Adjuvants for peptide-based cancer vaccines by Willem W Overwijk, Hiep Khong

“…In particular, immune checkpoint blockade therapies with anti-CTLA-4 and anti-PD-1/PD-L1 are causing dramatic tumor shrinkage and prolonged patient survival in a variety of cancers. However, many patients do not benefit, possibly due to insufficient spontaneous T cell reactivity against their tumors and/or lacking immune cell infiltration to tumor site. …”
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Heat integration retrofit for a sustainable energy-efficient design: a case study of Aramco’s refinery by Abdulrahman Hazazi, Zeeshan Farooq

“…The objective of this study is to identify all technically and economically viable operation and design options/actions/modifications that reduce the facility’s overall energy demand and greenhouse gas emissions. …”
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Innovative laboratory techniques shaping cancer diagnosis and treatment in developing countries by Azeez Okikiola Lawal, Tolutope Joseph Ogunniyi, Oriire Idunnuoluwa Oludele, Oluwaloseyi Ayomipo Olorunfemi, Olalekan John Okesanya, Jerico Bautista Ogaya, Emery Manirambona, Mohamed Mustaf Ahmed, Don Eliseo Lucero-Prisno

“…Laboratory advancements in cancer detection have transformed diagnostic capabilities, particularly through the use of biomarkers that play crucial roles in risk assessment, therapy selection, and disease monitoring. …”
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Changes of well-being over the pandemic: a survey across generational cohorts by Chen Wang, Yizi Nie, Xiaoyu Lan, Qianqian Huang, Qunsen Dai, Chao Zhou

“…Specifically, the Post-80s exhibited a significant increase in both Engagement and Accomplishment of well-being during the pandemic, and the Post-60s generation demonstrated a significant improvement in Engagement of well-being. However, the other generations did not show significant changes. …”
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Effect of double-induced on whey protein isolate nanoparticle formation and stabilized food-grade Pickering emulsions: Stability and gastrointestinal digestion by Shenghua He, Yonghui Wang, Guanghui Li, Xueli Gao, Zhiyan Chen, Weiyun Guo, Jihong Huang

“…PEs stabilized by double-induced WPINs showed a slower release rate of free fatty acid during gastrointestinal digestion. …”
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INTERNET-BASED APPROACH IN DISTANCE LEARNING OF PARAGRAPH-WRITING COURSE AT STKIP MUHAMMADIYAH BARRU by Siti Hardiyanti Amri

“…Besides, the research found that the students fast adapted to the new learning context for the ability to operate technology, yet they did not fully understand their roles and responsibilities during the learning process. …”
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Maternal environmental enrichment affects the corpora lutea and progesterone levels in pregnant mice by Fernanda Luz De la Cruz Borthiry, Jimena Soledad Beltrame, Julieta Aylen Schander, Aime Florencia Silva, Fernanda Parborell, Ana María Franchi, María Laura Ribeiro

“…Also, the number of primordial, primary, preantral, antral, and atretic follicles was similar for both treatments. However, the number and area (μm2) of corpora lutea were increased in the ovaries from the enriched group. …”
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A novel decomposer-exploiter interaction framework of plant residue microbial decomposition by Youzhi Miao, Wei Wang, Huanhuan Xu, Yanwei Xia, Qingxin Gong, Zhihui Xu, Nan Zhang, Weibing Xun, Qirong Shen, Ruifu Zhang

“…Abstract Background Plant residue microbial decomposition, subject to significant environmental regulation, represents a crucial ecological process shaping and cycling the largest terrestrial soil organic carbon pool. However, the fundamental understanding of the functional dynamics and interactions between the principal participants, fungi and bacteria, in natural habitats remains limited. …”
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The Current Status of Atmospheric Micro/Nanoplastics Research: Characterization, Analytical Methods, Fate, and Human Health Risk by Hsin-Chieh Kung, Chien-Hsing Wu, Nicholas Kiprotich Cheruiyot, Justus Kavita Mutuku, Bo-Wun Huang, Guo-Ping Chang-Chien

“…Since most polymers are inert, the adverse health risks include endocytosis and accumulation in the liver and spleen. However, most of the toxic effects of these contaminants are related to surface-bound compounds, including heavy metals and persistent organic pollutants. …”
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Practice of an improved many-objective route optimization algorithm in a multimodal transportation case under uncertain demand by Tianxu Cui, Ying Shi, Jingkun Wang, Rijia Ding, Jinze Li, Kai Li

“…Abstract In recent decades, multimodal transportation has played a crucial role in modern logistics and transportation systems because of its high capacity and low cost. …”
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Interplay between porin deficiency, fitness, and virulence in carbapenem-non-susceptible Pseudomonas aeruginosa and Enterobacteriaceae. by Hedi Mammeri, Youssouf Sereme, Eya Toumi, Hélène Faury, David Skurnik

“…Porins are outer membrane proteins, which play a key role in the bacterial permeability to allow nutrients to enter and toxic waste to leave. …”
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Nested chirality and multimode transfer around exceptional points driven by external forces in electric circuits by Naiqiao Pan, Tian Chen, Xiangdong Zhang

