Rescue of common and rare exon 2 skipping variants of the GAA gene using modified U1 snRNA by Paolo Peruzzo, Natascha Bergamin, Martina Bon, Sara Cappelli, Alessandra Longo, Elisa Goina, Cristiana Stuani, Emanuele Buratti, Andrea Dardis

“….-32-13T>G mutation with the U1+1 snRNA increased the amount of normal GAA mRNA by 1,8 fold and the GAA enzymatic activity by 70%. …”
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Mimosapudica L. aqueous extract protects mice against pilocarpine–picrotoxin kindling-induced temporal lobe epilepsy, oxidative stress, and alteration in GABAergic/cholinergic path... by Hart Mann Alain Youbi Mambou, Simon Pale, Orelien Sylvain Mtopi Bopda, Vanessa Tita Jugha, Nji Seraphin Ombel Musa, Tambong Ako Ojongnkpot, Bertrand Yuwong Wanyu, Raymond Bess Bila, Rashed N. Herqash, Abdelaaty A. Shahat, Germain Sotoing Taiwe

“…The animals were treated for seven consecutive days as follows: one normal group and one negative control group that received orally distilled water; four test groups that received orally four doses of Mimosa pudica (20, 40, 80, and 160 mg/kg), respectively; and one positive control group that received 300 mg/kg sodium valproate intraperitoneally. …”
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Exploring biomarkers and molecular mechanisms of Type 2 diabetes mellitus promotes colorectal cancer progression based on transcriptomics by Simin Luo, Yuhong Zhu, Zhanli Guo, Chuan Zheng, Xi Fu, Fengming You, Xueke Li

“…COX11 was the key gene for co-morbidities: in tumor tissues, COX11 expression was significantly higher than that in normal colon tissues. However, COX11 gene expression was significantly lower in patients with comorbidities than in patients without T2DM in tumor tissue. …”
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Identifikasi Gagal Ginjal Kronis dengan Mengimplementasikan Metode Support Vector Machine beserta K-Nearest Neighbour (SVM-KNN) by Alvin Tarisa Akbar, Novanto Yudistira, Achmad Ridok

“…Ginjal merupakan bagian vital bagi manusia karena berfungsi untuk menyaring atau membersihkan cairan yang kita minum agar dapat dikonsumsi oleh tumbuh secara normal. Gagal ginjal adalah situasi dimana ginjal mengalami penurunan funsionalnya secara terus-menerus yang mana dapat mengakibatkan ketidakmampuan ginjal untuk berfungsi untuk semestinya. …”
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Clinical significance of Helicobacter pylori infection in iron-deficiency anemia: features of comprehensive treatment approach by I. V. Mayev, S. A. Kochetov

“…To 56th day of treatment all patients have reached target hemoglobin levels, that corresponded to a normal range. Conclusions. Eradication therapy in patients with iron deficiency anemia, allows to achieve improvement of both physical signs and the laboratory scores in shorter terms, as well as more rapid symptom relief. …”
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A generative whole-brain segmentation model for positron emission tomography images by Wenbo Li, Zhenxing Huang, Hongyan Tang, Yaping Wu, Yunlong Gao, Jing Qin, Jianmin Yuan, Yang Yang, Yan Zhang, Na Zhang, Hairong Zheng, Dong Liang, Meiyun Wang, Zhanli Hu

“…Additionally, clinical tolerance rates, which are determined by the tumor background ratio, have confirmed the ability of the method to distinguish highly metabolic regions accurately from normal regions, reinforcing its clinical applicability. …”
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Case report: A severe myositis mimicking bulbar palsy after administration of immune checkpoint inhibitors by Philippe Rochigneux, Philippe Rochigneux, Alexandre Bertucci, Elika Loir, Alexia Mattei, Danielle Robert, Michael Dassa, Brice Chanez, Mikael Ebbo, Lea Gaigne, Anne Sophie Chretien, Giovanni Corazza, Giovanni Corazza, Nicolas Schleinitz

