Validity, Accuracy, and Safety Assessment of an Aerobic Interval Training Using an App-Based Prehabilitation Program (PROTEGO MAXIMA Trial) Before Major Surgery: Prospective, Inter... by Sara Fatima Faqar Uz Zaman, Svenja Sliwinski, Lisa Mohr-Wetzel, Julia Dreilich, Natalie Filmann, Charlotte Detemble, Dora Zmuc, Felix Chun, Wojciech Derwich, Waldemar Schreiner, Wolf Bechstein, Johannes Fleckenstein, Andreas A Schnitzbauer

“…Trial RegistrationGerman Clinical Trials Register DRKS00026985; https://drks.de/search/en/trial/DRKS00026985 and European Database on Medical Devices (EUDAMED) CIV-21-07-0307311. International Registered Report Identifier (IRRID)RR2-10.1136/bmjopen-2022-069394…”
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Myofibrillogenesis Regulator-1 in Smooth Muscle Cells Modulates Inflammation Signaling Pathways via Regulating ROCK1 Ubiquitination and Degradation to Impact Aortic Dissection by Yin H, Li X, Lu D, Zhao X, Yang Z, Wang Z, Xu F, Chen Y, Li C

“…In vitro experiments, human aortic smooth muscle cells were extracted, and an in vitro dissection model was constructed with angiotensin II. siRNA silencing studies were performed to investigate the effects of MR-1 and ROCK1 on the development of AD and their interconnections.Results: Analysis of aortic tissues revealed significantly elevated levels of MR-1 and ROCK1 in AD patients, and meanwhile the inflammatory indexes showed the same trend. …”
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Lactate Dehydrogenase-A-Forming LDH5 Promotes Breast Cancer Progression by Fang T, Hu L, Chen T, Li F, Yang L, Liang B, Wang W, Zeng F

“…We aimed to explore the roles of LDHA and LDH5 isoenzyme activity in BC, which provides a new insight into LDHA for the treatment of BC.Methods: The expression of LDHA in BC and its relationship with clinicopathological features were obtained from various databases including The Cancer Genome Atlas (TCGA), Human Protein Atlas (HPA), Breast Cancer-Gene Expression Miner (bc-GenExMiner), TNMplot, UALCAN. …”
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INTERNATIONAL AND NATIONAL LEGAL MECHANISMS OF JUDICIAL LIABILITY IN THE CONDITIONS OF ECONOMIC GLOBALISATION OF MODERN SOCIETY by Konul Akhundova

“…A direct dependence of the economic development and rule of law indices has been revealed, since under the condition of ensuring the latter, there is a guarantee of the harmonious existence of all sectors of society, and conditions are created to prevent the emergence of existential threats to the national interests of the state, including the provision of human rights and freedoms. The mechanism for bringing judges to disciplinary responsibility has been established in accordance with international standards, including 1) a special procedure for bringing judges to disciplinary responsibility, which is defined by law; 2) the formation of an independent body that should consider such cases; 3) ensuring the right of a judge to participate in such procedure directly or through a representative, to exercise his right of defence and to express his opinion; 4) the right to appeal against the decision taken on the basis of the results of this procedure; 5) the exhaustiveness of the sanctions that can be applied and their proportionality. …”
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High-Grade Cervical Intraepithelial Neoplasia: Impact of Colposcopic Lesion Area on Systemic Immune Responses by Mantoani PTS, Micheli DC, Jammal MP, Vieira JH, Michelin MA, Ferreira CGX, Silva HN, Murta EFC, Nomelini RS

“…The objectives of the study were to determine whether colposcopic lesion area is associated with serum levels of cytokines IL (interleukin) − 1, IL-6, IL-8, IL-10, IL-12 and TNF-α in precursor lesions of cervical cancer.Methods: The study population comprised patients with high-grade squamous intraepithelial lesion who had undergone colposcopy, cervical biopsy, and measurements of serum cytokines by ELISA (Enzyme-Linked Immunosorbent Assay). Genotyping for HPV (human papillomavirus) 16, 18, 45 and 52 was performed by PCR (Polymerase Chain Reaction). …”
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Yoruba Epistemology, Art, Language and the Universe of Meanings: A Meta-Analysis by Michael O. Afolayan

