Effectiveness, Safety, and Costs of Thromboprophylaxis with Enoxaparin or Unfractionated Heparin Among Medical Inpatients With Chronic Obstructive Pulmonary Disease or Heart Failur... by Alpesh N. Amin, Alex Kartashov, Wilson Ngai, Kevin Steele, Ning Rosenthal

“…Among patients with COPD, enoxaparin recipients had 21%, 37%, and 10% lower odds of VTE, major bleeding, and in-hospital mortality during index admission, and 17% and 50% lower odds of major bleeding and heparin-induced thrombocytopenia (HIT) during the readmission period, compared with UFH recipients (all _P_ <.006). In the HF cohort, 58&#8239;488 (58%) patients received enoxaparin and 42&#8239;726 (42%) received UFH. …”
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The combined effect of bed-to-nurse ratio and nurse turnover rate on in-hospital mortality based on South Korean administrative data: a cross-sectional study by Hyun-Young Kim, Yunmi Kim, Jiyun Kim

“…The risk of death among patients admitted to hospitals with a bed-to-nurse ratio of < 2.5 and a nurse turnover rate of ≥ 12% was lower than among patients admitted to hospitals with a bed-to-nurse ratio of ≥ 4.5 and a nurse turnover rate of ≥ 12% (odds ratio [OR] = 0.63; 95% confidence interval [CI], 0.48–0.82). The risk of in-hospital mortality decreased further when the nurse turnover rate was < 12% (OR = 0.59; 95% CI, 0.44–0.79). …”
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Analysis of Non-linear Relationship of PM2.5 Mass Concentration with Aerosol Extinction Coefficient and RH in Hefei, China by Yinan Chen, Shiguo Zhang, Yonghua Wu, Kee Yuan, Jian Huang, Dongfeng Shi, Shunxing Hu

“…Next, we evaluated the derived PM2.5 from aerosol extinction with the tapered element oscillating microbalance (TEOM), which independently observed PM2.5 in January 2021; their comparisons indicated good consistency and strong correlation with a linear correlation coefficient of R2 = 0.76. Finally, by applying the analytical function of PM2.5 and aerosol extinction, we obtained the spatial and vertical distribution of PM2.5 from the NASA/CALIPSO-observed aerosol extinction profiles, which showed reasonable agreement and good correlation with the TEOM-measured PM2.5 in several major cities in Anhui Province, China.…”
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The Impact of Vitamin D Deficiency on Coronary Artery Disease Severity Based on Myocardial Perfusion Imaging: A Cross-Sectional Study by Mahdi Haghighatafshar, Behnaz Shekasteband, Tahereh Firuzyar, Zahra Etemadi, Farinaz Farhoudi, Mesbah Shams

“…SSS was notably higher in patients with Vit D levels below 10 ng/mL (P=0.026).Conclusion: The findings of this study emphasize an association between Vit D level below 10 ng/mL and severe myocardial ischemia, as indicated by SSS.…”
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Impact of corticosteroids on the efficacy of first-line pembrolizumab plus chemotherapy in patients with advanced non-small-cell lung cancer by Amytis Roboubi, Eric Wasielewski, Soraya Bordier, Amélie Turlotte, Geoffrey Pavaut, Arnaud Scherpereel, Alexis Cortot, Clément Gauvain

“…However, SC dose was negatively associated with PFS (HR = 1.08 per 10 mg/day increment, 95% CI 1.01–1.16, p  = 0.01) especially at doses ⩾60 mg/day (HR = 3.27 per 10 mg/day increment, 95% CI 2.01–5.35, p  < 0.001). …”
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Maturation and detoxification of synphilin-1 inclusion bodies regulated by sphingolipids by Xiuling Cao, Xiang Wu, Lei Zhao, Ju Zheng, Xuejiao Jin, Xinxin Hao, Joris Winderickx, Shenkui Liu, Lihua Chen, Beidong Liu

“…Here, using a yeast imaging-based screen, we identified 84 potential synphilin-1 (SY1) IB regulators and isolated the conserved sphingolipid metabolic components in the most enriched groups. …”
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Towards the standardization of Hydra vulgaris bioassay for toxicity assessments of liquid samples by G. Farley, P. Bouchard, C. Faille, S. Trottier, F. Gagné

