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Elexacaftor/tezacaftor/ivacaftor and inflammation in children and adolescents with cystic fibrosis: a retrospective dual-center cohort study
Published 2025-02-01“…Data on immunoglobulins (Ig) (A, G, and M), γ-globulin, leukocyte levels, percent predicted forced expiratory volume in the first second (ppFEV1), sweat chloride (SC) concentration, and sputum cultures were collected at baseline, 12, and 24 months of treatment. …”
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Investigating the relationship between thought interference, somatic passivity and outcomes in patients with psychosis: a natural language processing approach using a clinical reco...
Published 2022-08-01“…Objectives We aimed to apply natural language processing algorithms in routine healthcare records to identify reported somatic passivity (external control of sensations, actions and impulses) and thought interference symptoms (thought broadcasting, insertion, withdrawal), first-rank symptoms traditionally central to diagnosing schizophrenia, and determine associations with prognosis by analysing routine outcomes.Design Four algorithms were developed on deidentified mental healthcare data and applied to ascertain recorded symptoms over the 3 months following first presentation to a mental healthcare provider in a cohort of patients with a primary schizophreniform disorder (ICD-10 F20-F29) diagnosis.Setting and participants From the electronic health records of a large secondary mental healthcare provider in south London, 9323 patients were ascertained from 2007 to the data extraction date (25 February 2020).Outcomes The primary binary dependent variable for logistic regression analyses was any negative outcome (Mental Health Act section, >2 antipsychotics prescribed, >22 days spent in crisis care) over the subsequent 2 years.Results Final adjusted models indicated significant associations of this composite outcome with baseline somatic passivity (prevalence 4.9%; adjusted OR 1.61, 95% CI 1.37 to 1.88), thought insertion (10.7%; 1.24, 95% CI 1.15 to 1.55) and thought withdrawal (4.9%; 1.36, 95% CI 1.10 to 1.69), but not independently with thought broadcast (10.3%; 1.05, 95% CI 0.91 to 1.22).Conclusions Symptoms traditionally central to the diagnosis of schizophrenia, but under-represented in current diagnostic frameworks, were thus identified as important predictors of short-term to medium-term prognosis in schizophreniform disorders.…”
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63
Randomised control trial to compare the efficacy of traditional Thai massage and ultrasound therapy for treating plantar heel pain
Published 2025-02-01“…Trial registration TCTR20210909001 (First Submitted Date: September 2021).…”
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The effect of educational intervention based on the mobile application on women’s knowledge, attitude, and practice on microplastics and health: study protocol for a randomized con...
Published 2025-02-01“…Primary outcome data (KAP scores) will be collected at baseline, immediately post-intervention, and 8 weeks post-intervention using self-reported questionnaires. …”
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Postoperative Pain and Opiate Requirement is Increased Following Second-Side Surgery Among Patients Undergoing Staged Total Knee Arthroplasty
Published 2025-02-01“…Patients with a history of chronic opioid dependency were excluded. Baseline demographics, primary outcome measures, including visual analog scale (VAS) pain scores, perioperative opioid utilization (MME/day), and surgical satisfaction were evaluated. …”
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Evaluation of in-office tooth whitening treatment with violet LED: protocol for a randomised controlled clinical trial
Published 2018-09-01“…Colour will be measured at baseline, immediately after the first session and at the 15 and 180 days follow-up using the Vita Classical and the digital Easyshade V spectrophotometer (Vita, Zahnfabrik, Germany). …”
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A Novel System and Iterative Schemes for Generalized Variational Inclusion Problems and its Approximation Solvability
Published 2024-07-01“…The variational inclusion problems are the generalizations of the variational inequality problems. First, it was noted by Hasounni and Moudafi in 1994. …”
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Healthy dietary patterns and the incidence of chronic kidney disease: results from a prospective cohort study
Published 2025-02-01“…Participants, who completed at least one online 24-hour dietary recall assessment, were included in the study. The baseline for analysis was the first 24-hour dietary recall in 2011, with follow-up extending until the earliest occurrence of CKD diagnosis, death, or the end of the study period. …”
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THE NEW WORLD INFORMATION AND COMMUNICATION ORDER DEBATE AND THE DEVELOPMENT OF INFORMATION AND COMMUNICATION TECHNOLOGY IN NIGERIA
