Maturation and detoxification of synphilin-1 inclusion bodies regulated by sphingolipids

Maturation and detoxification of synphilin-1 inclusion bodies regulated by sphingolipids

Due to proteostasis stress induced by aging or disease, misfolded proteins can form toxic intermediate species of aggregates and eventually mature into less toxic inclusion bodies (IBs). Here, using a yeast imaging-based screen, we identified 84 potential synphilin-1 (SY1) IB regulators and isolated...

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Bibliographic Details
Main Authors: Xiuling Cao, Xiang Wu, Lei Zhao, Ju Zheng, Xuejiao Jin, Xinxin Hao, Joris Winderickx, Shenkui Liu, Lihua Chen, Beidong Liu
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-02-01
Series:eLife
Subjects:
synphilin-1
sphingolipids
inclusion bodies
imaging-based screen
mitochondrion
mammalian cells
Online Access:https://elifesciences.org/articles/92180
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https://elifesciences.org/articles/92180

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