TGFβ-specific T cells induced by a TGFβ-derived immune modulatory vaccine both directly and indirectly modulate the phenotype of tumor-associated macrophages and fibroblasts by Mads Hald Andersen, Inés Lecoq, Evelina Martinenaite, Maria Perez-Penco, Lucia Lara de la Torre

“…We found that treatment with the TGFβ vaccine not only reduced the percentage of M2-like tumor-associated macrophages (TAMs) and cancer-associated fibroblasts (CAFs) in the tumor but polarized CAFs away from the myofibroblast-like phenotype. However, whether the immune modulatory properties of the TGFβ vaccine on TAM and CAF phenotypes are a direct consequence of the recognition and subsequent targeting of these subsets by TGFβ-specific T cells or an indirect consequence of the overall modulation induced within the TME remains unknown. …”
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The effect of emotional intelligence on nurses’ job performance: the mediating role of moral intelligence and occupational stress by Rozita Cheraghi, Naser Parizad, Vahid Alinejad, Mehri Piran, Laleh Almasi

“…Moral intelligence mediates the relationship between emotional intelligence and occupational stress (β = 0.0842, 95% CI: 0.0532, 0.1194). However, the mediating role of occupational stress between emotional intelligence and job performance was not supported (β = 0.003, 95% CI: − 0.0139, 0.0184). …”
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Pharmacists' knowledge, attitudes, and perceived barriers to cancer pain management: a cross-sectional survey in Chongqing, China by Yu Liu, Tao Chen, Xinyu Li, Jie Song, Fujun Zhang

“…Abstract Background The role of pharmacists in multidisciplinary cancer pain management teams is increasingly being recognized in Chinese medical practice. …”
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Avoiding ‘second victims’ in healthcare: what support do staff want for coping with patient safety incidents, what do they get and is it effective? A systematic review by Reema Harrison, Rebecca Lawton, Ruth Simms-Ellis, Raabia Sattar, Elizabeth Sweeting, Hannah Hartley, Matthew Morys-Edge

“…Objectives Incontrovertible evidence surrounds the need to support healthcare professionals after patient safety incidents (PSIs). However, what characterises effective organisational support is less clearly understood and defined. …”
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Terlipressin at esophageal varicose bleeding at liver cirrhosis with portal hypertension syndrome by B. N. Kotiv, I. I. Dzidzava, D. P. Kashkin, A. V. Smorodsky, A. V. Slobodyanik, S. A. Soldatov, M. V. Koldin

“…However in 60 min after injection of octreotide both parameters returned almost to baseline level (р>0,05). …”
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Transplantation and Pregnancy by Pinar Erkan Uc, Sermet Sagol

“…Factors that influence pregnancy outcomes in women undergoing organ transplantation include good general health within two years of transplantation, no evidence of organ rejection in the last year, stable graft conditions, absence of acute infections affecting the fetus, and adequate doses of immunosuppression drugs. However, factors that may adversely affect pregnancy include the etiology of the disease requiring transplantation, chronic allograft dysfunction, renal failure, cardiopulmonary diseases, hypertension, diabetes, obesity, and infections such as hepatitis B, hepatitis C, and Cytomegalovirus (CMV). …”
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Practical analysis of using PPPH and raPPPid for Precise Point Positioning in Europe by Saber Mohamed, El-Mewafi Mahmoud, Awad Ahmed

“…Data from 12 MGEX stations over two days were used, with one day dedicated to each of the 6 stations and a 30-second observation interval. …”
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Prospective evaluation of the diagnostic accuracy of FDG-PET/CT for the detection of sternal wound infection post-sternotomy by Angela Cai, Mehrshad Bakhshi, Yoan Lamarche, Francois Harel, Matthieu Pelletier-Galarneau

“…Methods We conducted a single center prospective study of consecutive patients referred for suspected SWI post-median sternotomy. …”
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Efficacy of Hymecromone in Post-Cholecystectomy Patients by A V. Okhlobystin, A. К. Ufimtseva, M. A. Tatarkina, O. Z. Okhlobystina, V. T. Ivashkin

“…All patients were diagnosed to have SOD according to Rome IV Diagnostic Criteria for functional biliary sphincter of Oddi disorder (E1b). …”
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Intra-specific variation in mortality of even-aged Cryptomeria japonica (L. f.) D. Don. forests can be explained using relationships among long-term stand characteristics by Keiko Fukumoto, Tomohiro Nishizono, Fumiaki Kitahara

“…Logistic regression is widely used to explain tree mortality based on site productivity, age, size, and competition. However, the explanatory variables are interrelated. …”
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Theologen van de twintigste eeuw en de christologie by A. van de Beek

“… Theologically the twentieth century can be conceived as a century of Christology. In order to fill in the background for this, we first sketch the opposite position, in Arnold Van Ruler’s idea of Christ as an emergency measure. …”
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Metabolite profile and antioxidant activities of Trikatu, black pepper, Javanese long pepper, and red ginger essential oils by Dewa Ayu Ika Pramitha, Tati Herlina, Iman Permana Maksum, Ari Hardianto, Abd. Wahid Rizaldi Akili, Jalifah Latip

