Mediator kinase inhibition suppresses hyperactive interferon signaling in Down syndrome by Kira A Cozzolino, Lynn Sanford, Samuel Hunter, Kayla Molison, Benjamin Erickson, Meaghan CS Courvan, Taylor Jones, Deepa Ajit, Matthew D Galbraith, Joaquín M Espinosa, David Bentley, Mary Ann Allen, Robin D Dowell, Dylan J Taatjes

“…Mediator-associated kinases CDK8 and CDK19 drive inflammatory responses through incompletely understood mechanisms. …”
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Effectiveness and safety profile of mesenchymal stem cell secretome as a treatment for severe cases of COVID-19: a randomized controlled trial [version 2; peer review: 1 approved,... by Hary Sakti Muliawan, Erlina Burhan, Mia Elhidsi, Heri Wibowo, Triya Damayanti, Jeanne Adiwinata Pawitan, Isabella Kurnia Liem, Ismail Hadisoebroto Dilogo, Mira Yulianti, Adityo Susilo, Irandi Putra Pratomo, Raden Rara Diah Handayani, Rahyussalim -, Murdani Abdullah, Cosphiadi Irawan, Robert Sinto, Dita Aditianingsih

“…The IL-6/IL-10 ratio in the control group was significantly increased (p=0.036) on the 14th day after placebo administration. …”
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Gestational weight gain and increased risk of cesarean delivery across body mass index categoriesAJOG Global Reports at a Glance by Pearl A. McElfish, PhD, Britni L. Ayers, PhD, Nicola L. Hawley, PhD, Aaron Caldwell, PhD, Austin Porter, DrPh, Michael D. Macechko, MD, Donya Watson, MD, Jennifer A. Callaghan-Koru, PhD, James P. Selig, PhD, Jennifer A. Andersen, PhD, Nirvana Manning, MD, Lanita White, PharmD, Enrique Gomez-Pomar, MD, Clare C. Brown, PhD

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Lower incidence of hepatocellular carcinoma with tenofovir alafenamide in chronic hepatitis B: Evidence from a large-scale cohort by Hye-Jin Yoo, Jae-Young Kim, Jeong-Ju Yoo, Hye Won Lee, Sang Gyune Kim, Young Seok Kim

“…In patients with cirrhosis, TAF had lower HCC incidence compared with TDF and ETV (30.25 vs. 39.56 and 38.51, respectively). In patients without cirrhosis, the TAF group had a lower HCC incidence compared with the TDF group (IRR 1.19, p = 0.030) but not the ETV group (IRR 0.85, p = 0.066). …”
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Pretpostavke za primjenu pojedinih sustava odgovornosti za štetu zbog smrti ili tjelesnih ozljeda kupača i drugih osoba u moru by Vesna Skorupan Wolff

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Efficacy of 5 µg and 10 µg Dexmedetomidine as Adjuvants to 3 mL 0.5% Hyperbaric Bupivacaine in Pelvic and Lower Limb Orthopaedic Surgeries: A Randomised Clinical Study by Jigisha Bharatbhai Mehta, Shreya Jatin Patel, Nilesh Vrajmohan Shah, Dinesh K Chauhan, Sara Mary Thomas

“…The onset of sensory block was earlier in group D2 (2.01±0.12 min) than in group D1 (2.87±0.36 min) (p-value <0.05). The onset of motor block was also earlier in group D2 (2.63±0.26 min) compared to group D1 (3.36±0.43 min). …”
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The effectiveness of Transcranial Photobiomodulation therapy (tPBM) on reducing anxiety, depression, and opioid craving in patients undergoing methadone maintenance treatment: a do... by Helya Helali, Nastaran Samani, Faraj Tabeie, Shiva Eiliaei, Ali Kheradmand

“…Results Both groups consisted of 32 (91.4%) males and 3 (8.6%) females, with the mean age of patients in the intervention group being 37.97 ± 10.58 years, and 39.66 ± 9.94 years in the control group (P = 0.495). …”
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Long term beef production in extensive cow-calf systems in the tropical savannas of eastern Colombia by R. R. Vera-Infanzón, C. A. Ramírez-Restrepo

“…A lo largo de nueve años de experimentación, la producción de ganancia de peso de vacas más terneros destetos varió entre 86 y 206 kg/ha/año, demostrando las consecuencias de largo plazo del amplio rango de estrategias de manejo experimentadas. …”
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Filtration efficiency of medical and community face masks against particles carrying SARS-CoV-2 by Sara Dalvand, Rasul Nasiri, Rasoul Yarahmadi, Farah Bokharaei-Salim, Ali-Asghar Farshad, Somayeh Soleimani-Alyar

“…Particle filtration efficiency for other masks, including surgical masks, ranged from 31%-68%, and for cloth masks, it was between 28%-86%. …”
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Differential Diagnosis of Jejunum and Ileum Tumours Based on Video Capsule Endoscopy Data Using Mathematical Analysis by E. D. Fedorov, E. V. Ivanova, S. E. Rauzina, D. E. Seleznev, A. V. Budykina

“…In the study, we analysed data on the examination and treatment of 65 patients (35 men and 30 women aged 18–80 years (mean age 46 ± 28 years)), who underwent VCE in the City Clinical Hospital No. 31 and in the Clinica K+31 during the period October 2008 — April 2017. …”
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Multistate Markov model application for blood pressure transition among the Chinese elderly population: a quantitative longitudinal study by Bin Zhao, Juan Xiong, Yuxin Wang, Xujuan Zheng, Yiqin Zhang, Liping Xu, Lina Zhou

