Oakland score to identify low-risk patients with lower gastrointestinal bleeding performs well among emergency department patients by Daniel D. DiLena, Sean C. Bouvet, Madeline J. Somers, Maqdooda A. Merchant, Theodore R. Levin, Adina S. Rauchwerger, Dana R. Sax

“…Results We identified 8,283 patients with LGIB, 52% were female, mean age was 68, 49% were non-White, and 27% had an adverse event. …”
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Challenges in developing a split drive targeting dsx for the genetic control of the invasive malaria vector Anopheles stephensi by Mireia Larrosa-Godall, Joshua X. D. Ang, Philip T. Leftwich, Estela Gonzalez, Lewis Shackleford, Katherine Nevard, Rob Noad, Michelle A. E. Anderson, Luke Alphey

“…Several promising suppression drives have been developed in An. gambiae that target the sex determination gene doublesex (dsx). …”
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Dietary index for gut microbiota and its protective role against kidney stones: evidence of diabetes as a mediator from NHANES cross-sectional data by Lei Wang, Junjun Wu, Ziwen Jiang, Chao Wang, Fuxiang Lin, Yuxiang Zhong, Pengpeng Zhao, Wei Wei, Jianhua Huang, Zhanping Xu

“…Multivariable logistic regression was employed to assess the association between DI-GM and KS prevalence, with statistical significance set at p < 0.05. Mediation analysis evaluated diabetes’s contribution to this relationship, and subgroup analyses were conducted based on sex, race/ethnicity, and alcohol consumption.ResultsHigher DI-GM scores were associated with lower KS prevalence (adjusted OR: 0.78, 95% CI: 0.65–0.92 per SD increase). …”
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Circular RNA encoded by PPARG in the peripheral blood and a lipopolysaccharide-induced cardiomyocyte inflammation model is identified as a marker of fulminant myocarditis by Shasha Huang, Shumin He, Fei Xiao, Yang Zhou, Su Lyu

“…Abstract Background Fulminant myocarditis (FM), a critical cardiac disease, is characterised by atypical initial symptoms and rapid progression and tends to lead to cardiomyocyte degeneration or necrosis. …”
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Development of a machine learning model related to explore the association between heavy metal exposure and alveolar bone loss among US adults utilizing SHAP: a study based on NHAN... by Jiayi Chen

“…The selected data were balanced using the Synthetic Minority Oversampling Technique (SMOTE) and divided into a training set and testing set at a 3:1 ratio. Logistic Regression (LR), Support Vector Machines (SVM), Random Forest (RF), K-Nearest Neighbor (KNN), Decision Tree (DT), and XGboost were used to construct the ML model. …”
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Longitudinal maternal glycemia during pregnancy and placental epigenetic age acceleration by Tesfa Dejenie Habtewold, Prabhavi Wijesiriwardhana, Richard J. Biedrzycki, Cuilin Zhang, Katherine L. Grantz, Jagteshwar Grewal, Fasil Tekola-Ayele

“…Abstract Background Dysregulation of maternal glucose homeostasis has been related to an increased risk of morbidity and mortality in mothers and fetuses, yet the mechanism remains unclear. …”
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Urinary interleukin 13 level in steroid sensitive and resistant nephrotic syndrome: a cross-sectional single center study by Behnam Ermian, Noosha Samieefar, Aida Vahidi, Daryoush Fahimi, Niloufar Peirovi, Mohamed Husein Aldokhi, Behnaz Bazargani, Arash Abbasi, Fahimeh Askarian, Mastaneh Moghtaderi

“…There was no significant difference between the urinary interleukin-13 levels between SSNS and SRNS groups (P-value: 0.84). Sex (P-value: 0.598) and age (P-value: 0.704) also had no association with interleukin-13 levels. …”
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Association of blood manganese and selenium levels with hepatic steatosis among adolescents: a nationwide cross-sectional analysis by Bin You, Bin You, Bin You, Bin You, Zhiyuan Chen, Zhiyuan Chen, Zhiyuan Chen, Zhiyuan Chen

