Free fatty acids may regulate the expression of 11β-hydroxysteroid dehydrogenase type 1 in the liver of high-fat diet golden hamsters through the ERS-CHOP-C/EBPα signaling pathway

Free fatty acids may regulate the expression of 11β-hydroxysteroid dehydrogenase type 1 in the liver of high-fat diet golden hamsters through the ERS-CHOP-C/EBPα signaling pathway

Abstract Objective Free fatty acids (FFA) can increase the expression of 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) in local tissues and organs. However, the mechanism underlying the effect of FFA on 11β-HSD1 expression remains unclear. Methods A total of 24 male Syrian golden hamsters (SPF grade...

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Main Authors: Dandan Liu, Peipei Tian, Yilin Hou, Tingxue Zhang, Xiaoyu Hou, Lifang Liu, Xiaolong Li, Kunjie Zheng, Chao Wang, Guangyao Song
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Lipids in Health and Disease
Subjects:
Free fatty acids
11β-hydroxysteroid dehydrogenase 1
Endoplasmic reticulum stress
CCAAT/enhancer-binding protein homologous protein
CCAAT/enhancer-binding protein α
Corticosterone
Online Access:https://doi.org/10.1186/s12944-025-02461-5
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https://doi.org/10.1186/s12944-025-02461-5

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