“…A control chart for Zn was developed from over 40 trials yielding an 96 h LC50 of 0.7 mg/L (0.66–0.77 95 % confidence interval-CI) and EC50 of 0.19 mg/L (0.17–0.21 95 % CI). …”
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Medical students and ChatGPT: analyzing attitudes, practices, and academic perceptions by Ahmed Samir Abdelhafiz, Maysa I. Farghly, Eman Anwar Sultan, Moaz Elsayed Abouelmagd, Youssef Ashmawy, Eman Hany Elsebaie

“…Prior to the study, most respondents (78.5%) had personal experience using it. Overall, respondents demonstrated positive perceptions, attitudes, and practices toward ChatGPT, with mean scores exceeding 3 for all three variables: 3.99 ± 0.60 for perceptions, 3.01 ± 0.46 for attitudes, and 3.55 ± 0.55 for practices. …”
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Effectiveness of Anti-Gravity Treadmill Exercise After Total Knee Arthroplasty: Protocol for a Randomized Controlled Trial by Elina Jääskeläinen, Mikko Manninen, Heikki Hurri, Mikko Rantasalo, Yun Zhou, Hannu Kautiainen, Leena Ristolainen

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Air Quality, Atmospheric Variables and Spread of COVID-19 in Delhi (India): An Analysis by Abhishek Dutta, Wanida Jinsart

“…The study found that under the epidemic control measure during 11 May–19 June 2020, the average concentrations of atmospheric air pollutants PM2.5, PM10, NO2, and CO were reduced to 42.15 µg m–3, 128.68 µg m–3, 27.31 ppb, and 0.83 ppm respectively, and were 73.85%, 46.48%, 63.43%, and 50.18% lower than the pre-COVID-19 level of January 2020, respectively. …”
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Flexibility in PAM recognition expands DNA targeting in xCas9 by Kazi A Hossain, Lukasz Nierzwicki, Modesto Orozco, Jacek Czub, Giulia Palermo

“…xCas9 is an evolved variant of the CRISPR-Cas9 genome editing system, engineered to improve specificity and reduce undesired off-target effects. …”
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Associations between phenol and paraben exposure and the risk of developing breast cancer in adult women: a cross-sectional study by Yao Xiong, Zhiyu Li, Xiong Xiong, Zixuan Luo, Kaixin Zhong, Jiawei Hu, Shengrong Sun, Chuang Chen

“…The results from the weighted multivariable regression models indicated that exposure to elevated concentrations of TRS increased the risk of developing BC by 2.33 (Q2: 95% CI = 1.45–3.75, p < 0.001) and 1.94 times (Q3: 95% CI = 1.21–3.09, p = 0.006), respectively. The nonlinear association between TRS concentrations and the risk of developing BC was statistically significant (P nonlinear = 0.007), with the restricted cubic splines (RCS) curve exhibiting an inverted U shape. …”
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Immunological Remission as a Basis for Dose Reduction of Immunosuppressors in Autoimmune Hepatitis: Results of Monocenter Surveillance Study by A. O. Bueverov, S. V. Koblov, P. O. Bogomolov

“…The data of 47 patients with AIH who received immunosuppressive therapy from April 2001 to August 2023 were analyzed: 10 men (21 %), 37 women (79 %); the average age was 37 (17–66) years. The follow-up period was 10–180 months. …”
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WEB-BASED LEARNING AND STUDENTS' SCHOLASTIC ACCOMPLISHMENT AT NATIONAL OPEN UNIVERSITY OF NIGERIA by Taofeek Gbolahan Muibi

“…A questionnaire with 53 questions titled: Experts validated the Online Learning and Learners' Academic Achievement in National Open University of Nigeria Scale (OLLAAS), and Cronbach's alpha yielded a reliability coefficient of 0.76. To test the hypotheses at the 0.05 level of significance, data were analyzed using Multiple Regressions and the Pearson Product Moment Correlation Coefficient. …”
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Efficacy of a simple intravitreal perfluoropropane injection in treating unclosed idiopathic macular holes following vitrectomy by Zexia Dou, Jindong Han, Shaozhen Zhao

