Real world study on combining local interventions with systemic therapy in unresectable hepatocellular carcinoma by Zhaosong Xue, Ming Yao, Kang Chen, Taiyun Huang, Jianjun Li, Jian Chen, Fei Huang, Yubin Huang, Xiaoyong Cai, Yihe Yan

“…Abstract  Combining local interventions with tyrosine kinase inhibitors (TKIs) plus anti-PD-1 antibodies in a triple therapy has demonstrated remarkable anti-tumor efficacy and facilitated conversion resection in patients with initially unresectable hepatocellular carcinoma (HCC). However, the long-term survival outcomes remain largely unexplored. …”
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Deciphering the multifaceted mechanism of Shuang Huang Lian in treating upper respiratory tract infections: A metabolomics-based network pharmacology approach by Gang Xu, Akshay Suresh Patil, Ruhan Wei, Dan Liu, Aimin Zhou, Yan Xu

“…Recommended by the 2011 Chinese Guidelines for Diagnosis and Treatment of Influenza, SHL's therapeutic potential has long been valued in clinical practice. However, its precise mechanisms of action against URTIs remain unclear, necessitating further exploration. …”
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Social and Travel Lockdown Impact Considering Coronavirus Disease (COVID-19) on Air Quality in Megacities of India: Present Benefits, Future Challenges and Way Forward by Suresh Jain, Tanya Sharma

“…This lockdown resulted in a considerable impact on the global as well as a local economy that will take a long time to perform with business as usual scenario. However, improvement in the air quality of the cities across the globe has emerged as a key benefit of this lockdown. …”
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Optimized fertilization patterns increase foxtail millet biomass on the distribution and transformation in Loess Plateau of China. by Tianyou Zhou, Qinhui Liu, Shuangshuang Yang, Zhihao Wang, Panpan Zhang, Xiaolin Wang, Xiaoling Ji, Xiong Zhang

“…The results showed that: (1) the above-ground dry matter accumulation with T4 and T5 increased by 15.04% and 33.68% during the flowering and pustulation stages, and the root/shoot ratio of T4 increased by 9.32% and 12.46% over two experimental years, respectively. (2) the leaf water use efficiency (WUEL) of T4 increased by 15.61%, 0.51% in two stages, respectively, (3) the yields and water use efficiency (WUE) of T3 exhibited a significantly increased by 11.06% and 37.61%, 9.50% and 37.51%, and increased stably by 9.23%-35.17% and 8.73%-35.11% in T4 and T5 respectively, over two seasons. …”
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Analysis of pressure-maintaining coring process in deep coal seams and gas content determination methods by Jian WU, Songhang ZHANG, Tengfei JIA, Weiwei CHAO, Wenchun PENG, Shilong LI

“…To accurately determine the actual gas content in deep coal seams and gas occurrence state, pressure-maintaining coring technology, which retains in-situ pressure and gas content in samples, is considered the most effective method. However, due to the unique characteristics of unconventional reservoirs, such as adsorption gas, there are currently no standardized coring processes or gas content determination methods. …”
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Prognostic impact of donor mitochondrial genomic variants in myelodysplastic neoplasms after stem-cell transplantation by Jing Dong, Shahram Arsang-Jang, Tao Zhang, Zhongyuan Chen, Yung-Tsi Bolon, Stephen Spellman, Raul Urrutia, Paul Auer, Wael Saber

“…Abstract Mitochondrial DNA (mtDNA) variants in patients with myelodysplastic neoplasms (MDS) are shown to be prognostic of outcomes after allogeneic hematopoietic cell transplantation (allo-HCT). However, the prognostic impact of donor mtDNA variants is unknown. …”
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Maternal neonicotinoid pesticide exposure impairs glucose metabolism by deteriorating brown fat thermogenesis by Wenwen Zhu, Jiali Fang, Chenbo Ji, Hong Zhong, Tianying Zhong, Xianwei Cui

“…Background: Neonicotinoids (NEOs) are well-designed highly selective pesticides that target nicotinic acetylcholine receptors. However, their extensive use, accumulation, and biomagnification pose significant risks to humans. …”
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Performance of current tools used for on-the-day assessment and diagnosis of mild traumatic brain injury in sport: a systematic review by Phoebe Haste, Leonardo de Almeida e Bueno, Antoine Jérusalem, Jeroen Bergmann

“…Studies of all designs were accepted, and no reference methods were required.Results 2534 unique records were retrieved, with 52 reports included in the review. …”
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TOURISM study (Treatment Outcomes in UteRIne SarcoMa): a 10-year retrospective evaluation of practice in the UK by Rebekah Webb, Mohammed Al-Zubaidi, Mark A Baxter, Karin Purshouse, James Robertson, Helen Creedon, Katherine Fair, Asma Sarwar, Laura Hannington, Adam L Peters, Samuel Mcinerney, Karen E Mactier, Georgina E Wood, Mai K Bishr, Leonie Eastlake, Katharine Lankester, Alison L Stillie

