Effectiveness of educational interventions to promote safe handling of pesticides: protocol for a systematic review and meta-analysis by Anne Cockcroft, Neil Andersson, Sergio Paredes-Solís, José Legorreta-Soberanis, Belén Madeline Sánchez-Gervacio, Víctor Manuel Alvarado-Castro, Miguel Flores-Moreno, Claudia Erika Rios-Rivera, Janet Saldaña-Almazán

“…A systematic review will collate evidence of the effectiveness of educational interventions among farmers regarding health hazards and the safe handling of pesticides. …”
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Comparative effectiveness of laparoscopic versus open colectomy in colon cancer patients: a study protocol for emulating a target trial using cancer registry data by Semaw Ferede Abera, Gabriele Robers, Anika Kästner, Ulrike Stentzel, Kerstin Weitmann, Wolfgang Hoffmann

“…The results will substantiate existing evidence on the comparative effectiveness of laparoscopic versus open colectomy in patients with stage I–III colon cancer and may guide clinical decisions as to whether a laparoscopic approach is as safe as an open approach in terms of improving 5-year overall survival in these patient groups.…”
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Ethnopharmocology, phytochemistry and pharmacology of the genus Orthosiphon: A review by Rui Wang, Ling Qiu, Qing-wen Zhang, Ligen Lin

“…Despite substantial bias in attention among various species of the genus Orthosiphon, its potential as health food and therapeutic agents is evident. The genus is an underexplored source of bioactive compounds with potential in various therapeutic areas. …”
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Elevated fasting serum xylitol levels are associated with a lower risk of incident type 2 diabetes among individuals with prediabetes in the Chinese population by Yicheng Qi, Xiaoyong Li, Yu Liu, Meng Wang, Yiming Wu, Qing Su, Li Qin, Jing Ma

“…This association was particularly evident in those with fasting hyperglycemia. These findings suggest that fasting serum xylitol levels may serve as an important predictor and protective factor against the development of diabetes.…”
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Advancing treatment choices: CDK4/6 inhibitor switching in HR+/HER2- metastatic breast cancer by Paola Zagami, Angela Esposito, Beatrice Taurelli Salimbeni, Pier Paolo Maria Berton Giachetti, Roberta Scafetta, Matteo Lambertini, Massimo Di Maio, Giuseppe Curigliano, Carmen Criscitiello, Saverio Cinieri

“…Yet, 49 % of respondents emphasized the need for more real world evidence on CDK4/6i switch safety and efficacy. 96 % of respondents reported discontinuation rates between 0% and 25 % of patients, with constipation and hematological toxicity being the most frequent treatment discontinuation reasons. …”
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Protocol of the Nurses’ Mental Health Study (NMHS): a nationwide hospital multicentre prospective cohort study by Jiaxin Yang, Chongmei Huang, Shuiyuan Xiao, Xuting Li, Meng Ning, Zengyu Chen, Yusheng Tian, Qiang Yu, Yamin Chen, Ya-Min Li

“…The results of NMHS will inform nursing research and practice by providing evidence to nurse managers, healthcare organisations and the government about the target mental health outcomes for early prevention and intervention.Trial registration number This study has been registered at the Chinese Clinical Trail Registry (ID: ChiCTR2300072142, https://www.chictr.org.cn/showproj.html?…”
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Prenatal exposure to polycyclic aromatic hydrocarbons and blood pressure in the early life of children by Xiaodong Chen, Lingling Dong, Lina Yang, Yan Yang, Liyu Yang, Sijia Han

“…BKMR showed no strong evidence for SBP or DBP but suggested potential positive associations for PP and MAP at higher exposure quantiles, indicating nuanced, exposure-dependent relationships with blood pressure outcomes. …”
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Database and geospatial mapping study of those eligible for extracorporeal cardiopulmonary resuscitation in the Thames Valley Region, England by Oscar Millerchip, Jasper Eddison, Alex Rosenberg, Jon Bailey, James Raitt

“…Global Moran’s analysis of the entire region found no significant clustering or dispersal, suggesting a near-random distribution despite some evidence of hotspots. Conclusion: ECPR can improve survival for out-of-hospital cardiac arrest, but time constraints preclude access to this therapy for many, which affects equitability across a geographical area. …”
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STUDENT ENGAGEMENT, CHALLENGES AND COPING MECHANISMS IN HIGH SCHOOL ONLINE DISTANCE LEARNING DURING COVID-19 PANDEMIC by Aurielle Lisa Z. Maypa, Dave E. Marcial, Jade O. Montemayor

“…It shows that attendance and quizzes are what students often visit. Quiz and Wiki are where students spend their time. …”
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Association of ambient temperatures with suicide attempts and violence with the future projections under climate change scenarios: a nationwide time-stratified case-crossover study... by Jiwoo Park, Jieun Oh, Whanhee Lee, Yeonsu Kim, Jeong Ho Park, Ho Kim, Seungsik Hwang

