Acidovorax temperans skews neutrophil maturation and polarizes Th17 cells to promote lung adenocarcinoma development by Joshua K. Stone, Natalia von Muhlinen, Chenran Zhang, Ana I. Robles, Amy L. Flis, Eleazar Vega-Valle, Akihiko Miyanaga, Masaru Matsumoto, K. Leigh Greathouse, Tomer Cooks, Giorgio Trinchieri, Curtis C. Harris

“…These T17 cells shared a common gene expression program predictive of poor survival in human LUAD. …”
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Trace metals induce microbial risk and antimicrobial resistance in biofilm in drinking water by Bowei Li, Ling Feng, Rakia Chouari, Sofia Samoili, Stefanos Giannakis

“…The overall exposure risk of antibiotic resistance genes (ARGs) increased, whereas Fe(III) enhanced the co-occurrence of ARGs and pathogens, potentially leading to serious hidden microbial risks. …”
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Gastroduodenal form of Crohn's disease by I. V. Mayev, D. N. Andreev, Yu. A. Kucheryavy

“…By the present time association of GDCD with L1007P mutation of NOD2/CARD15 gene is detected. Epigastric pain, loss of body weight, nausea and — in some cases — vomiting are the most frequent symptoms of this pathology. …”
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Integrative prognostic modeling of ovarian cancer: incorporating genetic, clinical, and immunological markers by Aidi Lin, Feifei Xue, Chenxiang Pan, Lijiao Li

“…Utilizing data from The Cancer Genome Atlas (TCGA), we identified significant prognostic genes through differential expression and survival analysis, integrating these with clinical features and immune landscape assessments including immune cell infiltration and checkpoint expression. …”
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Simulated gastrointestinal digestion of milk caseins containing A1 β-casein does not lead to increased production of inflammatory proteins in intestinal epithelial cells in vitro w... by Alan Aitchison, Teagan S. Edwards, Andrew S. Day

“…No difference was found in the effects of the digestion products of each β-casein on gene expression of inflammatory markers interleukin (IL)-8, carcinoembryonic antigen-related cell adhesion molecule (CEACAM)6 or intestinal alkaline phosphatase (IAP). …”
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Synergistical amelioration of muscle atrophy by modulating gut microbiota through the bioconversion of grape seed extract and whey using kefir lactic acid bacteria by Kun-Ho Seo, Eseul Kim, Hyunsook Kim

“…Supplementation with WDG synergistically ameliorated immobilization-induced sarcopenia by restoring grip strength, muscle weight, and the expression of genes related to muscle growth markers. Notably, WDG significantly modulated the abundance of butyrate-producing and intestinal barrier function-related gut bacteria, which were significantly and positively correlated with holding impulse and muscle growth markers. …”
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Apert syndrome: a rare congenital anomaly and experience from a low-resource country: a case report and review of the literature by Maimuna Abdatam, Charles John Nhungo, Frank Muhamba, Ally Hamis Mwanga, Larry Akoko, Charles A. Mkony

“…Apert syndrome is linked by autosomal dominant inheritance to fibroblast growth factors receptor gene alteration. Case presentation We present the case of a 20-month-old African boy who exhibited the characteristic facial features of Apert syndrome. …”
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Representative Metagenomes of Mesophilic Biogas Reactor Across South Korea by Darsha Prabhaharan, Young Wook Go, Hyunjin Kim, Seongcheol Kang, Byoung-In Sang

“…From 110 GB of raw DNA sequences, 401 metagenome-assembled genomes (MAGs) were created, which include 42,301 annotated genes. Of these, 187 MAGs (46.7%) were classified as high-quality based on Minimum Information about Metagenome-Assembled Genome (MIMAG) standards. …”
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Molecular Detection of Coxiella burnetii in Ticks Isolated from Domestic Animals in Slaughterhouses and Farms, Shahr-E-Rey, Tehran, Iran by Pedram Talaie, Maryam Tavassoli, Ehsan Mostafavi, Zakiyeh Telmadarraiy, Mahdi Rohani, Saber Esmaeili, Mohammad Mehdi Sedaghat

“…Tick samples were morphologically identified and evalu­ated for the presence of the C. burnetii IS1111 gene using real-time PCR. Results: Ticks were classified into four genera: Hyalomma (66.48%), Rhipicepalus (23.47%), Dermacentor (7.26%), and Ornithodoros (2.79%). …”
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Phospho-seq: integrated, multi-modal profiling of intracellular protein dynamics in single cells by John D. Blair, Austin Hartman, Fides Zenk, Philipp Wahle, Giovanna Brancati, Carol Dalgarno, Barbara Treutlein, Rahul Satija

“…We show that Phospho-seq can provide insights into cellular states and trajectories, shed light on gene regulatory relationships, and help explore the causes and effects of diverse cell signaling in neurodevelopment.…”
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Rutin attenuates zearalenone-induced ferroptosis of endometrial stromal cells in piglets through the p53 signaling pathway by Chenlong Wang, Chuangjiang Chen, MengYa Wang, Sajid Ur Rahman, Bin Wei, Hongyan Ding, Wanyue Huang, Xichun Wang

