Protocol of an open-label safety and feasibility pilot study of ketamine-assisted psychotherapy for methamphetamine use disorder (the KAPPA trial) by Jonathan Brett, Celia Morgan, Nadine Ezard, Brendan Clifford, Krista J Siefried, Robert May, Liam Acheson, Kathryn Fletcher, Harriet MacDonald, Gillinder Bedi, Alexandre Guerin, Elizabeth Knock, Michael Millard, Jess Doumany

“…Secondary outcomes (changes in methamphetamine use, cravings, withdrawal, quality of life and treatment satisfaction) will be assessed over a 24-week period.Ethics and dissemination This study has been approved by the St Vincent’s Hospital Human Research Ethics Committee, reference 2023/ETH00530. …”
Get full text

Effect of different ceramic materials and dentin sealing on occlusal veneers bond strength and fracture resistance by Dina Mohamed Nasr, Rewaa Gaber AboElHassan

“…Materials and methods Human mandibular molars (N = 64/test) were prepared for occlusal veneer restorations fabricated from Lithium disilicate ceramic (LS) (control group), Zirconia-reinforced lithium Silicate ceramic (ZLS), High translucent zirconia ceramic (HZ), and Resin nano ceramic (LU) (n = 16). …”
Get full text

Eunugs in die Bybel by F. P. Retief, S. J. P. K. Riekert, J. F. G. Cilliers

“…In Deuteronomy 23:1 the act of human castration is condemned, without using the word saris, while Leviticus 22:24 refers to animal castration by crushing (Hebrew word katut) of the testes. …”
Get full text

Estimating the Burden of Illness Related to Genital Warts in Russia: A Cross-Sectional Study by Vera N. Prilepskaya, Mikhail Gomberg, Smita Kothari, Karen Yee, Amit Kulkarni, Suzanne M. Garland, Anna R. Giuliano

“…**Background:** Human papillomavirus (HPV) infections are the etiologic agents of genital warts (GW). …”
Get full text

Development of Chatbot-Based Oral Health Care for Young Children and Evaluation of its Effectiveness, Usability, and Acceptability: Mixed Methods Study by Kittiwara Pupong, Jaranya Hunsrisakhun, Samerchit Pithpornchaiyakul, Supawadee Naorungroj

“… Abstract BackgroundChatbots are increasingly accepted in public health for their ability to replicate human-like communication and provide scalable, 24/7 services. …”
Get full text

Constructing a potential HLA haplo-homozygous induced pluripotent stem cell haplobank using data from an umbilical cord blood bank by Ji He, Yanmin He, Qigang Zhan, Zhipan Wu, Qi Sheng, Wei Zhang, Faming Zhu

“…Methods To study the feasibility of constructing an HLA (human leukocyte antigen)-matched induced pluripotent stem cell haplobank in China, 5421 umbilical cord blood samples were randomly collected from the Umbilical Cord Blood Bank of Zhejiang Province, China. …”
Get full text

Molecular prevalence and associated risk factors of Entamoeba spp. in donkeys in Shanxi Province, North China by Ze-Dong Zhang, Han-Dan Xiao, Dong-Yang Wang, Nan Su, Xun-Zhi Liu, Zi-Rui Wang, Shi-Chen Xie, Xing-Quan Zhu, Shuo Zhang, Wen-Wei Gao

“…Abstract Background The intestinal protozoa Entamoeba spp. can infect humans and various animals, including donkeys, causing diarrhea and malabsorption and presenting significant risks to animal husbandry and public health. …”
Get full text

Fecal microbiota transplantation modulates jejunal host-microbiota interface in weanling piglets by Shankumar Mooyottu, Muhammed Shafeekh Muyyarikkandy, Farnaz Yousefi, Ganwu Li, Orhan Sahin, Eric Burrough, Joy Scaria, Brett Sponseller, Alejandro Ramirez

“…Abstract Background Weaning-associated enteric diseases are a major concern in the swine industry. …”
Get full text

Dupilumab in children with eosinophilic esophagitis: a retrospective multicenter study by Mohammed Hasosah, Ghassan Sukkar, Asharf AlSahafi, Ali Zaidan, Nouf Ghous, Abdulmajed Alshahrani, Ziyad Al Zahrani, Naif Hasosah, Mansour Qurashi, Loie Goronfolah, Ali Alsharief, Nagla Kamal

“…Abstract Background Eosinophilic esophagitis (EoE) is a chronic inflammatory disorder characterized by symptoms of esophageal dysfunction and eosinophil-predominant inflammation. Dupilumab is a human monoclonal antibody that targets both IL-4 and IL-13 signaling. …”
Get full text

From fear to food: predation risk shapes deer behaviour, their resources and forest vegetation by Martin, Jean-Louis, Chamaillé-Jammes, Simon, Salomon, Anne, Gomez Pourroy, Devana Veronica, Schlaeflin, Mathilde, Le Saout, Soizic, Lucas, Annick, Bentaleb, Ilham, Chollet, Simon, Pattison, Jake, Martin-Blangy, Soline, Gaston, Anthony James

