A 5-year Retrospective Review of the Presentation Pattern and Management outcomes of Uterine Fibroids in a Nigerian Tertiary Hospital. by Madunatu, Chimezie Michael, Okoro, Chukwuemeka Chukwubuikem, Onyejiaka, Chukwudubem Chinagorom, Enechukwu, Chukwunonso Isaiah, Ofojebe, Chukwuemeka Jude, Ani, Vincent Chinedu, Eleje, George Uchenna, Mbachu, Ikechukwu Innocent, Okafor, Chigozie Geoffrey, Okoro, Amarachukwu Doris, Okafor, Christiana Nkiru, Oguejiofor, Charlotte Blanche, Eze, Stephen Chijioke

“…Abdominal swelling was the commonest (62.3%) pattern of presentation and most of the subjects presented late with a mean duration of symptoms of 38.2±9.82 months. Surgery was the commonest method of treatment with myomectomy being the modality used in 86.5% of subjects. …”
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Two decades of recipient and donor referrals for heart transplantation to Groote Schuur Hospital, Cape Town, South Africa: A retrospective study by R Kanyongo, G Calligaro, B Cupido, J Scherman, A Brooks, C Ofoegbu, N Da Silva, A Ryan, M Mofamadi, K Seele, P Human, J Brink, P Zilla, T Pennel

“…Contraindications for listing included social (n=106; 49.3%), medical (n=83; 38.6%) and psychological (n=26; 12.0%) factors, while 134 patients (21.4%) were considered too well. …”
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Associations between prior healthcare use, time to diagnosis, and clinical outcomes in inflammatory bowel disease: a nationally representative population-based cohort study by Alex Bottle, Sonia Saxena, Richard C G Pollok, Jonathan Blackwell, Irene Petersen, Hanna Creese, Nishani Jayasooriya, Richard CG Pollok

“…For CD, hospitalisation prior to diagnosis was associated with CD-related hospitalisation (aHR=1.30, 95% CI 1.01 to 1.68) and intestinal surgery (aHR=1.71, 95% CI 1.13 to 2.58); for UC, it was associated with immunomodulator use (aHR=1.42, 95% CI 1.11 to 1.81), UC-related hospitalisation (aHR=1.36, 95% CI 1.06 to 1.95) and colectomy (aHR=1.54, 95% CI 1.01 to 2.34). …”
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Recent centennial drought on the Tibetan Plateau is outstanding within the past 3500 years by Yu Liu, Huiming Song, Zhisheng An, Qiang Li, Steven W. Leavitt, Ulf Büntgen, Qiufang Cai, Ruoshi Liu, Congxi Fang, Changfeng Sun, Kerstin Treydte, Meng Ren, Lidong Mo, Yi Song, Wenju Cai, Quan Zhang, Weijian Zhou, Achim Bräuning, Jussi Grießinger, Deliang Chen, Hans W. Linderholm, Ashish Sinha, Hai Cheng, Lu Wang, Ying Lei, Junyan Sun, Wei Gong, Xuxiang Li, Linlin Cui, Liang Ning, Lingfeng Wan, Thomas W. Crowther, Constantin M. Zohner

“…Here, we present a precisely-dated 3476-year precipitation reconstruction derived from tree-ring δ18O data on the Tibetan Plateau, representing one of the few multi-millennia-long annually-resolved terrestrial δ18O records to date. …”
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Amyloidogenic immunoglobulin light chains disturb contractile function and calcium transients in a human cardiac spheroid model of light chain (AL) amyloidosis by Mélanie Bézard, Jean-Sébastien Vartanian-Grimaldi, Julien Henri, Denisa Calin, Amira Zaroui, Mounira Kharoubi, Thibaud Damy, Onnik Agbulut, Ekaterini Kordeli

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Validity, Accuracy, and Safety Assessment of an Aerobic Interval Training Using an App-Based Prehabilitation Program (PROTEGO MAXIMA Trial) Before Major Surgery: Prospective, Inter... by Sara Fatima Faqar Uz Zaman, Svenja Sliwinski, Lisa Mohr-Wetzel, Julia Dreilich, Natalie Filmann, Charlotte Detemble, Dora Zmuc, Felix Chun, Wojciech Derwich, Waldemar Schreiner, Wolf Bechstein, Johannes Fleckenstein, Andreas A Schnitzbauer

