Nano-delivery platform with strong protection and efficient delivery: preparation of self-assembled RNA pesticide with dual RNAi targets against Apolygus lucorum by Heng Qiao, Qinhong Jiang, Jing Zhao, Liubin Xiao, Keyan Zhu-Salzman, Dejin Xu, Guangchun Xu, Jie Shen, Aiguo Gu, Dejun Hao, Shuo Yan, Yongan Tan

“…Then, dsECR-A and dsTre-1 fragments were individually screened, and the dsECR-A and dsTre-1 fragments with good control effects were co-expressed in pET28-BL21 (DE3) RNase III − system to prepare the dsECR-A + Tre-1/SPc complex. …”
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Effect of crystalline lens decentration and tilt on visual performance in eyes implanted with bifocal or extended depth of focus intraocular lenses by Yu Zhang, Jiaqing Zhang, Chen Liang, Yifan Xu, Jiaying Wu, Junming Wu, Yifan Zhang, Aixia Jin, Xuhua Tan, Lixia Luo

“…Abstract Purpose To explore the potential of crystalline lens decentration and tilt as indicators for screening cataract patients for presbyopia-correcting intraocular lens (IOL) implantation. …”
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Mental health disorder symptom changes among public safety personnel after emotional resilience skills training by R.N. Carleton, S. Sauer-Zavala, T.A. Teckchandani, K.Q. Maguire, L. Jamshidi, R.E. Shields, T.O. Afifi, J. Nisbet, K.L. Andrews, S.H. Stewart, A.J. Fletcher, R. Martin, R.S. MacPhee, J.C. MacDermid, T.M. Keane, A. Brunet, M. McCarron, L.M. Lix, N.A. Jones, G.P. Krätzig, J.P. Neary, G. Anderson, R. Ricciardelli, H. Cramm, J. Sareen, G.J.G. Asmundson

“…Results: There were reductions in self-report and clinical diagnostic interview positive screens for PTSD and other PTSI from pre- to post-training (ps < 0.05), with mental health sustained or improved at 1-year follow-up. …”
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Prevalence and risk factors of postpartum depression, general depressive symptoms, anxiety and stress (PODSAS) among mothers during their 4-week postnatal follow-up in five public... by Boon How Chew, Subashini Ambigapathy, Saidatul Akmar Mohammad Redzuan, Priyasini Suntharalingam, Thenmoli Palaniyappan, Venotha Ganasan, Puteri Normalina Megat Abu Bakar, Paream Kaur, Lili Zuryani Marmuji, V Paranthaman

“…Findings from this study will be used to identify the needs for early screening and detection, encourage development of interventions to reduce its occurrence and support mothers with PODSAS.Methods and analysis This cross-sectional study will recruit 459 postpartum mothers during their 4-week postnatal follow-up in five selected public health clinics in Perak from September 2019 to May 2020. …”
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Antimicrobial and ADME properties of methoxylated, methylated and nitrated 2-hydroxynaphthalene-1 carboxanilides by Lucia Vrablova, Tomas Gonec, Tereza Kauerova, Michal Oravec, Izabela Jendrzejewska, Peter Kollar, Alois Cizek, Josef Jampilek

“…The investigated compounds meet the definition of Michael acceptors. Based on ADME screening, the investigated compounds 13, 22 and 27 should have suitable physico¬chemical parameters for good bioavailability in the organism. …”
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Modeling factors related to earthquake preparedness: a structural equation modeling approach by Azadeh Fatehpanah, Elham Maraghi, Anthony Coetzer-Liversage, Mahmood Karimy, Amir H. Pakpour, Majed Maripour, Nematollah Jaafarzadeh Haghighi Fard, Marzieh Araban

“…Conclusion The overall fit indexes were acceptable indicating the TPB model is a valid and reliable measurement model for screening population-level readiness for earthquake preparedness, developing and/or implementing health promotion interventions. …”
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Green gram yield prediction using linear regression by Tumusiime, Robert, Mabirizi, Vicent, Mirembe, D.P, Arinanye, T.R

“…The study used a dataset of 107 records (gardens) and 9 features obtained from National Semi-Arid Research Institute (NaSARRI), Serere, Uganda. The predictor variables used were; soil type, soil PH, soil fertility, rainfall distribution, weeding practice, pest and disease management, fertilizer application, plant spacing, and cropping system. …”
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Real-world effectiveness of sofosbuvir/velpatasvir, glecaprevir/pibrentasvir, and sofosbuvir/velpatasvir/voxilaprevir against genotype 3 hepatitis C virus infection: a systematic r... by Liwei Zhuang, Liwei Zhuang, Junnan Li, Yu Zhang, Shibo Ji, Huichun Xing, Huichun Xing