Published 2023-09-01“… While the New World Information and Communication Order (NWICO) debate underlines the centrality of information and communication development to societal transformation in the twenty-first century, it has unarguably led to explosion in human communication in ways previously thought impossible. …”
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Atmospheric microplastic accumulation in Ramalina celastri (Sprengel) Krog & Swinscow Thalli: a transplant study across different levels of urbanization
Published 2025-01-01“…This study investigates MP accumulation in natural populations of Ramalina celastri across an urbanization gradient in Luján, Argentina, marking the first report for this species. MP concentrations ranged from 16.54 ± 3.59 MPs g–1 in baseline sites to significantly higher levels in urban zones. …”
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Risk of All-Cause Mortality in US Adults With Preserved Ratio Impaired Spirometry: An Observational Study
Published 2025-02-01“…Participants aged 20– 79 years at baseline and who underwent spirometry were included. …”
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Short-term urban traffic forecasting in smart cities: a dynamic diffusion spatial-temporal graph convolutional network
Published 2025-01-01“…Compared to several baseline models, the experimental results show that the model is 7% better than other models on several metrics and demonstrates the necessity of the module through ablation experiments.…”
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Post-vaccination campaign evaluation of systemic and mucosal immunity of trivalent oral poliovirus vaccine in Karachi, Pakistan (2020–2021): a cross-sectional studyResearch in cont...
Published 2025-02-01“…The stool samples collected at baseline, 7, 14, and 28 days (after each tOPV dose) were tested for the presence of poliovirus. …”
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Perivascular space imaging during therapy for medulloblastoma.
Published 2025-01-01“…We examined 778 scans from 241 MB patients at baseline (0M), after 12 weeks (about 3 months) of radiotherapy and rest (3M), after chemotherapy completion (12M), and a follow-up (FollowUp) at 18- or 21-months post-baseline. …”
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Silent Neuroleptic Malignant Syndrome: A Case Report of Atypical Antipsychotic Induced Elevation of Creatinine Kinase and Altered Mental Status
Published 2022-08-01“…The first was in an adolescent who was titrated to a dose of risperidone 3mg/ day but the only abnormality was an increase in his CK levels. …”
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An algorithm for cardiac disease detection based on the magnetic resonance imaging
Published 2025-02-01“…This method is based on the YOLOv8 model but introduces several key modifications. Firstly, the standard Spatial Pyramid Pooling Fast module is replaced with a Multi-Channel Spatial Pyramid Pooling module. …”
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Prospective Evaluation of 24 h/2 Days’ Monitoring of Systemic Blood Pressure in Patients with Traumatic Paraplegia – A Single-center Study
Published 2023-07-01“…Objectives: The objective of the study is to evaluate baseline heart rate (HR), baseline BP, and ambulatory arterial blood pressure monitoring (ABPM) in traumatic paraplegia patients. …”
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Integrated hip fracture care pathway (IHFCP): reducing complications and improving outcomes
Published 2022-08-01“…The evaluation utilised a descriptive design, with outcomes analysed separately for each of the five years of the programme. First-year results were treated as baseline. Results: The main improvements in process and outcome measures over five years, when compared to baseline, were: (a) increase in surgeries performed within 48 hours of admission from 32.5% to 80.1%; (b) reduced non-operated patients from 19.6% to 11.9%; (c) reduced average length of stay at acute hospital among surgically (from 14.0 ± 12.3 days to 9.9 ± 1.0 days) and conservatively managed patients (from 19.1 ± 22.9 to 11.0 ± 2.5 days); (d) reduced 30-day readmission rate from 3.2% to 1.6%; and (e) improved Modified Functional Assessment Classification of VI to VII at six months from 48.0% to 78.2%. …”
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Are We Moving Too Fast?: Representation of Speed in Static Images
Published 2025-01-01“…In Experiment 1, we compared subjective speed ratings given for motion lines trailing behind movers, suppletion lines replacing parts of the movers and backfixing lines set in the background against the baseline of having no extra cue. Experiment 2 was a replication of the first experiment with an addition of several motion lines considering the effect of quantity on conveyed speed. …”
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