Genetically edited human placental organoids cast new light on the role of ACE2 by Anya L. Arthurs, Bianca Dietrich, Martin Knöfler, Caleb J. Lushington, Paul Q. Thomas, Fatwa Adikusuma, Jessica M. Williamson, Susan Babikha, Tyla Damhuis, Tanja Jankovic-Karasoulos, Melanie D. Smith, Kirsty G. Pringle, Claire T. Roberts

“…ACE2 knockout organoids had lower ACE protein expression, reduced organoid diameters and asymmetrical growth. …”
Get full text

Factors influencing the natural history of non-IgE-mediated gastrointestinal food allergies in paediatric age: a prospective multicentre cohort study by Giorgio Bedogni, Roberto Berni Canani, Laura Carucci, Rita Nocerino, Serena Coppola, Pasqualina Capasso, Veronica Giglio

“…The odds of 24-month immune tolerance acquisition rate was lower in children with family history of allergy (OR=0.41, 95% CI 0.19 to 0.89) and in those with multiple FAs at baseline (OR=0.24, 95% CI 0.11 to 0.51). …”
Get full text

Comparative Analysis of AES, Blowfish, Twofish, Salsa20, and ChaCha20 for Image Encryption by Rebwar Khalid Muhammed, Ribwar Rashid Aziz, Alla Ahmad Hassan, Aso Mohammed Aladdin, Shaida Jumaah Saydah, Tarik Ahmed Rashid, Bryar Ahmad Hassan

“…The results showed that ChaCha20 had the best average time for both encryption and decryption, being over 50% faster than some other algorithms. However, the Twofish algorithm had lower throughput during testing. …”
Get full text

Efficacy and prognosis of dapagliflozin in the treatment of patients with acute myocardial infarction complicated with type 2 diabetes in Xining area by Jinping Chai, Delian Li, Yanmin Liu, Xiaoling Su

“…There were no significant differences in the number of coronary artery lesions, treatment regimens, cardiovascular and hypoglycemic drugs between the two groups (P > 0.05). However, up to dapagliflozin group of patients after discharge significantly lower than the control group, the incidence of cardiovascular adverse events at dapagliflozin group of 4 cases of heart failure and cardiovascular death in 1 case and control group in heart failure 13 cases, 10 cases of cardiovascular death, cerebral hemorrhage 2 cases died. …”
Get full text

Predictors of food security status among informal caregivers of older adults residing in slums in Ghana by Dina Adei, Williams Agyemang-Duah, Bright Osei Boateng, Anthony Acquah Mensah

“…Abstract Background Informal caregivers of older adults play a crucial role, positively influencing the physical, mental, and social well-being of their care recipients, while concurrently contributing to substantial cost savings in the healthcare sector. …”
Get full text

A decomposition analysis of sociodemographic factors and non-cigarette tobacco use as contributors to the change in smoking rates in South Africa between 2017/18 and 2021 by K Kali, O Ayo-Yusuf

“…A Blinda-Oaxaca decomposition analysis was also used to explore the roles of various sociodemographic factors, including any differences in the use of TNPs, that may explain any observed differences in smoking rates between 2017/18 and 2021. …”
Get full text

Analysis of the predictive value of the prostate-specific antigen-to-neutrophil ratio for the diagnosis of prostate cancer by Yuxuan Chen, Haisheng Yan, Yaoqin Xu, Kexin Chen, Runqin Yang, Jiali Yang, Ruian Zhu, Rui Lin, Jiang Wang, Jie Liu, Pingsheng Gao, Lei Pang, Lexin Wang

“…Abstract Background Currently, serum PSA is the most commonly used screening tool in clinical practice. However, PSA levels in the range of 4–10 ng/ml are considered the ‘grey zone’ of prostate cancer screening. …”
Get full text

Exploring the effects of cannabidiol encapsulation in liposomes on their physicochemical properties and biocompatibility by Inga Jurgelane, Karina Egle, Andra Grava, Dana Galkina, Margarita Brante, Maksims Melnichuks, Marite Skrinda-Melne, Girts Salms, Arita Dubnika

“…Cannabidiol (CBD) is recognized for its therapeutic properties in various conditions. However, CBD’s limited water solubility and sensitivity to environmental stresses hinder its efficacy and bioavailability. …”
Get full text

DIGITAL TOOLS FOR MATCHING QUALIFICATIONS TO THE LEVELS OF THE NATIONAL QUALIFICATIONS FRAMEWORK by Volodymyr Kovtunets, Sergiy Londar, Serhii Melnyk, Oles Kovtunets

“…It is proven that each problem of qualification comparison with NQF level may be reduced to three options of decision. At the lower level of the decision-making process, there are 3-4 descriptors of qualification. …”
Get full text

Dietary index for gut microbiota and its protective role against kidney stones: evidence of diabetes as a mediator from NHANES cross-sectional data by Lei Wang, Junjun Wu, Ziwen Jiang, Chao Wang, Fuxiang Lin, Yuxiang Zhong, Pengpeng Zhao, Wei Wei, Jianhua Huang, Zhanping Xu