“…Background: Trikatu (TR) is an Ayurvedic formulation that consists of three pungent medicinal ingredients: long pepper fruit, black pepper, and ginger rhizome. However, the strong pungency of the TR constituents poses challenges for oral administration. …”
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Baseline atherogenic index of plasma and its trajectory predict onset of type 2 diabetes in a health screened adult population: a large longitudinal study by Yongbing Sun, Xinbei Lin, Zhi Zou, Caiwen Zhao, Ao Liu, Jing Zhou, Zhonglin Li, Xiaoling Wu, Shewei Dou, Jiadong Zhu, Tao Li, Xue Lv, Yong Wang, Yongli Li

“…The LCTM identified three trajectory patterns for AIP: with the low-stable group as the reference, the medium-stable and high-stable groups had HRs of 1.72 (95% CI: 1.50, 1.96) and 2.50 (95% CI: 2.06, 3.03), respectively, indicating a significantly elevated risk of T2DM (P < 0.05). …”
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Out-of-Pocket Expenditure (OOPE) on Selected Surgeries in the Obstetrics and Gynaecology Department incurred by Ayushman Bharat Pradhan Mantri Jan Arogya  Yojana (AB-PMJAY), Privat... by Dr. Kumar Sumit, Reena Verma, Prajwal Salins, Helmut Brand, Siddhartha Sankar Acharya, Sagarika Kamath, rajesh kamath, Dr. Vidya Prabhu

“…Discussion Findings of the study show that AB-PMJAY is highly effective in reducing OOPE and enhancing financial risk protection for OBG patients. Patients covered by private health insurance incurred less OOPE, yet the burden remained considerable. …”
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CD36 inhibition enhances the anti-proliferative effects of PI3K inhibitors in PTEN-loss anti-HER2 resistant breast cancer cells by You-Yu Liu, Wei-Lun Huang, Sin-Tian Wang, Hui-Ping Hsu, Tzu-Ching Kao, Wei-Pang Chung, Kung-Chia Young

“…Abstract Background HER2-positive patients comprise approximately 20% of breast cancer cases, with HER2-targeted therapy significantly improving progression-free and overall survival. However, subsequent reprogramed tumor progression due to PI3K signaling pathway activation by PIK3CA mutations and/or PTEN-loss cause anti-HER2 resistance. …”
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Cost-effectiveness of Catheter Ablation Versus Antiarrhythmic Drug Therapy for the Treatment of Atrial Fibrillation: A Canadian Perspective by Yaariv Khaykin, Peter J. Mallow, John A. Rizzo, Atul Verma, Lauren Chun, Shelby Olesovsky, Matthew R. Reynolds

“…Anti-arrhythmic drug (AAD) therapy and catheter ablation (CA) are the two common treatments for paroxysmal AF. However, the upfront costs of CA are quite substantial. …”
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Overcoming dietary complexity in type 2 diabetes: influencing factors and coping strategies by Yingying Tang, Dongmei Yang

“…Abstract Background Adherence to dietary guidelines is a fundamental aspect of diabetes management; however, it poses a significant challenge for patients with diabetes. …”
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Targeting sphingosine 1-phosphate receptor 3 inhibits T-cell exhaustion and regulates recruitment of proinflammatory macrophages to improve antitumor efficacy of CAR-T cells agains... by Weiting Liao, Ge Gao, Xia He, Pei Shu, Qizhi Ma, Benxia Zhang, Diyuan Qin, Yongsheng Wang

“…Recent studies have shown that sphingosine 1-phosphate receptor (S1PR)3 has tremendous potential in regulating the immune environment. However, the functional significance of S1PR3 in T-cell-based immunotherapies and the molecular mechanisms have not been fully understood.Methods Here, we studied the combination of EpCAM-specific CAR T-cell therapy with pharmacological blockade of S1PR3 against solid tumor. …”
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Effectiveness of Anti-Gravity Treadmill Exercise After Total Knee Arthroplasty: Protocol for a Randomized Controlled Trial by Elina Jääskeläinen, Mikko Manninen, Heikki Hurri, Mikko Rantasalo, Yun Zhou, Hannu Kautiainen, Leena Ristolainen

“…These are performed independently after surgery. However, a sedentary lifestyle is rather common among patients who have undergone TKA, with pain often limiting postoperative walking, training, and activities of daily living. …”
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Characterizing avocado production systems for Ugandan exports: the need for consolidation and support for sustainable development by Peter Sseruwagi, Peter Sseruwagi, Edouard Lehmann, Paul Sigombe, Gabriel Ddamulira, Jan Willem Van Casteren, Pieterjan De Bauw

“…Last decade, the contribution of East Africa has increased tremendously following several comparative advantages. However, despite substantial recent public and private investments, Uganda’s Hass production and export lags behind neighboring countries. …”
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