Molecular epidemiology of anaplasmosis in small ruminants along a human-livestock-wildlife interface in Uganda by Keneth Iceland, Kasozi, Susan Christina, Welburn

“…Methods: In this study a total of 712 DNA samples collected from small ruminants were analyzed for Anaplasmataceae and Anaplasma ovis using the 16S rRNA and MSP4 genes respectively. Infection risk was assessed by location, sex and age of the animals and qGIS® was used to construct spatial maps. …”
Get full text

TikTok’ta Bir Alt kültür Örneği Olarak Cadılık Kültürü ve Büyü Uygulamaları: WitchTok Örneği by Gülenay Pınarbaşı

“…Araştırma, TikTok platformu üzerinden geniş bir kitleye ulaşan cadılığın modern görünümünü anlama ve kutsalla olan ilişkisine yönelik bir yorumlama çabasıdır. …”
Get full text

Türk Sinemasının İlk Kıbrıs Filmi Kıbrıs’ın Belası Kızıl Eoka’da Terör ve Şiddet Olaylarının Temsili by Mehmet Işık

“…EOKA saldırılarının vahşeti ve bundan cesaret alan Rumların Türk komşularının sularını keserek selamlarını bile almaması, Kıbrıs Türklerinin karşı karşıya kaldıkları tehlikenin büyüklüğünü dolayısıyla da birleşme ihtiyacının aciliyetini ortaya koyduğu, karşı karşıya kalınan tehlike karşısında Kıbrıslı Türkler Ali ve geniş ailesi gibi canlarını ve topraklarını korumak için mücadele etmeye çağrıldığı belirlenmiştir.…”
Get full text

Investigation in blood-brain barrier integrity and susceptibility to immune cell penetration in a mouse model of Dravet syndrome by Cristina Alonso, Alicia García-Culebras, Valentina Satta, Inés Hernández-Fisac, Álvaro Sierra, José A. Guimaré, Ignacio Lizasoain, Javier Fernández-Ruiz, Onintza Sagredo

“…Dravet Syndrome (DS) is a pediatric encephalopathy caused by mutations in Scn1a gene encoding the α1 subunit of the NaV1.1 voltage-gated sodium channel, which lead to early febrile seizures that progress to severe tonic-clonic seizures and several long-term behavioural comorbidities. …”
Get full text

Genomic patterns of strain-specific genetic structure, linkage, and selection across fall armyworm populations by Ashley E. Tessnow, Rodney N. Nagoshi, Robert L. Meagher, Todd M. Gilligan, Ben M. Sadd, Yves Carrière, Holly N. Davis, Shelby J. Fleischer, Kelly Richers, John C. Palumbo, Patrick Porter, Jose Carlos Verle Rodrigues, Gregory A. Sword

“…We also show that a region of the Z-chromosome containing a circadian clock gene implicated in allochronic reproductive isolation is under strain-specific selection. …”
Get full text

Interleukin 28B polymorphism impact on early HCV kinetics in HCV-infected liver transplant recipients undergoing antiviral therapy by V. E. Syutkin, V. P. Chulanov, I. V. Karandashova, V. A. Dolgin, A. O. Chugunov

“…Blood samples were screened for single nucleotide polymorphisms (SNP) near the IL28B genes (rs8099917 T ≥G and rs12979860 C>T) by kit «AmpliSens® Genoscreen-IL28B-FL» (CRIE) in 24 HCV-infected recipients. …”
Get full text

Deconstructing the map of the paradigm struggle: tracing a nationwide debate on “I do not get it” in Art Magazine (Meishu) by Nan Li, Dawei Lu

“…Thus, if discourse is a “gene pool” for interpreting research outcomes, from which scholars can extract a specific range of knowledge, draw on statements and establish their theoretical frameworks, the shaping of discourse and the ensuing theoretical paradigm struggle are more likely to influence one’s scholarly judgements, particularly in his or her exploratory research. …”
Get full text

Clinical characteristics, metastasis patterns, and treatment outcomes of HER2-low breast cancer by Maria Elena Lacruz, Saskia Thies, Andrea Schmidt-Pokrzywniak, Ian Wittenberg, Tobias Engler, Fabian Reinwald, Monika Klinkhammer-Schalke, Sylke Ruth Zeissig, Bianca Franke, Kerstin Weitmann, Atanas Ignatov

“…HER2-low, characterized by low HER2 expression without gene amplification, recently gained attention. While new therapies are promising, its clinical significance remains unclear. …”
Get full text

Prognostic value of FCER1G expression and M2 macrophage infiltration in esophageal squamous cell carcinoma by Wei Peng, Yali Zhao, Ningning Yang, Yan Fang, Yintong Wu, Zhenzhong Feng, Qiang Wu, Xian Wang

“…Methods The expression of FCER1G and its prognostic value in ESCC was examined by The Cancer Genome Atlas and Gene Expression Omnibus databases. We also evaluated the relationship between FCER1G expression and 22 TIICs. …”
Get full text

A remarkable and durable response to tislelizumab treatment of an anaplastic thyroid carcinoma without targetable genomic alterations: a case report by Jingjing Chai, Jiaqi Lv, Jian Xiong, Xiuwen Chen, Senyuan Luo, Zhiguo Luo, Zhiguo Luo, Ming Luo

