Manganese-pyrochloric acid photosensitizer nanocomplexes against osteosarcoma: achieving both high activatability and high effectiveness by Xuran Zhang, Xuran Zhang, Jian Wang, Qun Feng, Li Lei, Zhiyong Zhu

“…Additionally, Mn2+ ions activated the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway, promoting maturation of dendritic cells (DCs) and augmenting CD8+-mediated antitumor immune responses.DiscussionThis study advances the on-demand activation of photosensitive drugs and photodynamic immunotherapy toward clinical applicability by exploiting Mn2+–PPa nanocomplexes with high activatability and effectiveness for targeted PDT and immunotherapy.…”
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A network medicine approach to investigating ME/CFS pathogenesis in severely ill patients: a pilot study by Li-Yuan Hung, Chan-Shuo Wu, Chia-Jung Chang, Peng Li, Kimberly Hicks, Joshua J. Dibble, Braxton Morrison, Chimere L. Smith, Ronald W. Davis, Wenzhong Xiao

“…This module demonstrated significant overlap with genes implicated in fatigue, cognitive disorders, and neurodegenerative diseases. …”
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Electroacupuncture regulates ferroptosis to improve postoperative cognitive dysfunction in mice through mediating GRX1/GSK-3β/Nrf2 axis by Xiaqing Zhang, Afen Zhang, Rui Li, Mingna Jiao, Rou Wen, Rongzhi Zheng

“…RT-qPCR, western blot and IHC were employed to detect abundance of genes and proteins. MDA, GSH and iron levels was measured by some commercial kits. …”
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Bio-primed machine learning to enhance discovery of relevant biomarkers by David M. Henke, Alexander Renwick, Joseph R. Zoeller, Jitendra K. Meena, Nicholas J. Neill, Elizabeth A. Bowling, Kristen L. Meerbrey, Thomas F. Westbrook, Lukas M. Simon

“…Abstract Precision medicine relies on identifying reliable biomarkers for gene dependencies to tailor individualized therapeutic strategies. …”
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Treatment with the CCR5 antagonist OB-002 reduces lung pathology, but does not prevent disease in a Syrian hamster model of SARS-CoV-2 infection. by Bryce M Warner, Robert Vendramelli, Amrit S Boese, Jonathan Audet, Nikesh Tailor, Courtney Meilleur, Nathan Glowach, Marnie Willman, Thang Truong, Estella Moffat, Kevin Tierney, Beata Kosak, Irfan Dhanidina, Jarret Engstrom, Bozena Korczak, Ian McGowan, Carissa Embury-Hyatt, Darwyn Kobasa

“…Daily treatment with OB-002 altered immune gene transcription in the lungs, and reduced pathology following infection, but did not prevent weight loss or viral replication in the lungs of infected animals, even in combination with the antiviral drug remdesivir. …”
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Karyotype uniformity in populations of the endemic Hemiancistrus fuliginosus (Loricariidae: Hypostomini) collected in the upper and middle Uruguai River by Jocicléia Thums Konerat, Vanessa Bueno, Ana Luiza de Brito Portela-Castro, Isabel Cristina Martins-Santos, Vladimir Pavan Margarido

“…The exclusivity of NORs polymorphism of the Antas River population can be attributed to the geomorphological characteristics of the tributary that restrict gene flow, while karyotypic similarities among the other three populations would be provided by the species’ ability to disperse.…”
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Flavones enrich rhizosphere Pseudomonas to enhance nitrogen utilization and secondary root growth in Populus by Jiadong Wu, Sijia Liu, Haoyu Zhang, Sisi Chen, Jingna Si, Lin Liu, Yue Wang, Shuxian Tan, Yuxin Du, Zhelun Jin, Jianbo Xie, Deqiang Zhang

“…Moreover, we confirm that Pseudomonas is strongly associated with tricin and apigenin biosynthesis and identify that gene GLABRA3 (GL3) is critical for tricin secretion. …”
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Kerkwees in die Branding. Die Nederduitse Gereformeerde Kerk in algemene sinodale verband 1994-2011 by Piet Strauss

“…Hierdie jaar het nie alleen in die Suid-Afrikaanse staatsopset ’n nuwe bedeling gebring nie, ook in die NG Kerk. Beter gestel, politiek Suid-Afrika het die NG Kerk in 1994 in ’n nuwe politieke gemeenskap met ’n nuwe etos – in ’n totale nuwe omgewing – geplaas. ’n Etos waarmee die NG Kerk moes rekening hou en wat ook aan hom sou afgee. …”
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Uncovering a novel SERPING1 pathogenic variant: insights into the aggregation of C1-INH in hereditary angioedema by Lingxi Jiang, Chao Dai, Suyang Duan, Tingting Wang, Chunbao Xie, Luhan Zhang, Zimeng Ye, Xiumei Ma, Yi Shi

“…Results In our investigation, we have discovered a novel pathogenic variant of the SERPING1 gene, specifically c.708T > G, in a Han family affected by HAE. …”
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Multiomics-based assessment of the impact of airflow on diverse plant callus cultures by June-Sik Kim, Muneo Sato, Mikiko Kojima, Muchamad Imam Asrori, Yukiko Uehara-Yamaguchi, Yumiko Takebayashi, Thi Nhung Do, Thi Yen Do, Kieu Oanh Nguyen Thi, Hitoshi Sakakibara, Keiichi Mochida, Shinjiro Ogita, Masami Yokota Hirai

