Molecular characterization of a rare TP63 variant associated with split-hand/split-foot malformation 4 and incomplete penetrance: disruption of the p63-Dlx signaling pathway by Jianlong Zhuang, Yanqing Li, Yu’e Chen, Hegan Zhang, Shufen Liu, Manman Hu, Chunnuan Chen

“…However, both of the sister and grandfather of the proband had the same variant but exhibited normal limb morphology. RNA sequencing results demonstrated an increased expression level of TP63 and its downstream genes (PERP, CDH3, and DLX5) compared with the controls, indicating an enrichment of cell adhesion molecules the differentially expressed genes in the patient. …”
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Contradictory Effect of Lymphocyte Therapy and Prednisolone Therapy on CD3+CD8+CD56+ Natural Killer T Population in Women with Recurrent Spontaneous Abortion by Fatemeh Rezayat, Nafiseh Esmaeil, Abbas Rezaei, Roya Sherkat

“…Statistical Analysis Used: Normality and comparisons between study groups were performed by non-parametric unpaired Mann–Whitney, Kruskal–Wallis rank sum test, and one-way ANOVA. …”
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Propuestas de reducción de emisiones de carbono negro para fuentes móviles en Costa Rica by Daniela Alvarado-Jiménez, Jorge Herrera-Murillo, José Félix Rojas-Marín, Manuel González-Rodríguez

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Clinical and angiographic profile of left main coronary artery disease in patients with chronic coronary syndrome: a retrospective study by Abdulsalam Mahmoud Algamal, Mahmoud Abdelbadie Salem, Ahmed Ibrahim Bedier, Mohammed Salah A. Hussein, Mona Malek Abdelrahim, Shady Hussein Elhusseiny

“…Age and sex-matched control groups included patients with normal coronary angiography and non-LMD. Results Obstructive LMD had a prevalence of 4.9%, a mean age of around 60 years, and a male to female ratio of approximately 3:1. …”
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Study of long-acting vs daily growth hormone: peak levels, AUC, action duration, and IGF-1 by Ashraf Soliman, Fawzia Alyafei, Nada Alaaraj, Noor Hamed, Shayma Mohamed, Ahmed Elawwa, Vincenzo De Sanctis

“…Objectives: This review assesses the impact of LAGH therapy on serum levels of GH and insulin-like growth factor-1 (IGF-1) and evaluates the potential metabolic and safety risks compared to the natural pulsatile secretion of GH and daily GH injections in normal children. Methods: A comprehensive literature search identified studies examining the effects of LAGH therapy on serum GH and IGF-1 levels. …”
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Phytochemical and toxicological evaluation of aqueous leaf extract of Premna integrifolia L. in male balb/c mice by Suman, Pratibha Gaurav, Rajesh Saini, Kavindra Nath Tiwari, Gautam Geeta Jiwatram

“…Both studies demonstrated no mortality and only minor alterations in relative organ weights, hematology, and serum biochemistry, suggesting a low toxicity profile. Additionally, the normal histoarchitecture of vital organs indicates the absence of significant morphological changes. …”
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Tabla de volumen comercial para teca clonal en diferentes índices de sitio en la Zona Norte de Costa Rica by Katherine Barrantes-Madrigal, Rafael Murillo-Cruz, Carlos Ávila-Arias, William Fonseca-González, Ana Isabel Barquero-Elizondo

“…[Resultados]: Los modelos seleccionados tuvieron buenos ajustes (R2≥ 94 %), bajos errores de estimación (≤ 3 %), muy prácticos por usar solo el diámetro normal (DAP) como variable predictora. [Conclusiones]: Junto con la tabla de volumen comercial construida, los modelos son una herramienta útil para cuantificar, de forma rápida y precisa, el volumen comercial con corteza de teca clonal hasta 15 cm de diámetro mínimo. …”
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Introducing 3D printed models of fractures in osteology learning improves clinical reasoning skills among first-year medical students: a pilot study by Abhishek Agarwal, Anne D Souza, B. Jyostna, Ashwija Shetty, Nandini Bhat

“…Abstract Background The human bone anatomy is commonly taught using normal adult bones. However, students often face difficulties comprehending the clinical correlations related to fractures, as they only rely on text content or diagrams without three-dimensional visual aids. …”
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Soil Erosion Process Under the Combined Action of Water and Gravity on Red Soil Slope by ZHANG Xiaohan, MA Lan, YU Chong, WU Zhiwei, WANG Jie

