CDK1 mediates the metabolic regulation of DNA double-strand break repair in metaphase II oocytes

CDK1 mediates the metabolic regulation of DNA double-strand break repair in metaphase II oocytes

Abstract Background During oocyte maturation, DNA double-strand breaks (DSBs) can decrease oocyte quality or cause mutations. How DSBs are repaired in dividing oocytes and which factors influence DSB repair are not well understood. Results By analyzing DSB repair pathways in oocytes at different sta...

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Bibliographic Details
Main Authors: Tian-Jin Xia, Feng-Yun Xie, Juan Chen, Xiao-Guohui Zhang, Sen Li, Qing-Yuan Sun, Qin Zhang, Shen Yin, Xiang-Hong Ou, Jun-Yu Ma
Format: Article
Language:English
Published: BMC 2025-02-01
Series:BMC Biology
Subjects:
Oocytes
Double-strand breaks
RAD51
53BP1
Break-induced replication
Theta-mediated end joining
Online Access:https://doi.org/10.1186/s12915-025-02142-w
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