“…It is shown theoretically that nested chiral behavior and multimode transfer appear in a two-dimensional non-Hermitian higher-order topological insulator with twofold degenerate second-order EPs by tuning the external forces. …”
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Synthetic transmembrane DNA receptors enable engineered sensing and actuation by Ze-Rui Zhou, Man-Sha Wu, Zhenglin Yang, Yuting Wu, Weijie Guo, Da-Wei Li, Ruo-Can Qian, Yi Lu

“…The construction and assembly of synthetic receptor analogs that can mimic such biological processes is a central goal of synthetic biochemistry and bionanotechnology to endow receptors with user-defined signal transduction effects. However, designing artificial transmembrane receptors with the desired input, output, and performance parameters are challenging. …”
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Comparison of different models to describe the lactation curve of Holstein cows in a small-scale dairy system by Luis Javier Montiel-Olguín, Felipe de Jesús Ruiz-López, Sergio Gómez-Rosales, Germinal Jorge Cantó-Alarcón, Eliab Estrada-Cortés, Héctor Raymundo Vera-Ávila

“…Modeling lactation curves with mathematical equations is useful to describe and predict the productivity of dairy cows. However, studies analyzing the performance of different models to describe lactation curves in small-scale dairy systems are sparse. …”
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Anti-Ebola virus mAb 3A6 protects highly viremic animals from fatal outcome via binding GP(1,2) in a position elevated from the virion membrane by Kathryn M. Hastie, Zhe Li Salie, Zunlong Ke, Peter J. Halfmann, Lisa Evans DeWald, Sara McArdle, Ariadna Grinyó, Edgar Davidson, Sharon L. Schendel, Chitra Hariharan, Michael J. Norris, Xiaoying Yu, Chakravarthy Chennareddy, Xiaoli Xiong, Megan Heinrich, Michael R. Holbrook, Benjamin Doranz, Ian Crozier, Yoshihiro Kawaoka, Luis M. Branco, Jens H. Kuhn, John A. G. Briggs, Gabriella Worwa, Carl W. Davis, Rafi Ahmed, Erica Ollmann Saphire

“…Anti-GP1,2 mAbs targeting the stalk and membrane proximal external region (MPER) potently neutralize EBOV in vitro and are protective in a mouse model of EVD. However, their neutralization mechanism is poorly understood because they target a GP1,2 epitope that has evaded structural characterization. …”
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An Integrated Database for Exploring Alternative Promoters in Animals by Feiyang Xue, Yuqin Yan, Weiwei Jin, Haotian Zhu, Yanbo Yang, Zhanhui Yu, Xuewen Xu, Jing Gong, Xiaohui Niu

“…Recent researches have also proven important effects of APs on animals. However, the landscape of APs in animals has not been fully recognized. …”
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Exploring environmental factors contributing to Parkinson’s disease in AfrAbian populations by Wael Mohamed

“… Parkinson’s disease (PD) is a global disease. However, there is a lack of research specifically focused on the AfrAbian population. …”
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Chemical characterization of Siraitia grosvenorii granules and their efficacy and mechanism of action on PM2.5-induced acute lung injury by Qi Shao, Yan Zhao, YuYu Shi, Fafeng Cheng, ZeHan Zhang, Ying Liu, ChangXiang Li, ZiLin Ren, Hua Bai, Haojie Cheng, Rolando Maddela, Junqiang Tian, Xueqian Wang

“…Results showed that PM2.5-induced lung damage was associated with oxidative stress, suppression of PI3K/AKT/Nrf2 pathway, and increased levels of certain alarmins & cytokines in blood and bronchial alveolar lavage fluid (BALF). However, SGG reversed these changes, particularly tissue damage and oxidative stress, suggesting that lung protection is mediated by the antioxidant effect, which mitigates the release of alarmin and inflammation.…”
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Forum: Attempting a dialectical reconciliation of the concept truth in the objectivism of evangelical Christianity and the relativism of postmodernism by E. K. Foshaugen

“…Evangelical Christians believe in Objectivism: the conviction that there exists some ahistorical source, foundation or framework to which we can appeal to in  determining the substance and nature of truth, knowledge, reality, right or wrong — and it is independent and external to personal experience or thinking. However, many no longer believe in absolute truth but in relativism. …”
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Severe Diverticulitis Associated to <i>Clostridioides difficile</i> Infection in a 91 Year Old Patient (Clinical Case) by A. A. Makushina, L.  N. Androsova, K. B. Puzakov, A. V. Okhlobystin, M. A. Tatarkina, O. S. Shifrin

“…According to the laboratory and instrumental examinations, the patient had signs of acute diverticulitis, antibacterial therapy was corrected twice, positive dynamics of the condition was noted. However, a few days later, the patient developed a clinic of C. difficile-associated disease, which required the prescription of anticlostridial therapy (vancomycin), until the laboratory confirmation of the accession of this infection was obtained. …”
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