Luteolin: exploring its therapeutic potential and molecular mechanisms in pulmonary diseases
Luteolin is a flavonoid widely found in plants, including vegetables, botanical drugs, and fruits. Owing to its diverse pharmacological activities, such as anticancer, oxidative stress protection, anti-inflammatory, and neuron-preserving effects, luteolin has attracted attention in research and medi...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1535555/full |
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| author | Jialian Lv Xinyue Song Zixin Luo Duoqin Huang Li Xiao Kang Zou |
| author_facet | Jialian Lv Xinyue Song Zixin Luo Duoqin Huang Li Xiao Kang Zou |
| author_sort | Jialian Lv |
| collection | DOAJ |
| description | Luteolin is a flavonoid widely found in plants, including vegetables, botanical drugs, and fruits. Owing to its diverse pharmacological activities, such as anticancer, oxidative stress protection, anti-inflammatory, and neuron-preserving effects, luteolin has attracted attention in research and medicine. Luteolin exhibits therapeutic effects on various pulmonary disease models through multiple molecular mechanisms; these include inhibition of activation of the PI3K/Akt-mediated Nuclear Factor kappa-B (NF-κB) and MAPK signaling pathways, as well as the promotion of regulatory T cell (Treg) function and enhancement of alveolar epithelial sodium channel (ENaC) activity (alleviating inflammation and oxidative stress responses). Luteolin has therapeutic effects on chronic obstructive pulmonary disease (COPD), acute lung injury/acute respiratory distress syndrome (ALI/ARDS), pulmonary fibrosis, allergic asthma, and lung cancer. Luteolin, a naturally occurring polyphenol, is poorly water-soluble. The oral route may be ineffective because the gut poorly absorbs this type of flavonoid. Therefore, although luteolin exhibits significant biological activity, its clinical application is limited by challenges associated with its poor water solubility and low bioavailability, which are critical factors for its efficacy and pharmacological application. These challenges can be addressed by modifying the chemical structure and enhancing pharmaceutical formulations. We summarized the research advancements in improving the solubility and bioavailability of luteolin, as well as the effects of luteolin on various pulmonary diseases and their related mechanisms, with the aim of providing new ideas for researchers. |
| format | Article |
| id | doaj-art-12356c43607948b4910211dbd4b16454 |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-12356c43607948b4910211dbd4b164542025-02-12T07:26:10ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-02-011610.3389/fphar.2025.15355551535555Luteolin: exploring its therapeutic potential and molecular mechanisms in pulmonary diseasesJialian Lv0Xinyue Song1Zixin Luo2Duoqin Huang3Li Xiao4Kang Zou5The First Clinical Medical College, Gannan Medical University, Ganzhou, Jiangxi, ChinaThe First Clinical Medical College, Gannan Medical University, Ganzhou, Jiangxi, ChinaThe First Clinical Medical College, Gannan Medical University, Ganzhou, Jiangxi, ChinaThe First Clinical Medical College, Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Rehabilitation Medicine, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Critical Care Medicine, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaLuteolin is a flavonoid widely found in plants, including vegetables, botanical drugs, and fruits. Owing to its diverse pharmacological activities, such as anticancer, oxidative stress protection, anti-inflammatory, and neuron-preserving effects, luteolin has attracted attention in research and medicine. Luteolin exhibits therapeutic effects on various pulmonary disease models through multiple molecular mechanisms; these include inhibition of activation of the PI3K/Akt-mediated Nuclear Factor kappa-B (NF-κB) and MAPK signaling pathways, as well as the promotion of regulatory T cell (Treg) function and enhancement of alveolar epithelial sodium channel (ENaC) activity (alleviating inflammation and oxidative stress responses). Luteolin has therapeutic effects on chronic obstructive pulmonary disease (COPD), acute lung injury/acute respiratory distress syndrome (ALI/ARDS), pulmonary fibrosis, allergic asthma, and lung cancer. Luteolin, a naturally occurring polyphenol, is poorly water-soluble. The oral route may be ineffective because the gut poorly absorbs this type of flavonoid. Therefore, although luteolin exhibits significant biological activity, its clinical application is limited by challenges associated with its poor water solubility and low bioavailability, which are critical factors for its efficacy and pharmacological application. These challenges can be addressed by modifying the chemical structure and enhancing pharmaceutical formulations. We summarized the research advancements in improving the solubility and bioavailability of luteolin, as well as the effects of luteolin on various pulmonary diseases and their related mechanisms, with the aim of providing new ideas for researchers.https://www.frontiersin.org/articles/10.3389/fphar.2025.1535555/fullluteolinpulmonary diseasesmolecular mechanismsbioavailabilitypharmacokineticspharmacological activities |
| spellingShingle | Jialian Lv Xinyue Song Zixin Luo Duoqin Huang Li Xiao Kang Zou Luteolin: exploring its therapeutic potential and molecular mechanisms in pulmonary diseases Frontiers in Pharmacology luteolin pulmonary diseases molecular mechanisms bioavailability pharmacokinetics pharmacological activities |
| title | Luteolin: exploring its therapeutic potential and molecular mechanisms in pulmonary diseases |
| title_full | Luteolin: exploring its therapeutic potential and molecular mechanisms in pulmonary diseases |
| title_fullStr | Luteolin: exploring its therapeutic potential and molecular mechanisms in pulmonary diseases |
| title_full_unstemmed | Luteolin: exploring its therapeutic potential and molecular mechanisms in pulmonary diseases |
| title_short | Luteolin: exploring its therapeutic potential and molecular mechanisms in pulmonary diseases |
| title_sort | luteolin exploring its therapeutic potential and molecular mechanisms in pulmonary diseases |
| topic | luteolin pulmonary diseases molecular mechanisms bioavailability pharmacokinetics pharmacological activities |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1535555/full |
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