“…However, limited data are available on the antiviral effect of sofosbuvir (SOF) + velpatasvir (VEL) ± ribavirin (RBV), SOF + VEL + voxilaprevir (VOX), and glecaprevir (GLE) + pibrentasvir (PIB) in treating patients infected with HCV GT3 in a real-world setting.MethodsUsing the EMBASE, PubMed, and Cochrane Library databases, articles were screened from 1 January 2016 to 1 June 2024. The sustained virologic response (SVR) rates were analyzed using the Freeman–Tukey double arcsine transformation in a random-effects model in R4.1.0 software.ResultsWe recruited 3,177 patients with HCV GT3 in 19 studies from 9 countries. …”
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Ethnobotany, floristic and phytochemical studies of medicinal plants used to treat uterine fibroids in Mbarara City, Uganda by Calton Nantinda, Esther Lynnet Kisakye, David Musana, Isaac Ssessanga, Ukashar Ssenabulya, Timothy Omara, Ivan Kahwa, Florence Nalimu

“…Classical phytochemical screening of plant organs from the eight most cited species indicated flavonoids, phytosterols, terpenoids, saponins and alkaloids. …”
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Clinical Practice Guidelines of Russian Gastroenterological Association, Scientific Society for the Clinical Study of Human Microbiome, Russian Society for the Prevention of Non-Co... by V. T. Ivashkin, T. L. Lapina, I. V. Maev, O. M. Drapkina, R. S. Kozlov, A. A. Sheptulin, A. S. Trukhmanov, S. R. Abdulkhakov, O. P. Alekseeva, S. A. Alekseenko, D. N. Andreev, D. S. Bordin, N. N. Dekhnich, I. L. Klyaritskaya, N. V. Korochanskaya, M. F. Osipenko, E. A. Poluektova, A. S. Sarsenbaeva, V. I. Simanenkov, A. V. Tkachev, A. I. Ulyanin, I. B. Khlynov, V. V. Tsukanov

“…Chronic gastritis caused by Н. pylori infection, including asymptomatic persons, may be considered as an indication for eradication therapy of Н. pylori as etiological therapy and opportunistic screening for gastric cancer prevention. Indications, for obligatory anti-Helicobacter therapy include peptic ulcer, gastric MALT lymphoma, early gastric cancer (EGC) with endoscopic resection. …”
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The study of miRNA-211 affects melanogenesis progress in Cashmere goats via suppressing <i>AP1S2</i> by B. Zhang, R. Liu, T. Ma, X. Li, Y. Zhao, H. Su, J. Li, Y. Li, H. Jiang, Q. Zhang

“…First, the target gene <i>AP1S2</i> of miRNA-211 was screened by TargetScan and GO/KEGG, and then the targeted relationship was confirmed by the dual-luciferase reporter experiment. …”
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Effect of remote ischemic preconditioning on perioperative neurocognitive disorder in elderly patients undergoing major surgery and associated genetic variant analysis: a randomize... by Feifei Xu, Tingting Liu, Huiqing Liu, Jiao Deng, Shan He, Zhihong Lu, Haopeng Zhang, Hailong Dong

“…Methods From August 2020, 250 patients scheduled for major surgeries under general anesthesia were screened and 120 patients were randomly assigned to the control group or the RIPC group. …”
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Effectiveness of flipped classrooms in Chinese students of clinical medicine major undergoing clinical practice: a meta-analysis by Xinrui Sun, Xin Yuan, Linyu Zhang, Yi Zhang, Xue Xiao, Hanmin Liu, Fang Ma

“…Methods Two researchers independently screened all the retrieved articles and did data extraction. …”
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Microtubule inhibition as a proposed mechanism for the anthelmintic effect of phytochemicals isolated from Cicerbita alpina by Mark James Horgan, Ines Sigg, Ioanna Poulopoulou, Francisco J. Rodriguez-Mejias, Eva Albertini, Pietro Fusani, Florian Fischer, Eftychia Martinidou, Daniela Schuster, Stefan Martens, Pidder Jansen Dürr, Matthias Gauly, Hermann Stuppner, Alexander Weiss, Veronika Temml, Bianka Siewert

“…Together with in silico virtual screening studies, these results suggest microtubule stabilisation as a possible anthelmintic target and mechanism of action. …”
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Disturbed sleep after lung transplantation is associated with worse patient-reported outcomes and chronic lung allograft dysfunction by Aric A. Prather, PhD, Ying Gao, MS, Legna Betancourt, BS, Rose C. Kordahl, BS, Anya Sriram, BS, Chiung-Yu Huang, PhD, Steven R. Hays, MD, Jasleen Kukreja, MD, Daniel R. Calabrese, MD, Aida Venado, MD, Bhavya Kapse, PhD, John R. Greenland, MD, PhD, Jonathan P. Singer, MD, MS