“…We also discussed the elimination of differential diagnoses (notably with normal MRI and cerebrospinal fluid analysis) and finally the clinical management of this severe irAE.ResultsA 57 years woman presented multiple sub-diaphragmatic adenopathies related with an advanced melanoma of unknown primary. …”
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Synergistic effects of allantoin and Achyranthes japonica-biochar profoundly alleviate lead toxicity during barley growth by Ghulam Murtaza, Najmaldin Ezaldin Hassan, Muhammad Usman, Gang Deng, Zeeshan Ahmed, Javed Iqbal, Mohamed S. Elshikh, Humaira Rizwana, Basharat Ali, Rashid Iqbal, Maximilian Lackner

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Prediction of Soil Organic Carbon Content in <italic>Spartina alterniflora</italic> by Using UAV Multispectral and LiDAR Data by Jiannan He, Yongbin Zhang, Mingyue Liu, Lin Chen, Weidong Man, Hua Fang, Xiang Li, Xuan Yin, Jianping Liang, Wenke Bai, Fuping Li

“…The results show that the following. 1) The prediction accuracy is improved by classifying the data into three types: unlodging <italic>S. alterniflora</italic> (ULSA), lodging <italic>S. alterniflora</italic> (LSA), and mudflats. 2) XGBoost outperformed RF and SVM in accurately predicting SOC content, with <italic>R</italic>²; values of 0.743 for ULSA, 0.731 for LSA, and 0.705 for mudflats; 3) In the XGBoost models constructed for ULSA, LSA, and mudflats, spectral features contributed 75.7&#x0025;, 73.1&#x0025;, and 63.1&#x0025;, respectively, with the normalized difference vegetation index emerging as the most critical spectral feature. …”
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The ameliorative effects of melatonin against BDE-47-induced hippocampal neuronal ferroptosis and cognitive dysfunction through Nrf2-Chaperone-mediated autophagy of ACSL4 degradati... by Quan Yuan, Mingwei Wang, Zhaoxiang Zhang, Ruofei Wang, Dechao Wang, Zichun Sang, Pu Zhao, Xiaoli Liu, Xiaoying Zhu, Gaofeng Liang, Hua Fan, Dongmei Wang

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Biblijne podstawy teologii zaślubin z Bogiem – punkt wyjścia dla teologii małżeństwa by Ksawery Knotz

“…Odsłaniają one tajemnicę obecności Boga w życiu człowieka. Pojawia się nowa para: Jezus Chrystus, Syn Boga i Maria, Matka Boga, drugi Adam i druga Ewa. …”
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Kurčiųjų ar neprigirdinčiųjų tėvų ir girdinčiųjų vaikų šeima: dviejų atvejų tyrimas by Laura Mikelevičiūtė, Kristina Jakaitė-Bulbukienė

“… Pristatomame tyrime analizuojama dviejų kurčiųjų ar neprigirdinčiųjų tėvų ir girdinčiųjų vaikų šeimų kalbų politika. Norą tyrinėti šią temą lėmė tai, kad šeimų, kurias sudaro kurtieji tėvai ir girdintieji vaikai, kalbinė situacija yra neaptarta arba medžiaga yra neprieinama nemokantiems lietuvių gestų kalbos. …”
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EGFR inhibition augments the therapeutic efficacy of the NAT10 inhibitor Remodelin in Colorectal cancer by Yongbin Zheng, Dan Song, Ming Guo, Chenhong Wang, Mingzhen Ma, Gongcai Tao, Licui Liu, Xiaobo He, Fengyu Cao, Dan Luo, Qingchuan Zhao, Zhongyuan Xia, Yanxin An

“…Methods NAT10 expression levels were analyzed in CRC samples and compared with those in corresponding normal tissues. The potential mechanisms of NAT10 in CRC were investigated using RNA sequencing, RNA immunoprecipitation sequencing, and acetylated RNA immunoprecipitation sequencing. …”
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Recent centennial drought on the Tibetan Plateau is outstanding within the past 3500 years by Yu Liu, Huiming Song, Zhisheng An, Qiang Li, Steven W. Leavitt, Ulf Büntgen, Qiufang Cai, Ruoshi Liu, Congxi Fang, Changfeng Sun, Kerstin Treydte, Meng Ren, Lidong Mo, Yi Song, Wenju Cai, Quan Zhang, Weijian Zhou, Achim Bräuning, Jussi Grießinger, Deliang Chen, Hans W. Linderholm, Ashish Sinha, Hai Cheng, Lu Wang, Ying Lei, Junyan Sun, Wei Gong, Xuxiang Li, Linlin Cui, Liang Ning, Lingfeng Wan, Thomas W. Crowther, Constantin M. Zohner