“…Median overall survival was 37 months; however, survival varied significantly by stage at diagnosis (stage I: 105 months; stage II: 33 months; stage III: 19 months; stage IV: 14 months).Conclusions Our data highlight the diversity in patient management in uterine sarcoma and a marked survival advantage for patients diagnosed with stage I disease. …”
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Case report: A severe myositis mimicking bulbar palsy after administration of immune checkpoint inhibitors by Philippe Rochigneux, Philippe Rochigneux, Alexandre Bertucci, Elika Loir, Alexia Mattei, Danielle Robert, Michael Dassa, Brice Chanez, Mikael Ebbo, Lea Gaigne, Anne Sophie Chretien, Giovanni Corazza, Giovanni Corazza, Nicolas Schleinitz

“…ObjectivesImmune Checkpoint Inhibitors (ICI) are nowadays a cornerstone of anti-cancer treatments. However, the wide spectrum of immune-related adverse events (irAEs) represents a challenge in the oncological practice. …”
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Challenges for funders in monitoring compliance with policies on clinical trials registration and reporting: analysis of funding and registry data in the UK by Rachel L Knowles, Frances Rawle, Kam Pou Ha, Julia Mueller, Rosa Parker

“…Reporting of the main findings was achieved for most trials within 24 months of completion; however, the number of unreported trials remains a concern and should be a focus for future funder policy initiatives. …”
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Production of possible ΣcΣ¯c molecular states in nucleon-antinucleon collision by Lin-Qing Song, Jun He

“…Using the parameters determined from this analysis, we also investigate the reaction pp¯→ΛcΛ¯c, predicting a cross-section on the order of 10 pb with a dip near the ΣcΣ¯c threshold. …”
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“Sleepless nights are a daily reality for us” how women experiencing homelessness in Addis Ababa, Ethiopia describe street life: a photovoice study by Kalkidan Yohannes, Kalkidan Yohannes, Kalkidan Yohannes, Mats Målqvist, Hannah Bradby, Yemane Berhane, Dagmawit Tewahido, Dagmawit Tewahido, Sibylle Herzig van Wees, Sibylle Herzig van Wees

“…Based on participants’ proposal for change, comprehensive services are needed to address women’s multifaceted issues. However, the mitigation strategies and long-term effects of women’s homelessness require further research.…”
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Trends and factors associated with delays in the first prenatal consultation in Guinea by Tiany Sidibe, Mamadou Dioulde Balde, Sadan Camra, Ramata Diallo, Bienvenu Salim Camara, Karifa Kourouma, Madeleine Toure, Kaba Saran Keita, Fanta Barry, Maimouna Balde

“…The trend of this proportion decreased from 86% in 2007 to 61% in 2010, from 85% in 2013 to 61% in 2016; however, it increased from 61% in 2010 to 85% in 2013 and from 66% in 2016 to 76% in 2018. …”
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Enucleated bone marrow-derived mesenchymal stromal cells regulate immune microenvironment and promote testosterone production through efferocytosis by Lu Sun, Jiayu Huang, Xuezi Wang, Peng Huang, Baolin Dong, Zehang Liang, Jiahong Wu, Jiancheng Wang

“…Stem cell therapy has been wildly studied in vitro. However, due to the multidirectional differentiation potential and heterogeneity of stem cells, it is difficult to achieve the good efficiency and reproducibility in basic research and clinical applications. …”
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Environmental Challenges Faced by a Kindergarten and a School in the Katima Mulilo Education Circuit by Давид Нкенгбеза, Мундія Кілібоні Еустінах, Євген Літаба Маемеко, Муквамбо Музва

“…A favorable educational environment – social, cultural, biological, and physical – plays a crucial role in achieving children’s academic goals. The educational environment increases children’s interest in learning. …”
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Optimizing fully-efficient two-stage models for genomic selection using open-source software by Javier Fernández-González, Julio Isidro y Sánchez

“…Two-stage models, preferred for their simplicity and efficiency, first calculate adjusted genotypic means accounting for spatial variation within each environment, then use these means to predict GEBVs. However, unweighted (UNW) two-stage models assume independent errors among adjusted means, neglecting correlations among estimation errors. …”
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Peroral endoscopic myotomy with fundoplication (POEM-F) for achalasia: Systematic review and meta-analysis by Harishankar Gopakumar, Eugene Annor, Ishaan Vohra, Iman Andalib, Amy Tyberg, Avik Sarkar, Haroon Shahid, Mine Carames, Juan Carlos Carames, Giovanna Porfilio Gularte, Abed Al-Lehibi, Resheed Alkhiari, Amol Bapaye, Carlos Robles-Medranda, Michel Kahaleh

“…It appears to offer clinical benefit in mitigating post-POEM GER. However, further standardization for evaluating clinically significant post-POEM GER and long-term benefit of POEM-F is warranted. …”
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Vertical Characteristics of Potential PM2.5 Sources in the Urban Environment by Ho-Tang Liao, Yu-Chi Lai, Hsing Jasmine Chao, Chang-Fu Wu

“…Source apportionment of urban PM2.5 provides information to develop effective control strategies, thus reducing the exposure concentrations and health risks. However, this is a challenging task in metropolitan areas where people live in high-rise buildings. …”
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Comparative survival outcomes of neoadjuvant and adjuvant therapy in patients with T1c, node-negative, triple-negative breast cancer: A population-based analysis by Yi-Zi Zheng, Jia-Qi Ying, Ting-Ting Wu, Yong-Hui Su, Ou-Chen Wang

“…Conclusions: In patients with T1cN0M0-stage TNBC, both NAT and AT resulted in equivalent OS and BCSS. However, NAT precisely helped select patients with worse prognosis.…”
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