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4041
Profile of STING agonist and inhibitor research: a bibliometric analysis
Published 2025-02-01“…Bibliometric information was extracted with CiteSpace and VOSviewer software for visualization.ResultsIt shows that research on both STING agonists and inhibitors is burgeoning rapidly. …”
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4042
Increasing the concentration of plasma molecules improves the biological activity of platelet-rich plasma for tissue regeneration
Published 2025-02-01“…However, it is crucial to go beyond simple platelet concentration and examine the complex molecular composition both inside and outside platelets. The present work studies the effectiveness of a novel type of PRP named ‘balanced protein-concentrate plasma’ (BPCP). …”
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4043
Frk positively regulates innate antiviral immunity by phosphorylating TBK1
Published 2025-02-01“…Mechanistically, Frk promotes the K63 ubiquitination of TBK1 and subsequent activation of the transcription factor IRF3 by phosphorylating TBK1 at tyrosine residues 174 and 179, thereby enhancing the production of IFN-β in macrophages. Employing both in vivo and in vitro viral infection assays, we demonstrated that IFN-β mediated by Frk inhibits the replication of VSV or HSV-1 and alleviates lung lesions. …”
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4044
Genetic analysis of pathways regulated by the von Hippel-Lindau tumor suppressor in Caenorhabditis elegans.
Published 2004-10-01“…Genomic clustering, predicted functional similarities, and a common pattern of dysregulation in both vhl-1 worms and a set of mutants (dpy-18, let-268, gon-1, mig-17, and unc-6), with different defects in extracellular matrix formation, suggest that dysregulation of these genes reflects a discrete HIF-1-independent function of VHL-1 that is connected with extracellular matrix function.…”
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4045
Vasorelaxant effects and its mechanisms of the rhizome of Acorus gramineus on isolated rat thoracic aorta
Published 2025-02-01“…In addition, the blockage of Ca2+ influx was observed in both groups treated with PE and KCl. Therefore, AGR appears to block Ca2+ influx through ROCC and VDCC. …”
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4046
A Study of Selected Pre-Colonial Political Entities in the Niger- Benue Confluence Region of Nigeria
Published 2022-12-01“…The methodology employed in this study is the historical method of analysis which involved the use of both primary and secondary sources of information. …”
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4047
DEMOCRATIC PRINCIPLES AND THE ROLES OF TRADITIONAL POLITICAL INSTITUTIONS IN PROMOTING PEACE AND SECURITY IN NORTHERN NIGERIA: A CASE STUDY OF GOMBE STATE.
Published 2024-06-01“…This paper will examine the roles of traditional political institution in promoting peace and security in Northern Nigeria and look at the impact of democratic principles on traditional political institution of Northern Nigeria and Gombe State in particular. The study will use both primary and secondary sources of data. The structural functional theory will be employed to explain the topic under discussion. …”
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4048
NOMA Performance Improvement with Downlink Sectorization
Published 2025-02-01“…A Sequential Power Allocation (SePA) algorithm was introduced to enhance power distribution within sectors, aiming to maximize both user capacity and overall sum rate. The methods employed included detailed simulations comparing the performance of traditional NOMA systems and those incorporating sectorization. …”
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4049
Posterior vertebrodesis and Ponte osteotomies in surgical treatment of adolescent idiopathic scoliosis type Lenke 1-4
Published 2023-09-01“…The study encompasses patients with more than 60 degrees Cobb angle rigid deformities in the frontal plane with correction below 40% percents in the bending tests. Patients with both hyperkyphosis reported in the T5-T12 segment and marked hypokyphosis in the same area of the thoracic zone were also included in the study. …”
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4050
The effect of mild-stage Alzheimer’s disease on the acoustic parameters of voice
Published 2025-02-01“…The Voice Handicap Index-10 (VHI-10) and Voice-Related Quality of Life Scale (V-RQOL) were employed for the subjective assessments. Results In both males and females, the jitter and shimmer values in the study group were considerably higher than those in the control group (p < 0.000). …”
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4051
Development and functional validation of a disulfidoptosis-related gene prognostic model for lung adenocarcinoma based on bioinformatics and experimental validation
Published 2025-02-01“…IHC showed elevated TNS4 levels in LUAD tissues, while in vitro TNS4 knockdown reduced both cell proliferation and migration.ConclusionThis study highlights the role of DRGs in LUAD, with a validated gene signature offering new avenues for targeted therapies, potentially improving LUAD treatment outcomes.…”
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4052
The Lingua Franca Core: A Plausible Option?
