Estimation of median LC50 and toxicity of environmentally relevant concentrations of thiram in Labeo rohita by Sana Alam, Gulnaz Afzal, Riaz Hussain, Hafiz Muhammad Ali, Amtul Sami, Rabbiah Manzoor Malik, Raheela Jabeen, Farid Shokry Ataya, Kun Li

“…Moreover, comet assay revealed significant (p < 0.05) DNA damage in the isolated cells of kidneys, heart and brain at higher doses (80 μg/L and 120 μg/L) of thiram that was further confirmed by histo-pathological alterations in these tissues. …”
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Exploring the genetic correlation and causal relationships between breast cancer and meningioma using bidirectional Mendelian randomization by Lu Ding, Bo Chen, Zhou Zhou, Zhaojun Mei, Kan Cao, Xinyu Lu, Wei Chen

“…ER-related signaling pathways and the regulation of DNA damage may play a critical role in the pathogenesis of both diseases.…”
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Meta-analysis of the association between overexpression of RAD51 family genes and prognosis and clinical features in breast cancer by Yong-Cheng Liu, Jun Shen

“…Abstract The RAD51 family of genes play a crucial role in the repair of DNA damage, and increasing evidence suggests a close link between the aberrant expression of RAD51 family genes and the development of breast cancer. …”
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The immunogenicity of PRV ΔgE/TK/UL49.5 three-gene-deleted vaccine in mice by Chenmeng Ding, Yawei Sun, Xianfeng Zhang, Mengmeng Shi, Han Yang, Xin Zhou, Shuangshuang Li, Yongtao Li, Xia Yang, Linyang Yu, Lu Chen

“…No obvious pathological damage was observed in lung, brain and trigeminal ganglion of mice immunized with PRV ΔgE/TK/UL49.5, and the tissue viral load was the lowest. …”
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Theranostic nanoemulsions suppress macrophage-mediated acute inflammation in rats by Riddhi Vichare, Yalcin Kulahci, Rebecca McCallin, Fatih Zor, Fatma Nurefsan Selek, Lu Liu, Caitlin Crelli, Anneliese Troidle, Michele Herneisey, James M. Nichols, Andrew J. Shepherd, Vijay S. Gorantla, Jelena M. Janjic

“…Abstract In inflammatory diseases or following an injury, dysregulated inflammation is a common driver of pain and tissue damage. Macrophages are immune cells that contribute to the initiation, maintenance, and resolution of inflammation due to their phenotypic plasticity in response to signals from inflammatory microenvironments. …”
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Antioxidant and Anti-Inflammatory Potential of Cymbopogon nardus Ethanol Extract on 3T3-L1 Cells by Rohmawaty E, Wiraswati HL, Zahra TA, Amalina SN, Ramadhanti J, Rosdianto AM, Laelalugina A, Nasution GTD, Kamisah Y

“…Enny Rohmawaty,1 Hesti Lina Wiraswati,1 Tamara Aliya Zahra,2 Shabrina Nur Amalina,2 Julia Ramadhanti,1 Aziiz Mardanarian Rosdianto,1 Amila Laelalugina,3 Gita Tiara Dewi Nasution,1 Yusof Kamisah4 1Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Bandung, 40161, Indonesia; 2Undergraduate Program Medical Doctor, Faculty of Medicine, Universitas Padjadjaran, Bandung, 40161, Indonesia; 3Oncology and Stem Cell Working Group, Universitas Padjadjaran, Bandung, 40161, Indonesia; 4Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, 53000, MalaysiaCorrespondence: Enny Rohmawaty, Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Jl. …”
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Multiple low-dose radiation ameliorates type-2 diabetes mellitus via gut microbiota modulation to activate TLR4/MyD88/NF-κB pathway by Lijing Qin, Rongrong Liu, Zhen Jia, Weiqiang Xu, Li Wang, Hongyuan Tian, Xinru Lian, Wen Li, Yali Qi, Huan He, Zhicheng Wang

“…The changes of blood glucose levels, body weight, and the damage of pancreas were measured. In addition, 16 S rDNA amplicon sequencing was used to detect gut microbiota alteration. …”
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Cloned airway basal progenitor cells to repair fibrotic lung through re-epithelialization by Yu Zhao, Yueqing Zhou, Weipan Zhang, Mingzhe Liu, Jun Duan, Xiaopeng Zhang, Qiwang Ma, Yujia Wang, Yuzhen Zhang, Zhongliang Guo, Ting Zhang, Wei Zuo

“…Abstract Irreversible damage of the lung epithelium in idiopathic pulmonary fibrosis (IPF) patients causes high mortality worldwide, with no lung repair approaches available currently. …”
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The effect of silymarin on ischemia-reperfusion injury in skeletal muscles of rats by Abdullah Ozer, Basak Kocak, Mustafa Arslan, Baris Mardin, Aysegul Kucuk, Saban Cem Sezen, Mustafa Hakan Zor, Mustafa Kavutcu

“…In Group S-I/R, muscle atrophy /hypertrophy, internalization of the muscle nucleus/oval/central nucleus, fragmentation/hyalinization, and leukocyte cell infiltration were observed to improve these damaged areas compared to Group I/R. MDA levels in the Group I/R were significantly higher compared to Group C and S-I/R. …”
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LDHA-mediated glycolysis in stria vascularis endothelial cells regulates macrophages function through CX3CL1-CX3CR1 pathway in noise-induced oxidative stress by Ying Yi, Min-Yu Wu, Kai-Tian Chen, An-Hai Chen, Lin-Qiu Li, Qin Xiong, Xian-Ren Wang, Wen-Bin Lei, Guan-Xia Xiong, Shu-Bin Fang

