Comparison of handheld rebound tonometry with Goldmann applanation tonometry in children with glaucoma: a cohort study by Catey Bunce, Peng Tee Khaw, John Brookes, Maria Papadopoulos, Amanda Lewis, Poornima Rai, Renata Puertas, Annegret Hella Dahlmann-Noor, Shenille Tabasa-Lim, Ahmed El-Karmouty, Mustafa Kadhim, Nicholas Kloster Wride, Dawn Grosvenor

“…Objective To test agreement of two methods to measure intraocular pressure (IOP): rebound tonometry (RBT) and gold standard Goldmann applanation tonometry (GAT) in children with glaucoma.Design Observational prospective cohort study.Setting Tertiary paediatric glaucoma clinic at a single centre.Participants 102 individuals attending a paediatric glaucoma clinic, mean (SD) age 11.85 (3.17), of whom 53 were male.Primary and secondary outcome measures Intraocular pressure, central corneal thickness, child preference for measurement method.Results Limits of agreement for intraobserver and interobserver were, respectively, (−2.71, 2.98) mm Hg and (−5.75, 5.97) mm Hg. …”
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Temporal shifts in dengue epidemic in Guangdong Province before and during the COVID-19 pandemic: a Bayesian model study from 2012 to 2022. by Jiaqing Xu, Xiaohua Tan, Yi Quan, Dexin Gong, Hui Deng, Jianguo Zhao, Xing Huang, Yingtao Zhang, Zhoupeng Ren, Zuhua Rong, Weilin Zeng, Xing Li, Wenyuan Zheng, Shu Xiao, Jianpeng Xiao, Meng Zhang

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The use of strong analgesics for prehospital pain management in children in the region of Southern Denmark: a register-based study by Josefine Tvede Colding-Jørgensen, Gina Maj Graven Brandstrup, Vibe Maria Laden Nielsen, Josefine Gradman, Line Anker Bang Thybo, Peter Martin Hansen, Daniel Wittrock, Stig Nikolaj Fasmer Blomberg, Helle Collatz Christensen, Søren Mikkelsen

“…The median fentanyl-equipotent doses of opioids were 1.7 µg/kg adjusted according to standardised patient weight. …”
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Patients with chronic heart failure and predominant left atrial versus left ventricular myopathy by Xuanyi Jin, Wan Ting Tay, Dinna Soon, David Sim, Seet Yoong Loh, Sheldon Lee, Fazlur Jaufeerally, Lieng Hsi Ling, A. Mark Richards, Adriaan A. Voors, Carolyn S. P. Lam, Joost P. van Melle

“…LA reservoir strain and LV global longitudinal strain (LVGLS) were measured using dedicated software of the two-dimensional speckle tracking analysis to evaluate LA and LV function and to define the myopathy. …”
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Multi-omics uncovers immune-modulatory molecules in plasma contributing to resistance exercise-ameliorated locomotor disability after incomplete spinal cord injury by Ren Zhou, Jibao Chen, Yunhan Tang, Chuijin Wei, Ping Yu, Xinmei Ding, Li’ao Zhu, Jiajia Yao, Zengqiang Ouyang, Jing Qiao, Shumin Xiong, Liaoliao Dong, Tong Yin, Haiqing Li, Ye Feng, Lin Cheng

“….: ChiCTR2400087038) at https://www.chictr.org.cn/ .…”
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Clinical characteristics and outcomes in Asian patients with heart failure with mildly reduced ejection fraction by Julian Cheong Kiat Tay, Shaw Yang Chia, Siew Hui Michelle Koh, David Kheng Leng Sim, Ping Chai, Seet Yoong Loh, Fazlur Rehman Jaufeerally, Sheldon Shao Guang Lee, Patrick Zhan Yun Lim, Jonathan Yap

“…HFmrEF patients were more likely to be gender neutral, of mid-range age and have concomitant diabetes mellitus, hyperlipidaemia, peripheral vascular disease and coronary artery disease (P < 0.001). The two-year overall mortality rates for HFrEF, HFmrEF and HFpEF were 32.9%, 31.8% and 29.1%, respectively. …”
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Binding of HCN channels to GABAB receptors in dopamine neurons of the VTA limits synaptic inhibition and prevents the development of anxiety by Enrique Pérez-Garci, Kateryna Pysanenko, Giorgio Rizzi, Florian Studer, Daniel Ulrich, Thorsten Fritzius, Simon Früh, Alessandra Porcu, Valérie Besseyrias, Adolf Melichar, Martin Gassmann, Tania Rinaldi Barkat, Rostislav Tureček, Kelly R. Tan, Bernhard Bettler

