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  1. 4041

    Profile of STING agonist and inhibitor research: a bibliometric analysis by Xuemei Wang, Qian Wang, Yidan Gao, Lijuan Jiang, Lingli Tang

    Published 2025-02-01
    “…Bibliometric information was extracted with CiteSpace and VOSviewer software for visualization.ResultsIt shows that research on both STING agonists and inhibitors is burgeoning rapidly. …”
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  2. 4042

    Increasing the concentration of plasma molecules improves the biological activity of platelet-rich plasma for tissue regeneration by Mikel Sánchez, Jon Mercader Ruiz, Daniel Marijuán Pinel, Pello Sánchez, Nicolás Fiz, Jorge Guadilla, Juan Azofra, Maider Beitia, Diego Delgado

    Published 2025-02-01
    “…However, it is crucial to go beyond simple platelet concentration and examine the complex molecular composition both inside and outside platelets. The present work studies the effectiveness of a novel type of PRP named ‘balanced protein-concentrate plasma’ (BPCP). …”
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  3. 4043

    Frk positively regulates innate antiviral immunity by phosphorylating TBK1 by Xiaomei Zhang, Ying You, Tingrong Xiong, Tingrong Xiong, Xiaokai Zhang, Haibo Wang, Jinxia Geng, Miao Wang, Yanyan Xu, Shanshan Gao, Shanshan Gao, Xiaoyan Wu, Yue Zheng, Xianhua Wen, Haoyu Yang, Yu Wang, Yu Wang, Xiaohua Wen, Congcong Zhao

    Published 2025-02-01
    “…Mechanistically, Frk promotes the K63 ubiquitination of TBK1 and subsequent activation of the transcription factor IRF3 by phosphorylating TBK1 at tyrosine residues 174 and 179, thereby enhancing the production of IFN-β in macrophages. Employing both in vivo and in vitro viral infection assays, we demonstrated that IFN-β mediated by Frk inhibits the replication of VSV or HSV-1 and alleviates lung lesions. …”
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  4. 4044

    Genetic analysis of pathways regulated by the von Hippel-Lindau tumor suppressor in Caenorhabditis elegans. by Tammie Bishop, Kah Weng Lau, Andrew C R Epstein, Stuart K Kim, Min Jiang, Delia O'Rourke, Christopher W Pugh, Jonathan M Gleadle, Martin S Taylor, Jonathan Hodgkin, Peter J Ratcliffe

    Published 2004-10-01
    “…Genomic clustering, predicted functional similarities, and a common pattern of dysregulation in both vhl-1 worms and a set of mutants (dpy-18, let-268, gon-1, mig-17, and unc-6), with different defects in extracellular matrix formation, suggest that dysregulation of these genes reflects a discrete HIF-1-independent function of VHL-1 that is connected with extracellular matrix function.…”
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  5. 4045

    Vasorelaxant effects and its mechanisms of the rhizome of Acorus gramineus on isolated rat thoracic aorta by Jueon Lee, Sujin Shin, Junkyu Park, Ho-Young Choi, Kyungjin Lee

    Published 2025-02-01
    “…In addition, the blockage of Ca2+ influx was observed in both groups treated with PE and KCl. Therefore, AGR appears to block Ca2+ influx through ROCC and VDCC. …”
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  6. 4046

    A Study of Selected Pre-Colonial Political Entities in the Niger- Benue Confluence Region of Nigeria by Hadizat Audu Salihu

    Published 2022-12-01
    “…The methodology employed in this study is the historical method of analysis which involved the use of both primary and secondary sources of information. …”
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  7. 4047

    DEMOCRATIC PRINCIPLES AND THE ROLES OF TRADITIONAL POLITICAL INSTITUTIONS IN PROMOTING PEACE AND SECURITY IN NORTHERN NIGERIA: A CASE STUDY OF GOMBE STATE. by AHMED MUSA, BASHIR ABDULLAHI, MOHAMMED AUWAL, UMAR MUHAMMAD JUNGUDO

    Published 2024-06-01
    “…This paper will examine the roles of traditional political institution in promoting peace and security in Northern Nigeria and look at the impact of democratic principles on traditional political institution of Northern Nigeria and Gombe State in particular. The study will use both primary and secondary sources of data. The structural functional theory will be employed to explain the topic under discussion. …”
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  8. 4048

    NOMA Performance Improvement with Downlink Sectorization by Hurianti Vidyaningtyas, . Iskandar, . Hendrawan, Aloysius A. Pramudita

    Published 2025-02-01
    “…A Sequential Power Allocation (SePA) algorithm was introduced to enhance power distribution within sectors, aiming to maximize both user capacity and overall sum rate. The methods employed included detailed simulations comparing the performance of traditional NOMA systems and those incorporating sectorization. …”
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  9. 4049

    Posterior vertebrodesis and Ponte osteotomies in surgical treatment of adolescent idiopathic scoliosis type Lenke 1-4 by Adelin Ivanov

    Published 2023-09-01
    “…The study encompasses patients with more than 60 degrees Cobb angle rigid deformities in the frontal plane with correction below 40% percents in the bending tests. Patients with both hyperkyphosis reported in the T5-T12 segment and marked hypokyphosis in the same area of the thoracic zone were also included in the study. …”
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  10. 4050

