RGD-HSA-TAC nanoparticles targeted delivery of tacrolimus and attenuation of podocyte injury in diabetic kidney disease by Zhaochen Guo, Shaohui Gao, Feng Xu, Zige Chen, Qinger Wang, Zhaojie Liu, Ziyue Wang, Weisong Qin, Caihong Zeng, Zhihong Liu, Hao Bao

“…Administration of SANPs and CNPs resulted in elevated levels of tacrolimus in podocytes, leading to a reduction in podocyte damage and albuminuria in diabetic nephropathy mice. …”
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Indications, contributing factors, and short-term outcomes of pneumonectomy: an 8-year retrospective study in a resource-limited setting by Mekonnen Feyissa Senbu, Dereje Gulilat, Hiwot Tadesse Habtamu

“…To reduce the need for pneumonectomy, strategies should focus on tuberculosis prevention, screening, and proper patient evaluation and diagnosis before treatment, to prevent extensive lung damage that often necessitates this procedure.…”
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Real-World Health Care Outcomes and Costs Among Patients With Juvenile Idiopathic Arthritis in Spain by Jordi Antón, Estefania Moreno Ruzafa, Mireia Lopez Corbeto, Rosa Bou, Judith Sánchez Manubens, Sonia Carriquí Arenas, Joan Calzada Hernández, Violetta Bittermann, Carolina Estepa Guillén, Juan Mosquera Angarita, Lucía Rodríguez Díez, Estíbaliz Iglesias, Miguel Marti Masanet, Berta Lopez Montesinos, Maria I. González Fernández, Alfonso de Lossada, Carmen Peral, Mónica Valderrama, Noelia Llevat, María Montoro Álvarez, Immaculada Calvo Penadés

“…If inflammation is not adequately treated, joint damage, long-term disability, and active disease during adulthood can occur. …”
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Incidence and pathological features of IgA nephropathy before and during the COVID-19 pandemic by Wen Liu, Ricong Xu, Di Wu, Zhihang Su, Yuan Cheng, Haofei Hu, Xinzhou Zhang, Qijun Wan

“…Our results indicate that the incidence of IgAN has risen during the COVID-19 pandemic, along with exacerbated renal damage and elevated proportions of M1 and E1 in the Oxford classification.…”
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Blimp-1 orchestrates macrophage polarization and metabolic homeostasis via purine biosynthesis in sepsis by Wenjuan Peng, Qiushi Qin, Rui Li, Yujia Liu, Lan Li, Yue Zhang, Liuluan Zhu

“…Knockdown of Blimp-1 by macrophage-targeted adeno-associated virus in this model resulted in decreased survival rates, exacerbated tissue damage, and impaired M2 polarization, underscoring its protective role in sepsis. …”
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Genomic characterization of chronic lymphocytic leukemia in patients of African ancestry by Cecilia Bonolo de Campos, Chantal E. McCabe, Laura A. Bruins, Daniel R. O’Brien, Sochilt Brown, Renee C. Tschumper, Cristine Allmer, Yuan Xiao Zhu, Kari G. Rabe, Sameer A. Parikh, Neil E. Kay, Huihuang Yan, James R. Cerhan, John N. Allan, Richard R. Furman, J. Brice Weinberg, Danielle M. Brander, Diane F. Jelinek, Marta Chesi, Susan L. Slager, Esteban Braggio

“…We sequenced 59 putative driver genes and found an increased frequency of high-impact mutations in AA CLL, including genes of the DNA damage repair (DDR) pathway. Telomere erosion was also increased in AA CLL, amplifying the notion of increased genomic instability in AA CLL. …”
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Structural Characterization and Antioxidant Activity in Vivo of Polysaccharides from the Leaves of Hippophae rhamnoides L. by Niannian SONG, Yuxin YI, Xiaoping ZHANG, Bo YANG, Mangsier SAINAWAER, Abuduwaili AYITUXUN

“…The HE staining results indicated that HRLP had protective effect on liver and kidney tissue cells and structure damage in mice. The medium dose group of HRLP could increase the number of gut microbiota species in mice and promote the synthesis of short-chain fatty acids in the body. …”
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A plant endophytic bacterium Burkholderia seminalis strain 869T2 increases plant growth under salt stress by affecting several phytohormone response pathways by Hau-Hsuan Hwang, Yu-Ting Huang, Pei-Ru Chien, Fan-Chen Huang, Chih-Lin Wu, Liang-Yu Chen, Shih-Hsun Walter Hung, I-Chun Pan, Chieh-Chen Huang

“…Conclusions The plant endophytic bacterium strain B. seminalis 869T2 may affect various phytohormone responses and reduce oxidative stress damage to increase salt and drought stress tolerances of host plants.…”
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Modulation of the thiol redox proteome by sugarcane ash-derived silica nanoparticles: insights into chronic kidney disease of unknown etiology by Arthur D. Stem, Cole R. Michel, Peter S. Harris, Keegan L. Rogers, Matthew Gibb, Carlos A. Roncal-Jimenez, Richard Reisdorph, Richard J. Johnson, James R. Roede, Kristofer S. Fritz, Jared M. Brown

“…SiNPs have high potential for generation of reactive oxygen species (ROS), and their accumulation in kidney could result in oxidative stress induced kidney damage consistent with CKDu pathology. Methods In order to characterize the impact of sugarcane ash derived (SAD) SiNPs on human kidney proximal convoluted tubule (PCT) cells and identify potential mechanisms of toxicity, HK-2 cells were exposed to treatments of either pristine, manufactured, 200 nm SiNPs or SAD SiNPs and changes to cellular energy metabolism and redox state were determined. …”
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Synergistic effects of PS-NPs and Cd on ovarian toxicity in adolescent rats: Ferroptosis by induction of mitochondrial redox imbalance via the SIRT3-SOD2/Gpx4 pathway by Hua Wu, Lihua Feng, Huang Wu, Lihong Wang, Hengyi Xu, Fen Fu

