Differentially expressed microRNAs in pre-transplant lung biopsies target immune checkpoint proteins and can predict primary graft dysfunction in lung transplantation by Vitale Miceli, Pia Ferrigno, Claudio Centi, Claudia Carcione, Gioacchin Iannolo, Valentina Agnese, Giovanna Lo Iacono, Rosa Liotta, Pier Giulio Conaldi, Massimo Pinzani, Lavinia De Monte, Alessandro Bertani

“…Lung transplantation (LTx) significantly improves outcomes for patients with end-stage respiratory failure. However, primary graft dysfunction (PGD) remains one of the most relevant hurdles. …”
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Blood coagulation system in patients with chronic kidney disease: a prospective observational study by Xi Yang, Yang Wang, Ri-bao Wei, Ting-yu Su, Meng-jie Huang, Ping Li, Xiang-mei Chen, Ping Di, Qing-ping Li

“…Haemostatic alterations are possible causes of these complications, but their roles remain poorly characterised. In the prospective observational study, we investigated the entire coagulation process in patients with CKD to elucidate the mechanisms of their high thromboembolic risk.Methods A total of 95 patients with CKD and 20 healthy controls who met the inclusion criteria were consecutively recruited from September 2015 to March 2016. …”
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Geological characteristics of deep coal rock and main geological factors controlling coalbed methane enrichment: a case study of the M area in the eastern Ordos Basin by Xiaojiao GUO, Lei WANG, Xianzhou YAO, Xu LI, Linke ZHANG, Xiaoshuang WANG

“…The 8# thick coal seam is widely distributed with high organic matter thermal maturity at the top of the Upper Carboniferous Benxi Formation in the M area of the Ordos Basin. However, the coal seams in this area are characterized by large burial depth, rapid lateral changes, strong heterogeneity, and unclear basic geological features and enrichment patterns of deep coalbed methane (CBM). …”
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Treatment Interruption and Regimen Change in Firstgeneration versus Second-generation Tyrosine Kinase Inhibitors used as First-line Therapy for Chronic Myeloid Leukemia by Melea A. Ward, Gang Fang, Kristy L. Richards, Christine M. Walko, Stephanie R. Earnshaw, Laura E. Happe, Susan J. Blalock

“…**Background:** Research has shown that treatment interruptions are associated with worse failure-free survival in chronic myeloid leukemia (CML); however they are commonly used in clinical trials to manage adverse events. …”
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A Systematic Literature Review and Bucher Indirect Comparison: Tildrakizumab versus Guselkumab by Kristian Garn Du Jardin, Pepi Hurtado Lopez, Mette Lange, Rachael McCool, Silvia Maeso Naval, Sandra Quickert

“…In its pivotal Phase III trial, tildrakizumab demonstrated greater efficacy than etanercept in moderate-to-severe psoriasis. However, there are no head-to-head trials comparing tildrakizumab with guselkumab. …”
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Preterm nutrition and brain development by Chiara Nava, Gianluca Lista, Enrica Lupo

“…Eventually, current knowledge on the role of micronutrient supplementation (e.g,. iron, lutein, iodine), is still scarce. …”
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Geospatial digital mapping of soil organic carbon using machine learning and geostatistical methods in different land uses by Yahya Parvizi, Shahrokh Fatehi

“…The LAM method was estimated wider range of the SOC change (SOC = 0.18–4.82%) among different simulation model. However, the RF model (R2 = 0.64 and RMSE = 0.58%) was the most accurate in predicting SOC quantity comparing the other simulation models. …”
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Optimal needle characteristics for classical inferior alveolar nerve block anesthesia: a systematic review by Mennat Allah Ashraf Abd-Elsabour, Ayat Gamal-AbdelNaser

“…Conclusions The level of the available evidence introduced by primary studies hinder concluding the optimal needle characteristics; keeping the research question unanswered. However, within the limitations of the heterogenous studies, available data favors thinner needles for less pain during needle insertion; otherwise, data of the other outcomes was inconclusive. …”
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Assessment of students’ ability to represent determinants of health and health systems science content on concept maps in a pre-clerkship curriculum by Tovah Tripp, Miriam Hoffman, Mitchell Miller, Joshua S. Josephs

“…Conclusions Students sometimes include DoH on their concept maps and this improves from the first three courses towards the end of the first academic year. However, students do not prioritize inclusion of DoH in their concept maps at the end of the pre-clerkship curriculum. …”
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Network pharmacology and experimental verification to investigate the mechanism of isoliquiritigenin for the treatment of Alzheimer’s disease by Waimao Gao, Guang Yang, Xinjuan Liu, Kaifan Hu, Jie Pan, Xingyu Wang, Yan Zhao, Ying Xu

“…Abstract Isoliquiritigenin (ISL), a flavone isolated from licorice, has been demonstrated to exhibit anti-inflammatory and antioxidant properties in the treatment of Alzheimer’s disease (AD). However, the molecular details of the contribution of ISL to AD remain largely elusive. …”
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Diversity and Conservation Status of Large Mammals in Ghamot National Park, Azad Jammu and Kashmir, Pakistan by Muhammad Jahangeer, Siddique Muhammad, Muhammad Shakeel, Mir Muhammad Saleem, Ali Usman, Hussain Abid