“…During GABAergic synaptic transmission, G protein-coupled GABAB receptors (GBRs) activate K+ channels that prolong the duration of inhibitory postsynaptic potentials (IPSPs). …”
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Immunogenicity and safety of a live-attenuated SARS-CoV-2 vaccine candidate based on multiple attenuation mechanisms by Mie Suzuki Okutani, Shinya Okamura, Tang Gis, Hitomi Sasaki, Suni Lee, Akiho Kashiwabara, Simon Goto, Mai Matsumoto, Mayuko Yamawaki, Toshiaki Miyazaki, Tatsuya Nakagawa, Masahito Ikawa, Wataru Kamitani, Shiro Takekawa, Koichi Yamanishi, Hirotaka Ebina

“…BK2102 did not kill the Tg mice, even when virus was administered at a dose of 106 plaque-forming units (PFUs), while 102 PFU of the D614G strain or an attenuated strain lacking the furin cleavage site of the spike was sufficient to kill mice. …”
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Fear of electrocardiogram interpretation (ECGphobia) among medical students and junior doctors by Ching-Hui Sia, Nicholas Wen Sheng Chew, Clarissa Wei Shuen Cheong, Tin Wei Yuen, Erica Lauren Soong, Yi-Jing Ong, Tiong-Cheng Yeo, Kian-Keong Poh, Shirley Beng Suat Ooi, William Kok-Fai Kong

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Development of highly bioactive long-acting recombinant porcine FSH for batch production management of sows by Jiawei Zhang, Lei Shi, Xiaorong Zhong, Yunhe Bai, Jun Dou, Lu Zhang, Xiaochao Shi, Bingchun Wu, Zemin Tan, Lin Yan, Jinku Yu, Jingru Zhang, Guo Han, Jiansheng Xiong, Hua Zhang, Xingyuan Cao, Haoshu Luo

“…Equine chorionic gonadotropin (eCG) is widely used to stimulate follicular development in both experimental and farm animals. …”
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Risk of Stroke Associated with Temperature and PM2.5: Taiwan Stroke Registry-based Study by Fung-Chang Sung, Hei-Tung Yip, Cheng-Li Lin, Jiann-Shing Jeng, Jiunn-Tay Lee, Yu Sun, Cheng-Yu Wei, Po-Yen Yeh, Kuang-Hsi Chang, Shang-Yu Chien, Kai-Cheng Hsu, TSR team

“…The highest incidence of ischemic strokes appeared at PM2.5 greater than 37.0 µg m−3 during 20–24°C, whereas the highest incidence of hemorrhagic strokes appeared at PM2.5 greater than 37.0 µg m−3 at less than 15°C. …”
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VSIG4+ tumor-associated macrophages mediate neutrophil infiltration and impair antigen-specific immunity in aggressive cancers through epigenetic regulation of SPP1 by Zongfu Pan, Jinming Chen, Tong Xu, Anqi Cai, Bing Han, Ying Li, Ziwen Fang, Dingyi Yu, Shanshan Wang, Junyu Zhou, Yingying Gong, Yulu Che, Xiaozhou Zou, Lei Cheng, Zhuo Tan, Minghua Ge, Ping Huang

“…In our study, we found targeting VSIG4+ TAMs by VSIG4 deficiency or blockade remarkably limited tumor growth and metastasis, especially those derived from anaplastic thyroid cancer (ATC) and pancreatic cancer, two extremely aggressive types. …”
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A platform for Bioengineering Tissue Membranes from cell spheroids by Quang Bach Le, Hariharan Ezhilarasu, Weng Wan Chan, Alok Tanala Patra, Priya Murugan, Shashaank Abhinav Venkatesh, Yean Kai Tay, Shin Ru Lim, Ahmad Amirul Abdul Rahim, Jia Sheng Zach Lee, Xuezhi Bi, Deepak Choudhury

“…To overcome this, we developed a method to assemble spheroids into a thin layer by using two mesh scaffolds to spread them evenly, and a solid frame with grid to secure the assembly. …”
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Interaction of counter-propagating relativistic laser pair with subwavelength thin solid-density foil by X. R. Jiang, D. B. Zou, M. Y. Yu, K. Y. Feng, X. H. Yang, H. W. Chen, L. X. Hu, W. Q. Wang, G.B. Zhang, F. Q. Shao, W. H. Tang, T. P. Yu

