Hypothermia regulates mitophagy and apoptosis via PINK1/Parkin-VDAC 3 signaling pathway during oxygen-glucose deprivation/recovery injury by Luying Zhang, Song Yang, Hao Cui, Chenchen Hang, Xingsheng Wang, Le An, Zhenyu Shan, Zhen Liang, Rui Shao, Ziren Tang

“…However, whether hypothermia can regulate both apoptosis and mitophagy through the PINK1/Parkin-VDAC3 signaling pathway or not. …”
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A comparative analysis of global and Chinese trends in the burden of kidney cancer from 1990 to 2021 by Zhongli Qiao, Jun Xiong, Shenyu Zhang, Lin Chen, Jialin Wang, Runze Chen

“…The age-standardized incidence rate and prevalence rate of kidney cancer in males showed a greater increase compared to females, both in China and globally. Additionally, the age-standardized rate of kidney cancer in males was notably higher than in females, particularly among middle-aged males. …”
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Prevalence and factors associated with water, sanitation and hygiene (WASH) facilities deprivation among children in Nigeria by Chima Victor, Joseph Ayodeji Kupoluyi, Funmilola Folasade Oyinlola, Victor Ojoajogwu Sule

“…A merged dataset comprising a total of 22,059 weighted observations from both the under-five children and children aged 5–17 years was used for this study. …”
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Postnatal cytomegalovirus infection and its effect on hearing and neurodevelopmental outcomes among infants aged 3-10 months: A cohort study in Eastern Uganda. by Noela Regina Akwi Okalany, David Mukunya, Peter Olupot-Olupot, Martin Chebet, Francis Okello, Andrew D Weeks, Fred Bisso, Thorkild Tylleskär, Kathy Burgoine, Ingunn Marie Stadskleiv Engebretsen

“…Exploration into the feasibility of incorporating hearing and CMV screening into routine care will play a vital role in early identification and intervention, improving the management of both hearing and CMV-related conditions in resource-limited settings.…”
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Sequence-based GWAS in 180,000 German Holstein cattle reveals new candidate variants for milk production traits by Ana-Marija Križanac, Christian Reimer, Johannes Heise, Zengting Liu, Jennie E. Pryce, Jörn Bennewitz, Georg Thaller, Clemens Falker-Gieske, Jens Tetens

“…These can also come with both computational and time burdens, as presented in our study. …”
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Comparing Prednisone and Methotrexate to Off-label Biologic Infliximab for Management of Ocular Uveitis: A Cost-minimization Analysis by William V. Padula, Miguel Cordero-Coma, Taygan Yilmaz, William V. Padula, Michéal J. Gallagher, Jonathan D. Campbell

“…**Conclusion:** This cost-effectiveness analysis suggests that despite advances in the use of biologics for treating sight-threatening posterior uveitis and panuveitis, infliximab had lower effectiveness and higher costs compared to both prednisone and methotrexate. As compared to prednisone, methotrexate was associated with increased costs and QALYs and was found to be a good value. …”
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Implementing adaptive e-learning for newborn care in Tanzania: an observational study of provider engagement and knowledge gains by Peter Andrew Meaney, Christine Lynn Joyce, Ambrose Agweyu, Joseph R Mwanga, Marc Berg, Adolfine Hokororo, Hanston Ndosi, Alex Dahlen, Theopista Jacob, Florence Salvatory Kalabamu, Rishi Mediratta, Boris Rozenfeld, Zachary Haines Smith, Neema Chami, Namala Mkopi, Castory Mwanga, Enock Diocles

“…Median clinical experience was 4 years (IQR 1–9) and 45 (23%) had previous in-service training for both newborn essential and sick newborn care. Efficacy was 42% (SD ±17%). …”
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CSF shunts as conduits for metastasis: is there a discrepancy between retrograde and antegrade spread? by Andrea Cuschieri, Robert Pisani, Shawn Agius

“…The study focused on the metastasis of both CNS malignancy to extra-neural sites and the retrograde metastasis of extra-neural tumours to the CNS along CSF shunts. …”
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Dupilumab in children with eosinophilic esophagitis: a retrospective multicenter study by Mohammed Hasosah, Ghassan Sukkar, Asharf AlSahafi, Ali Zaidan, Nouf Ghous, Abdulmajed Alshahrani, Ziyad Al Zahrani, Naif Hasosah, Mansour Qurashi, Loie Goronfolah, Ali Alsharief, Nagla Kamal

“…Dupilumab is a human monoclonal antibody that targets both IL-4 and IL-13 signaling. It is currently indicated for the treatment of asthma, atopic dermatitis, and EoE. …”
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Cissus quadrangularis L. hexane extract infused glyoxal cross-linked chitosan-collagen scaffold elicits early osteoinduction by Praseetha R. Nair, P.S. Unnikrishnan, Sachin J. Shenoy, G.S. Sailaja

“…Continual examination designates the formation of mature lamellar bone formation at 12 weeks both in the middle and periphery regions of the defect site. …”
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Tone or tissue? A comparison of trends and risk factors of severe postpartum hemorrhage according to uterine atony or retained tissue in a hospital setting. by Silje Pettersen, Ragnhild Sørum Falk, Siri Vangen, Lill Trine Nyfløt