“…Oxidative stress-mediated damage to the stria vascularis (SV) is one of the pathogenic mechanisms of NIHL. …”
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Proinflammatory Tear Cytokines in Human Adenoviral Keratoconjunctivitis and Clinical Eye Severity by Santacruz Valdés C, Ponce-Rosas ER, Jimenez-Martinez MC

“…Animal models have provided insight into the role of the innate immune system in clinical damage, but the human immune response at the ocular surface remains poorly understood. …”
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<i>Clostridium difficile</i>-associated disease by V. T. Ivashkin, O. S. Shifrin, A. S. Tertycnhy, Ye. A. Poluektova, T. L. Lapina, O. S. Lyashenko, K. V. Ivashkin

“…Influence of toxins induces damage and inflammation of intestinal wall due to impairment of intestinal epithelial barrier, stimulation of proinflammatory cytokine production, apoptosis and necrosis of epithelial cells. …”
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Role of gut microbiota and fecal metabolites in the protective effect of soybean pulp-rich diet against estrogen-induced cholestasis in rats by Jiawei Wang, Qichao Hu, Jianying Wang, Liwei Lang, Shizhang Wei, Haotian Li, Manyi Jing, Xiao Ma, Yanling Zhao, Xuelin Zhou

“…Notably, DAI treatment significantly alleviated the abnormalities in serum TBA, alanine aminotransferase, and aspartate aminotransferase levels and mitigated the liver tissue damage in the EIC model. In summary, during cholestasis, variations in gut microbiota and metabolite profiles occurred. …”
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Clinical and endoscopical and morphofunctional scores in evaluation of development of gastroesophageal reflux disease in various age groups by M. A. Osadchuk, A. M. Zolotovitskaya, N. V. Kireyeva, S. N. Nikolenko, I. M. Kvetnoy

“…It results in more severe damage of esophageal mucosa with development of erosive esophagitis and extraesophageal manifestations. …”
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Dose-dependent effects of hydroquinone on liver injury and lipid dysregulation based on SCD1/AMPK signaling pathway in C57BL/6 mice by Lijun Zou, Fen Lin, Jinying Wen, Jinyu Huang, Yue Tan, Hui Huang, Gonghua Hu

“…In contrast, the highest dose (50.0 mg/kg) resulted in elevated liver enzyme levels, indicative of liver damage, while lipid levels decreased. Notably, the mRNA or protein levels of SCD1 were upregulated in response to the lower doses of HQ (12.5 and 25.0 mg/kg), whereas AMPK activation and enhanced autophagy were observed in the 50.0 mg/kg HQ-treated group, reflecting an energy stress response. …”
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A CD36-based prediction model for sepsis-induced myocardial injury by Yun Xie, Hui Lv, Daonan Chen, Peijie Huang, Zhigang Zhou, Ruilan Wang

“…Plasma CD36 levels were measured within 48 h of ICU admission, prior to the diagnosis of sepsis-associated myocardial injury. Myocardial damage was assessed using troponin levels. Results: Two significant risk factors for SIMI were identified: age and elevated CD36 levels. …”
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An overview of hereditary spherocytosis and the curative effects of splenectomy by Kyril Turpaev, Elizaveta Bovt, Elizaveta Bovt, Soslan Shakhidzhanov, Soslan Shakhidzhanov, Elena Sinauridze, Elena Sinauridze, Nataliya Smetanina, Larisa Koleva, Larisa Koleva, Nikita Kushnir, Nikita Kushnir, Anna Suvorova, Fazoil Ataullakhanov, Fazoil Ataullakhanov, Fazoil Ataullakhanov

“…The clinical benefit of splenectomy results from elimination the primary site of RBC damage and destruction. Splenectomy is a curative approach but can cause complications and should be undertaken after examination by various laboratory approaches. …”
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Mitigating effects of Jiawei Chaihu Shugan decoction on necroptosis and inflammation of hippocampal neurons in epileptic mice by Qin Wang, Baijun Qin, Han Yu, Jiawei Zeng, Jingjing Fan, Qiong Wu, Rong Zeng, Haichun Yu, Xian Zhang, Mingfen Li, Yanying Zhou, Limei Diao

“…In mice, the model group had heightened epileptic discharges, neuronal damage, and apoptosis, along with increased expression of the same markers (P < 0.05). …”
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Saussurea gossypiphora extracts reduce inflammation by reversing inflammatory cytokine levels in in-vitro and in-vivo by Kalyani Jatoth, Pawan Kumar Anoor, Ramesh Kande, Sandeepta Burgula

“…Rats treated with MESGD showed minimum side effects such as liver damage, hemoglobin, platelet and WBC count were increased when compared with animals treated with standard anti-inflammatory drug Indomethacin. …”
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Health benefits of algae and marine-derived bioactive metabolites for modulating ulcerative colitis symptoms by Najmeh Oliyaei, Saghar Zekri, Aida Iraji, Alireza Oliyaei, Romina Tanideh, Nadiar M. Mussin, Amin Tamadon, Nader Tanideh

“…It has been reported that algal sulfated polysaccharides, peptides, pigments, polyphenols, and marine oil are useful for controlling ulcerative colitis via different pathways including modulating of TNF-α and other related inflammatory cytokines secretion, increasing the antioxidant enzymes [superoxide dismutase (SOD) and catalase(CAT)] activities, reduction of myeloperoxidase (MPO) activity and malondialdehyde (MDA) production, improving the intestinal barrier function and repairing histological damage in the colon. This review focused on the pathology of ulcerative colitis, pathogenesis and key inflammatory pathways, and the role of algae and marine-based metabolites for reduction of ulcerative colitis signs via alleviating the inflammation cytokines secretion, and improving the barrier function and gut microbiota.…”
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