“…Regression analysis revealed a significant impact of the BMI (odds ratio 0.90, 95% CI 0.82-0.98, P=.02) and Timed Up and Go Test score (odds ratio 0.12, 95% CI 0.03-0.55, P=.006) on the accuracy of heart rate measurement; 29 (39%) patients experienced adverse events: pain (5/12, 42%), ECG electrode–related skin irritations (2/42, 17%), dizziness (2/42, 17%), shortness of breath (2/42, 17%), and fatigue (1/42, 8%). …”
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Assessing Mental Illness Referral Request Acceptance: A Nationwide E-Referral Data From Saudi Arabia by Alharbi AA, Aljerian NA, Alghamdi HA, Binhotan MS, Alsultan AK, Arafat MS, Aldhabib A, Aloqayli AI, Alwahbi EB, Horner RD

“…Lower acceptance rates were observed for ages 15– 25 years (aOR = 0.84; 95% CI = 0.70– 0.99) and 46– 65 years (aOR = 0.83; 95% CI = 0.70– 0.99) compared to ages 26– 35 years. …”
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Enhancing deep learning methods for brain metastasis detection through cross-technique annotations on SPACE MRI by Tassilo Wald, Benjamin Hamm, Julius C. Holzschuh, Rami El Shafie, Andreas Kudak, Balint Kovacs, Irada Pflüger, Bastian von Nettelbladt, Constantin Ulrich, Michael Anton Baumgartner, Philipp Vollmuth, Jürgen Debus, Klaus H. Maier-Hein, Thomas Welzel

“…Relative to MPRAGE-NAQ, the MPRAGE-HAQ F1-score detection increased on all additional test datasets by 2.5–9.6 points (p < 0.016) and sensitivity improved on three datasets by 4.6–8.5 points (p < 0.001). …”
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Supplementation of Arjun (Terminalia arjuna) bark powder prevented oxidative stress and enhanced antioxidants in kidneys on isoproterenol-treated Swiss albino mice model by Rashedul Haque, Sajib Paul, Md. Tipu Sultan, Faizul Islam Chowdhury, Md. Kawser, Shariful Islam Nayan, S.M. Hafiz Hassan, Afsana Kabir Chowdhury, Raiyana Huda, Sauda Sumaya Dina, Sheikh Zahir Raihan

“…Catalase plasma (ISO- 15.90 U/min, ISO + Arjun 2.5%- 19.75 U/min, P = 0.0070) and in catalase kidney (ISO- 381.6 U/min/g protein, ISO + Arjun 2.5%- 581.9 U/min/g protein, P = 0.0082). …”
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Factors and barriers to sulfadoxine-pyrimethamine uptake for intermittent preventive treatment during pregnancy in Ghana by Akua Kumi Yeboah, Patrick Ohemeng Gyaase, Richmond Bediako Nsiah, Regina Amoa-Tutu, Saida Abdul-Rahman Zakaria, Lynna Naa Adede Obeng, Frank Prempeh, Phenihas Kwadwo Opoku, Amos Andoono, Gilbert Elara Dagoe, Kwame Kusi Agyemang, Jonathan Mawutor Gmanyami, Dominic Nyarko, Paul Kofi Awuah, Gifty Sefaah Owusu, Solomon Anum-Doku

“…A significant proportion (43.7%) of participants received three or more doses of IPTp-SP, while 56.3% received two or fewer doses. Key barriers to uptake included being unmarried (AOR = 0.36, [95% CI 0.145–0.881], p = 0.025) and unemployed (COR = 0.61, [95% CI 0.38–0.98], p = 0.042). …”
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Effects of macitentan and selexipag across prognostic age groups in patients with pulmonary arterial hypertension by Richard Channick, MD, Sarah Medrek, MD, Marion Delcroix, MD, Sean Gaine, MD, Pavel Jansa, MD, PhD, Irene Lang, MD, Vallerie McLaughlin, MD, Sanjay Mehta, MD, Tomas Pulido, MD, Bhagavatula Sastry, MD, Rogerio Souza, MD, PhD, Adam Torbicki, MD, Carol Zhao, MS, Paul Strachan, MD, Peter Agron, PhD, Joseph Yen, PhD, Olivier Sitbon, MD, PhD