“…Risk factors associated only with uterine atony were multiple pregnancy, macrosomia, Asian ethnicity and operative delivery, while induction of labor, augmentation of labor, use of anticoagulants and assisted reproduction were associated with both uterine atony and retained tissue.<h4>Conclusion</h4>The observed increased rate of PPH in the study period was mainly driven by an increase in atonic PPH, while the rate of severe PPH caused by retained tissue remained stable. …”
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Synergistic enhancement of hydrophobic dental adhesives: autonomous strengthening, polymerization kinetics, and hydrolytic resistance by Burak Korkmaz, Erhan Demirel, Qiang Ye, Qiang Ye, Anil Misra, Anil Misra, Candan Tamerler, Candan Tamerler, Candan Tamerler, Paulette Spencer, Paulette Spencer, Paulette Spencer

“…Dynamic mechanical properties were measured at 37 and 70°C in both dry and wet conditions. Under dry conditions, the storage moduli of NC1 and NE1 were comparable and the glass transition temperature (Tg) of NC1 was statistically significantly lower (p &lt; 0.001) than NE1. …”
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Evaluation of Ecosystem Services and Tradeoff and Synergy in the Alpine and Canyon Region of Southwest China Based on Multi-source Geographic Data by LIU Jing, XIANG Jiayi, ZHANG Donghai, LAN Mengyao, GUAN Yinghui

“…In contrast, soil retention services was overall deteriorated, decreasing from 263.50 t/(km2·a) to 226.25 t/(km2·a), with a reduction of 27.50% in the northwest Yunnan alpine canyon ecological maintenance zone. (2) The proportion of the area of ecosystem service hotspot areas increased by 5.41%, following a distribution pattern of the first-class hotspot areas > the non-hot spot areas > the second-class hotspot areas > the third-class hotspot areas form 2000 to 2020. (3) Carbon sequestration services exhibited a synergistic relationship with both water retention services and soil retention services, with synergy areas accounting for 54.91% and 44.46% of the total area, respectively. …”
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Tick-borne encephalitis vaccination in persons with a recent history of Lyme borreliosis: Insights from a Knowledge, Attitudes and Behaviour survey in Bavaria, Germany by Stefanie Böhm, Andreas Beyerlein, Volker Fingerle, Merle M. Böhmer, Manfred Wildner

“…Engaging trusted sources, such as medical professionals, and both implementing broad public campaigns and focusing on high-risk groups are key strategies for increasing vaccination uptake.…”
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Enhancing anthropometric proficiency: Effect of a structured training program on skills of Anganwadi workers in rural areas of Raebareli District, Uttar Pradesh by Mukesh Shukla, Abhay Singh, Sourabh Paul, Mritunjay Kumar, Ravinder Singh Bedi

“…Methods and Material: The skills of AWWs in anthropometric measurement domains (weight, height/length, and mid-upper arm circumference) were assessed using a pre-tested observatory checklist both before and after the training sessions. The skills for each domain were assessed on four points i.e. standard procedure applied to the child, assurance of safety precautions, observer protocol during anthropometry, and precision and accuracy in recording measurement. …”
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An optimized data analytics pipeline for improving healthcare diagnosis using ensemble learning by Lomat Haider Chowdhury, Shaira Tabassum, Swakkhar Shatabda, Ashir Ahmed

“…To reaffirm the rectification of our model, we experimented with it on another COVID-19 routine blood test dataset. In both cases, our proposed model acquired better results regarding different performance measures. …”
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Targeted detection of endogenous LINE-1 proteins and ORF2p interactions by Mathias I. Nielsen, Justina C. Wolters, Omar G. Rosas Bringas, Hua Jiang, Luciano H. Di Stefano, Mehrnoosh Oghbaie, Samira Hozeifi, Mats J. Nitert, Alienke van Pijkeren, Marieke Smit, Lars ter Morsche, Apostolos Mourtzinos, Vikram Deshpande, Martin S. Taylor, Brian T. Chait, John LaCava

“…Abstract Background Both the expression and activities of LINE-1 (L1) retrotransposons are known to occur in numerous cell-types and are implicated in pathobiological contexts such as aging-related inflammation, autoimmunity, and in cancers. …”
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Factors influencing the natural history of non-IgE-mediated gastrointestinal food allergies in paediatric age: a prospective multicentre cohort study by Giorgio Bedogni, Roberto Berni Canani, Laura Carucci, Rita Nocerino, Serena Coppola, Pasqualina Capasso, Veronica Giglio

“…Background We aimed at identifying the factors influencing the natural history of non-IgE-mediated gastrointestinal food allergies (non-IgE-GIFA), a group of common paediatric conditions including food protein–induced: enteropathy (FPE), allergic proctocolitis (FPIAP), enterocolitis syndrome (FPIES), and motility disorders (FPIMD).Methods Prospective multicentre cohort study involving paediatric patients (both sexes, aged ≤14 y) with non-IgE-GIFA diagnosed and followed for 24 months at a Tertiary Centre for Paediatric Allergy, Gastroenterology and Nutrition. …”
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Efficacy of rifaximin in the treatment of chronic relapsing diverticulitis by S. I. Achkasov, A. I. Moskalyov, Yu. L. Trubachyova, A. F. Filon

“…According to US data, no changes in both groups were observed. At the 14th day intensity of clinical symptoms in the main group was 0,26 points (in the control group – 0,71 points; р=0,09). …”
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One stage transanal versus one stage laparoscopic-assisted transanal endorectal pull-through in managing Hirschsprung’s disease in pediatric age group; a retrospective study by Ahmed Elrouby, Sameh Shehata, Saber Waheeb, Ahmed Khairi, Doaa AbdAl-Aziz, Baher Looka

“…Our study compared the surgical and functional outcomes of both approaches. Methods Our retrospective study included 72 pediatric patients presented with Hirschsprung’s Disease to Elshatby University Hospital, 40 patients were treated by TAERPT (Group A) and 32 patients were treated by LAERPT (Group B). …”
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