“…Over four weeks, calli were cultured under continuous moisture without airflow or gradually reduced ambient moisture with airflow. For each sample, gene expression was profiled with high-throughput RNA sequencing, 442 metabolites were measured using liquid chromatography (LC) with triple-quadrupole mass spectrometry (LC–QqQMS), and 31 phytohormones were quantified using ultra-performance LC coupled with a tandem quadrupole mass spectrometer equipped with an electrospray interface (UPLC-ESI-qMS/MS) and ultra-high-performance LC–orbitrap MS (UHPLC-Orbitrap MS). …”
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Antifungal and enzymatic activities of endophytic fungi associated with Tamarix nilotica by Helal F. Al-Harthi

“…A total of 49 isolates were collected and categorized into 21 operational taxonomic units using the rRNA gene’s internal transcribed spacer region. The most prevalent species were Penicillium chrysogenum (16 isolates), Fungal sp. (12), and Alternaria alternata (10). …”
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R-loops acted on by RNase H1 influence DNA replication timing and genome stability in Leishmania by Jeziel D. Damasceno, Emma M. Briggs, Marija Krasilnikova, Catarina A. Marques, Craig Lapsley, Richard McCulloch

“…Furthermore, we demonstrate that such differential organisation of R-loops, RNase H1 and DNA replication timing across the parasite’s chromosomes correlates with size-dependent differences in chromatin accessibility, G quadruplex distribution and sequence content. Using conditional gene excision, we show that loss of RNase H1 leads to transient growth perturbation and permanently abrogates the differences in DNA replication timing across chromosomes, as well as altering levels of aneuploidy and increasing chromosome instability in a size-dependent manner. …”
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Debatten i debatten by Jenny Eklöf

“…Based on the concept of knowledge cartographies, this study highlights how the main actors in the debate tried to make sense of what gene technology entailed, but also, and more importantly, how knowledge about the technology and its consequences should be communicated and disseminated in society. …”
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Comparisons of performances of structural variants detection algorithms in solitary or combination strategy. by De-Min Duan, Chinyi Cheng, Yu-Shu Huang, An-Ko Chung, Pin-Xuan Chen, Yu-An Chen, Jacob Shujui Hsu, Pei-Lung Chen

“…Structural variants (SVs) have been associated with changes in gene expression, which may contribute to alterations in phenotypes and disease development. …”
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The emerging roles of aberrant alternative splicing in glioma by Reda Ben Mrid, Sara El Guendouzi, Marco Mineo, Rachid El Fatimy

“…Splicing of pre-messenger RNAs concerns at least 95% of transcripts and constitutes an important mechanism in gene expression regulation. Dysregulation of this process, through variations in spliceosome components, aberrant splicing factors and RNA-binding protein activity, disproportionate regulation of non-coding RNAs, and abnormal mRNA methylation, can contribute to the disruption of AS. …”
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The mutational landscape of ARMC5 in Primary Bilateral Macronodular Adrenal Hyperplasia: an update by Lucas Bouys, Anna Vaczlavik, Isadora P. Cavalcante, Florian Violon, Anne Jouinot, Annabel Berthon, Patricia Vaduva, Stéphanie Espiard, Karine Perlemoine, Peter Kamenicky, Marie-Christine Vantyghem, Antoine Tabarin, Gérald Raverot, Cristina L. Ronchi, Ulrich Dischinger, Martin Reincke, Maria C. Fragoso, Constantine A. Stratakis, Albain Chansavang, Eric Pasmant, Bruno Ragazzon, Jérôme Bertherat, for the COMETE and ENSAT Networks

“…Germline inactivating variants of the tumor suppressor gene ARMC5 are responsible for 20–25% of apparently sporadic PBMAH cases and 80% of familial presentations. …”
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The NIN transcription factor coordinates CEP and CLE signaling peptides that regulate nodulation antagonistically by Carole Laffont, Ariel Ivanovici, Pierre Gautrat, Mathias Brault, Michael Anthony Djordjevic, Florian Frugier

“…Here, we show that rhizobia, Nod Factors, and cytokinins induce a symbiosis-specific CEP gene, MtCEP7, which positively regulates rhizobial infection. …”
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Untargeted metabolomic and proteomic analysis implicates SIRT2 as a novel therapeutic target for diabetic nephropathy by Ruijing Zhang, Runze Chang, Heng Wang, Jinshan Chen, Chuanlong Lu, Keyi Fan, Yuhang Zhang, Lizheng Li, Sheng Yan, Honglin Dong

“…Animal models were used to validate the characterized genes. Correlation analysis of major differentially abundant metabolites and differentially expressed proteins revealed that SIRT2 might be a key hub linking energy metabolism and innate immune responses. …”
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Unveiling microbial succession dynamics on different plastic surfaces using WGCNA. by Keren Davidov, Sheli Itzahri, Liat Anabel Sinberger, Matan Oren

“…Our findings also revealed that the most significant variations in microbiome composition across surfaces occurred during the initial succession stages, with potential intra-genus relationships that are linked to surface preferences. …”
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Disruption of Energy Metabolism and Reactive Oxygen Species Homeostasis in Honglian Type-Cytoplasmic Male Sterility (HL-CMS) Rice Pollen by Wang Mingyue, Zhao Weibo, Feng Xiaoya, Chen Yi, Li Junhao, Fu Jinmei, Yan Yingchun, Chu Zhaohui, Huang Wenchao

“…However, the mechanisms by which sterility genes regulate metabolic alterations and changes in mitochondrial morphology in the pollen of HL-CMS remain unclear. …”
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