“…Further studies revealed that PS-NPs and Cd synergistically repressed the SIRT3-SOD2/Gpx4 pathway, inducing mitochondrial oxidative stress and ferroptosis, resulting in damage to ovarian structure and function. However, the addition of the mitochondrion-targeted antioxidant SS-31 and the ferroptosis inhibitor Fer-1 reversed the harm to the ovaries from co-exposure to PS-NPs and Cd, the aberrant expression of genes related to the SIRT3-SOD2/Gpx4 pathway was also improved. …”
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Genome-based analysis of the genetic pattern of black sheep in Qira sheep by Wen Zhou, Xiaopeng Li, Xuechen Zhang, Lijun Zhu, Yuwei Peng, Cheng-long Zhang, Zhipeng Han, Ruizhi Yang, Xinyu Bai, Quanfeng Wang, Yuejun Zhao, Shudong Liu

“…Abstract Objective Black wool can effectively prevent sheep from DNA damage as well as fungal infection, and can improve reproductive performance. …”
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Human and Nature Effects Detection on the Environmental Properties of Archaeological Historic Cairo City in Egypt Based on Space and Ground Remote Sensing Data by Abdelaziz Elfadaly, Osama Wafa, Ahmed Gad, Hossam Khedr, Ghada Atta

“…These factors played a major role in increasing the groundwater level beneath these sites, causing serious damage to them. This article aims to monitor and mitigate the geo-hazard that threatens the heritage sites of Historical Cairo using the integration between space data and in situ measurements. …”
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Non-Alcoholic Fatty Liver Disease in Cardiac Patients with Overweight and Obesity by I. V. Logacheva, T. A. Ryazanova, V. R. Makarova, O. V. Surnina

“…Another objective consisted in establishing a relationship between liver damage and the pathology of the heart and blood vessels.Materials and methods. …”
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Enucleated bone marrow-derived mesenchymal stromal cells regulate immune microenvironment and promote testosterone production through efferocytosis by Lu Sun, Jiayu Huang, Xuezi Wang, Peng Huang, Baolin Dong, Zehang Liang, Jiahong Wu, Jiancheng Wang

“…Conclusions In summary, this study pioneered the application of stromal cell enucleation technology to repair tissue damage in the reproductive system, explored the potential of cell burial in the treatment of reproductive system diseases and provided a new approach for the clinical treatment of male infertility.…”
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Oxidative impact on lipoprotein structure: Insights from dynamic light scattering by Nickolette Kong, Natalia Penaloza, Gustavo Agreda, Angela B. Nguyen, Joseph Gutheinz, Alison Tran, Nhi Nguyen, Tuong Vi Ho, Ana Marin, Birgit Mellis, Richa Chandra

“…Here it is demonstrated that dynamic light scattering (DLS) is sensitive and effective at measuring variation in lipoprotein size distributions following oxidative damage caused by peroxidation and nitration—two common physiological processes that play dual roles in both normal and pathogenic states. …”
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Evaluation of Active Intraoperative Nerve Monitoring in Severe Developmental Dysplasia of the Hip Patients Undergoing Total Hip Arthroplasty by Alireza Manafi Rasi, MD, Sina Afzal, Dr., MD, Mojtaba Baroutkoub, MD, Hasan Shakiba, MD, Pooya Kalani, MD, Mehdi Tavassoli, MD, Reza Zarei, MD

“…Background: Total hip arthroplasty (THA) stands as the standard treatment in neglected developmental dysplasia of the hip (DDH), and its application in severe cases may be linked to debilitating outcomes, including nerve damage. Here, we aimed to report the results of intraoperative nerve monitoring (IONM) via an active method. …”
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Nanoparticle-mediated gene delivery techniques in plant systems by Kuber Shivashakarappa, Sureshbabu Marriboina, Korsi Dumenyo, Ali Taheri, Zeinab Yadegari

“…Apart from species constraints, these methods have unique advantages and limitations, including random gene integration, low gene transfer efficiency, tissue damage, united gene alterations, time-consuming and labor-intensive plant regeneration protocols. …”
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Health Behavior Study in Natural Disaster Vulnerability in Palu City (Case Study of Tondo Huntap, Palu City) by Arwan Arwan, Sadly Syam, Muhammad Zikra, Firmansyah Firmansyah, Muhammad Sabri Syahrir, Muhammad Aji Satria

“…Therefore, mental health interventions are needed to enhance preparedness for disasters and take action to reduce disaster losses and damage.…”
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α-amanitin induces hepatotoxicity via PPAR-γ inhibition and NLRP3 inflammasome activation by Haowei Wang, Huijie Zhang, Lin Miao, Chan Wang, Hanxin Teng, Xiaodong Li, Xiaoxing Zhang, Genmeng Yang, Shangwen Wang, Xiaofeng Zeng

“…In vivo, α-amanitin induced dose-dependent liver injury in mice, evident by elevated serum ALT and AST, and histological liver damage. MCC950 pretreatment offered protection against hepatotoxicity, while PPAR-γ inhibition with GW9662 worsened the condition. …”
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A Prospective Observational Study to Establish a Correlation Between Tinnitus and Hearing Loss by Anshu Chopra, Madhurima Bannerjee, Sanjoy Ghosh

“…Both tinnitus and sensorineural hearing loss can occur when there is damage throughout the auditory pathway from the inner ear to auditory cortex. …”
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