“…In these populations deer had a remarkable tolerance to human presence (short flight initiation and travel distances when disturbed), a willingness to consume foreign bait or to investigate baited traps, and a propensity to be active at daytime. …”
Get full text

The ground beneath our feet: A critical reflection on 135 years of landscape evolution models for southern Africa by Rivoningo Khosa, Vela Mbele, Kelly Kirsten, Robyn Pickering

“…As we mark the centenary of the Taung discovery, we look toward a new era of landscape evolution research: one characterised by technological advancements and more diverse, local teams that will produce more quantitative, nuanced models for southern Africa and create richer, more dynamic backdrops for our own human evolution. Significance: We provide a review of over 100 years of models used to characterise landscape evolution in southern Africa. …”
Get full text

The mcpC mutant of Salmonella enteritidis exhibits attenuation and confers both immunogenicity and protective efficacy in mice by Lu Zhang, Li Chen, Xuqiang Zhang, Yang Li, Qingfeng Zheng, Yun Li, Ning Li, Qiumei Shi, Yanying Zhang, Tonglei Wu

“…BackgroundSalmonella enteritidis (SE) is a Gram-negative, facultative anaerobic intracellular pathogen that not only causes disease and mortality in livestock and poultry but also contaminates animal-derived products, leading to foodborne illnesses in humans. This presents a significant threat to public health. …”
Get full text

Comprehensive Analysis of VOCs in an Industrial Harbor City: Spatiotemporal Distribution, Health Risk, and Potential Sources by Thi-Hieu Le, Chung-Shin Yuan, Chitsan Lin, Zhi-Ping Hsu, I-Hsin Hsu, Lin-Chi Wang

“…The results are conducive to developing control strategies for VOC emissions to reduce human exposure risk to ambient air.…”
Get full text

Trend analysis of precipitation and temperature in Lahaul-Spiti district, Himachal Pradesh, India by Pankaj Kumar, Dhanjit Deka, Md. Arif Husain, Manish Kumar, Pandurang Choudhari, Shipra Singh, Azka Kamil, Abhishek Banerjee

“…Changes in the pattern of precipitation and temperature affect the socioeconomic structure of the region, affecting sectors such as agriculture, livestock, forestry, tourism, and human health. According to the perceptions of people, the temperature rise has accelerated the melting of glaciers and reduced the snow cover area. …”
Get full text

Akin Ogundiran: The Historian and Archaeologist of Yoruba-Atlantic becomes Chancellor Professor at the University of North Carolina at Charlotte by Toyin Falola

“…And if, as he treats the local, he engages in issues around production and trade—as all his objects indicate—he is forced to engage in the understanding of how society relates to nature: that is, how humans ultimately relate to their environments, using and destroying them at the same time, and sometimes renewing them as well. …”
Get full text

Wnt/β-catenin signalling underpins juvenile Fasciola hepatica growth and development. by Rebecca Armstrong, Nikki J Marks, Timothy G Geary, John Harrington, Paul M Selzer, Aaron G Maule

“…Infection by the liver fluke, Fasciola hepatica, places a substantial burden on the global agri-food industry and poses a significant threat to human health in endemic regions. Widespread resistance to a limited arsenal of chemotherapeutics, including the frontline flukicide triclabendazole (TCBZ), renders F. hepatica control unsustainable and accentuates the need for novel therapeutic target discovery. …”
Get full text

CircHIPK2 recruits SRSF1 to increase TXNIP mRNA stability and promotes autophagy-dependent ferroptosis and apoptosis in myocardial ischemia-reperfusion injury by Zhu Zhang, Jinqi Hao, Qinghong Qiao, Junting Song, Yanqin Yu

“…In this study, the role and mechanism of circHIPK2 in MIRI were evaluated. Methods Human cardiac myocytes (HCM) were cultured under Hypoxia/Reoxygenation (H/R) condition to establish a MIRI model in vitro. …”
Get full text

Impacts of drought on respiratory mortality in the upper midwest United States: a population subgroup assessment by Yeongjin Gwon, Yuanyuan Ji, Jesse D Berman, Azar M Abadi, Ronald D Leeper, Jared Rennie, Jesse E Bell

“…Its frequency and intensity are expected to increase due to climate change, posing significant threats to human health. Despite these risks, there remains a notable gap in research on the health impacts of drought, particularly at the regional level within the United States. …”
Get full text

A comprehensive analysis of molecular characteristics of hot and cold tumor of gastric cancer by Chenxi Lv, Tianwei Chen, Jiangtao Li, Yuqiang Shan, Hong Zhou

“…Finally, immunofluorescence staining for CD8, CD45, and CXCR4 was performed on human GC tissue samples. Results A total of 1,298 GC patients were included in this comprehensive analysis. …”
Get full text

The prevalence and distribution of malaria in Mpumalanga Province before and during COVID-19 (2017 - 2022) by I Kleinhans, S Mahanjana, F Els, M Mabona, L A Pitso, G Malatje, G Kok, J Raman

“…Although COVID-19-related restrictions on human movement greatly reduced the malaria burden in Mpumalanga Province, the high-risk group (young mobile men) remained unchanged over the study period. …”
Get full text