“…Subgroup analyses did not reveal statistically significant interactions by age, sex, or obesity status, although associations appeared stronger in younger adolescents.ConclusionElevated blood manganese and selenium levels are associated with a higher prevalence of hepatic steatosis in adolescents. …”
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Spatially mapping the tumour immune microenvironments of non-small cell lung cancer by Lysanne Desharnais, Mark Sorin, Morteza Rezanejad, Bridget Liu, Elham Karimi, Aline Atallah, Anikka M. Swaby, Miranda W. Yu, Samuel Doré, Saskia Hartner, Benoit Fiset, Yuhong Wei, Baharak Kadang, Roni Rayes, Philippe Joubert, Sophie Camilleri-Broët, Pierre-Olivier Fiset, Daniela F. Quail, Jonathan D. Spicer, Logan A. Walsh

“…The spatial architectural differences between lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) are relatively unexplored. Here, we applied imaging mass cytometry to a balanced cohort of LUAD and LUSC patients, matched for clinical factors such as age, sex, and smoking history, to analyze 204 histopathology images of tumours from 102 individuals with non-small cell lung cancer (NSCLC). …”
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Adverse health effects after breast cancer up to 14 years after diagnosis by Marianne J. Heins, Kelly M. de Ligt, Janneke Verloop, Sabine Siesling, Joke C. Korevaar, Annette Berendsen, Daan Brandenbarg, Anneriet Dassen, Agnes Jager, Jacqueline Hugtenburg, Gerda van der Weele

“…Methods: We retrieved data on 11,495 women diagnosed with breast cancer in 2000–2016 and 23,242 age and sex matched controls from the PSCCR-Breast Cancer, a database containing data about cancer diagnosis, treatment and primary healthcare. …”
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Early therapeutic drug monitoring of methotrexate and its association with acute kidney injury: A retrospective cohort study by Nicolás Tentoni, Miriam Hwang, Gabriela Villanueva, Ryan Combs, Jennifer Lowe, Laura B. Ramsey, Zachary L. Taylor, Thais Murciano Carrillo, María Dolores Aumente, Teresa López‐Viñau López, Carmelo Rizzari, Scott C. Howard

“…Abstract Introduction High‐dose methotrexate (HDMTX) use can be limited by the development of acute kidney injury (AKI). …”
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Global, regional, and national disease burden attributable to high systolic blood pressure in youth and young adults: 2021 Global Burden of Disease Study analysis by Chuan He, Saien Lu, Haijie Yu, Yingxian Sun, Xueyao Zhang

“…Participants were aged 15–39 years from 204 countries/territories. We analysed HSBP-related disease burden by region, sex, age, and temporal trends. …”
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Predictors of biochemical and structural response to medical therapy in patients with active acromegaly following surgery: a real-world perspective by Maryam Rafieemanesh, Manizhe Ataee Kachuee, Ali Zare Mehrjardi, Alireza Khajavi, Mohammad Ghorbani, Mohammad Reza Mohajeri-Tehrani, Nahid Hashemi-Madani, Mohammad E. Khamseh

“…Abstract Background Somatostatin receptor analogs (SRAs) and dopamine agonists (DAs) are the main medical treatments for patients with acromegaly who fail to achieve remission after surgery. We aimed to explore the potential role of select clinical, biochemical, and radiological factors in predicting biochemical and structural responses to medical therapy in a real-world setting. …”
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Unveiling inequalities: Racial, ethnic, and socioeconomic disparities in diabetes: Findings from the 2007-2020 NHANES data among U.S. adults by Yangyang Deng, Mohammad Moniruzzaman, Breanna Rogers, Lu Hu, Ram Jagannathan, Kosuke Tamura

