Exploring BCL2 regulation and upstream signaling transduction in venetoclax resistance in multiple myeloma: potential avenues for therapeutic intervention by Rodrigo Fonseca, Yuan Xiao Zhu, Laura A. Bruins, Joseph Ahmann, Cecilia de Bonolo Campos, Esteban Braggio, Xianfeng Chen, Mariano Arribas, Susie Darvish, Seth Welsh, Erin Meermeier, Kiran K. Mangalaparthi, Richard K. Kandasamy, Greg Ahmann, J. Erin Wiedmeier-Nutor, Akhilesh Pandey, Marta Chesi, P. Leif Bergsagel, Rafael Fonseca

“…We conducted a multi-omic characterization of established VTX-resistant isogenic human myeloma cell lines (HMCL) and primary MM patient samples pre- and post-VTX treatment. …”
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Spatial frequency preferences of representations of indoor and natural scene categories in scene-selective regions under different conditions of contrast by Yuanyuan Zhang, Qiaomu Miao, Baolin Liu

“…The results showed the scene-selective regions were more efficient in distinguishing natural scene categories in LSF, and the LSF was preferentially used along with high luminance contrast in recognition of natural scenes. On the other hand, humans preferentially used HSF information in distinguishing indoor scenes.DiscussionThis distinct SF preferences maybe caused by the different aspects of information conveyed by LSF and HSF, as well as the different strategies of spatial perception in natural and indoor scenes recognition.…”
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Case report: Patients with positive HER-2 amplification locally advanced gastroesophageal junction cancer achieved pathologic complete response with the addition of pembrolizumab t... by Huanhuan Li, Chao Ren, Donghai Cui, Tao Wu, Zhiyong Nie

“…BackgroundHuman epidermal growth factor receptor 2(HER-2) is the most prominent therapeutic target for gastric (G)/gastroesophageal junction (GEJ) cancer. …”
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Isolation, Identification, and Antimicrobial Study of Yersinia spp. Isolated from Traditional and Industrial Olivier Salad Specimens in Tehran by Farnaz Eskandarzadeh, Mohammad Reza Mohammadi, Abbas Rahimi Foroushani, Mohammad Mehdi Soltan Dallal

“…The biotype of Yersinia enterocolitica was investigated, and three strains of biotype 1A and one strain of biotype 1B were identified. The human pathogenic serotype was not found in the serotype analysis. …”
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Which curriculum components do medical students find most helpful for evaluating AI outputs? by William J. Waldock, George Lam, Ana Baptista, Risheka Walls, Amir H. Sam

“…Abstract Introduction The risk and opportunity of Large Language Models (LLMs) in medical education both rest in their imitation of human communication. Future doctors working with generative artificial intelligence (AI) need to judge the value of any outputs from LLMs to safely direct the management of patients. …”
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OsHMA3 overexpression works more efficiently in generating low-Cd rice grain than OsNramp5 knockout mutation by Yuejing Gui, Joanne Teo, Dongsheng Tian, Raji Mohan, Zhongchao Yin

“…Abstract Objective Cadmium (Cd) is a highly toxic metal element and a carcinogen to humans. Rice is prone to taking up Cd from paddy fields and accumulating it in grain, which raises health concerns for rice consumers. …”
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Espaço vivido e espaço mental: Dalton Trevisan e a dicotomia social do urbanismo curitibano by Nelson H. Vieira

“…Besides illustrating how Trevisan’s short stories tend toward the universal, due to their highly conscious dialog with the reader and in spite of its regional focus, we underscore how the contradiction between the sardonic and the affective uncovers the sentimental yet disturbing side of this Human Comedy. With allusions to his stories and haikus as “thinking images” (coined by Walter Benjamin), this reading also emphasizes the performative aspect of his work that serves to unmask the hidden hypocrisy within the urban consciences of his protagonists and those of his readers. …”
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THE ROLE OF PUBLIC PRIVATE PARTNERSHIP IN DEVELOPING CATASTROPHE INSURANCE MARKET by Darko Blazhevski

“… Natural and man made disasters cause severe human, physical and economic damage, both for the economy and for the population. …”
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Oncogenic PIK3CA corrupts growth factor signaling specificity by Ralitsa R Madsen, Alix Le Marois, Oliwia N Mruk, Margaritis Voliotis, Shaozhen Yin, Jahangir Sufi, Xiao Qin, Salome J Zhao, Julia Gorczynska, Daniele Morelli, Lindsay Davidson, Erik Sahai, Viktor I Korolchuk, Christopher J Tape, Bart Vanhaesebroeck

