Advancing Alzheimer’s disease risk prediction: development and validation of a machine learning-based preclinical screening model in a cross-sectional study by Yanfei Chen, Bing Wang, Yankai Shi, Wenhao Qi, Shihua Cao, Bingsheng Wang, Ruihan Xie, Jiani Yao, Xiajing Lou, Chaoqun Dong, Xiaohong Zhu, Danni He

“…The XGBoost model exhibited superior performance compared with other models, achieving area under the curve of 0.915, sensitivity of 76.2% and specificity of 92.9%. The most influential predictors were educational level, total medication count, age, sbp and BMI.Conclusions The proposed classifier can help guide preclinical screening of AD in the elderly population.…”
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Effect of Alkali Lignin on Laccase Activity and Mycelial Biomass of Flammulina velutipes by Mei-Ling Han, Yi-Lin Zhao, Tian-Yu Liu, Lu-Sen Bian, Zi-Han Li, Ming-Xue Li, Jia Li, Xiao-Qi Yang, Qi An

“…F. velutipes were more suitable for secreting laccase at 26 ℃ due to the maximum laccase activity measured at 26 ℃ (73.42 ± 4.74 U/L) higher than that measured at 33 ℃ (70.71 ± 6.89 U/L). …”
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Effects of pesticide dichlorvos on liver injury in rats and related toxicity mechanisms by Pengcheng Zhang, Zixian Zhou, Jiaqi Yao, Yuhong Jiang, Hang Lei, Zhijun Xie, Juan Li, Xianlin Zhao, Lv Zhu, Meihua Wan, Ling Liu, Wenfu Tang

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Proteomics unveil candidate biomarkers and pathogenesis of subacute thyroiditis by Litong Ran, Xiufei Liu, Yongfeng Tian, Jiaran Zhu, Zhengyuan Gong, Qiao Qiao, Xin Jiang, Yuren Wang, Guojun Yang, Hongting Zheng, Yi Zheng, Hua Qu

“…The results revealed that each factor demonstrated an area under the curve score above 0.8. Thus, these high-abundance proteins can potentially serve as biomarkers for SAT diagnosis and outcome prediction. …”
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Identification of a ubiquitin-protein ligase MaUPL6 modulating the response to Fusarium wilt in banana by Yaoyao Li, Jingfang Shi, Yile Huo, Xueyi Xie, Qiaosong Yang, Chunhua Hu, Ou Sheng, Fangcheng Bi, Chunyu Li, Ganjun Yi, Wei Wei, Tongxin Dou

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Original vegetation condition and precipitation growth rate bifurcate sediment flux trend on the Qinghai-Tibet Plateau by Jinhao Guo, Yao Yue, Wenxin Huai, Xia Yan, Alistair G. L. Borthwick, Yuanfang Chai, Shuolin Li, Zhiwei Li, Yichu Wang, Chiyuan Miao, Zhonghua Yang

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Flavones enrich rhizosphere Pseudomonas to enhance nitrogen utilization and secondary root growth in Populus by Jiadong Wu, Sijia Liu, Haoyu Zhang, Sisi Chen, Jingna Si, Lin Liu, Yue Wang, Shuxian Tan, Yuxin Du, Zhelun Jin, Jianbo Xie, Deqiang Zhang

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Genetics and biological characteristics of duck reoviruses isolated from ducks and geese in China by Xiaohong Sun, Jing Guo, Jinyan Shen, Mengdi Guan, Lili Liu, Yujiao Xie, Hongke Xu, Mengjing Wang, Anran Ren, Wenxi Li, Feng Cong, Xuyong Li

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Evaluation of risk factors associated with fragility fractures and recommendations to optimise bone health in children with long-term neurological condition by Xue Yi Jessica Leow, Jonathan Tian Ci Tan, Tong Hong Yeo, Kenneth Pak Leung Wong, Arjandas Mahadev, Bixia Ang, Rashida Farhad Vasanwala, Zhi Min Ng

“…Results: In a tertiary clinic population of 136 patients with LTNC, 65% were dependent on mobility (Gross Motor Function Classification System [GMFCS] V), 60% were underweight and 60% were fed via gastrostomy or nasogastric tube, or were on oral pureed diet. …”
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Retrospective comparative survival analysis of ablation plus systemic therapy versus systemic therapy alone for breast cancer liver metastases, stratified by extrahepatic metastase... by Xuxiazi Zou, Hong-Liang Zou, Xuan Luo, Xu-Wei Chen, Wei-Ling Huang, Chao Zhang, Ge Ren, Jin-Hua Huang, Xue Han, Yi-Quan Jiang

