R-loops acted on by RNase H1 influence DNA replication timing and genome stability in Leishmania by Jeziel D. Damasceno, Emma M. Briggs, Marija Krasilnikova, Catarina A. Marques, Craig Lapsley, Richard McCulloch

“…Leishmania, a human protozoan parasite, displays an unconventional DNA replication program in which the timing of DNA replication completion is chromosome size-dependent: larger chromosomes complete replication later then smaller ones. Here we show that both R-loops and RNase H1, a ribonuclease that resolves RNA-DNA hybrids, accumulate in Leishmania major chromosomes in a pattern that reflects their replication timing. …”
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Retention of locally injected human iPS cell-derived cardiomyocytes into the myocardium using hydrolyzed gelatin by Jun Iida, Kazuki Kotani, Kozue Murata, Keisuke Hakamada, Wusiman Maihemuti, Yoshinobu Mandai, Yosuke Hiraoka, Kenji Minatoya, Hidetoshi Masumoto

“…The solubility of HG allows precise control over its concentration, influencing the distribution and leakage of injected solutions, which may affect therapeutic outcomes. Using both ex vivo and in vivo rat models, we investigated how varying HG concentrations affect the retention of solution and diffusion within the myocardium. …”
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Airway clearance technique therapy for atelectasis induced by scoliosis surgery: a case report by Rui Zhai, Hairong Su, Yaxu Wu, Rong Tan, Xiaoli Zhang, Ye Tian, Mei Hu

“…Moreover, blood gas analysis indicated significant improvements in both the PaO2/FiO2 ratio and base excess of whole blood. …”
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Ankle and Distal Tibia Megaprostheses in Orthopedic Oncology: A Report of Two Cases and Review of the Literature by Edoardo Ipponi, Martina Cordoni, Elena Bechini, Fabrizia Gentili, Fabio Cosseddu, Antonio D'Arienzo, Lorenzo Andreani

“…Materials and methods: We report two cases who suffered from malignant bone tumors localized in the distal tibia and treated with wide resections and the implant of 3D printed custom-made megaprostheses to replace the distal tibia and the ankle. Results: Both patients had excellent functional results (MSTS 30/30) one year after surgery. …”
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Psychological assessment and support in functional neurological disorder: a longitudinal study by Yvonne Radin, Matteo Bulfon, Paola Caruso, Egidio Barbi, Paolo Manganotti, Andrea Clarici

“…This comparison sought to identify any alignment or discrepancies in the perception of symptoms and therapeutic progress, as measured by both the ANPS and SWAP-200 scales. The study’s preliminary findings are reported to provide valuable insights into the impact of psychotherapeutic interventions for FND, including an understanding of the degree to which patient self-reports correspond with clinical assessments. …”
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Estimation of bed shear stress and settling velocity with inertial dissipation method of suspended sediment concentration in cohesive sediment environments by Jongwi Chang, Guan-hong Lee, Ojudoo Darius Ajama, Wenjian Li

“…Comprehensive observations were conducted on the Songdo tidal flats over more than one month in 2023, using both acoustic and optical instruments. Our results suggest that the improved IDM_Sed enhances the accuracy of computed shear stress. …”
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Comparisons of performances of structural variants detection algorithms in solitary or combination strategy. by De-Min Duan, Chinyi Cheng, Yu-Shu Huang, An-Ko Chung, Pin-Xuan Chen, Yu-An Chen, Jacob Shujui Hsu, Pei-Lung Chen

“…In this study, we evaluated the efficacy of six advanced SV detection algorithms, including the commercial software DRAGEN, using the GIAB v0.6 Tier 1 benchmark and HGSVC2 cell lines. We employed both individual and combination strategies, with systematic assessments of recall, precision, and F1 scores. …”
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Arginine methyltransferase PRMT1 promotes ferroptosis through EGR1/GLS2 axis in sepsis-related acute lung injury by Min Li, Longhui Hu, Qiao Ke, Zhao Li, Chujun Ruan, Hanjing Lu, Xiaoran Liu

“…Here we show, there were elevated ferroptosis and increased expression levels of protein arginine methyltransferase 1 (PRMT1), early growth response 1 (EGR1), and glutaminase 2 (GLS2) in both in vitro and in vivo ALI models. Additionally, EGR1 was found to induce the transcription of GLS2, thereby promoting ferroptosis. …”
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Modulating the developing gut microbiota with 2’-fucosyllactose and pooled human milk oligosaccharides by Simone Renwick, Annalee Furst, Mikael Knip, on behalf of the DIABIMMUNE Study Group, Lars Bode, Jayne S. Danska, Emma Allen-Vercoe

“…Results Exposure to pHMOs induced significant shifts in both the microbial community composition and metabolic output, including an increased abundance of several genera, notably Bacteroides, and the production of health-associated metabolites. …”
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Prioritize Effective Factors of Scheduling in Tehran Metro Station with Fuzzy TOPSIS Model by Vinh Phuc Dung, Minh Tien Nhung