“…Although short in quantity, I consider it to be loaded in quality, contents, intents, intensities, and in its ability to problematize a discourse critical to our understanding of indigenous scholarship and all its epistemological implications that span the entire landscape of the humanities. Indeed, Okediji’s pedagogy is the proverbial Yoruba drum of “ògìdìgbó” which is revealed only to the wise and the prudent, and they are the only two capable of effectively dancing to its rhythm. …”
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USC-Derived Small Extracellular Vesicles-Functionalized Scaffolds Promote Scarless Vaginal Defect Repair via Delivery of Decorin and DUSP3 Proteins by Xu Y, Li J, Qiu Y, Wu F, Xue Z, Liu B, Fan H, Zhou Y, Wu Q

“…Designing functional scaffolds that incorporate sEVs is a promising approach for scarless vaginal defect repair.Methods: sEVs-loaded scaffolds were developed through electrostatic interactions between negatively charged sEVs secreted by urine-derived stem cells (USC-sEVs) and positively charged human acellular amniotic membranes. The efficacy of sEVs-loaded scaffolds in the treatment of vaginal defects in rabbits was assessed by histological analysis. …”
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Design and Validation of Policy Making Model with Open Government Approach by Zahra Mohammadi, Abdolmajid Imani, Farahnaz Ahang

“…Behavioral factors encompass leadership and management styles, human resources management, educational initiatives, and organizational justice practices. …”
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Assessing the Factors Influencing Attrition of Health Workers in Government Health Units in Lyantonde District, Uganda. by Kansiime, Benon

“…Methodology Across sectional study of collecting qualitative and quantitative data was conducted on 171 study participants including health workers, Chief Administrative Officer, the District Health Officer, the District Principal Human Resource Officer, Secretary District Service Commission, the Chairperson District Service Commission, the District Principal Internal Auditor, and Secretary for Health, Medical superintendent Lyantonde Hospital, District Planner and the Chief Finance Officer. …”
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Odgovornost za opasnost od zakašnjenja u prijevozu robe morem by Vesna Polić Foglar

“…Tuženik je odbio organizirati zamjenski prijevoz zrakom, iako je bio nužan da se izbjegne nastup zakašnjenja i zastoj u proizvodnji automobila. …”
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Clinical Characteristics and Treatment Options of Peripheral Spondyloarthritis by ZENG Lulu, JI Xiaojian, HU Lidong, HU Jiawen, ZHANG Yinan, ZHANG Jiaxin, LIU Xingkang, YANG Shiwei, HUANG Feng

“…Compared to axSpA patients, pSpA patients had fewer male patients(62.5% vs. 79.7%, P < 0.001), later onset age(33.8 years vs. 22.0 years, P < 0.001), shorter diagnostic delays(6.0 months vs. 14.2 months, P=0.004), more associated peripheral arthritis(71.7% vs. 9.3%, P < 0.001) and dactylitis(6.5% vs. 0.3%, P < 0.001), more cases of psoriasis(52.7% vs. 1.1%, P < 0.001) and a more common family history of psoriasis(11.4% vs. 3.4%, P < 0.001). pSpA patients had higher levels of inflammatory markers but a lower positive rate of human leukocyte antigen(HLA)-B27(43.5% vs. 87.4%, P < 0.001). …”
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An optimized approach for predicting water quality features and a performance evaluation for mapping surface water potential zones based on Discriminant Analysis (DA), Geographical... by Abhijeet Das

“…Globally, ecosystems, and human health are in danger because river water quality is deteriorating. …”
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Risk Management in Sustainable Construction Projects: A Systematic Review and Bibliometric Analysis by Kasra Hosseini, Youness Javid

“…The content analysis of the articles, based on research themes, indicated that the articles were classified into five main themes: general risks of sustainability, sustainable procurement, supply chain, technology adoption, and human resources. A deeper exploration of the papers revealed that SCPs' risks were primarily categorized into eight dimensions: financial and economic; social; executive, managerial, and organizational; knowledge and skills; governmental and legal; stakeholders/employers; environmental; and technology, equipment, and resources. …”
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Fabrication of Nano-Silver Composite Using Amomum longiligulare Fruit Polysaccharides and Their Biological Activities by Lian Y, Ma N, Cheng Q, Luo M, Xu Z, He F, Zhou X, Zhang Y, Jin D, Kong Y, Wang Y, Wei N