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Evolution of aroma compounds in round soy sauce aroma type baijiu during aging and the effect of aging markers on the lasting aroma in finished glass by Shi-Yi Wang, Chen Li, Yu-Jie Li, Guang-Qian Liu, Zhen-Ming Lu, Li-Juan Chai, Hong-Yu Xu, Jin-Song Shi, Song-Tao Wang, Cai-Hong Shen, Xiao-Juan Zhang, Zheng-Hong Xu

“…Kinetic analysis showed that short/medium-chain ethyl esters reach equilibrium in the esterification-hydrolysis reactions, whereas long-chain ethyl esters favor esterification, with their reaction quotient (Qc) diverging from the equilibrium point. Linoleic acid ethyl ester, identified as a key aging marker, was found to reduce the volatilization rate of critical aroma compounds in the finished glass, thereby prolonged the duration of lingering aromas. …”
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Electroacupuncture for mild-to-moderate dry eye: study protocol for a multicentre, randomised, single-blind, sham-controlled trial by Yue Zhao, Guang Yang, Yun-Qiong Lu, Mei-Yan Li, Jue Hong, Yan-Ting Yang, Xue-Jun Wang, Xie-He Kong, Zhao Ma, Xin-Yun Huang, Yue-Lan Zou, Xing-Tao Zhou, Xiao-Peng Ma

“…The secondary outcomes include tear meniscus height, the Schirmer I test, corneal and conjunctival sensation, the ocular surface disease index, corneal fluorescein staining, the numerical rating scale and the Chinese DE-related quality of life scale.Ethics and dissemination The trial protocol and informed consent were approved by the Ethics Committee of Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine (identifier: 2021–119), Shanghai Eye Disease Prevention and Treatment Center (identifier: 2022SQ003) and Eye and ENT Hospital of Fudan University (identifier: 2022014).Trial registration number NCT05552820.…”
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Association of lower-limb strength with different fall histories or prospective falls in community-dwelling older people: a systematic review and meta-analysis by Ringo Tang-Long Zhu, Jenny Jing-Jing Zuo, Ke-Jing Li, Freddy Man Hin Lam, Arnold Yu Lok Wong, Lin Yang, Xue Bai, Man Sau Wong, Timothy Kwok, Yong-Ping Zheng, Christina Zong-Hao Ma

“…Tests of entire lower-limb power required the cumulative and coordinated contractions of more leg muscles, possibly explaining why they could identify the fallers whereas the RTD or power of a single muscle group could not. …”
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Upadacitinib in active non-radiographic axial spondyloarthritis: 2-year data from the phase 3 SELECT-AXIS 2 study by Filip Van den Bosch, Atul Deodhar, Denis Poddubnyy, Walter P. Maksymowych, Désirée van der Heijde, Tae-Hwan Kim, Mitsumasa Kishimoto, Xenofon Baraliakos, Xianwei Bu, Ivan Lagunes-Galindo, In-Ho Song, Peter Wung, Koji Kato, Anna Shmagel

“…Patients were randomized 1:1 to receive double-blinded treatment with upadacitinib 15 mg once daily (QD) or placebo for 52 weeks, after which all patients received open-label treatment with upadacitinib 15 mg QD. …”
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Overcoming hypoxia-induced breast cancer drug resistance: a novel strategy using hollow gold-platinum bimetallic nanoshells by Lian-Ying Zhang, Xiao-Tong Chen, Rong-Tian Li, Wei Meng, Guo-Qin Huang, Yong-Jian Chen, Feng-Jun Ge, Qun Zhang, Yu-Jun Quan, Cai-Tao Zhang, Yi-Fei Liu, Ming Chen, Jin-Xiang Chen

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Ion suppression correction and normalization for non-targeted metabolomics by Iqbal Mahmud, Bo Wei, Lucas Veillon, Lin Tan, Sara Martinez, Bao Tran, Alexander Raskind, Felice de Jong, Yiwei Liu, Jibin Ding, Yun Xiong, Wai-kin Chan, Rehan Akbani, John N. Weinstein, Chris Beecher, Philip L. Lorenzi

“…Here we report a method, the IROA TruQuant Workflow, that uses a stable isotope-labeled internal standard (IROA-IS) library plus companion algorithms to: 1) measure and correct for ion suppression, and 2) perform Dual MSTUS normalization of MS metabolomic data. …”
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