Establishment and characterization of three gemcitabine-resistant human intrahepatic cholangiocarcinoma cell lines
Abstract Intrahepatic cholangiocarcinoma (ICC) is a highly malignant liver tumor associated with a dismal prognosis, largely due to chemotherapy resistance. However, the mechanisms underlying gemcitabine (GEM) resistance in ICC remain poorly understood. In this study, we established three GEM-resist...
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Main Authors: | Jiandong Li, Yanxin Hu, Jiayao Zhang, Weiguang Zhang, Jianhua Yu, Baochun Lu |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2025-02-01
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Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-025-89423-0 |
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