“…Clarifying the nature of this association may have important screening implications.…”
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Patient participation in free cataract surgery: a cross-sectional study of the low-income elderly in urban China by Bo Qu, Hui Chen, Xuhua Tan, Xiaohang Wu, Haotian Lin, Zhenzhen Liu, Lixia Luo, Bo Zhang, Erping Long, Duoru Lin, Weirong Chen, Yizhi Liu, Haofeng Jiang, Jingjing Chen, Zhuoling Lin, Xiaoyan Li, Jinzhu Tang, Yingfen Lin

“…Only 21.5% of the respondents underwent physical examinations that included regular eye screening, and only 6.30% were highly educated patients. …”
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Meta-analysis of the association between overexpression of RAD51 family genes and prognosis and clinical features in breast cancer by Yong-Cheng Liu, Jun Shen

“…Two independent researchers screened the literature according to predefined inclusion and exclusion criteria and extracted relevant data. …”
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Meta-Analysis of the Effect of Resistance Exercise Prescription on Glucose and Lipid Metabolism in Overweight and Obese Adults by SUN Yuxin, GUO Xiaoyuan, CHEN Shi, PAN Hui, ZHU Huijuan

“…The type of literature was limited to randomized controlled studies in which the exercise intervention included resistance exercise in the test group but did not include resistance exercise in the control group. The literature was screened by 2 researchers according to inclusion and exclusion criteria and relevant data were extracted.Meta-analysis of included literature was performed using RevMan 5.3 software, and publication bias was assessed using funnel plots.ResultsA total of 17 papers and 700 study subjects were included, with 351 cases in the test group, and 349 cases in the control group.Meta-analysis results showed that compared with the control group, the glycosylated hemoglobin of the test group with resistance exercise[SMD (95% CI) =-0.30(-0.53--0.07), P=0.010], fasting blood glucose[SMD (95% CI)=-0.58(-0.90--0.26), P < 0.001], insulin resistance index[SMD (95% CI) =-0.90 (-1.42--0.38), P < 0.001], and low-density lipoprotein cholesterol (LDL-C)[SMD (95% CI) =-0.28 (-0.53--0.04), P=0.020] levels were reduced.Subgroup analysis showed that the glucose metabolism levels of the test group with only resistance exercise and a combination of resistance-anaerobic exercise were significantly lower than those of the control group(both P < 0.05).The heterogeneity of the effect of resistance exercise on glucose metabolism in Asian populations(I2=57%) was smaller than that in Caucasion(I2=76%) and other populations(I2=94%), and the level of decrease in glucose metabolism indexes was significant[SMD(95% CI)=-1.15(-1.73--0.57), P < 0.001].ConclusionResistance exercise can significantly reduce the level of glycolipid metabolism indexes in overweight or obese people.…”
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Microbiota governs host chenodeoxycholic acid glucuronidation to ameliorate bile acid disorder induced diarrhea by Zishen Lin, Yue Feng, Jinping Wang, Zhaoyue Men, Xi Ma

“…In vitro, important gene involved in the reduction of BA disorder induced-diarrhea were screened by RNA transcriptomics sequencing, and activation pathway of FXR-SIRT1-LKB1 to alleviate BA disorder diarrhea and P53-mediated apoptosis were proposed in vitro by multifarious siRNA interference, CO-IP, immunofluorescence, and so on, which mechanism was also verified in a variety of mouse models. …”
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Defining and measuring long COVID fatigue: a scoping review by Deborah Edwards, Jennifer Davies, Christine Bundy, Rachael Pattinson, Bethan Thomas, Carys Dale, Benjamin Jenkins, Helena Lande

“…To advance our understanding, this review summarises the definitions and measures of long COVID fatigue being used by researchers.Design This is a scoping review that follows the JBI methodology and reports using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews.Data sources Medline, Scopus, CINAHL, PsycINFO, EMCARE, Web of Science, Epistemonikos, Cochrane Central Register of Controlled Trials, Dimensions, Overton and ProQuest Dissertations &amp; Theses databases were searched from January 2020 to May 2023.Eligibility criteria This review included quantitative and qualitative studies that included any definition of long COVID and/or measurement tool that purported to quantify either the impact, severity or symptoms of long COVID fatigue.Data extraction and synthesis Two independent reviewers screened the title, abstract and full text of the selected studies based on the inclusion criteria. …”
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