CCL21-CCR7 blockade prevents neuroinflammation and degeneration in Parkinson’s disease models by Felipe Saceanu Leser, Flavio de Souza Júnyor, Iohanna Bianca Pagnoncelli, Anna Beatriz Delgado, Isabelle Medeiros, Ana Clara Campanelli Nóbrega, Brenda da Silva Andrade, Maiara Nascimento de Lima, Nícolas Emanoel da Silva, Laurent Jacob, Kevin Boyé, Luiz Henrique Medeiros Geraldo, Alessandra Mendonça Teles de Souza, Tatiana Maron-Gutierrez, Hugo Castro-Faria-Neto, Cristian Follmer, Carolina Braga, Gilda Angela Neves, Anne Eichmann, Luciana Ferreira Romão, Flavia Regina Souza Lima

“…Herein, we identified the neuronal chemokine CCL21 as a major cause of microglial cell imbalance through the CCR7 receptor pathway with therapeutic implications for PD. In humans, we found that CCL21 transcript expression was increased in dopaminergic neurons (DANs) of the substantia nigra in PD patients. …”
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Secretory phospholipase A2 inhibitory activity in Tragia hispida: A novel and promising therapeutic agent for dengue fever by D.V. Dayangi Hemalika, U.G. Chandrika, Ajita M. Abeysekera, Sameera R. Samarakoon, Ananda Wijewickrama, Gathsaurie Neelika Malavige

“…Furthermore, THB exhibited significant inhibition of sPLA2 activity in human serum from dengue patients (n = 31, p < 0.0001) than that exhibited by CAY 10590. …”
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Results of a modified Delphi consensus on the optimal testing pathway for oesophago-gastric cancer care in the UK by Philippe Taniere, Manuel Rodriguez-Justo, Naureen Starling, Wasat Mansoor, Thomas Bird, Martin Eatock

“…Given the level of agreement and that the stopping criteria were met, it was decided not to undertake further Delphi rounds.Conclusion The recommendations support the use of a reflex testing approach for human epidermal growth factor receptor 2, programmed death ligand 1 and microsatellite instability high/mismatch repair deficiency in patients diagnosed with OG cancer who are suitable for treatment with targeted therapy.…”
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Clinicopathological characteristics and long-term prognosis of triple-negative breast cancer patients with HER2-Low expression: a retrospective propensity score-matched cohort stud... by Xin Liu, Kaihua Zhao, Ziyan Zhang, Meiyan Liu, Hongwu Chu, Xiao Zou

“…Abstract Purpose The objective of the current research was to assess the clinicopathological characteristics and long-term prognosis of triple-negative breast cancer (TNBC) patients with human epidermal growth factor receptor 2 (HER2)-low status following breast surgery. …”
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A systematic review of neurological symptoms and brain abnormalities in SARS-CoV-2 infections by Daniel Montoya, Jacobo Albert, Sarah Lopez-Martin

“… The aim of this systematic review is to show some clear evidence of COVID-19 infections in the human brain and draw attention to the neurological symptoms that were described during the early stages of the pandemic. …”
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Comparative immobilization of lead, cadmium, and copper in soil using dead bacterial biomass and graphitic carbon nitride nanomaterials by Asifa Farooqi, Ejaz ul Haq, Hooria Ikram Raja, Hafiz Abdul Malik, Yousaf Shad Muhammad, Syed Hamza Safeer, Sohail Yousaf, Maximilian Lackner

“…Heavy metals (HM) are known to pose severe harm to the soil, crops, and human beings. The usefulness and efficiency of metal immobilization of Pb, Cd, and Cu ions using different doses of dead bacterial biomass (BM) and graphitic carbon nitride (g-C3N4) was evaluated and compared in spiked soil. …”
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The multidrug-resistant Candida auris, Candida haemulonii complex and phylogenetic related species: Insights into antifungal resistance mechanisms by Lívia S. Ramos, Pedro F. Barbosa, Carolline M.A. Lorentino, Joice C. Lima, Antonio L. Braga, Raquel V. Lima, Lucas Giovanini, Ana Lúcia Casemiro, Nahyara L.M. Siqueira, Stefanie C. Costa, Célia F. Rodrigues, Maryam Roudbary, Marta H. Branquinha, André L.S. Santos

“…The rise of multidrug-resistant (MDR) fungal pathogens poses a serious global threat to human health. Of particular concern are Candida auris, the Candida haemulonii complex (which includes C. haemulonii sensu stricto, C. duobushaemulonii and C. haemulonii var. vulnera), and phylogenetically related species, including C. pseudohaemulonii and C. vulturna. …”
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Primordial Cause of Armament, Disarmament, Weaponry and Weapons of Mass Destruction by Effiong Ekpo

“… The entirety of humanity has been confronted with a serious threat to security, especially since after the cold war. …”
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Differences in phenotypes of normal and malignant cells concerning chromosomal fragility and ganglioside expression by Iskra Sainova, Vera Kolyovska, Desislava Drenska, Dimitar Maslarov, Dimitrina Dimitrova-Dikanarova, Tzvetanka Markova

