Impairment of cocaine-mediated behaviours in mice by clinically relevant Ras-ERK inhibitors by Alessandro Papale, Ilaria Maria Morella, Marzia Tina Indrigo, Rick Eugene Bernardi, Livia Marrone, Francesca Marchisella, Andrea Brancale, Rainer Spanagel, Riccardo Brambilla, Stefania Fasano

“…We designed two new cell-penetrating peptides - RB1 and RB3 - that penetrate the brain and, in the micromolar range, inhibit phosphorylation of ERK, histone H3 and S6 ribosomal protein in striatal slices. Furthermore, a screening of small therapeutics currently in clinical trials for cancer therapy revealed PD325901 as a brain-penetrating drug that blocks ERK signalling in the nanomolar range. …”
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Prognostics optical coherence tomography biomarker in macular oedema secondary to retinal vein occlusion by Andrea R. Silitonga, Hanna T.H. Silitonga, Rova Virgana, Iwan Sovani, Arief Kartasasmita, Erwin Iskandar, Grimaldi Ihsan, Made Indra

“…Result: There was a significant improvement in mean BCVA from 1.15 ± 0.42 logMAR to 0.80 ± 0.55 logMAR (P  0.001) and a reduction in mean central macular thickness (CMT) from 732.2 μm ± 298.9 μm to 437.7 μm ± 352.9 μm (P  0.001). …”
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Using computer modeling to find new LRRK2 inhibitors for parkinson’s disease by María C. García, Sebastián A. Cuesta, José R. Mora, Jose L. Paz, Yovani Marrero-Ponce, Frank Alexis, Edgar A. Márquez

“…The best ensemble model showed exceptional predictive performance, with five-fold cross-validation and external validation metrics exceeding 0.8 (Q2cv = 0.864 and Q2ext = 0.873). The DrugBank screening resulted in three promising drugs—triamterene, phenazopyridine, and CRA_1801—with predicted pIC50 values greater than 7, warranting further investigation as novel PD treatments. …”
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Diversidade na formação em saúde: vivências de estudantes de graduação de uma universidade federal by Caroline Izabela Silva, Natália Sevilha Stofel, Flávio Adriano Borges, Irai Maria de Campos Teixeira, Natália Rejane Salim

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Features of the Expression of Second-Type Melatonin Receptors by Esophagus Epiteliocytes in Gastroesophageal Reflux Disease by O. A. Karpovich, T. T. Shtabinskaya, V. I. Shishko, Ya. A. Kolodzeysky

“…A significant decrease in the expression of MTNR1B receptors was noted in patients with ERD compared to NERD patients (0.127 (0.059, 0.156) and 0.436 (0.123, 0.668), respectively; p = 0.017) and patients in the control group (0.437 (0.202, 0.692); p = 0.033). …”
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Assisting significance of lncRNA ASB16-AS1 in the early detection and prognosis prediction of patients with deep venous thrombosis by Menglan Li, Yingying Li, Dawei Zhang, Cheng Cheng, Meiying Yang, Xiuyin Zhang, Xinming Yu, Bo Lu, Min Wang

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Health systems efficiency in China and ASEAN, 2015–2020: a DEA-Tobit and SFA analysis application by Jing Kang, Rong Peng, Zhen Li, Fen Huang, Yujun Chen, Jun Feng, Junyuan Wei, Fu Yu, Xiaorong Su, Xianjing Qin, Qiming Feng

“…In the past 6 years, the TFP index of the health system in Malaysia was higher than 1, while the TFP index of other countries was lower than 1. …”
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Burnout in Healthcare Professionals during Covid-19 Crisis by Nasim Hajipoor Kashgsaray, Maryam Soleimanpour, Sina Behmanesh, Hassan Soleimanpour

“…Results: According to the comparison of the high burnout rate in the Copenhagen burnout scale, 50% of doctors and 57.1% of nurses had personal burnout, 56.8% of doctors and 66.7% of nurses had work-related burnout, 69.4% of doctors and 69% of nurses had patient-related burnout, and the overall rate of high burnout in doctors was reported as 62.9% and nurses as 70.4%. …”
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Serum calprotectin and renal function decline in ANCA-associated vasculitides: a post hoc analysis of MAINRITSAN trial by Xavier Romand, Benjamin Terrier, Athan Baillet, Philippe Gaudin, Loic Guillevin, Christian Pagnoux, Minh Vu Chuong, Marie Hélène Paclet

“…Serum calprotectin increased from baseline to month 6 in patients with renal function decline (7940 (−226.0, 28 691) ng/ml vs −4800 (−18 777, 3708) ng/ml; p<0.001). …”
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Comparative efficacy of acupuncture therapies in premature ovarian failure: A systematic review and network meta-analysis by Yonghang Yi, Fengjun Ma, Yang Jiao, Rongqi Zhang, Yunhao Yi, Yuxia Ma

“…The NMA results indicated that moxibustion_catgut implantation at acupoint (MB_CIA) (P-score = 0.88; pooled mean difference (95 % CI): 22.07 (1.61–302.48)) showed the highest improvement in overall effectiveness, while warming acupuncture (WA) (0.95; −27.56 (-45.35 to −9.78)) improved follicle-stimulating hormone (FSH) levels best. …”
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Changes in Tropospheric Nitrogen Dioxide Vertical Column Densities over Japan and Korea during the COVID-19 Using Pandora and MAX-DOAS by Yongjoo Choi, Yugo Kanaya, Hisahiro Takashima, Kihong Park, Haebum Lee, Jihyo Chong, Jae Hwan Kim, Jin-Soo Park

