to exerted forces by the muscle groups adhered thereto, play a key role in the clinical-surgical routine, both in veterinary and human medicine. Therefore, the need for repairing orthopedic procedures is clear. …”
Get full text

Delayed Postoperative Ambulation Results in a Significant Increase in 90-Day Mortality in Surgically Treated Hip Fractures by Robert S. Wood DO, Maddie Vergun BS, Elizabeth Herrera MPH, Jacqueline Krumrey MD

“…Despite existing knowledge, there is a need for high-quality studies to understand mid- to long-term outcomes and the impact of postoperative variables on mortality. …”
Get full text

The antibiotic procurement saga: a long-neglected stewardship target to combat antimicrobial resistance in Pakistan by Shairyar Afzal, Mishal Bajwa, Nabeel Ahmed, Jawaria Jabeen, Mian Shahzeb Haroon, Rana Muhammad Zahid Mushtaq, Zikria Saleem

“…This study elucidates significant policy, practice, and education gaps regarding antibiotic use and procurement in Pakistan. There is a critical need for comprehensive antibiotic policies, including a revision in SML, enhancing pharmacist authority in procurement decisions, more rational prescribing, and ensuring access to antibiotics through more informed and data-driven processes to combat AMR effectively.…”
Get full text

STUDENT ENGAGEMENT, CHALLENGES AND COPING MECHANISMS IN HIGH SCHOOL ONLINE DISTANCE LEARNING DURING COVID-19 PANDEMIC by Aurielle Lisa Z. Maypa, Dave E. Marcial, Jade O. Montemayor

“…Preferences in terms of learning resources and activities are multi-faceted. There is a need to improve the variation of asynchronous activities like interactive multimedia, such as gamification. …”
Get full text

Targeted therapy and immunotherapy for gastric cancer: rational strategies, novel advancements, challenges, and future perspectives by Dong Luo, Yunmei Liu, Zhengmao Lu, Lei Huang

“…Further studies remain needed to address the issues of drug resistance and adverse events pertaining to such therapies for GC. …”
Get full text

Finding mobility in place attachment research: lessons for managed retreat by Robin Willcocks-Musselman, Robin Willcocks-Musselman, Julia Baird, Karen Foster, Julia Woodhall-Melnik, Kate Sherren

“…Beyond informing managed retreat scholars and practitioners, this research synthesis identifies several areas that need more attention. These needs include more qualitative research to better understand the dualistic role of place attachments in decisions to relocate, more longitudinal research about relocation experiences to fully comprehend the place attachment process during and after relocation, and increased exploration of whether place attachments can help provide stability and continuity during relocation.…”
Get full text

Repeated exposure to low doses of light induces retinal damage in vivo in a wavelength-dependent manner by Anaïs Françon, Laurent Jonet, Francine Behar-Cohen, Alicia Torriglia

“…All of this points out the need to rethink the current phototoxicity standards by taking into account the cumulative effect of the exposure to light and the role of the different parts of the emission spectrum.…”
Get full text

ASSESSING THE RESULTS OF TRAINING IN DIGITAL ENTREPRENEURSHIP IN THE AGE OF HIGH AND DEEP TECH by Oleg Kaminsky, Julia Yereshko, Sergii Kyrychenko, Maryna Duchenko

“…In addition, we are seeing a shift in the basic skills needed in science, research and development, engineering, IT, management, entrepreneurship, and more. …”
Get full text

Modeling and Planning a Transmission Network Expansion System in a Regulated Electricity Market by Considering Demand-Side Management via a Developed Fuzzy-Salp Optimization Algori... by Yuying Zhang, Lei Xu, Ji Li, Long Zhang, Zhi Yuan

“…With the daily rise in power demand, the penetration of dispersed generations (DG) such as wind turbines, the operation of series reactive compensator devices, and the progress of reconfiguration in power system management, there is a dire need for optimally planning the expansion of transmission network lines. …”
Get full text

Evaluating the cost-effectiveness of prosthetic rehabilitation for partially edentulous teeth in India: A comparative study of Clasp-Retained RPDs, Thermoplastic Resin RPDs, and Ca... by Subhash V, Aswini Kumar K, Vineetha Karuveettil

“…Patients with fewer than 20 teeth often experience a reduction in Oral Health-Related Quality of Life (OHRQoL), emphasizing the need for effective tooth replacement. Removable partial dentures (RPDs) are versatile, cost-effective solutions for partial tooth loss, including metal clasp-retained RPDs (MC-RPDs), thermoplastic resin RPDs (TR-RPDs), and cast partial dentures (CPDs). …”
Get full text

Examining tolerability, safety, and blinding in 1032 transcranial electrical stimulation sessions for children and adolescents with neuropsychiatric and neurodevelopmental disorder... by Andrea Battisti, Giulia Lazzaro, Luciana Ursumando, Barbara D’Aiello, Valeria Zanna, Floriana Costanzo, Stefano Vicari, Deny Menghini

“…In conclusion, this study provides comprehensive insights into tES tolerability and safety in paediatric clinical populations, emphasizing the need for further AEs exploration in tES and blinding procedure refinement in future research.…”
Get full text

Barlow Twins deep neural network for advanced 1D drug–target interaction prediction by Maximilian G. Schuh, Davide Boldini, Annkathrin I. Bohne, Stephan A. Sieber

“…The use of our hybrid approach of deep learning and gradient boosting machine as the underlying predictor ensures fast and efficient predictions without the need for substantial computational resources. We also propose the use of an influence method to investigate how the model reaches its decision based on individual training samples. …”
Get full text

A study looking at how missed somatropin injections affect growth in children with growth hormone deficiency: a plain language summary of publication by Jane Loftus, Bradley S. Miller, Craig S. Parzynski, Jose Alvir, Yong Chen, Priti Jhingran, Anu Gupta, Mitch DeKoven, Victoria Divino, Jenny Tse, Jing He, Michael Wajnrajch

“…. • As prescribed, somatropin needs to be injected once a day under the skin. Some children may miss many of their somatropin injections, and this is known as having “low adherence ” to treatment. …”
Get full text

Impact of Ramadan Intermittent Fasting on Salivary pH, Flow Rate, and Electrolyte Levels in Healthy Adult Men by Sinda Yacoub, Mehdi Khemiss, Amira Besbes, Helmi Ben Saad

“…The lack of reference values for salivary calcium limits assessment of its clinical impact. There is a need for further research on the effects of RIF on saliva secretion.…”
Get full text