“…Season had little effect on species richness, diversity, and composition across or within habitat types. However, the richness of species varied greatly across seasons among the four habitat types. …”
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The state of combined thoracoabdominal triple-organ transplantation in the United States by Emily G. Dunbar, BS, Ye In Christopher Kwon, BA, Matthew Ambrosio, MS, Inna F. Tchoukina, MD, Keyur B. Shah, MD, David A. Bruno, MD, Walker A. Julliard, MD, Josue Chery, MD, Vigneshwar Kasirajan, MD, Zubair A. Hashmi, MD

“…Conclusions: The prevalence of TOTs has dramatically increased over the past decade. While overall survival between TOTs appears similar, adding a liver to a heart-lung transplant may be associated with a poorer prognosis compared to adding a kidney. …”
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TAB2 deficiency induces dilated cardiomyopathy by promoting mitochondrial calcium overload in human iPSC-derived cardiomyocytes by Wenrui Sun, Jianchao Zhang, Shuang Li, Wanrong Fu, Yangyang Liu, Mengduan Liu, Jianzeng Dong, Xiaoyan Zhao, Xiaowei Li

“…IPSCs are not species-dependent, are readily accessible, and raise fewer ethical concerns. Results TAB2 disruption had no impact on the cardiac differentiation of iPSCs and led to confirmed TAB2 deficiency in human iPSC-derived cardiomyocytes (hiPSC-CMs). …”
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Pregnancy, childbirth, and breastfeeding experience of women with epilepsy in Me’enit community, South West Ethiopia by Rahel Yaekob, Tefera Belachew

“…Maternal mortality in women with epilepsy was considered to be high. However, it was noted that epilepsy was not aggravated by the pregnancy and women with epilepsy breastfeed their children similarly to their non-epileptic peers. …”
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Olfactory mucosa-mesenchymal stem cells with overexpressed Nrf2 modulate angiogenesis and exert anti-inflammation effect in an in vitro traumatic brain injury model by Zigui Chen, Chunyuan Zhang, Yuhua Fang, He Zhang, Jiawei Luo, Changfeng Miao, Jiale Li, Jun Peng, Yingqi Qiu, Ying Xia, Qisheng Luo

“…Conclusion This study proved the effects of OM-MSCsNrf2 on modulating PC12 and BV2 cells in vitro, which, however, necessitates further in vivo validation.…”
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Cassava–soybean intercropping alleviates continuous cassava cropping obstacles by improving its rhizosphere microecology by Huixian Chen, Lixia Ruan, Sheng Cao, Wen He, Haixia Yang, Zhenhua Liang, Hengrui Li, Wanling Wei, Zhenling Huang, Xiu Lan

“…Correlation analysis showed that Trichoderma was significantly negatively correlated with fumaric acid, succinic acid, phosphoenolpyruvic acid, and soil bulk density. However, there was significant positive correlation with phenol glucuronide, alpha-CEHC deoxyguanosine and other carbohydrates, nucleotide substances, organic matter, and pH. …”
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Comparison and Impact Factor Analysis of Ground PM2.5 Retrieved by Aqua and Himawari-8 Satellite Products in Guangdong, China by Tingyuan Li, Xuejiao Deng, Jingyang Chen, Jie Xu, Jin Shen

“…The two satellites had similar performances for the annual mean, dry season mean, and hourly data; however, H8 performed better than Aqua for the wet season and monthly averages. …”
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A longitudinal study of the association between the outcome of bariatric surgery and mental health indicators in Chinese patients: an examination of the interaction effect by Hung-Yen Lin, Te-Chang Changchien, Tsung-Jen Hsieh, Cheng-Sheng Chen, Yung-Chieh Yen

“…We collected and compared pre- and post-operative mental health status (using the Chinese Health Questionnaire, CHQ, and the Taiwanese Depressive Questionnaire, TDQ) and physical indicators to evaluate and establish their relationships. …”
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Effect of the hour-1 bundle on clinical outcomes in patients with sepsis and septic shock: A protocol for systematic review and meta-analysis. by Shukun Hong, Hongye Wang, Xiaoguang Fan, Jian Liu, Lujun Qiao

“…<h4>Background</h4>According to the 2018 bundle guidelines of the Surviving Sepsis Campaign, many emergency departments and intensive care units currently adopt the hour-1 bundle as a standard practice for sepsis management. However, recent studies on the hour-1 bundle for sepsis treatment have yielded inconsistent results, raising questions and challenges about its clinical efficacy.…”
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Unlocking the link: predicting cardiovascular disease risk with a focus on airflow obstruction using machine learning by Xiyu Cao, Jianli Ma, Xiaoyi He, Yufei Liu, Yang Yang, Yaqi Wang, Chuantao Zhang

“…Inclusion criteria were participants aged over 40 with complete AO and CVD data; exclusions were those with missing key data. …”
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