“…High negative relative changes were observed from May to September (−30% to −18%) at the three urban sites; Cape Hedo, a remote site, did not show a significant difference in relative changes between previous years and 2020, suggesting that only anthropogenic emission sources decreased dramatically. …”
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Prevalence of childhood overweight and obesity in Malaysia: a systematic review and meta-analysis by Ker Yang Chua, Ker Yung Chua, Karuthan Chinna, Chooi Ling Lim, Maheeka Seneviwickrama

“…Boys had a significantly higher proportion of obesity (12.5% [95% CI, 11.1%–14.1%] vs. 9.1% [95% CI, 8.1%–10.1%]) and excess weight (25.7% [95% CI, 23.5%–28.1%] vs. 20.7% [95% CI, 18.8%–22.8%]) than girls. …”
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Is There a Role of 25-Hydroxy Vitamin D in the Pathogenesis of Mild and Moderate-to-Severe Endometriosis? by Nevin Tuten, Serdar Acikgoz, Zahid Mammadov, Eduard Malik, Abdullah Tuten, Onur Guralp

“…The women who had bilateral endometrioma had significantly lower levels of 25-hydroxy vitamin D compared to the women with unilateral endometrioma (8.4±2.7 ng/mL vs 11.1±5.6 ng/mL, p=0.047). Mean serum 25-hydroxy vitamin D levels in women with and without dysmenorrhea were not significantly different from each other in the endometriosis and non-endometriosis subgroups. …”
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Analysis of Surface Level PM2.5 Measured by Low-Cost Sensor and Satellite-Based Column Aerosol Optical Depth (AOD) over Kathmandu by Jeevan Regmi, Khem N. Poudyal, Amod Pokhrel, Nabin Malakar, Madhu Gyawali, Lekhendra Tripathee, Mukesh Rai, Srikanthan Ramachandran, Katrina Wilson, Rudra Aryal

“…PurpleAir records PM2.5 with a maximum average of 101 ± 26.31 µg m−3, in winter, 55.58 ± 11.42 µg m−3, in spring, 45.46 ± 12.16 µg m−3, in autumn, and a minimum of 22.78 ± 3.23 µg m−3, in the summer. …”
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Prenatal malaria exposure and risk of adverse birth outcomes: a prospective cohort study of pregnant women in the Northern Region of Ghana by Akbar Fotouhi, Masud Yunesian, Hawawu Hussein, Mansour Shamsipour, Mohammad Sadegh Hassanvand, Percival Delali Agordoh, Mashoud Alabi Seidu

“…After adjusting for newborn admissions to the neonatal intensive care unit, parity, maternal age and glucose-6-phosphate dehydrogenase, women who were exposed to malaria during the third trimester of pregnancy had 2.02 times (95% CI 1.36 to 2.99) higher odds of premature delivery. …”
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A Pilot Study Assessing Left Ventricle Diastolic Function in the Parasternal Long-axis View by Mümin Murat Yazici, Nurullah Parça, Enes Hamdioğlu, Meryem Kaçan, Özcan Yavas¸i, Özlem Bilir

“…The study population of 40 (included rate 14%) was formed after the exclusion criteria were applied to 285 patients who met these conditions. Patients included in the study underwent spectral Doppler measurements in the apical four-chamber (A4C) view followed by M-mode measurements in the PSLA view. …”
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Economic and Clinical Impact of Stroke and Warfarin Use for Patients with Non-valvular Atrial Fibrillation by Li Wang, Elyse Fritschel, Onur Baser

“…Stroke patients were older on average (78.94 vs. 77.28 years, p-value<0.0001) with significantly higher risk-adjusted inpatient mortality (7.14% vs. 2.09%, p-value<0.0001), emergency room visits (79.97% vs. 46.34%, p-value<0.0001), and average LOS measures (overall: 10.20 vs. 6.83 days, p<0.0001; cardiovascular-related: 8.35 vs. 5.90 days, p-value<0.0001). …”
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Outcomes of Surgical Treatment of Multiple Primary Colorectal and Prostate Cancer by I. S. Ignatov, V. V. Balaban, E. A. Bezrukov, A. V. Nikishina, M. He, P. V. Tsarkov

“…Radical prostatectomy was performed via laparotomy significantly less frequently in the group with the synchronous variant than in the group with the metachronous cancer (0 % vs. 58.8 %; p = 0.046). No significant differences were found when comparing overall and recurrence-free survival in groups with metachronous and synchronous variants of multiple primary cancer.Conclusions. …”
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Аналіз конструкцій та методика розрахунку мазутних пальників для опалювальних систем by Ігор Токарський, Володимир Габрінець

“…PURL: https://purl.org/cims/2403.006 …”
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The Impact of Reich’s Vegetotherapy on Emotional Regulation and Postural Balance in Military Personnel: A Non-Pharmacological Approach to Combat Stress by Sana Khadhrani, Imed Touhemi, Amri Hammami, Chiraz Goumni, Jihen Khalfoun, Mohanad Omar, Rebai Haithem, Abderraouf Ben Abderrahman

“…The EG experienced a greater improvement (-68%) compared to the CG (−9%) ( p  = .036). In the open-eyes postural balance test, the EG showed a significant improvement ( p  = .029), with a time × group interaction effect ( p  = .04), although no significant difference was found between the groups ( p  > .05). …”
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