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Influence of spine biomechanics and sagittal balance on the outcome of lumbar discectomy by José Poblete Carrizo, José Poblete Carrizo, Jesús Martínez, Julio González, Alejandra Mosteiro, Ramon Torné, Ramon Torné, Alberto Di Somma, Alberto Di Somma, José Ríos, Joaquim Enseñat, Joaquim Enseñat, Salvador Fuster, Salvador Fuster

“…Noteworthy, the radicular and lumbar pain and disability outcomes 12 and 24 months after surgery were significantly better in the group with normal sagittal balance (ODI 14.52 vs. 40.06 p &lt; 0.001; radicular VAS 2.74 vs. 5.58 p &lt; 0.001; lumbar VAS 3.61 vs. 4.06 p &lt; 0.001).ConclusionLumbar degenerative disc disease represents a major burden for healthcare systems; thus, its management is determinant. …”
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The chromosome-level genome provides insights into the adaptive evolution of the visual system in Oratosquilla oratoria by Daizhen Zhang, Xiaoli Sun, Lianfu Chen, Lianyu Lin, Chijie Yin, Wenqi Yang, Jun Liu, Qiuning Liu, Huabin Zhang, Senhao Jiang, Yongxin Li, Boping Tang, Gang Wang

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Acetyl-CoA synthesis in the skin is a key determinant of systemic lipid homeostasis by Phuong T.T. Nguyen, Mia Shiue, Nina Kuprasertkul, Pedro Costa-Pinheiro, Luke T. Izzo, Laura V. Pinheiro, Hayley A. Affronti, Gabriel Gugiu, Shivani Ghaisas, Joyce Y. Liu, Jordan C. Harris, Charles W. Bradley, John T. Seykora, Xiaolu Yang, Taku Kambayashi, Clementina Mesaros, Brian C. Capell, Kathryn E. Wellen

“…Here, we developed inducible whole-body Acly-knockout mice to determine the requirement for ACLY in normal tissue functions, uncovering its crucial role in skin homeostasis. …”
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Enhancing deep learning methods for brain metastasis detection through cross-technique annotations on SPACE MRI by Tassilo Wald, Benjamin Hamm, Julius C. Holzschuh, Rami El Shafie, Andreas Kudak, Balint Kovacs, Irada Pflüger, Bastian von Nettelbladt, Constantin Ulrich, Michael Anton Baumgartner, Philipp Vollmuth, Jürgen Debus, Klaus H. Maier-Hein, Thomas Welzel

“…Methods Retrospective contrast-enhanced (gadobutrol 0.1 mmol/kg) SPACE and MPRAGE data of 157 patients with BM were used, either annotated on MPRAGE resulting in normal annotation quality (NAQ) or on coregistered SPACE resulting in HAQ. …”
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Clinical characteristics and prognosis of amyopathic dermatomyositis patients with interstitial lung disease: insights from a retrospective cohort by Yanan Ying, Tingting Wu, Long Wang, Yun Zhang, Yiming Yu, Zaichun Deng, Qunli Ding

“…Notably, 81.26% of patients with ADM-NSIP/OP had LDH levels above normal. The serum LDH levels could be used to distinguish patients with ADM-NSIP/OP (sensitivity: 73.91%, specificity: 82.64%). …”
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Penerapan Decision Tree dan Random Forest dalam Deteksi Tingkat Stres Manusia Berdasarkan Kondisi Tidur by Sza Sza Amulya Larasati, Elok Nuraida Kusuma Dewi, Brahma Hanif Farhansyah, Fitra Abdurrachman Bachtiar, Fajar Pradana

“…Each feature has a different value range, so normalization is performed to standardize these ranges. …”
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