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Nutritional assessment using subjective global assessment identifies energy malnutrition and predicts mortality in patients with liver cirrhosis by Takao Miwa, Tatsunori Hanai, Kayoko Nishimura, Sachiyo Hirata, Shinji Unome, Yuki Nakahata, Kenji Imai, Atsushi Suetsugu, Koji Takai, Masahito Shimizu

“…Regarding mortality, 125 patients (54%) died over a median follow-up period of 2.8 years. After adjustment, SGA-B (hazard ratio, 1.81; 95% CI, 1.08–3.03) and SGA-C (hazard ratio, 3.35; 95% CI, 1.28–8.76) were predictors of mortality in cirrhosis patients, while energy malnutrition and FFA were not. …”
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Examining reliability of WHOBARS: a tool to measure the quality of administration of WHO surgical safety checklist using generalisability theory with surgical teams from three New... by Jennifer M Weller, Carmen Skilton, Derryn A Gargiulo, Oleg N Medvedev, Simon J Mitchell, Alan F Merry

“…All elective and acute cases (adults and children) involving surgery under general anaesthesia during normal working hours were eligible.Participants The study included 243 surgical staff members, 138 (50.12%) women.Main outcome measure Absolute generalisability coefficient that accounts for variance due to items, phases, sites and raters for the WHOBARS measure of the quality of WHO Surgical Safety Checklist administration.Results The WHOBARS in its present form has demonstrated good generalisability of scores across teams and raters (G absolute=0.83). The largest source of measurement error was the interaction between the surgical team and the rater, accounting for 16.7% (95% CI 16.4 to 16.9) of the total variance in the data. …”
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Initial use of supplementary oxygen for trauma patients: a systematic review by Trine Grodum Eskesen, Josefine Stokholm Baekgaard, Jacob Steinmetz, Lars S Rasmussen

“…Two independent reviewers screened and identified studies and extracted data from included studies.Results 6142 citations were screened with an inter-rater reliability (Cohen’s kappa) of 0.88. One interventional trial of intubated trauma patients was included. 68 trauma patients were randomised to receive an FiO2 of 0.80 (intervention group) or 0.50 (control group) during mechanical ventilation (first 6 hours). …”
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Hydrochemistry of a Tropical harbor: Influence of Industrial and Municipal inputs by Balogun Kayode James, Ladigbolu Ismail Adejare, Olaji Ebenezer Dayo

“…Surface water of the Harbour was characterized by fairy constant temperature with a range of ( 25.67 – 28.33oC), alkaline pH (7.70 – 8.42mg/l), brackish salinity (7.00 – 22.47PSU), BOD5 and COD values of (0.80 – 3.33mg/l) and (6.10 – 11.30mg/l) respectively, total dissolved solids(6.00 – 19.00mg/l), dissolved oxygen content (4.13 – 7.60mg/l) which fell below FEPA limit of 10mg/l, alkalinity (8.00 – 15.33mg/l), low Nitrate value (0.08 – 0.12mg/l), moderately high Phosphate (0.57 – 1.60mg/l), high Silicate values (1.27 – 9.23mg/l), moderate concentration of heavy metals salts such as Cr (0.03 – 0.60mg/l), Pb (0.22 – 0.61mg/l), Cd (nd – 0.02mg/l, Fe (0.67 – 1.41mg/l) and high Cu values (4.53 – 5.55mg/l). …”
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Psychosocial work characteristic profiles and health outcomes in registered nurses at different stages of their careers: a cross-sectional study by Katri Lönnqvist, Timo Sinervo, Anu-Marja Kaihlanen, Marko Elovainio

“…Methods This cross-sectional study was conducted with 624 early-career registered nurses and 1,016 later-career registered nurses. Data were collected using an electronic survey with internationally validated measures including the Organizational Justice Scale, the Nurse Stress Index Scale, the Job Content Questionnaire, the Team Climate Inventory, the Psychological Distress Questionnaire, the Sleep Problems Questionnaire, and the Self-Rated Health Questionnaire. …”
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