“…Dose-dependent expression of PIK3CA H1047R in human cervical cancer and induced pluripotent stem cells corrupted the fidelity of growth factor-induced information transfer, with preferential amplification of epidermal growth factor receptor (EGFR) signaling responses compared to insulin-like growth factor 1 (IGF1) and insulin receptor signaling. …”
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Raw Camera Data Object Detectors: An Optimisation for Automotive Video Processing and Transmission by Pak Hung Chan, Chuheng Wei, Anthony Huggett, Valentina Donzella

“…RGB data has been traditionally optimised for human vision and is a highly re-elaborated and interpolated version of the collected raw data. …”
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Surgical treatment methods in the course of psychiatric disorders: Deep brain stimulation—Novel insights and indications by Ugo Giordano, Jakub Mizera, Elżbieta Żak, Justyna Pilch, Paulina Tomecka, Tomasz Dudzik, Mikołaj Palczewski, Weronika Biziorek, Patryk Piotrowski

“…Nonetheless, numerous studies are being carried out to examine its influence on the human brain and develop new treatment indications. …”
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பாரதியாரின் பார்வையில் கல்வி / Education in the Viewpoint of Bharathiyar by முனைவர் பா. விக்னேஷ்குமார் / Dr. P. Vignesh Kumar

“…Education is a fundamental human necessity throughout history. From nomadic societies to the modern technological age, it has been the driving force behind social evolution. …”
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Negative effects of humor in marketing communications by Baltezarević Ivana, Baltezarević Radoslav

“…Humor is an essential component of human psyche. Smart businesses recognize the value of incorporating humor into their marketing communications. …”
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Artificial Neural Networks as Digital Twins for Whispering Gallery Mode Optical Sensors in Robotics Applications by Amir R. Ali, Mohamed W. A. Ramadan

“…So, this paper can be very beneficial not only to the sensing technologies that are used in robotics, which are subjected to the dynamic environments, but also to the industrial automation and human-machine interface.…”
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How Trichoderma Enhances Plant Defense Enzymes in Food Crops: Current Insights and Future Perspectives in Asia by Hasan Albana, Nurbailis Nurbailis, Darnetty Darnetty

“… Food crops are plants grown for consumption by humans and animals. These crops face threats from both abiotic and biotic factors. …”
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Sinemada Motion Capture Uygulamalarında Yazılım Şirketlerin Estetik ve Teknolojik Çözümleri by Ersin Kozan

“…Çalışmamız bu belirtilen amaç doğrultusunda motion capture uygulamaları için geliştirilen Adobe, Autodesk, Blender, Daz3D, Houdini, MakeHuman gibi yazılım şirketlerinin üretmiş olduğu çözümleri doküman incelemesi tekniği ile inceleyerek yazılımların birbirinden ayrılan teknolojik yönlerini, kullanıcıya sunmuş olduğu fırsatları ve geleceğe yön veren inovatif kimliğine dair bileşenleri tespit etmiştir.…”
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Vedolizumab for inflammatory bowel diseasesI by Igor L. Khalif, M. V. Shapina

“…The vedolizumab is anti-α4β7-integrin humanized class IgG1 antibodies which suppresses migration of leukocytes in intestinal tissue, interfering thereby with development of pathologic inflammation. …”
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5-Fluorouracil-β-Cyclodextrin conjugates:Linker strategies to enhance the anticancer efficacy and reduce the side effects by Liangliang Hu, Ting Meng, Davies Marabada, Zhichao Jin, Qing Huang, Shijie Wei, Zhizhong Wang

“…The cytotoxicity assays on human colon cancer cell lines HT-29 and normal colon epithelial cells NCM-460 demonstrated that the IC50 value of the 5-FUBA-β-CD conjugate for the HT-29 cells was 38.72 ± 0.13 μM, indicating superior antitumor activity compared to both 5-FUBA-β-CD and 5-FU. …”
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Fifty years after the discovery of the association of HLA B27 with ankylosing spondylitis by Joachim Sieper, Juergen Braun

“…The human lymphocyte antigen B27 (HLA B27) is a member of the HLA class I family of genes in the major histocompatibility complex whose name goes back to its discovery in studies of transplanted tissue compatibility. …”
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Road safety behavior and related injuries among college students of urban Bengaluru by Rana Sarvar, P. K. Sreenath Menon, M. D. Sangeetha

“…INTRODUCTION: Road traffic injury is the persistent public health challenge in most regions of the world, comprising substantial human and economic losses. This study was, therefore, aimed to identify risk factors associated with risky driving behaviors and related injuries among college students in urban Bengaluru, where increased urbanization, economic development, and lifestyle changes have raised road traffic exposure. …”
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