“…Most of the methods that led to optimization in routing in the past, both in the airline and on the ground, are based on smart methods. …”
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User Model for Virtual Learning Based on Adaptive Gamification by Intan Yusrina Zairon, Tengku Siti Meriam Tengku Wook, Syahanim Mohd Salleh, Hadi Affendy Dahlan

“…The user model integrates both stereotypical and dynamic modeling approaches, allowing for initial categorization and continuous adaptation based on learner interactions. …”
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IMPLICATIONS OF XENOPHOBIC ATTACKS ON NIGERIANS AND NIGERIA-SOUTH AFRICA DIPLOMATIC RELATIONS: A REVIEW OF RE-CURRENT ISSUES by ABDULRASHEED ABDULYAKEEN, MUHAMMAD RABIU

“…The consequential effect cut across economic, political and socio-cultural diplomatic relations between both countries. The study offers some practical steps to tackle the menace which include: South African government should enhance her diplomatic relations with Nigeria and other African countries whose citizens have fall victims of xenophobic attacks in their countries, a pragmatic measures should be taken to eradicate discrimination in South Africa. …”
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Performance optimization of Maisotsenko cycle heat exchangers: A three-dimensional parametric analysis by Seyed Esmail Razavi, Tohid Adibi, Mohanad Naji Halool Abohned, Shams Forruque Ahmed, Hammad Alotaibi

“…Results indicate that reducing inlet humidity and increasing flow rate improves heat transfer, while channel geometry is critical to performance. Higher humidity in both the wet and dry channels minimizes the effectiveness of the heat exchanger. …”
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It is not just your opinion. Gender equity endorsement of Latin American students and their peers at school by Natalia López-Hornickel, Diego Carrasco, Siugmin Lay, Ernesto Treviño

“…Findings highlight the pivotal influence of civic knowledge and open classroom discussions as protective factors against authoritarian beliefs, which are negatively associated with gender equity support at both individual and contextual levels. Moreover, peer-group ideological climates significantly shape student attitudes, demonstrating the importance of school environments in fostering or hindering egalitarian beliefs. …”
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Progress in the Study of Dry Shrinkage Deformation and Drying Stress of Raw Bamboo by Jiayi Zhu, Lin Yang

“…The paper also summarizes progress in stress-strain research at both macroscopic and cellular scales. Current challenges include species-specific shrinkage variations, limitations in measurement techniques, and insufficient research on shrinkage above the fiber saturation point. …”
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Citizen science and its applicability for sustainability and a healthy planet by Medani P. Bhandari

“…It underscores the value of both traditional and scientific knowledge systems. …”
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From the Neolithic to the end of Early Bronze Age: developments in the construction of entrance gates and city walls at settlements in Burdur (Turkey) and the surrounding region by Gülsün Umurtak

“…The centres mentioned in this article represent very significant stages in both the development of defence architecture in the region and also in our understanding of the process of urbanisation in Anatolia. …”
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The impact of data from future lepton colliders on light hadrons fragmentation functions by Bin Zhou, Jun Gao

“…We perform analyses of FFs at NLO by including a wide range of pseudo-data from future lepton colliders, such as measurements on hadron multiplicities in the production of two jets and W boson pairs, at various center of mass energies, and from hadronic decays of the Higgs boson, including both to heavy quarks and to gluons. The high luminosity and high energies of future lepton colliders allow for quark flavor separations and ensure a precise determination of FFs based solely on data from electron-positron collisions. …”
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The mutational landscape of ARMC5 in Primary Bilateral Macronodular Adrenal Hyperplasia: an update by Lucas Bouys, Anna Vaczlavik, Isadora P. Cavalcante, Florian Violon, Anne Jouinot, Annabel Berthon, Patricia Vaduva, Stéphanie Espiard, Karine Perlemoine, Peter Kamenicky, Marie-Christine Vantyghem, Antoine Tabarin, Gérald Raverot, Cristina L. Ronchi, Ulrich Dischinger, Martin Reincke, Maria C. Fragoso, Constantine A. Stratakis, Albain Chansavang, Eric Pasmant, Bruno Ragazzon, Jérôme Bertherat, for the COMETE and ENSAT Networks

“…Based on literature review and own observation, this study aims to give an overview of both published and unpublished ARMC5 genetic alterations and to compile the available evidence to discriminate pathogenic from benign variants. …”
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Non-Destructive Testing of the Quality of Wooden Columns in Zeng Jingyi’s Ancient Wooden Structures by Jing Yang, Shaojie Wu, Yingcai Fang, Benhuan Xu, Zheng Wang

“…The CT scan findings align with the pilot nail test results, both accurately pinpointing the condition and precise locations of defects within the columns. …”
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