“…Yong Lian,1,&ast; Ning Ma,2,&ast; Qianying Cheng,1,&ast; Mingquan Luo,1 Zhen Xu,1 Fei He,1 Xiaomei Zhou,1 Ying Zhang,1 Dejun Jin,1 Yidan Kong,1 Yong Wang,1 Na Wei1 1Hainan Provincial Key Laboratory of R&D on Tropical Herbs, Engineering Research Center of Tropical Medicine Innovation and Transformation of Ministry of Education, International Joint Research Center of Human-Machine Intelligent Collaborative for Tumor Precision Diagnosis and Treatment of Hainan Province, School of Pharmacy, Hainan Medical University, Haikou, 571199, People’s Republic of China; 2Reproductive Medical Center, Hainan Women and Children’s Medical Center, Haikou, Hainan Province, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Na Wei; Yong Wang, Hainan Provincial Key Laboratory of R&D on Tropical Herbs, School of Pharmacy, Hainan Medical University, Haikou, 571199, People’s Republic of China, Email [email protected]; [email protected]: Study aims to optimize the synthesis conditions for silver nanoparticle composites [ALP(D)-AgNPs] using a rapid and environmentally friendly method and investigate the antioxidant, antibacterial, and anticancer activities of the fabricated composite.Methods: The polysaccharide component ALP-D was extracted and purified from the fruits of Amomum longiligulare and subsequently used for further experiments. …”
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Call for Papers - Advancing Astropharmacy and Sports Pharmacy by Ashley Anderson, Ahmer Raza, Shireen Aziz, Misbah Noreen

“…Her research interest are on pharmacokinetic and pharmacodynamic (PKPD) changes in space, drug stability under space conditions, and the effects of the space environment on human physiopharmacology. In addition to her clinical pharmacy research, Shireen is actively working on advancing the concept of Astropharmacy, exploring innovative pharmaceutical solutions for long-duration space missions and extraterrestrial environments. …”
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Divulgação de evidências científicas sobre Práticas Integrativas e Complementares em Saúde by Luciana Fernandes Paulino, Maria Eduarda Ramos da Silva, Yasmin Aguiar Faria Lima, Marina Soares Gonçalves, Thaís Matera Ferraro Teixeira, Neemias Lima da Silva, Bárbara de Lacerda Santos Oliveira, Bianca Nunes Gomes, Fátima Helena do Espírito Santo, Gleyce Moreno Barbosa

“…In this context, the concept of humanized care and understanding of health occur in physical, psycho-emotional, mental, and social dimensions. …”
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Investigating the Role of Artificial Intelligence Enablers and Companies' Readiness in Adopting an Artificial Intelligence-integrated Customer Relationship Management System by Soheila Mohammadzadeh Vanestan, Rahim Abedi

“…In terms of existing limitations such as time and financial limitations as well as human resources required for quick response and establishing online communication, the use of communication and response programs based on artificial intelligence seems to be an efficient and effective alternative that can improve the financial and non-financial performance of the organization.…”
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Development of a Sensitive Quantum Dot-Linked Immunoassay for the Multiplex Detection of Biochemical Markers in a Microvolumeric Format by Kalvaityte U, Bagdonas E, Kirdaite G, Kausaite-Minkstimiene A, Uzieliene I, Ramanaviciene A, Popov A, Butkiene G, Karabanovas V, Denkovskij J, Mobasheri A, Bernotiene E

“…The purpose of the present research was to develop sensitive multiplex detection model of QD-based ELISA (QLISA), through the spectroscopic QD-analyte complex measurements in microvolume liquid droplets on a glass microslide.Methods: QLISA was used for the detection of cartilage oligomeric matrix protein (COMP) and human growth hormone (hGH) as model analytes. The QLISA detection method included the formation of complexes consisting of analyte antigens, biotinylated antibodies and streptavidin-coated QDs. …”
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Approaches to modulate buffalo gut microbiome for efficient feed utilization and reduced environmental pollution by Vijit Dey, Puran C. Lailer, Tirtha K. Datta

“…Therefore, insight study of buffalo rumen microbiome and dietary interventions through strategic feeding and development of new products for rumen stimulants, anti-methanogenic compounds, or alternate hydrogen sinks in the rumen could be the promising strategies for modulating gut health for efficient conversion of human inedible feeds to edible animal products so reducing the impact of buffalo production on environmental pollution. …”
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IGJR 1/2020: Housing crisis: How can we improve the situation for young people? by IF and FRFG

“…The IGJR publishes articles from humanities, social sciences, and international law. …”
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