    The effect of mild-stage Alzheimer’s disease on the acoustic parameters of voice by Emel Arslan-Sarımehmetoğlu, Elife Barmak

    Published 2025-02-01
    “…The Voice Handicap Index-10 (VHI-10) and Voice-Related Quality of Life Scale (V-RQOL) were employed for the subjective assessments. Results In both males and females, the jitter and shimmer values in the study group were considerably higher than those in the control group (p < 0.000). …”
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  11. 4051

    Development and functional validation of a disulfidoptosis-related gene prognostic model for lung adenocarcinoma based on bioinformatics and experimental validation by Tao Shen, Tao Shen, Zhuming Lu, Sisi Yang, Dongxi Zhang, Yongwen Ke, Zhuowen Chen, Jinqiang Wu, Jinqiang Wu, Weidong Wu

    Published 2025-02-01
    “…IHC showed elevated TNS4 levels in LUAD tissues, while in vitro TNS4 knockdown reduced both cell proliferation and migration.ConclusionThis study highlights the role of DRGs in LUAD, with a validated gene signature offering new avenues for targeted therapies, potentially improving LUAD treatment outcomes.…”
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  12. 4052

    The Lingua Franca Core: A Plausible Option? by Marco Sandro Antonio Ugarte Olea

    Published 2019-07-01
    “…This necessarily entails a disadvantage in terms of both time and teaching materials to be allocated by the English Language Teaching (ELT) professional. …”
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  13. 4053

    EFFECT OF ACADEMIC STAFF UNION OF UNIVERSITIES STRIKE ON THE PSYCHOSOCIAL WELLBEING OF UNDERGRADUATES IN LAGOS STATE, NIGERIA by Omozusi Mercy Omosefe, William Oluwaseyi Emmanuel, Joy Tinuade Adeyanju

    Published 2023-09-01
    “… Education is necessity for the proper development of both individuals in particular and the nation at large. …”
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  14. 4054

    OUTSOURCING IN RETAIL by Radojko Lukić

    Published 2012-05-01
    “… Modern strategic techniques have been increasingly applied in recent years, both in manufacture and retail, individually or concurrently. …”
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  15. 4055

    FOREIGN DIRECT INVESTMENT AND TECHNOLOGY TRANSFER IN DEVELOPING COUNTRIES: THEORETICAL DISCOURSE by Hamisu Ibrahim

    Published 2023-08-01
    “… The study of Foreign Direct Investment (FDI) and transfer of technology have been a great interest area for academics, policy makers and industries in both developed and developing countries. There is an increased level of link between foreign direct investment and technology transfer made by multinational corporations in developing countries and it is widely believed that FDI help to transfer technology to the benefit of the domestic industries and host country. …”
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  16. 4056

    Phase transitions from heating to non-heating in $SU(1,1)$ quantum dynamics: Applications to Bose-Einstein condensates and periodically driven coupled oscillators by Heng-Hsi Li, Po-Yao Chang

    Published 2025-02-01
    “…We consider two experimentally feasible systems where their quantum dynamics exhibit the $SU(1,1)$ structure: the quench dynamics of the Bose-Einstein condensates and the periodically driven coupled oscillators. In both cases, the heating, non-heating phases, and their boundary manifest through distinct signatures in the phonon population where exponential, oscillatory, and linear growths classify these phases. …”
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  17. 4057

    THE ROLE OF THE MULTINATIONAL JOINT TASK FORCE IN COUNTER INSURGENCY IN NORTH EASTERN NIGERIA: THE BOKO- HARAMINSURGENCY by ODO CHRISTOPHER UBA

    Published 2024-08-01
    “… This study examines the role of the Multinational Joint Task Force (MNJTF) in counter insurgency in northern eastern Nigeria. The research uses both primary and secondary sources of data from various experts and stakeholders in Borno, Yobe, Bauchi, Adamawa, Taraba, Gombe in the North Eastern Nigeria and Nigeria Institute for Policy and Strategic Studies Kuru near Jos Data was generated through questionnaires, interviews and Focus Group Discussions which were later analysed using descriptive method and thematic and content analysis of the secondary data. …”
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  18. 4058

    Abernethy Malformation in Combination with Gilbert’s Syndrome by N. B. Gubergrits, E. L. Bondar, E. A. Dyadyk, E. V. Berezhnaya, Yu. E. Chirkov, N. V. Byelyayeva, G. M. Lukashevich, T. L. Mozhyna

    Published 2020-12-01
    “…The conducted instrumental observation revealed echo-signs of malformation (agenesia) of the portal vein, which was further confirmed by both X-ray-contrast computed tomography and the pathohistological analysis of liver biopsy slides. …”
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  19. 4059
  20. 4060

    Real-time analysis of initiation regulation systems during the progression of the reconstituted chromosomal replication cycle by Koki Kanoh, Masayuki Su’etsugu

    Published 2025-02-01
    “…Abstract Chromosome replication in Escherichia coli is primarily regulated at the initiation stage, where the DnaA protein activates replication at the chromosomal origin, oriC. Both DnaA and oriC undergo feedback regulation based on replication progression. …”
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