A rare case of Ewing's sarcoma in a 4-year-old child treated by tumor endoprosthetics using 3D printing by Vladimir Stavrev, Luben Stokov, Petko Ganev, Georgi Georgiev

“…Future expectations are that non-invasive lengthening mechanisms or a biological approach will be able to meet the special needs of this population. …”
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TDP-43 as a potential retinal biomarker for neurodegenerative diseases by Margit Glashutter, Margit Glashutter, Printha Wijesinghe, Joanne A. Matsubara, Joanne A. Matsubara

“…Despite these advances, more research is needed to develop therapeutic strategies. A major limitation of human autopsy studies is the lack of corresponding brain pathology assessments to confirm TDP-43 proteinopathy diagnosis and staging. …”
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Fast In-House Next-Generation Sequencing in the Diagnosis of Metastatic Non-small Cell Lung Cancer: A Hospital Budget Impact Analysis by Ubong Silas, Maximilian Blüher, Antonia Bosworth Smith, Rhodri Saunders

“…The heterogeneity of hospital inputs and the cost of send-out NGS means context-specific inputs are needed. **Conclusion:** Using in-house NGS testing could reduce the testing turnaround time and increase the number of patients on targeted therapy. …”
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Emergency care utilization by refugee children compared to controls: A statewide database analysis. by Anna H Abrams, Jan Leonard, Sarah E Brewer, Janine Young, Kathleen M Adelgais

“…<h4>Conclusion</h4>Proportion of ED claims was higher in a refugee population compared to controls with no differences in LOS, indicating higher ED utilization among refugees for all acuity levels. Further study is needed to determine if healthcare disparities account for this difference and if population specific services may support the care of the refugee children.…”
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Effects of Neoadjuvant Denosumab on Radiological and Histological Responses in Patients Undergoing En Bloc Resection for Giant Cell Tumor of Bone: A Systematic Review by Hendra Aditama, Yo Tendy Pratama, Dhanan Prastanika S, Dita Anggara K, Rhyan Dharma S

“…However, further research is needed to confirm these findings.…”
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Rural Development in Community Empowerment Through the Governance of Village-Owned Enterprises (BUMDES) by Sofyan Hadi, Auradian Marta, Raja Muhammad Amin, Rury Febrina

“…In an effort to build Indonesia from villages, among others, village-owned enterprises are needed, which are supported by the legislation of Law Number 6 of 2014 concerning villages. …”
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Akram’s lifestyle: An effective remedy for the management of gastroesophageal reflux disease by Sadia A. Khan, Javeria Z. Khan, Tayyab S. Akhter, Hamama-Tul-Bushra Khaar, Talay Yar, Mohammad A. Randhawa

“…Further investigations with larger samples are needed to confirm the findings.…”
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Assessing the impact on mode competitiveness of improvements of the Trans-Eurasian railway network by Seyed Mohseni, Edwin van Hassel, Thierry Vanelslander

“…Fourth, looking at what would be needed to make a further shift to rail materialize on the Eurasian connection, three items pop up: rail border crossing capacity, traffic balance between both directions and backups to the TEN-T rail network.…”
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Training and education provided to local change champions within implementation trials: a rapid systematic review by Laura Jolliffe, Natasha A. Lannin, Stacy Larcombe, Brendan Major, Tammy Hoffmann, Elizabeth Lynch

“…Most programs were not individualized, and details of training and support were poorly reported. Conclusions Training needs and educational outcomes of change champions are poorly reported in implementation trials. …”
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Health Care Costs attributable to Hospital-diagnosed Back Pain: A Longitudinal Register-based Study of the Danish Population by Rikke Søgaard, Jan Sørensen

“…Analytical studies that guide the management of this disease are strongly needed, but there is a lack of cost estimates for the attributable cost of severe or chronic back pain in particular. …”
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Microbial dysbiosis in periodontitis and peri-implantitis: pathogenesis, immune responses, and therapeutic by Ziwei Cui, Peng Wang, Weiyue Gao

“…Strategies focusing on controlling pathogenic bacteria, modulating immune responses, and promoting tissue regeneration are key to restoring periodontal stability. Further research is needed to clarify the mechanisms underlying the transition from peri-implant mucositis to peri-implantitis and to optimize prevention and treatment approaches, considering the complex interactions between the microbiome and host immunity.…”
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Gender-specific secular trends and related factors of high perceived stress level among Korean older adults: a nation-wide serial cross-sectional study by Eunjeong Choi, Hyun-Ju Seo, Kye Ha Kim, Sun-Young Jung

“…Public health policies should prioritize stress reduction strategies tailored to address gender-specific needs and socio-economic disparities in older adults.…”
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Travel Burden and the Direct Medical Costs of Urologic Surgery by Daniel J. Olson, John L. Gore, Kenn B. Daratha, Kenneth P. Roberts

“…However, travel may also be associated with a decision by the healthcare provider to increase the length of stay due to a decreased ability to return to the primary hospital should complications arise. Thus, research is needed to understand the relationship between the distance a patient must travel and their outcomes following urologic surgery. …”
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Spi-VSTL: Image data collection platform using off-the shelf hardware for vertically supported crops in state-of-the-art glasshouses by Namal Jayasuriya, Malith Weerasekara, Oula Ghannoum, Yi Guo, Wen Hu

“…Image data collection platforms are needed to be tailored according to the infrastructure and nature of the crop. …”
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Traditional Chinese Medicine Prescription Generation Model Based on Search Enhancement by ZHAO Zijuan, REN Xueting, SONG Kai, QIANG Yan, ZHAO Juanjuan, ZHANG Junlong

“…Either large number of standardized dataset is needed to train the model, or the domain knowledge and expertise of TCM are required. …”
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Detrimental effects of cadmium on male infertility: A review by Nebojša Zečević, Jovana Kocić, Milan Perović, Aleksandar Stojsavljević

“…However, new, in-depth studies are needed to confirm or reject the causal relationship of Cd with male infertility.…”
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Contributions of Biomass Burning and Other Sources to Fine Particle Level and Oxidative Potential in Suburban Tokyo, Japan by Akihiro Fushimi, Ana M. Villalobos, Akinori Takami, Kiyoshi Tanabe, James J. Schauer

“…To develop effective countermeasures against PM2.5 emission sources, its origin needs to be efficiently characterized. Atmospheric PM2.5 samples were collected from a suburban Tokyo city, Tsukuba, Japan in 2012–2013 to estimate source contributions, with a focus on biomass open burning. …”
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Alcohol, alcoholism and related consequences by M. V. Mayevskaya

“…Special techniques are applied in motivational interview: empathy (realized compassion to current emotional status of the other person), reflective listening (conducting thematically directed dialogue between psychologist and the patient to obtain data), resistance following, account of actual readiness for changes and actual needs, achievement of specific targets with assessment of specific effects. …”
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Flexible and cost-effective deep learning for accelerated multi-parametric relaxometry using phase-cycled bSSFP by Florian Birk, Lucas Mahler, Julius Steiglechner, Qi Wang, Klaus Scheffler, Rahel Heule

“…Abstract To accelerate the clinical adoption of quantitative magnetic resonance imaging (qMRI), frameworks are needed that not only allow for rapid acquisition, but also flexibility, cost efficiency, and high accuracy in parameter mapping. …”
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A decade-long overview of adverse events in a tertiary surgical service in South Africa by H Wain, D L Clarke, S Wall

“…A sustained and multi-faceted approach is needed to address the challenge they pose. …”
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