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Composition Characteristics and Potential Regions of PM2.5 during Winter Haze Pollution in Typical Industrial Areas, NW-China by Liyao Guo, Chao Gu, Kaiyuan Dong, Shengju Ou, Xueyan Zhao, Xinhua Wang, Zhensen Zheng, Wen Yang

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Semen Parameters Can be Used as a Credible Marker with Doppler Ultrasonography in the Diagnosis of Subclinical Varicocele Cases by Tulay Irez, Bahar Sarikaya, Mine Erguven, Emre Salabas

“…Forward sperm motility in the CG was higher than in the TG (p<0.001, p<0.05). Sperm with normal morphology in the TG was lower than in the CG (p<0.001, p<0.05). …”
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Role and mechanism of dexmedetomidine in regulating bone metabolism in tail-suspended osteoporotic rats by GUO Yunliang, WANG Can, ZHANG Xinyu

“…Dex at a dose of 10 μg/kg was given intraperitoneally, once every other day from the day of tail suspension. And equal amount of normal saline was given to the control and model group. …”
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Protective effects and antioxidant mechanisms of lactobacillus combined with carnosine on the stomach and small intestine by Jian Qin, Ziyi Luo, Xu Yang, Yunqing Zhang, Huiying Li, Conghui Wang, Zhiqiang Zou, Yue Ma, Jing Ma, Daoyou Yue, Dipeng Zhao, Sen Qin, Rong Du

“…Here, we report the protective effects of LAB and/or CAR on the gastrointestinal tissues in normal or dexamethasone (Dex)-induced stress mice. …”
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A Case of Exacerbation of Chronic Pancreatitis Against the Background of COVID-19 Complicated by Pancreaticopleural Fistula with Enzymatic Pleurisy by I. I. Kotov, I. Yu. Kalinina, A. R. Propp, D. A. Sulim

“…It was possible to restore the normal passage of bile and pancreatic secretions, as well as to stop the functioning of the pancreaticopleural fistula using pancreatoduodenal resection. …”
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The Effect of Delegation of Responsibilities on Teachers’ Performance in Selected Secondary Schools in Kabale Municipality, Kabale District. by Seth, Ahumuza

“…They also develop the willingness to work beyond normal time, putting in more effort and have better attitudes towards their jobs. …”
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Village Savings and loan associations and socio-economic empowerment of vulnerable people in Kamuganguzi Sub-County Kabale, District, Uganda. by Deus, Mwijukye, Moses, Agaba

“…According to UBOS 2018, Kamuganguzi Sub County which was the study area was among the poorest sub counties of Ndorwa County, Kabale District where a total of 3,516 people were food insecure, 769 people had no access to safe water, 691 children (6-17years) were out of school, 1,142 children were involved in child labour and 110 children were currently married. …”
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Irritable bowel syndrome concept from the gut microbiom point of view by Anna F. Sheptulina, Vladimir T. Ivashkin

“…Among factors which promote IBS development specific features of the patient and environmental factors, first of all nutritional stereotype and dietary pattern are considered nowa­ days. These in turn exert direct impact on quantitative and qualitative spectrum of gastrointestinal microbiota which changes, as it was demonstrated in the recent original studies, is an integral part of IBS pathogenesis and is the cornerstone of symptom origin of this func­ tional disorder. …”
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La seguridad y salud en el trabajo ante la futura reforma de la Ley de Prevención de Riesgos Laborales by Fernando Benavides, José María Ramada

“…La reforma de la Ley de Prevención de Riesgo Laborales, como norma central que afecta de pleno al derecho fundamental a una vida laboral longeva y saludable, ha de contemplar en su aplicación estas interacciones entre el sistema productivo y los sistemas de seguridad social, definido por la Ley General de Seguridad Social, y de salud, definido por la Ley general de Sanidad. …”
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Kościół wobec zagrożeń związanych z wykluczeniem przez starość by Jan Dziedzic

“… Współczesna dyskusja na temat starości koncentruje się wokół pogłębiającego się niżu demograficznego. Ta nowa rzeczywistość staje się wielkim wyzwaniem dla państwa, społeczeństwa, rodziny i Kościoła. …”
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Ewangelizator napełniony Duchem Świętym. Formacja świadków Ewangelii w Zgromadzeniu Sióstr Benedyktynek Misjonarek by Mariola Małgorzata Michalak

“…Świadomość daru chrztu świętego, wprowadzającego niejako przez „bramę” w nową jakość życia – życia według Ducha, sprawia, że każde działanie benedyktynki misjonarki jest uwielbieniem Boga, komunią z Nim i „źródłem” więzi z każdym człowiekiem. …”
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