“…These findings highlight the role of dietary interventions targeting gut microbiota in KS prevention and call for longitudinal studies to confirm these results and develop tailored dietary strategies.…”
Get full text

Exploring MAP3K genes in gastric cancer: biomarkers, tumor microenvironment dynamics, and chemotherapy resistance by Senhui Wei, Ying Li, Jing Zhou, Yongming Xia

“…Furthermore, the diagnostic potential was demonstrated through robust Receiver operating characteristics (ROC) curve analysis, indicating the strong discriminatory power of these genes in distinguishing GC patients. …”
Get full text

Targeting transforming growth factor-β1 by methylseleninic acid/seleno-L-methionine in clear cell renal cell carcinoma: Mechanisms and therapeutic potential by Aseel O. Rataan, Yan Xu, Sean M. Geary, Yousef Zakharia, Eman S. Kamel, Youcef M. Rustum, Aliasger K. Salem

“…Data obtained from western blotting demonstrated higher levels of TGF-β1 and PD-L1 and lower levels of VEGF in sarcomatoid ccRCC cell lines compared to non-sarcomatoid ccRCC cell lines. …”
Get full text

Different smoking processes with the special fuel rods: Impart a smoky aroma to Souchong black tea by Weisu Tian, Jiao Feng, Jinyuan Wang, Hongzheng Lin, Qianlian Chen, Jiayun Zhuang, Guanjun Pan, Jiake Zhao, Lirong Tang, Zhilong Hao

“…Key volatiles such as β-caryophyllene, nerolidol, guaiacol, and α-terpineol, known for their woody or smoky aroma, were prominent in both DS and TS (the traditional Lapsang Souchong process) samples (OAV > 1, VIP > 1 and P < 0.05). However, DS exhibited significantly lower concentration of these volatiles than TS, giving it a more pleasant aroma. …”
Get full text

Continuous overnight monitoring of body temperature during embryo transfer cycles as a proxy for establishing progesterone fluctuations by comparison with P4 blood progesterone res... by T.G. Knowles, J.A. García-Velasco, M. Toribio, N. Garrido, A.I. Barrio Pedraza, C. Colomé Rakosnik, A. Salazar Vera, R. Milnes

“…Further graphical analyses showed an apparent lower luteal level of P4 for cycles flagged as atypical by OvuSense, and for negative outcomes, except on embryo transfer day. …”
Get full text

Early weight gain after stopping smoking: a predictor of overall large weight gain? A single-site retrospective cohort study by Alexandra Pankova, Eva Kralikova, Kamila Zvolska, Lenka Stepankova, Milan Blaha, Petra Ovesna, Paul Aveyard

“…The regression coefficient per 1% rise in the first 3 months was +0.13% (95% CI −0.04% to 0.30%). A receiver operating curve analysis showed that patients gaining more than 0.98% of their baseline weight during first 3 months had a sensitivity of 66% and specificity of 44% for gaining 7% or more weight by 12 months. …”
Get full text

Role of Computed Tomography in Predicting Programmed Death Ligand-1 Positivity in Gastric Adenocarcinoma by Yu ZH, Ma WQ, Ren JW, Zhang XT, Chu L

“…A nomogram was developed to assess the model’s predictive performance, which was evaluated using the receiver operating characteristic (ROC) curve, calibration curve, and decision curve analysis (DCA). …”
Get full text

The South African Traditional Communities and Women for Rural Democracy and Land Rights by Wandile Brian Zondo

“…Nevertheless, the role of rural women has resulted in some strides toward the democratization of traditional governance and land administration. …”
Get full text

Lifespan trajectories of motor control and neural oscillations: A systematic review of magnetoencephalography insights by Xinbi Zhang, Mingming Huang, Xiaoxia Yuan, Xiaoke Zhong, Shengyu Dai, Yingying Wang, Qiang Zhang, Kanya Wongwitwichote, Changhao Jiang

“…In older adults, motor performance deteriorates, presenting as slower movement and prolonged duration, alongside heightened resting beta power, elevated MRBD, and reduced PMBR. …”
Get full text

La realidad de mujeres transexuales y sus movimientos sociales en Sudamérica en tiempos de COVID-19 by Alessandra Mawu Defendi Oliveira

“…Based on this information, our purpose was to structure a criticism around the limits of the State and its power structure, and the absence of trans people in the decisions of the governments; questioning the limited access to health in which these people are victims because rejection of the State against injustices and their support in the marginalization of these identities.…”
Get full text

Clinical Guidelines of the Russian Gastroenterological Association on the Diagnostics and Treatment of Eosinophilic Esophagitis by V. T. Ivashkin, I. V. Maev, A. S. Trukhmanov, T. L. Lapina, D. N. Andreev, E. K. Baranskaya, A. S. Tertychny, S. S. Pirogov, A. A. Sheptulin, D. I. Abdulganieva, D. T. Dicheva, A. V. Zaborovsky, N. Yu. Ivashkina, N. V. Korochanskaya, A. V. Paraskevova

“…The diagnostic criterion is the eosinophilic infiltration of the esophageal mucosa with an eosinophil density of ≥ 15 per high power field (×400) in at least one of the biopsy specimens (about 60 eosinophils in 1 mm2). …”
Get full text