“…Additionally, the presence and expression of the tumor-suppressor gene HACE-1 in the genome of mouse embryonic stem cells (mESCs) and malignant human cervical carcinoma HeLa cells, both containing an additional copy of this gene, inserted by transfection with appropriate recombinant DNA vectors containing a copy of the tumor-suppressor gene, were tested. …”
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Bacterial community assembly of specific pathogen-free neonatal mice by Elizabeth A. Kennedy, James S. Weagley, Andrew H. Kim, Avan Antia, Anna L. DeVeaux, Megan T. Baldridge

“…Abstract Background Neonatal mice are frequently used to model diseases that affect human infants. Microbial community composition has been shown to impact disease progression in these models. …”
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Efficacy of unified protocol for transdiagnostic treatment of emotional disorders in adolescents (UP-A) in China: protocol for a randomised controlled trial by Xue Gao, Lu Liu, Mei-Rong Pan, Hai-Mei Li, Yu-Feng Wang, Xue-Ying Liu, Zhong-Fang Fu, Qiujin Qian

“…The findings may contribute to providing an effective and feasible transdiagnostic intervention in Chinese clinical settings.Ethics and dissemination This trial has been approved by the Ethics and Clinical Research Committees of Peking University Sixth Hospital and will be performed under the Declaration of Helsinki with the Medical Research Involving Human Subjects Act (WMO). The results will be disseminated in a peer-reviewed journal and a conference presentation.Trial registration number ChiCTR2300069354.…”
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Assessment of Teaching Quality of Traditional Decorative Patterns in Colleges and Universities Using an MCDM Approach and Circular Intuitionistic Information by Zi Wang, Liping Pan

“…Evaluating the teaching quality of traditional decorative patterns in colleges and universities is critical, especially when human judgment and subjective opinions are involved. …”
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A traffic prediction method for missing data scenarios: graph convolutional recurrent ordinary differential equation network by Ming Jiang, Zhiwei Liu, Yan Xu

“…Due to various factors, both human and natural, traffic data often contains missing values. …”
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Toplumsal Sistem ve Sibernetik İlişkisi: Sosyo-Sibernetiğin Doğuşu by Hale Nur Uyanık

“…Duruma bu perspektiften bakıldığında bilimler arası etkileşimi sağlayan genç ve birçok bilim dalıyla koordinasyon kuran bir bilim dalı olan sibernetik karşımıza çıkar. …”
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Content and Dynamics of Nutrients in the Surface Water of Shallow Lake Mulehe in Kisoro District, South–western Uganda. by Saturday, Alex, Kangume, Susan, Bamwerinde, Wilson

“…The recorded overall WQI value places Lake Mulehe’s water quality into the ‘poor’ category in terms of worthiness for human consumption. The study, therefore, recommends continuous pollution monitoring and enforcement of local regulations to reduce pollution in the lake as a result of anthropogenic activities.…”
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An Investigation into Information Security Managerial Practices in Selected Public Sector Organizations. by Ahimbisibwe, Benjamin K., Nabende, Peter, Musiimenta, Florence

“…Focus was made on information security practices critical to managing information like human security, information classification, procedures for information labelling, compliance, standards, command and control techniques. …”
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Community Development in the Rural Areas through Traditional Indigenous Knowledge by Godfrey, Barigye, Siraje, Kaaya

“…This progressive change is synonymous with sustainable development designed to improve the economic and social means that the total stock of environment (resources) be put into use in socio-economic and other related aspects to satisfy human needs.…”
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The Impact of Covid-19 Pandemic on Women: A Case Study of Northern Division Kabale Municipality Kabale District. by Ankunda, Tomson

“…This is because they need to be adequately supported with human and financial resources, but without reducing resources from women's programs.…”
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Content and dynamics of nutrients in the surface water of shallow Lake Mulehe in Kisoro District, South–western Uganda by Saturday, Alex, Kangume , Susan, Bamwerinde, Wilson

“…The recorded overall WQI value places Lake Mulehe’s water quality into the ‘poor’ category in terms of worthiness for human consumption. The study, therefore, recommends continuous pollution monitoring and enforcement of local regulations to reduce pollution in the lake as a result of anthropogenic activities.…”
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Hepatoprotective potential of Tamarindus indica following prenatal aluminum exposure in Wistar rat pups by Helen Ruth Yusuf a , Sunday Abraham Musa a , Abel Nosereme Agbon , Ejike Daniel Eze , Akeem Ayodeji Okesina , Ismail Onanuga , Theophilus Pius , Victor Archibong , Mario Edgar Fernandez Diaz , Juma John Ochieng , Nicholas Kusiima , Bot Yakubu Sunday , Ibe Michael Usman

“…Over time, the use of plant-derived agents in the management of various human health conditions has gained a lot of attention. …”
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