“…Objective: Despite persistent disparities in diabetes prevalence among racial and ethnic minorities, there remains a significant lack of understanding regarding the intersectionality of racial and ethnic groups and socioeconomic status (SES) with diabetes. Methods: The data came from the National Health and Nutrition Examination Survey (NHANES; N = 30,754, mean age = 47.4) using cross-sectional survey cycles from 2007 to 2008 through 2017–2020. …”
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Screening of COPD patients using the COPD diagnostic questionnaire and a portable spirometer in primary healthcare institutions: a cross-sectional, diagnostic study by Feng Chen, Qingrong Nie, Xuefeng Han, Chunjuan Li, Qimeng Liu, Feifei Xu, Li Zhang, Le Qiao, Maoxin Li, Ying Zhang, Haiyan Wang

“…An FEV1/FVC ratio of < 70% indicated COPD, while an FEV1/FVC ratio of ≥ 70% was classified as non-COPD. …”
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Changes in Internet Activities and Influencing Factors for Problematic Internet Use During the COVID-19 Pandemic in Korean Adolescents: Repeated Cross-Sectional Study by Sol I Kim, Jae-Chan Jin, Seo-Koo Yoo, Doug Hyun Han

“…Adolescents spent more time on gaming and social media, reflecting a notable shift in use patterns. ObjectiveWe hypothesized that the COVID-19 pandemic changed internet use patterns among Korean adolescents, including content types, time spent on web-based activities, and pathological use prevalence. …”
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Investigation of risk factors associated with Ancylostoma spp. infection and the benzimidazole F167Y resistance marker polymorphism in dogs from the United States by Pablo D. Jimenez Castro, Jennifer L. Willcox, Haresh Rochani, Holly L. Richmond, Heather E. Martinez, Cecilia E. Lozoya, Christian Savard, Christian M. Leutenegger

“…Ancylostoma caninum is the most significant intestinal nematode parasite of dogs. We acquired fecal surveillance data from a large population of dogs in the United States (US). …”
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Validity and reliability of the Manchester Oxford Foot Questionnaire (MOXFQ) in one-year postoperative ankle fracture patients—a validation study by Michael Quan Nguyen, Marjolein Memelink Iversen, Knut Harboe, Ingvild Dalen, Aksel Paulsen

“…The PROM has three domains: (1) Pain; (2) Walking/Standing; and (3) Social Interaction. One study found sufficient content validity for the Pain and Walking/Standing domains when used in the evaluation of ankle fracture patients. …”
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Phthalate exposure induces microRNA-5010/Nrf2-EGR1/GDF15 signaling expression in prostate cancer by Yuh-Shyan Tsai, Yeong-Chin Jou, Ian Seng Cheong, Hsiu-Ting Tung, Lin-Nei Hsu, Hsin-Tzu Tsai, Tzong-Shin Tzai

“…Unlike MIR-205, a known tumor suppressor gene in prostate cancer, gene set enrichment analysis revealed that higher MIR-5010 expression was linked to increased Nrf-2 downstream signaling (enriched score: 0.35; p = 0.17). …”
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RNA editing-based biomarker blood test for the diagnosis of bipolar disorder: protocol of the EDIT-B study by Andrea Miranda-Mendizabal, Diana Vetter, Juan Zambrano, Jeff Zarp, Victor Chavarría, Anna Giménez-Palomo, Meritxell Gonzalez-Campos, Marc Valenti, Lara Walczer Baldinazzo, Sara Siddi, Maurizio Ferrari, Dinah Weissmann, Chantal Henry, Josep Maria Haro, Lars Vedel Kessing, Eduard Vieta

“…The EDIT-B is a blood-based test that combines RNA editing biomarkers and individual data (e.g., age, sex, and tobacco consumption). The clinical validation performance of the EDIT-B will be evaluated using the area under the curve, sensitivity, specificity, positive and negative predictive values, and likelihood ratios. …”
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