“…Comprehensive Sanger sequencing of the resected tumor tissue revealed no mutations in the TERT promoter or the BRAF V600E gene. The patient exhibited rapid recurrence post-surgery and was deemed unsuitable for immediate surgical intervention. …”
Get full text

Legume-derived phenolic acids influence Fusarium oxysporum f.sp. strigae compatibility and biocontrol potential in a Striga push–pull system by Mekuria Wolde Assena, Jochen Schöne, Frank Rasche

“…Legume presence enhanced FOS proliferation, with Mucuna and Desmodium increasing FOS gene copy numbers by over 44 %. LC-MS analysis identified nine phenolic acids, with p-coumaric (85–128 µg g−1) and p-hydroxybenzoic (50–97 µg g−1) acid being most abundant; the latter positively correlated with FOS abundance. …”
Get full text

Lower urinary dysfunction as a long-term effect of childhood vincristine treatment, with potential influences by sex and dose by Nao Iguchi, Ali Teimouri, Duncan T. Wilcox, Anna P. Malykhina, Nicholas G. Cost

“…Significant changes in gene expression levels associated with neuroinflammation and nociception were observed in both the bladder and lumbosacral dorsal root ganglia (Ls-DRG) of the VCR group. …”
Get full text

Amniotic fluid microbiota and metabolism with non-syndromic congenital heart defects: a multi-omics analysis by Wenli Xu, Lu Li, Hong Kang, Meixian Wang, Yanqun Liu, Guicun Wang, Ping Yu, Juan Liang, Zhen Liu

“…Methods and results A case-control study was conducted with 17 cases diagnosed with non-syndromic CHDs (CHDs group) and 34 controls without congenital anomalies (control group) at a ratio of 1:2. The 16 S rDNA gene sequencing and metabolomics methods were employed to assess 51 amniotic fluid samples. …”
Get full text

Effects of pyrazosulfuron-ethyl on caudal fin regeneration in zebrafish larvae by Chenkai Ge, Zhijun Ye, Weitao Hu, Jingrong Tang, Huimin Li, Fasheng Liu, Xinjun Liao, Jianjun Chen, Shouhua Zhang, Zigang Cao

“…Pyrazosulfuron-ethyl exposure resulted in the decreased number of neutrophils and macrophages, and the downregulation of immune related gene expression levels during caudal fin. Using LPS to activate inflammation can effectively rescue the fin regeneration defects induced by pyrazosulfuron-ethyl. …”
Get full text

Capivasertib enhances chimeric antigen receptor T cell activity in preclinical models of B cell lymphoma by Hui-Ju Hsieh, Ryan Urak, Mary C. Clark, Larry W. Kwak, Stephen J. Forman, Xiuli Wang

“…Mechanistically, capivasertib changed gene and protein expression patterns related to the functions of memory and effector CAR T cells. …”
Get full text

Sphingosine kinase 1 promotes M2 macrophage infiltration and enhances glioma cell migration via the JAK2/STAT3 pathway by Zihan Song, Zijun Zhao, Xuehua Liu, Yiran Song, Siyu Zhu, Ziyang Jia, Yijie Li, Zairan Wang, Boyu Sun, Qianxu Jin, Shiyang Zhang, Zongmao Zhao, Liqiang Liu

“…The correlation between SPHK1 and various cancer pathways was analyzed using the Kyoto encyclopedia of genes and genomes (KEGG) analysis. The SPHK1 influence on glioma migration was examined using transwell and wound healing experiments. …”
Get full text

The emerging role of blood-based biomarkers in early detection of colorectal cancer: A systematic review by Faris Shweikeh, Yuhao Zeng, Abdur Rahman Jabir, Erica Whittenberger, Saurav P. Kadatane, Yuting Huang, Mohamad Mouchli, Dani Ran Castillo

“…For instance, methylation patterns in genes such as MYO1-G and NDRG4 exhibited high diagnostic accuracies with AUCs reaching up to 0.996. …”
Get full text

Immune-mediated mechanisms in acute osteofascial compartment syndrome: insights from multi-omics analysis by Qinzhen Lu, He Ling, Yonghui Lao, Junjie Liu, Wei Su, Zhao Huang

“…Results Our research findings indicate that AOCS is an immune-mediated inflammatory disease, primarily involving immune cells, especially neutrophils. In addition, genes associated with ferroptosis, a form of regulated cell death, are found to be upregulated in the rat model, with non-coding RNAs playing a role in regulatory interactions. …”
Get full text

Decreased expression of miR-200a and miR-223-3p in endometriosis during the secretory phase of menstrual cycle: Insights from a case-control study on molecular biomarkers and disea... by Yasaman Nazari Hagh, Mohamadreza Ahmadifard, Sedigheh Esmaelzadeh, Soheila Abbaszadeh, Naser Shokrzadeh

“…Conclusion: Our results suggest that miR-200a and miR-223-3p are involved in the EM pathogenesis, while other genes and signaling pathways are probably involved in the implantation failure. …”
Get full text

Competitive displacement of lipoprotein lipase from heparan sulfate is orchestrated by a disordered acidic cluster in GPIHBP1 by Anamika Biswas, Samina Arshid, Kristian Kølby Kristensen, Thomas J.D. Jørgensen, Michael Ploug

“…When the acidic tail was neutralized in gene-edited mice, LPL remained trapped in the sub-endothelial spaces triggering hypertriglyceridemia. …”
Get full text