“…Our findings might provide informative evidence for relevant action plans against climate change and intentional injuries.…”
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Historical and projected forest cover changes in the Mount Kenya Ecosystem: Implications for sustainable forest management by Brian Rotich, Abdalrahman Ahmed, Benjamin Kinyili, Harison Kipkulei

“…The study's methods offer a replicable framework for assessing FCC in similar ecosystems to inform evidence-based conservation and land management policies.…”
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Health and associated economic benefits of reduced air pollution and increased physical activity from climate change policies in the UK by Heather Walton, David Dajnak, Mike Holland, Dimitris Evangelopoulos, Dylan Wood, Christian Brand, Nosha Assareh, Gregor Stewart, Andrew Beddows, Shawn YC Lee, Daniela Fecht, Yunzhe Liu, Bethan Davies, Anna Goodman, Tuan Vu, Sean Beevers

“…We quantified and monetised the health benefits of the Balanced Net Zero (BNZP) and Widespread Innovation (WI) Pathways.Air pollution concentrations were predicted using Chemical Transport Models and population-weighted. …”
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Activity-based chemical proteomics reveals caffeic acid ameliorates pentylenetetrazol-induced seizures by covalently targeting aconitate decarboxylase 1 by Guanjun Li, Ling Huang, Di Gu, Peili Wang, Letai Yi, Wenhua Kuang, Ying Zhang, Junzhe Zhang, Dandan Liu, Qiaoli Shi, Huan Tang, Jichao Sun, Guohua Zeng, Xin Peng, Jigang Wang

“…Conclusion In summary, this study elucidates, for the first time, the potential antiepileptic targets and mechanism of action of caffeic acid using the ABPP strategy. Our study provides evidence supporting the utilization of caffeic acid as a promising therapeutic agent for treating epilepsy and neuroinflammation-related disorders.…”
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Genetic interaction between oxidative stress and body mass index in a Spanish population by Francisco Lara-Hernández, Rebeca Melero, María Elena Quiroz-Rodríguez, Celeste Moya-Valera, Mariana de Jesús Gallardo-Espinoza, Luis Álvarez, Ingrid Lizeth Valarezo-Torres, Laisa Briongos-Figuero, Jessica Abadía-Otero, Francisco Javier Mena-Martin, Guillermo Saez, Josep Redon, Juan-Carlos Martín-Escudero, Ana-Bárbara García-García, Guillermo Ayala, Felipe Javier Chaves

“…The results provide compelling evidence of a significant relationship between oxidative stress levels and genetic background. …”
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(RE) FAZENDO A MATÉRIA: projeto e seleção* by Matthew Kearnes

“… Esse texto examina as raízes da reorganização da matéria em física, biologia e química. …”
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Strengthening identification and characterization of causes of perinatal deaths in Kaski district of Nepal (Perinatal MITS Nepal) by Nuwadatta Subedi, Sunita Ranabhat, Sanjib Mani Regmi, Mukesh Mallik, Dela Singh, Shree Krishna Shrestha, Bandana Gurung, Arjun Bhattarai, Madan Prasad Baral, Sudhir Raman Parajuli, Ramchandra Bastola, Junu Shrestha, Sahisnuta Basnet, Eva Gauchan, Sabita Paudel

“…Discussion The mechanism of counting and accounting for deaths in a systematic manner is important and it can provide evidence to determine changes in clinical practice and to develop guidelines and training packages for preventive measures. …”
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Dynamic responses characteristics of bedrock and overburden layer slope with anchored frame piles based on shaking table test by Lei Wang, Qianhui Pu, Guangpeng Chen, Jing Lian, Changwei Yang, Mingming Dai

“…The results indicate that the overall effectiveness of anchored frame piles for slope reinforcement is superior, and the synergistic impact of front and back piles is evident. Anchor cables effectively reduce the variability of bedrock and overburden layer vibrations. …”
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Assessing the Impacts of Climate Change on Livelihoods in Rujumbura Rukungiri District. by Niwagaba, Alfred

“…The most affected crops were beans, cassava, maize, banana, potatoes, coffee and rice. On the climate change perceptions, there has been increase in drought conditions, variations in seasons, increase in temperatures, decrease in rainfall, erratic rains and increased flooding conditions. …”
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Pharmacists' knowledge, attitudes, and perceived barriers to cancer pain management: a cross-sectional survey in Chongqing, China by Yu Liu, Tao Chen, Xinyu Li, Jie Song, Fujun Zhang

“…This study assessed pharmacists' attitudes and competencies in cancer pain management, identified major barriers in China, and provided evidence for the development of targeted interventions. …”
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Effects of Sex and Age on Quadriceps and Hamstring Strength and Flexibility in High School Basketball Athletes by Takashi Nagai, Nathaniel Bates, April McPherson, Rena Hale, Timothy Hewett, Nathan D. Schilaty

“…These normative values may further assist sports medicine specialists to develop screening tests, interventions, and return-to-sport criteria in this population. # Level of Evidence 3B…”
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