“…After PSM, among patients with BCLM (≤3 tumors, each ≤3 cm), the median overall survival (OS) for those treated with AS or systemic therapy alone was 65.5 and 40.4 months, respectively (HR = 0.48, p = .003); in the subset of patients with extrahepatic metastases, the median OS for those treated with AS and systemic therapy alone was 46.4 and 40.8 months, respectively (HR = 0.58, p = .047). …”
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Diisooctyl phthalate (DIOP) exposure leads to cell apoptosis to HUVEC cells and toxicity to Caenorhabditis elegans through increasing the oxidative stress by Siyuan Luo, Junnan Li, Yuqing Zhou, Zihang Zhai, Qiang Li, Zhenglin Huang, Wencan He, Kejun Zhong, Bo Kong, Zanxian Xia, Hang Fai Kwok, Lipeng Zhu

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EGFR inhibition augments the therapeutic efficacy of the NAT10 inhibitor Remodelin in Colorectal cancer by Yongbin Zheng, Dan Song, Ming Guo, Chenhong Wang, Mingzhen Ma, Gongcai Tao, Licui Liu, Xiaobo He, Fengyu Cao, Dan Luo, Qingchuan Zhao, Zhongyuan Xia, Yanxin An

“…Additional in vivo and in vitro experiments, including CCK-8 assays, colony formation and mouse xenograft models, were conducted to explore the biological role of NAT10-mediated ac4C modifications. …”
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A novel high-throughput screen identifies phenazine-1-carboxylic acid as an inhibitor of African swine fever virus replication in primary porcine alveolar macrophages by Jing Lan, Rui Luo, Di Liu, Changxing Qi, Xin Song, Zhanhao Lu, Ruojia Huang, Yuying Yang, Yuan Sun, Yonghui Zhang, Tao Wang, Hua-Ji Qiu

“…Using the HTS platform established with rASFV-Gluc/EGFP, we screened and identified phenazine-1-carboxylic acid (PCA) as an effective inhibitor of ASFV replication from 246 small molecule compounds in PAMs. Importantly, PCA was found to reduce ASFV replication by as much as 100-fold at a concentration of 25 μM. …”
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Heterologous expression of SpsTAC2 in Arabidopsis affected branch angle and secondary vascular system development by Fangshu Niu, Mengru Yuan, Hongxia Zhao, Zhi Pang, Jie Yan, RuiXie Ning, Lin Shi, Fengqiang Yu, Dongshan Wei, Rong Yang, Runming Zhang, Haifeng Yang

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Association of blood cadmium and physical activity with mortality: A prospective cohort study by Yilin Chen, Cien Zhen, Lin Zeng, Hongliang Feng, Jinyu Wang, Qi Yong H. Ai, Sizhi Ai, Jihui Zhang, Yannis Yan Liang, Huachen Xue, Yujing Zhou

“…During a median follow-up of 7.6 years, a total of 2002 (9.89 %) all-cause deaths occurred, of which 581 (2.87 %) participants were due to cardiovascular disease (CVD) and 498 (2.46 %) died of cancer. …”
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Optical time-lapsed in situ mechanochemical studies on metal halide perovskite systems by Yonghao Xiao, David G. Bradley, Wei Xin Chan, Xinwen Hu, Lian Xiao, Zhenpeng Liu, Zi Yang Tan, Xin Zhao, Chenfei Li, Mansour Sadek, Vikash Kumar Ravi, Ying Hern Tam, Xiaotao Wang, Felipe García, Handong Sun, Seow Chin Low, Poh Boon Phua, Tze Chien Sum, Xiuwen Zhou, Yee-Fun Lim, John V. Hanna, Han Sen Soo

“…The TLIS spectrometer enabled real-time observation of the impact of varying the compositions on the absorption properties of formamidinium/methylammonium lead iodide (FA x MA1-x PbI3, x = 0 to 1) and facilitated optimization of the synthesis duration. …”
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Integrative analysis of immunogenic PANoptosis and experimental validation of cinobufagin-induced activation to enhance glioma immunotherapy by Yonghua Cai, Heng Xiao, Shuaishuai Xue, Peng Li, Zhengming Zhan, Jie Lin, Zibin Song, Jun Liu, Wei Xu, Qixiong Zhou, Songtao Qi, Xi’an Zhang, Ziyi Luo

“…Cinobufagin effectively induced PANoptosis, leading to increased immunogenic cell death, facilitated tumor-associated microglia/macrophages (TAMs) polarization towards an M1-like phenotype while augmenting CD4+/CD8 + T cell infiltration and activation. Importantly, cinobufagin combined with anti-PD-1 therapy exhibited significant synergistic effects and prolonged survival in GBM models. …”
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