Published 2019-07-01“…This necessarily entails a disadvantage in terms of both time and teaching materials to be allocated by the English Language Teaching (ELT) professional. …”
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4053
EFFECT OF ACADEMIC STAFF UNION OF UNIVERSITIES STRIKE ON THE PSYCHOSOCIAL WELLBEING OF UNDERGRADUATES IN LAGOS STATE, NIGERIA
Published 2023-09-01“… Education is necessity for the proper development of both individuals in particular and the nation at large. …”
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4054
OUTSOURCING IN RETAIL
Published 2012-05-01“… Modern strategic techniques have been increasingly applied in recent years, both in manufacture and retail, individually or concurrently. …”
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4055
FOREIGN DIRECT INVESTMENT AND TECHNOLOGY TRANSFER IN DEVELOPING COUNTRIES: THEORETICAL DISCOURSE
Published 2023-08-01“… The study of Foreign Direct Investment (FDI) and transfer of technology have been a great interest area for academics, policy makers and industries in both developed and developing countries. There is an increased level of link between foreign direct investment and technology transfer made by multinational corporations in developing countries and it is widely believed that FDI help to transfer technology to the benefit of the domestic industries and host country. …”
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4056
Phase transitions from heating to non-heating in $SU(1,1)$ quantum dynamics: Applications to Bose-Einstein condensates and periodically driven coupled oscillators
Published 2025-02-01“…We consider two experimentally feasible systems where their quantum dynamics exhibit the $SU(1,1)$ structure: the quench dynamics of the Bose-Einstein condensates and the periodically driven coupled oscillators. In both cases, the heating, non-heating phases, and their boundary manifest through distinct signatures in the phonon population where exponential, oscillatory, and linear growths classify these phases. …”
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4057
THE ROLE OF THE MULTINATIONAL JOINT TASK FORCE IN COUNTER INSURGENCY IN NORTH EASTERN NIGERIA: THE BOKO- HARAMINSURGENCY
Published 2024-08-01“… This study examines the role of the Multinational Joint Task Force (MNJTF) in counter insurgency in northern eastern Nigeria. The research uses both primary and secondary sources of data from various experts and stakeholders in Borno, Yobe, Bauchi, Adamawa, Taraba, Gombe in the North Eastern Nigeria and Nigeria Institute for Policy and Strategic Studies Kuru near Jos Data was generated through questionnaires, interviews and Focus Group Discussions which were later analysed using descriptive method and thematic and content analysis of the secondary data. …”
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4058
Abernethy Malformation in Combination with Gilbert’s Syndrome
Published 2020-12-01“…The conducted instrumental observation revealed echo-signs of malformation (agenesia) of the portal vein, which was further confirmed by both X-ray-contrast computed tomography and the pathohistological analysis of liver biopsy slides. …”
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4059
Hormonal Contraceptives and Athletic Outcomes - analysis of potential effects of oral contraceptives on strength, endurance, mood, and overall competitive results
Published 2025-02-01“…Further, well-controlled research is needed to clarify these effects, enabling more targeted guidance for both athletes and healthcare professionals. …”
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4060
Real-time analysis of initiation regulation systems during the progression of the reconstituted chromosomal replication cycle
Published 2025-02-01“…Abstract Chromosome replication in Escherichia coli is primarily regulated at the initiation stage, where the DnaA protein activates replication at the chromosomal origin, oriC. Both DnaA and oriC undergo feedback regulation based on replication progression. …”
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