Stapled peptides: targeting protein-protein interactions in drug development
Protein-protein interactions (PPIs) impersonate a significant role in many biological processes and are potential therapeutic targets in numerous human diseases. Stapled peptides, as the most promising therapeutic candidate for interfering with PPIs, have a higher degree of α-helicity, improved bind...
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| Format: | Article |
| Language: | English |
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Open Exploration
2024-04-01
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| Series: | Exploration of Drug Science |
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| Online Access: | https://www.explorationpub.com/uploads/Article/A100841/100841.pdf |
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| _version_ | 1825199550886838272 |
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| author | Qian Zhang Ziyang Wang Xiaohan Mei Quan Chen Chunqiu Zhang |
| author_facet | Qian Zhang Ziyang Wang Xiaohan Mei Quan Chen Chunqiu Zhang |
| author_sort | Qian Zhang |
| collection | DOAJ |
| description | Protein-protein interactions (PPIs) impersonate a significant role in many biological processes and are potential therapeutic targets in numerous human diseases. Stapled peptides, as the most promising therapeutic candidate for interfering with PPIs, have a higher degree of α-helicity, improved binding affinity, more resistance to proteolytic digestion, longer serum half-life, and enhanced cell permeability, which exhibits higher pharmacological activity compared with small molecule drugs and biologics. This review outlined the continuous progress of stapled peptides mainly concerning the design principle, structural stability, bioactivity, cell permeability, and potential applications in therapeutics, which is aimed at providing a broad reference for the design and exploration of stapled peptides with enhanced biological and pharmacokinetic properties as the next-generation therapeutic peptide drugs targeting various diseases. |
| format | Article |
| id | doaj-art-14f7b8423e2c44498f14da4c6f023e71 |
| institution | Kabale University |
| issn | 2836-7677 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | Open Exploration |
| record_format | Article |
| series | Exploration of Drug Science |
| spelling | doaj-art-14f7b8423e2c44498f14da4c6f023e712025-02-08T04:48:17ZengOpen ExplorationExploration of Drug Science2836-76772024-04-012215418910.37349/eds.2024.00041Stapled peptides: targeting protein-protein interactions in drug developmentQian Zhang0https://orcid.org/0009-0005-8395-5244Ziyang Wang1https://orcid.org/0009-0003-9300-0965Xiaohan Mei2https://orcid.org/0009-0000-1623-2285Quan Chen3https://orcid.org/0000-0001-7539-8728Chunqiu Zhang4https://orcid.org/0000-0001-8674-880XState Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials of Ministry of Education and College of Life Sciences, Nankai University, Tianjin 300071, ChinaState Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials of Ministry of Education and College of Life Sciences, Nankai University, Tianjin 300071, ChinaState Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials of Ministry of Education and College of Life Sciences, Nankai University, Tianjin 300071, ChinaState Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials of Ministry of Education and College of Life Sciences, Nankai University, Tianjin 300071, ChinaState Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials of Ministry of Education and College of Life Sciences, Nankai University, Tianjin 300071, ChinaProtein-protein interactions (PPIs) impersonate a significant role in many biological processes and are potential therapeutic targets in numerous human diseases. Stapled peptides, as the most promising therapeutic candidate for interfering with PPIs, have a higher degree of α-helicity, improved binding affinity, more resistance to proteolytic digestion, longer serum half-life, and enhanced cell permeability, which exhibits higher pharmacological activity compared with small molecule drugs and biologics. This review outlined the continuous progress of stapled peptides mainly concerning the design principle, structural stability, bioactivity, cell permeability, and potential applications in therapeutics, which is aimed at providing a broad reference for the design and exploration of stapled peptides with enhanced biological and pharmacokinetic properties as the next-generation therapeutic peptide drugs targeting various diseases.https://www.explorationpub.com/uploads/Article/A100841/100841.pdfstapled peptidesprotein-protein interactionspharmacological |
| spellingShingle | Qian Zhang Ziyang Wang Xiaohan Mei Quan Chen Chunqiu Zhang Stapled peptides: targeting protein-protein interactions in drug development Exploration of Drug Science stapled peptides protein-protein interactions pharmacological |
| title | Stapled peptides: targeting protein-protein interactions in drug development |
| title_full | Stapled peptides: targeting protein-protein interactions in drug development |
| title_fullStr | Stapled peptides: targeting protein-protein interactions in drug development |
| title_full_unstemmed | Stapled peptides: targeting protein-protein interactions in drug development |
| title_short | Stapled peptides: targeting protein-protein interactions in drug development |
| title_sort | stapled peptides targeting protein protein interactions in drug development |
| topic | stapled peptides protein-protein interactions pharmacological |
| url | https://www.explorationpub.com/uploads/Article/A100841/100841.pdf |
| work_keys_str_mv | AT qianzhang stapledpeptidestargetingproteinproteininteractionsindrugdevelopment AT ziyangwang stapledpeptidestargetingproteinproteininteractionsindrugdevelopment AT xiaohanmei stapledpeptidestargetingproteinproteininteractionsindrugdevelopment AT quanchen stapledpeptidestargetingproteinproteininteractionsindrugdevelopment AT chunqiuzhang stapledpeptidestargetingproteinproteininteractionsindrugdevelopment |