“…RESULTS: Three age groups (< 35, 35–64, ≥ 65 years) showed good M/M risk discrimination (c-statistic 0.69, SERAPHIN; 0.66, GRIPHON). M/M risk was higher in placebo patients < 35 versus 35–64 years (SERAPHIN: hazard ratio [HR] 1.73, 95% confidence interval [CI] 1.10–2.72, p = 0.02; GRIPHON: HR 1.81, 95% CI 1.28–2.56, p < 0.001). …”
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Exploring expressed concerns and uncanny feeling in patients with shortness of breath calling out-of-hours primary care by Michelle Spek, Dorien L. Zwart, Esther de Groot, Michelle R. Timmerman, Maarten van Smeden, Daphne C. A. Erkelens, Anna S. M. Dobbe, Mathé Delissen, Frans H. Rutten, Roderick P. Venekamp

“…Potential LTEs were similarly present among those who did and did not express concerns (OR: 1.07; 95% CI 0.84–1.37, mOR: 1.07; 95% CI 0.83–1.36), whereas potential LTEs were more often present among those with an uncanny feeling compared to those without such feeling (OR: 1.36; 95% CI 1.06–1.75, mOR: 1.35; 95% CI 1.05–1.74). …”
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Центральное венозное давление как показатель возможной эффективности инфузионной терапии: систематический обзор и метаанализ... by И. В. Кузнецов, Л. Б. Берикашвили, П. В. Рыжков, Е. М. Короленок, М. Я. Ядгаров, П. А. Поляков, А. Е. Скворцов, А. А. Яковлев, Валерий Владимирович Лихванцев

“…Общий AUROC для оценки ЦВД составил 0,6 (95%-й доверительный интервал [95% ДИ] [0,57; 0,62]), что указывает на низкую диагностическую точность метода (качество доказательства среднее). …”
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Mitochondrial reactive oxygen species trigger metformin-dependent antitumor immunity via activation of Nrf2/mTORC1/p62 axis in tumor-infiltrating CD8T lymphocytes by Kazuhiro Kakimi, Hirokazu Matsushita, Masaaki Komatsu, Eiryo Kawakami, Mikako Nishida, Nahoko Yamashita, Taisaku Ogawa, Keita Koseki, Eiji Warabi, Tomoyuki Ohue, Katsuyuki Shiroguchi, Heiichiro Udono

“…Conditional deletion of Nrf2 in CD8TILs abrogates mTORC1 activation and antitumor immunity by Met. …”
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Insulin resistance surrogates are associated with all-cause mortality and cardiovascular mortality in population with metabolic syndrome: a retrospective cohort study of NHANES by Jinhao Liao, Linjie Wang, Lian Duan, Fengying Gong, Huijuan Zhu, Hui Pan, Hongbo Yang

“…As IGR gradually approached inflection points, the two types of mortality risks descended by 15%[HR 0.85(0.80,0.91)] and 19%[HR 0.81(0.71,0.92)], respectively. …”
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BOOK REVIEW: GRACE UPON GRACE. REFLECTIONS ON THE MEANING OF LIFE by M. Laubscher

“…(Stellenbosch: African Sun Media, 2020) 96 pp. ISBN: 978-1-928314-71-4 (R230); e-ISBN: 978-1-928314-72-1 (R185). …”
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Fall Prevention: Reduce Your Risk! by Jennifer Hillan

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Pesticides and Prior Informed Consent by Frederick M. Fishel

“…PI222, a 6-page illustrated fact sheet by Frederick M. Fishel, describes this international information exchange sponsored by the United Nations to assist countries throughout the world in decisions on whether to allow import of chemicals of concern, such as pesticides. …”
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Célpontban a megbízhatósági vizsgálat by Alexa Bejczi

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Reducing Conflict in the Wildland-Urban Interface by Martha C. Monroe

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