“…The corresponding probabilities for elderly men were 21.73%, 38.56% and 51.70%, respectively. For elderly women starting in the elevated state, the probabilities of developing hypertension were 25.07%, 43.03% and 56.32% in the next 1, 2 and 3 years, respectively; while the corresponding changes for elderly men were 20.96%, 37.65% and 50.86%. …”
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Advanced analysis of soil pollution in southwestern Ghana using Variational Autoencoders (VAE) and positive matrix factorization (PMF) by Raymond Webrah Kazapoe, Daniel Kwayisi, Seidu Alidu, Samuel Dzidefo Sagoe, Aliyu Ohiani Umaru, Ebenezer Ebo Yahans Amuah, Millicent Obeng Addai, Obed Fiifi Fynn

“…The PMF revealed three factors: Factor 1 (geogenic): Ba (77.5%), Cu (54.4%), Ni (66.4%), V (54.0) and Cr (46.8%). Factor 2 (mixed) Co (61.6%), Pb (64.8%) and Zn (71.0%). …”
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Overview of Aerosol and Air Pollution in South Eastern Asia Countries by Tsrong-Yi Wen, Somporn Chantara, Juliana Jalaludin, Puji Lestari, Arie Dipareza Syafei, Pham Van Toan, Ying I. Tsai

“…Meanwhile, main sources of PM2.5-10 were soil dust and port industry, construction, road dust, and sea salt, with contributions of 32%, 28.8%, 14%, and 10%, respectively. In Chiang Mai, the highest PM mass and PAHs concentrations were found in the finest particle sizes (0.65 µm–0.43 µm) in periods of intensive open burning (IOB) and low open burning (LOB), in both urban and rural areas, and the PAHs concentration (5.10 ng m−3) in the fine fraction accounted for 45% to 47% and 32% to 37% during IOB and LOB periods, respectively. …”
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Economic evaluation of encorafenib with cetuximab in patients with BRAF V600E-mutant metastatic colorectal cancer in France: a cost-effectiveness analysis using data from the BEACO... by David Malka, Philippe Laramée, Mondher Toumi, Jean-Baptiste Trouiller, Bérengère Macabeo, Andrew Poll, Dan Howard, Andy Buckland, Marine Sivignon, Emilie Clay, Emmanuelle Samalin

“…Deterministic and scenario analyses were conducted.Results The ICER for encorafenib with cetuximab versus cetuximab with FOLFIRI or irinotecan, FOLFIRI alone and bevacizumab with FOLFIRI was €69 823/QALY, €70 421/QALY and €72 336/QALY, respectively. Encorafenib with cetuximab was considered cost-effective compared with the three comparators at a willingness to pay threshold of €90 000/QALY, with probabilities of being cost-effective of 89.8%, 98.2% and 86.4%, respectively.Conclusions This analysis showed encorafenib with cetuximab to be a cost-effective treatment in mCRC patients with a BRAF V600E mutation.…”
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Digital sleep phenotype and wrist actigraphy in individuals at clinical high risk for psychosis and people with schizophrenia spectrum disorders: a systematic review and meta-analy... by Andrea Cipriani, Edoardo Giuseppe Ostinelli, John Torous, Paolo Brambilla, Philip McGuire, Dominic Oliver, Rosario Aronica, Charlotte Austin

“…TST results were inconclusive for CHR-P (MD −4.88 min (95% CI −20.57 to 10.81)), while SSD participants showed an increase in TST compared with HC (MD 106.13 min (86.02 to 124.24)). …”
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Current status and development trends of deep coalbed methane research in China by Wei JU, Shu TAO, Zhaobiao YANG, Jiayao CHENG, Haiyan SHANG, Weike NING, Chunlong WU

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Enhanced vehicle routing for medical waste management via hybrid deep reinforcement learning and optimization algorithms by Norhan Khallaf, Osama Abd-El Rouf, Abeer D. Algarni, Mohy Hadhoud, Ahmed Kafafy

“…Compared to other algorithms that require 5 or 7 vehicles, it reduces the fleet size by 20 and 42.86%, respectively. Additionally, it maximizes vehicle capacity utilization at 100%, unlike other methods, which utilize only 33 to 66% of vehicle capacity. …”
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Caracterización de la biomasa residual de genotipos de alcaucil para su potencial aplicación en alimentos by R. Rotondo, D. Romero, R. Grasso, M. Ortiz Mackinson, D. Balaban, D. Samardich, G. Rodríguez, C. Périgo, A. Escalante

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Efficacy of Group O Washed Red Blood Cell Transfusion on Vital Signs and Hematologic Stability in Trauma Patients With Different Blood Types by Gou XJ, Li LF, He XL, Chen X, Yu AY, Tian WY

“…Both blood pressure and SI enhanced significantly after transfusion (P < 0.05), although no significant change in heart rate (HR) was detected (P = 0.87). Patients with blood group A experienced a significant reduction in HR post-transfusion. …”
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Surveillance and characteristics of vancomycin-resistant Enterococcus isolates in a Chinese tertiary hospital in Shenzhen, 2018 to 2024 by Hongwei Shen, Qiaomin Zhang, Shaobo Li, Tingting Huang, Wen Ma, Daming Wang, Peng Li

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