“…When porcine ESCs were co-cultured with the addition of Rutin and ZEA following p53 gene silencing via siRNA transfection, Rutin significantly mitigated ZEA-induced mitochondrial damage, oxidative stress, and Fe2 + content through the p53 pathway. …”
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Endothelial SHANK3 regulates tight junctions in the neonatal mouse blood-brain barrier through β-Catenin signaling by Yong-Eun Kim, Minseong Kim, Sunwhi Kim, Raham Lee, Yusuke Ujihara, Esther Magdalena Marquez-Wilkins, Yong-Hui Jiang, Esther Yang, Hyun Kim, Changhoon Lee, Changwon Park, Il Hwan Kim

“…Here we report that SHANK3, an ASD-risk gene, expresses in the BBB-forming brain endothelial cells (BECs) and regulates tight junctional (TJ) integrity essential for BBB’s barrier function. …”
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Spatial proteomics identifies a CRTC-dependent viral signaling pathway that stimulates production of interleukin-11 by Benjamin J. Ravenhill, Marisa Oliveira, George Wood, Ying Di, Joanne Kite, Xinyue Wang, Colin T.R. Davies, Yongxu Lu, Robin Antrobus, Gill Elliott, Nerea Irigoyen, David J. Hughes, Paul A. Lyons, Betty Chung, Georg H.H. Borner, Michael P. Weekes

“…Many of them exhibit subcellular relocalization upon activation, resulting in the expression of interferon and antiviral genes. To comprehensively identify signaling factors, we analyzed protein relocalization on a global scale during viral infection. cAMP-responsive element-binding protein (CREB)-regulated transcription coactivators 2 and 3 (CRTC2/3) exhibited early cytoplasmic-to-nuclear translocation upon infection with multiple viruses in diverse cell types. …”
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Chromosome-level genome sequencing and assembly of the parasitoid wasp Leptopilina myrica by Zhi Dong, Zixuan Xu, Junwei Zhang, Yulong Guo, Qichao Zhang, Lan Pang, Ting Feng, Wenqi Shi, Yifeng Sheng, Jianhua Huang, Jiani Chen

“…By comparing the protein-coding genes of L. myrica with those of other Hymenoptera species, we gained insights into the evolutionary history of parasitoid wasps. …”
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Association between microplastics and the functionalities of human gut microbiome by Bei Gao, Lixia Chen, Lizhi Wu, Shirui Zhang, Sunan Zhao, Zhe Mo, Zhijian Chen, Pengcheng Tu

“…Associations were found between microplastics and microbial species, as well as microbial genes encoding invasion-related virulence factors, quorum sensing, autoinducer and transporter system, and microplastic biodegradation enzymes. …”
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Critical functions for STAT5 tetramers in the maturation and survival of natural killer cells by Jian-Xin Lin, Ning Du, Peng Li, Majid Kazemian, Tesfay Gebregiorgis, Rosanne Spolski, Warren J. Leonard

“…Here we show that STAT5 dimers are sufficient for NK cell development, whereas STAT5 tetramers mediate NK cell maturation and the expression of maturation-associated genes. Unlike the defective proliferation of Stat5 DKI CD8+ T cells, Stat5 DKI NK cells have normal proliferation to IL-15 but are susceptible to death upon cytokine withdrawal, with lower Bcl2 and increased active caspases. …”
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Iron-regulatory liver hormone hepcidin and its place in the system of congenital immunity by O. A. Smirnov

“…Hepcidin is coded by HAMP gene (Hepcidin Antimicrobial Peptide) in chromosome 19. …”
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STUDY OF Bacillus licheniformis BACTERIA AS A BIO-CONTROL AGENT IN REDUCING AFLATOXIN B1 TOXICITY IN DRIED GRAPE SAMPLES by H. Z. Hussein, E. K. Abdul-Karim, M. I. Alghannoum

“…The isolate with the highest toxin production was identified through nucleotide sequences deposited in the World Genomic Organization's Gene Bank under accession number OR192858. The results demonstrated the ability of the live bacteria Bacillus licheniformis to inhibit fungal growth, reaching 94.4%, compared to 72.56% for the killed bacterial filtrate. …”
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RNA helicase MOV10 suppresses fear memory and dendritic arborization and regulates microtubule dynamics in hippocampal neurons by Temirlan Shilikbay, Aatiqa Nawaz, Megan Doon, Stephanie Ceman

“…Numa1 mRNA is a MOV10 CLIP target and is among the genes significantly decreased in Mov10 Deletion hippocampus. …”
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Autoimmune hepatitis with abnormally high level of serum alpha-fetoprotein (Clinical case) by A. O. Bueverov, Ye. S. Dolmagambetova

“…Derepression of respective gene may serve as the mechanism of serum AFP concentration increase at active hepatitis which, however, in absence of neoplastic proliferation is under control of certain regulatory factors. …”
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